DK0721470T3 - Monoklonale antistoffer der er nyttige til diagnosticering og behandling af colorektal kræft - Google Patents

Monoklonale antistoffer der er nyttige til diagnosticering og behandling af colorektal kræft

Info

Publication number
DK0721470T3
DK0721470T3 DK94923816T DK94923816T DK0721470T3 DK 0721470 T3 DK0721470 T3 DK 0721470T3 DK 94923816 T DK94923816 T DK 94923816T DK 94923816 T DK94923816 T DK 94923816T DK 0721470 T3 DK0721470 T3 DK 0721470T3
Authority
DK
Denmark
Prior art keywords
pct
chain
sequence
human
residues
Prior art date
Application number
DK94923816T
Other languages
English (en)
Inventor
Lorna Mary Dyet Stewart
Walter Fred Bodmer
Helga Durbin
David Snary
Susan Young
Paul Alan Bates
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of DK0721470T3 publication Critical patent/DK0721470T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK94923816T 1993-08-21 1994-08-19 Monoklonale antistoffer der er nyttige til diagnosticering og behandling af colorektal kræft DK0721470T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939317423A GB9317423D0 (en) 1993-08-21 1993-08-21 Monoclonal antibodies
PCT/GB1994/001816 WO1995006067A1 (en) 1993-08-21 1994-08-19 Monoclonal antibodies for use in diagnosis and treatment of colorectal cancer

Publications (1)

Publication Number Publication Date
DK0721470T3 true DK0721470T3 (da) 2003-02-24

Family

ID=10740834

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94923816T DK0721470T3 (da) 1993-08-21 1994-08-19 Monoklonale antistoffer der er nyttige til diagnosticering og behandling af colorektal kræft

Country Status (12)

Country Link
US (1) US5965710A (da)
EP (1) EP0721470B1 (da)
JP (1) JP3492373B2 (da)
AT (1) ATE226596T1 (da)
AU (1) AU7390694A (da)
CA (1) CA2168440C (da)
DE (1) DE69431602T2 (da)
DK (1) DK0721470T3 (da)
ES (1) ES2187529T3 (da)
GB (1) GB9317423D0 (da)
PT (1) PT721470E (da)
WO (1) WO1995006067A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872215A (en) * 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
GB9621295D0 (en) * 1995-12-07 1996-11-27 Cambridge Antibody Tech Specific binding members,materials and methods
US6417337B1 (en) * 1996-10-31 2002-07-09 The Dow Chemical Company High affinity humanized anti-CEA monoclonal antibodies
AU8691398A (en) * 1997-08-04 1999-02-22 Ixsys, Incorporated Methods for identifying ligand specific binding molecules
DE19739685A1 (de) * 1997-09-10 1999-03-11 Eichel Streiber Christoph Von Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
WO2001013937A1 (en) * 1999-08-26 2001-03-01 Skubitz Keith M Peptides capable of modulating the function of cd66 (ceacam) family members
US6835549B2 (en) * 2000-02-24 2004-12-28 University Of Medicine & Dentistry Of New Jersey Immunoassay method for the diagnosis of gastric intestinal metaplasia associated with gastric carcinoma
US6774209B1 (en) 2000-04-03 2004-08-10 Dyax Corp. Binding peptides for carcinoembryonic antigen (CEA)
WO2002068601A2 (en) * 2001-02-28 2002-09-06 Skubitz Keith M Small peptides capable of modulating the function of cd66 (ceacam) family members
CN100523216C (zh) * 2001-03-02 2009-08-05 匹兹堡大学 Pcr方法
CA2633171C (en) * 2001-06-20 2012-11-20 Genentech, Inc. Antibodies against tumor-associated antigenic target (tat) polypeptides
CA2517908A1 (en) * 2003-03-04 2005-02-10 Auburn University Methods of forming monolayers of phage-derived products and uses thereof
US7457855B2 (en) * 2004-04-30 2008-11-25 Aol Llc Network configuration management
US8187595B2 (en) 2004-05-07 2012-05-29 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I
KR20070085275A (ko) * 2004-09-20 2007-08-27 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 멀티플 모드에 의한 멀티플렉스 반응 억제 방법
CA2618796C (en) * 2005-08-11 2018-01-02 Arpi Matossian-Rogers Peptides for treatment and diagnosis of autoimmune disease
WO2007041206A2 (en) * 2005-09-30 2007-04-12 Auburn University Drug delivery nanocarriers targeted by landscape phage
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
WO2009106102A1 (de) * 2008-02-29 2009-09-03 Signalomics Gmbh Optimierte adhäsin-fragmente und entsprechende nanopartikel
BR112012003983A2 (pt) * 2009-08-31 2021-09-14 Roche Glycart Ag Molecula de ligação abm moleculas de ligação de antigenos abm variante polipeptideo isolado molecula de ligação de antigeneos humanizada anticorpo polinucleotideo isolado composição vetor celula hospedeira metodo de produção de abm metodo de indução da lise celular de tumor, metodo de diagnostico de doença em pacientes que possuem um cancer metodo de aumento de tempo de sobrevivencia em pacientes que possuem um cancer metodo de indução em pacientes de regressão de um motor uso abm e invenção
PL2483310T3 (pl) 2009-09-29 2015-01-30 Roche Glycart Ag Bispecyficzne przeciwciała agonistyczne dla receptora śmierci
US10126216B2 (en) 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
JP5732078B2 (ja) 2010-03-04 2015-06-10 ベンタナ メディカル システムズ， インコーポレイテッド 音響エネルギーを使用して標本を処理するための処理システム
US10539487B2 (en) 2010-03-04 2020-01-21 Ventana Medical Systems, Inc. Systems and methods for monitoring tissue sample processing
RS56793B1 (sr) * 2011-03-02 2018-04-30 Roche Glycart Ag Cea antitela
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
CN104768975A (zh) 2012-08-31 2015-07-08 北卡罗来纳大学教堂山分校 用于增强或抑制胰岛素-样生长因子1(igf-1)的单克隆抗体
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
US9753036B2 (en) 2014-04-29 2017-09-05 Edp Biotech Corporation Methods and compositions for screening and detecting biomarkers
IL315205A (en) 2022-03-23 2024-10-01 Synaffix Bv Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU625613B2 (en) * 1988-01-05 1992-07-16 Novartis Ag Novel chimeric antibodies

Also Published As

Publication number Publication date
DE69431602T2 (de) 2003-06-26
JPH09501571A (ja) 1997-02-18
ATE226596T1 (de) 2002-11-15
JP3492373B2 (ja) 2004-02-03
CA2168440A1 (en) 1995-03-02
PT721470E (pt) 2003-03-31
DE69431602D1 (de) 2002-11-28
AU7390694A (en) 1995-03-21
WO1995006067A1 (en) 1995-03-02
ES2187529T3 (es) 2003-06-16
CA2168440C (en) 2002-07-23
US5965710A (en) 1999-10-12
GB9317423D0 (en) 1993-10-06
EP0721470B1 (en) 2002-10-23
EP0721470A1 (en) 1996-07-17

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