ATE226951T1 - Chinazolinen als inhibitoren des endothelin konvertierenden enzyme - Google Patents

Chinazolinen als inhibitoren des endothelin konvertierenden enzyme

Info

Publication number: ATE226951T1
Authority: AT; Austria
Prior art keywords: inhibitors; endothelin; endotheline; quinazolines; ischemia
Prior art date: 1994-12-22

Application number

AT95941477T

Other languages

English (en)

Inventor

Kyunghye Ahn

Xue-Min Cheng

Annette Marian Doherty

Edward Faith Elslager

Brian Kornberg

Chitase Lee

Daniele M Leonard

Sham Shribhar Nikam

Leslie Morton Werbel

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-22

Filing date

1995-11-27

Publication date

2002-11-15

1995-11-27 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE226951T1 publication Critical patent/ATE226951T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 title 1
108090000790 Enzymes Proteins 0.000 title 1
206010040070 Septic Shock Diseases 0.000 abstract 2
208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
206010002383 Angina Pectoris Diseases 0.000 abstract 1
201000006474 Brain Ischemia Diseases 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
102000002045 Endothelin Human genes 0.000 abstract 1
108050009340 Endothelin Proteins 0.000 abstract 1
102000048186 Endothelin-converting enzyme 1 Human genes 0.000 abstract 1
108030001679 Endothelin-converting enzyme 1 Proteins 0.000 abstract 1
206010014824 Endotoxic shock Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
208000032456 Hemorrhagic Shock Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
208000003782 Raynaud disease Diseases 0.000 abstract 1
208000012322 Raynaud phenomenon Diseases 0.000 abstract 1
208000033626 Renal failure acute Diseases 0.000 abstract 1
206010049771 Shock haemorrhagic Diseases 0.000 abstract 1
208000032851 Subarachnoid Hemorrhage Diseases 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
201000011040 acute kidney failure Diseases 0.000 abstract 1
208000012998 acute renal failure Diseases 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
230000006793 arrhythmia Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
230000003143 atherosclerotic effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
206010008118 cerebral infarction Diseases 0.000 abstract 1
208000020832 chronic kidney disease Diseases 0.000 abstract 1
208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
230000006378 damage Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000002124 endocrine Effects 0.000 abstract 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
231100000284 endotoxic Toxicity 0.000 abstract 1
230000002346 endotoxic effect Effects 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
231100000268 induced nephrotoxicity Toxicity 0.000 abstract 1
208000001286 intracranial vasospasm Diseases 0.000 abstract 1
208000023569 ischemic bowel disease Diseases 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
208000031225 myocardial ischemia Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000011461 pre-eclampsia Diseases 0.000 abstract 1
208000002815 pulmonary hypertension Diseases 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1
230000036303 septic shock Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT95941477T 1994-12-22 1995-11-27 Chinazolinen als inhibitoren des endothelin konvertierenden enzyme ATE226951T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/363,104 US5658902A (en)	1994-12-22	1994-12-22	Quinazolines as inhibitors of endothelin converting enzyme
PCT/US1995/015366 WO1996019474A1 (en)	1994-12-22	1995-11-27	Quinazolines as inhibitors of endothelin converting enzyme

Publications (1)

Publication Number	Publication Date
ATE226951T1 true ATE226951T1 (de)	2002-11-15

Family

ID=23428818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95941477T ATE226951T1 (de)	1994-12-22	1995-11-27	Chinazolinen als inhibitoren des endothelin konvertierenden enzyme

Country Status (11)

Country	Link
US (2)	US5658902A (de)
EP (1)	EP0799221B1 (de)
JP (1)	JPH10510834A (de)
AT (1)	ATE226951T1 (de)
CA (1)	CA2206046A1 (de)
DE (1)	DE69528711T2 (de)
DK (1)	DK0799221T3 (de)
ES (1)	ES2186734T3 (de)
PT (1)	PT799221E (de)
SI (1)	SI0799221T1 (de)
WO (1)	WO1996019474A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5480883A (en) *	1991-05-10	1996-01-02	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US6184226B1 (en)	1998-08-28	2001-02-06	Scios Inc.	Quinazoline derivatives as inhibitors of P-38 α
DE19916719A1 (de) *	1999-04-13	2000-10-19	Basf Ag	Neue ECE-Inhibitoren, ihre Herstellung und Verwendung
WO2002022605A1 (en) *	2000-09-15	2002-03-21	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
JP2004509876A (ja) *	2000-09-20	2004-04-02	メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング	４−アミノ−キナゾリン
US7192939B2 (en) *	2002-01-30	2007-03-20	Montana State University	Pestalotiopsis microsporia isolates and compounds derived therefrom
US7345018B2 (en)	2002-04-25	2008-03-18	Reception Aps	Method of treating side effects induced by therapeutic agents
CA2560522A1 (en) *	2003-03-26	2004-10-07	Recepticon Aps	Use of compounds for the prevention of drug-induced cell toxicity
US7217794B2 (en) *	2003-04-02	2007-05-15	Daiamed, Inc.	Compounds and methods for treatment of thrombosis
JP2007510642A (ja) *	2003-11-03	2007-04-26	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	中枢神経系障害の治療のための新規ノルエピネフリン再取込み阻害薬
CN101277939A (zh)	2005-09-09	2008-10-01	布里斯托尔-迈尔斯斯奎布公司	无环ikur抑制剂
JP2017001954A (ja) *	2013-11-08	2017-01-05	石原産業株式会社	含窒素飽和複素環化合物
WO2020214537A1 (en) *	2019-04-15	2020-10-22	Tosk, Inc.	Modulators of ras gtpase

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB857362A (en) *	1958-12-03	1960-12-29	Ici Ltd	Quinazoline derivatives
NL265777A (de) *	1960-06-09
US3340260A (en) *	1962-12-03	1967-09-05	Ciba Geigy Corp	4-amino-pyrimidines
US3301855A (en) *	1963-04-22	1967-01-31	Ciba Geigy Corp	Derivatives of 4-nu-(2-nu, nu-dimethylaminolower alkyl)-amino quinazoline
GB1199768A (en) *	1966-10-31	1970-07-22	Pfizer & Co C	Nitrogen Heterocycles and process for their preparation
US3470182A (en) *	1967-02-09	1969-09-30	Sandoz Ag	4-amino-substituted quinazolines
CH509039A (de) *	1967-10-02	1971-06-30	Ici Ltd	Handelsfähiges fungizides Mittel und Verwendung zur Bekämpfung von Pilzkrankheiten von Pflanzen
CH578556A5 (en) *	1973-02-20	1976-08-13	Sandoz Ag	2-(5-Nitro-heterocyclyl)-substd 4-amino-quinazolines - with bactericidal, trichomonacidal and amoebicidal activity
SU466233A1 (ru) *	1973-06-08	1975-04-05	Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе	Способ получени производных 2-метил-4-диалкиламиноалкиламинохиназолина
US3997538A (en) *	1975-12-29	1976-12-14	Morton-Norwich Products, Inc.	2-(3,4-Dichlorophenyl)-4-(substituted amino)-quinazolines
JPS542327A (en) *	1977-06-07	1979-01-09	Sankyo Co Ltd	Agricultural and horticultural pesticide
EP0126087A1 (de) *	1982-09-24	1984-11-28	Beecham Group Plc	Amino-azabicycloalkyl-derivate als dopamin-antagonisten
FR2582514B1 (fr) *	1985-05-30	1988-02-19	Rhone Poulenc Sante	Medicaments a base d'amides, nouveaux amides et leur preparation
IL89029A (en) *	1988-01-29	1993-01-31	Lilly Co Eli	Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
CA2032559C (en) *	1989-12-28	2001-11-06	Kiyofumi Ishikawa	Endothelin antagonistic cyclic pentapeptides
CA2100355A1 (en) *	1991-02-04	1992-08-05	Lynne H. Parker Botehlo	Endothelin converting enzyme
JPH05105698A (ja) *	1991-06-13	1993-04-27	Takeda Chem Ind Ltd	ホスホン酸誘導体、その製造法および用途
PT100905A (pt) *	1991-09-30	1994-02-28	Eisai Co Ltd	Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5187168A (en) *	1991-10-24	1993-02-16	American Home Products Corporation	Substituted quinazolines as angiotensin II antagonists
DE4208254A1 (de) *	1992-03-14	1993-09-16	Hoechst Ag	Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
JP2657760B2 (ja) *	1992-07-15	1997-09-24	小野薬品工業株式会社	４−アミノキナゾリン誘導体およびそれを含有する医薬品

1994
- 1994-12-22 US US08/363,104 patent/US5658902A/en not_active Expired - Fee Related
1995
- 1995-11-27 DK DK95941477T patent/DK0799221T3/da active
- 1995-11-27 JP JP8519802A patent/JPH10510834A/ja not_active Ceased
- 1995-11-27 DE DE69528711T patent/DE69528711T2/de not_active Expired - Fee Related
- 1995-11-27 AT AT95941477T patent/ATE226951T1/de not_active IP Right Cessation
- 1995-11-27 PT PT95941477T patent/PT799221E/pt unknown
- 1995-11-27 WO PCT/US1995/015366 patent/WO1996019474A1/en not_active Ceased
- 1995-11-27 EP EP95941477A patent/EP0799221B1/de not_active Expired - Lifetime
- 1995-11-27 ES ES95941477T patent/ES2186734T3/es not_active Expired - Lifetime
- 1995-11-27 SI SI9530621T patent/SI0799221T1/xx unknown
- 1995-11-27 CA CA002206046A patent/CA2206046A1/en not_active Abandoned
1997
- 1997-04-14 US US08/837,176 patent/US5773444A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2186734T3 (es)	2003-05-16
WO1996019474A1 (en)	1996-06-27
PT799221E (pt)	2003-03-31
DK0799221T3 (da)	2003-02-24
EP0799221B1 (de)	2002-10-30
CA2206046A1 (en)	1996-06-27
DE69528711T2 (de)	2003-08-14
US5658902A (en)	1997-08-19
EP0799221A1 (de)	1997-10-08
US5773444A (en)	1998-06-30
MX9704040A (es)	1997-09-30
DE69528711D1 (de)	2002-12-05
SI0799221T1 (en)	2003-02-28
JPH10510834A (ja)	1998-10-20

Legal Events

Date

Code

Title

Description

2003-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0799221

Country of ref document: EP

2007-08-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE226951T1 (de)	2002-11-15	Chinazolinen als inhibitoren des endothelin konvertierenden enzyme
AU5787894A (en)	1994-09-22	Phenoxyphenylacetic acid derivatives
MX9308191A (es)	1994-06-30	Antagonistas de endotelina.
MX9702687A (es)	1997-06-28	Antagonistas no peptidos de la endotelina.
EP0834563A3 (de)	1998-11-25	Menschlicher transmembraner Rezeptor der Chemokinrezeptor-Familie, auch Strl-33 genannt
EP0848060A3 (de)	2000-02-02	Humane 11CB Splice-Varianten
EP0875566A3 (de)	1999-12-29	Neuartiger G-Protein gekoppelter Rezeptor
PL321866A1 (en)	1997-12-22	Benzothiazine dioxides as endothelin antagonista
EP0867508A3 (de)	2001-09-05	Geruchs Rezeptor von dem 7-Transmembran-Rezeptor Familie - OLRCC15 Rezeptor
EP0875565A3 (de)	1999-12-29	Neuartiger G-Protein gekoppelter Rezeptor (HFGAN72Y)
ATE195948T1 (de)	2000-09-15	Endothelinantagonisten
EP0885960A3 (de)	2000-01-12	Protein G-gekoppelter Rezeptor (H7TBA62)
EP0881289A3 (de)	2000-01-26	7TM Receptor (H2CAA71)
EP0908515A3 (de)	2000-04-26	Bauchspeicheldrüsen-polypeptid
WO2001094385A3 (en)	2002-05-10	Human hm74-like g protein coupled receptor
WO2001077320A3 (en)	2002-03-14	Regulation of human hm74-like g protein coupled receptor
BG104222A (en)	2001-02-28	Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists
WO2001068842A3 (en)	2002-01-24	Regulation of human p2y-like gpcr protein
WO2001068701A3 (en)	2002-03-21	Regulation of human seven transmembrane - like g protein - coupled receptor (7tm-gpcr)
WO2002024885A3 (en)	2002-10-31	Regulation of human g protein-coupled receptor
WO2001070970A3 (en)	2002-03-07	Regulation of human opsin-related g protein-coupled receptor
EP0837128A3 (de)	1999-04-28	Menschlicher G-Protein gekoppelter Rezeptor, HLYAZ61