ATE227281T1 - Verbindungen als farnesyl-protein transferase inhibitoren - Google Patents
Verbindungen als farnesyl-protein transferase inhibitorenInfo
- Publication number
- ATE227281T1 ATE227281T1 AT98926276T AT98926276T ATE227281T1 AT E227281 T1 ATE227281 T1 AT E227281T1 AT 98926276 T AT98926276 T AT 98926276T AT 98926276 T AT98926276 T AT 98926276T AT E227281 T1 ATE227281 T1 AT E227281T1
- Authority
- AT
- Austria
- Prior art keywords
- protein transferase
- compounds
- farnesyl
- transferase inhibitors
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Materials For Medical Uses (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87773997A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011494 WO1998057955A1 (en) | 1997-06-17 | 1998-06-15 | Compounds useful for inhibition of farnesyl protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE227281T1 true ATE227281T1 (de) | 2002-11-15 |
Family
ID=25370613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98926276T ATE227281T1 (de) | 1997-06-17 | 1998-06-15 | Verbindungen als farnesyl-protein transferase inhibitoren |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0993459B1 (de) |
| JP (1) | JP2002504143A (de) |
| KR (1) | KR20010013953A (de) |
| CN (1) | CN1286690A (de) |
| AT (1) | ATE227281T1 (de) |
| AU (1) | AU7815198A (de) |
| CA (1) | CA2294351C (de) |
| DE (1) | DE69809238T2 (de) |
| ES (1) | ES2182324T3 (de) |
| HU (1) | HUP0002186A3 (de) |
| IL (1) | IL133447A0 (de) |
| NZ (1) | NZ501617A (de) |
| WO (1) | WO1998057955A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110483384B (zh) * | 2018-05-14 | 2021-05-14 | 新发药业有限公司 | 一种3,5-二卤代-4-吡啶酮-1-乙酸的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| JP2875393B2 (ja) * | 1993-10-15 | 1999-03-31 | シェーリング コーポレイション | Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物 |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| ES2229340T3 (es) * | 1996-09-13 | 2005-04-16 | Schering Corporation | Compuestos triciclicos antitumorales, inhibidores de farnesil-proteina-tranferasa. |
-
1998
- 1998-06-15 NZ NZ501617A patent/NZ501617A/en unknown
- 1998-06-15 CA CA002294351A patent/CA2294351C/en not_active Expired - Fee Related
- 1998-06-15 AU AU78151/98A patent/AU7815198A/en not_active Abandoned
- 1998-06-15 KR KR1019997011979A patent/KR20010013953A/ko not_active Withdrawn
- 1998-06-15 AT AT98926276T patent/ATE227281T1/de not_active IP Right Cessation
- 1998-06-15 DE DE69809238T patent/DE69809238T2/de not_active Expired - Lifetime
- 1998-06-15 ES ES98926276T patent/ES2182324T3/es not_active Expired - Lifetime
- 1998-06-15 IL IL13344798A patent/IL133447A0/xx unknown
- 1998-06-15 WO PCT/US1998/011494 patent/WO1998057955A1/en not_active Ceased
- 1998-06-15 JP JP50448999A patent/JP2002504143A/ja not_active Ceased
- 1998-06-15 EP EP98926276A patent/EP0993459B1/de not_active Expired - Lifetime
- 1998-06-15 HU HU0002186A patent/HUP0002186A3/hu unknown
- 1998-06-15 CN CN98808207A patent/CN1286690A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1024686A1 (en) | 2000-10-20 |
| CA2294351C (en) | 2008-09-02 |
| HUP0002186A2 (hu) | 2001-04-28 |
| EP0993459A1 (de) | 2000-04-19 |
| JP2002504143A (ja) | 2002-02-05 |
| WO1998057955A1 (en) | 1998-12-23 |
| KR20010013953A (ko) | 2001-02-26 |
| IL133447A0 (en) | 2001-04-30 |
| EP0993459B1 (de) | 2002-11-06 |
| NZ501617A (en) | 2001-09-28 |
| HUP0002186A3 (en) | 2002-04-29 |
| AU7815198A (en) | 1999-01-04 |
| DE69809238D1 (de) | 2002-12-12 |
| CA2294351A1 (en) | 1998-12-23 |
| ES2182324T3 (es) | 2003-03-01 |
| DE69809238T2 (de) | 2003-09-18 |
| CN1286690A (zh) | 2001-03-07 |
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| DE69731544D1 (de) | Trizyklische antitumor verbindungen mit farnesyl protein transferase inhibierender wirkung | |
| DE69709774D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren | |
| NO991235D0 (no) | Forbindelser anvendelige for inhibering av farnesylproteintransferase | |
| DE69809238D1 (de) | Verbindungen als farnesyl-protein transferase inhibitoren | |
| DE69805619D1 (en) | Benzo[5,6]cyclohepta[1,2-b]pyridin derivate als farnesyl protein transferase inhibitoren | |
| IL133392A0 (en) | Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase | |
| ATE281450T1 (de) | Verbindungen als inhibitoren von farnesylprotein- transferase | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |