ATE286046T1 - Trizyklische inhibitoren der farnesyl protein transferase - Google Patents
Trizyklische inhibitoren der farnesyl protein transferaseInfo
- Publication number
- ATE286046T1 ATE286046T1 AT97941480T AT97941480T ATE286046T1 AT E286046 T1 ATE286046 T1 AT E286046T1 AT 97941480 T AT97941480 T AT 97941480T AT 97941480 T AT97941480 T AT 97941480T AT E286046 T1 ATE286046 T1 AT E286046T1
- Authority
- AT
- Austria
- Prior art keywords
- protein transferase
- farnesyl protein
- tricyclic inhibitors
- compounds
- formula
- Prior art date
Links
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- JXBSHSBNOVLGHF-BUJBXKITSA-N (6E,10E)-2,6,10-trimethyldodeca-2,6,10-triene Chemical compound C\C=C(/C)CC\C=C(/C)CCC=C(C)C JXBSHSBNOVLGHF-BUJBXKITSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Cereal-Derived Products (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71332396A | 1996-09-13 | 1996-09-13 | |
| PCT/US1997/015907 WO1998011093A1 (en) | 1996-09-13 | 1997-09-11 | Tricyclic inhibitors of farnesyl protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE286046T1 true ATE286046T1 (de) | 2005-01-15 |
Family
ID=24865689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97941480T ATE286046T1 (de) | 1996-09-13 | 1997-09-11 | Trizyklische inhibitoren der farnesyl protein transferase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0929545B1 (de) |
| JP (1) | JP2001500510A (de) |
| KR (1) | KR20000036120A (de) |
| CN (1) | CN1104427C (de) |
| AT (1) | ATE286046T1 (de) |
| AU (1) | AU4337997A (de) |
| BR (1) | BR9712831A (de) |
| CA (1) | CA2266016C (de) |
| CZ (1) | CZ84399A3 (de) |
| DE (1) | DE69732120T2 (de) |
| ES (1) | ES2235252T3 (de) |
| HU (1) | HUP0000121A2 (de) |
| ID (1) | ID21699A (de) |
| IL (1) | IL128928A0 (de) |
| NO (1) | NO991234L (de) |
| NZ (1) | NZ334453A (de) |
| PL (1) | PL332242A1 (de) |
| SK (1) | SK33899A3 (de) |
| TR (1) | TR199901276T2 (de) |
| WO (1) | WO1998011093A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3962B (en) | 1993-12-21 | 1996-05-27 | Albright & Wilson | Funcional fluids |
| US5939416A (en) * | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
| AU2335699A (en) | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| CN1289336A (zh) | 1998-01-21 | 2001-03-28 | 千禧药品公司 | 趋化因子受体拮抗剂和其使用方法 |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
| US9579088B2 (en) | 2007-02-20 | 2017-02-28 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical visualization and device manipulation |
| TW200902007A (en) * | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
| EP3078344B1 (de) | 2007-07-12 | 2020-02-26 | Board of Regents of the University of Nebraska | Betätigung in robotischen vorrichtungen |
| CA2695615A1 (en) | 2007-08-15 | 2009-02-19 | Board Of Regents Of The University Of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
| EP3977951B1 (de) | 2011-06-10 | 2023-11-08 | Board of Regents of the University of Nebraska | Chirurgische endeffektoren |
| EP3588217A1 (de) | 2011-07-11 | 2020-01-01 | Board of Regents of the University of Nebraska | Robotische chirurgische vorrichtungen, systeme und entsprechende verfahren |
| CA2880220C (en) | 2011-10-03 | 2020-10-13 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| WO2013106569A2 (en) | 2012-01-10 | 2013-07-18 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical access and insertion |
| JP2015531608A (ja) | 2012-05-01 | 2015-11-05 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 単孔式ロボット機器および関連システムと方法 |
| EP3424651B1 (de) | 2012-06-22 | 2020-02-12 | Board of Regents of the University of Nebraska | Robotische chirurgische vorrichtungen mit lokaler steuerung |
| JP2015526171A (ja) | 2012-08-08 | 2015-09-10 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ロボット手術用デバイス、システム及び関連の方法 |
| US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| US9743987B2 (en) | 2013-03-14 | 2017-08-29 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
| CA2906672C (en) | 2013-03-14 | 2022-03-15 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
| EP4628042A3 (de) | 2013-03-15 | 2025-12-31 | Virtual Incision Corporation | Robotische chirurgische vorrichtungen und systeme |
| CA2918531A1 (en) | 2013-07-17 | 2015-01-22 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| EP4487795A3 (de) | 2014-09-12 | 2025-03-19 | Board of Regents of the University of Nebraska | Schnell lösbare endeffektoren sowie zugehörige systeme und verfahren |
| CA2967593C (en) | 2014-11-11 | 2024-02-27 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and related systems and methods |
| EP3331453B1 (de) | 2015-08-03 | 2025-05-14 | Virtual Incision Corporation | Robotische chirurgische vorrichtungen und systeme |
| EP3457951B1 (de) | 2016-05-18 | 2024-03-06 | Virtual Incision Corporation | Robotische chirurgische vorrichtungen und systeme |
| EP3503829A4 (de) | 2016-08-25 | 2020-04-15 | Board of Regents of the University of Nebraska | Schnell lösbare werkzeugkopplung sowie zugehörige systeme und verfahren |
| CN109890580B (zh) | 2016-08-30 | 2022-06-28 | 内布拉斯加大学董事会 | 具有紧凑型关节设计和附加自由度的机器人装置及相关系统和方法 |
| CN110139620B (zh) | 2016-11-22 | 2022-09-20 | 内布拉斯加大学董事会 | 改进的粗定位装置及相关系统和方法 |
| WO2018102430A1 (en) | 2016-11-29 | 2018-06-07 | Virtual Incision Corporation | User controller with user presence detection and related systems and methods |
| US10722319B2 (en) | 2016-12-14 | 2020-07-28 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
| JP7405432B2 (ja) | 2017-09-27 | 2023-12-26 | バーチャル インシジョン コーポレイション | 追跡カメラ技術を有するロボット手術デバイスならびに関連するシステムおよび方法 |
| CA3087672A1 (en) | 2018-01-05 | 2019-07-11 | Board Of Regents Of The University Of Nebraska | Single-arm robotic device with compact joint design and related systems and methods |
| CN114302665B (zh) | 2019-01-07 | 2025-12-19 | 虚拟切割有限公司 | 机器人辅助手术系统以及相关装置和方法 |
| EP4175576A4 (de) | 2020-07-06 | 2024-08-07 | Virtual Incision Corporation | Positionierungssystem für chirurgischen roboter sowie zugehörige vorrichtungen und verfahren |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| JPH0676403B2 (ja) * | 1991-01-18 | 1994-09-28 | エスエス製薬株式会社 | 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤 |
| ATE210652T1 (de) * | 1993-10-15 | 2001-12-15 | Schering Corp | Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111257A0 (en) * | 1993-10-15 | 1994-12-29 | Schering Corp | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| MY119007A (en) * | 1995-12-22 | 2005-03-31 | Schering Corp | Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases. |
-
1997
- 1997-09-11 AU AU43379/97A patent/AU4337997A/en not_active Abandoned
- 1997-09-11 CN CN97199598A patent/CN1104427C/zh not_active Expired - Fee Related
- 1997-09-11 NZ NZ334453A patent/NZ334453A/xx unknown
- 1997-09-11 WO PCT/US1997/015907 patent/WO1998011093A1/en not_active Ceased
- 1997-09-11 TR TR1999/01276T patent/TR199901276T2/xx unknown
- 1997-09-11 AT AT97941480T patent/ATE286046T1/de not_active IP Right Cessation
- 1997-09-11 ES ES97941480T patent/ES2235252T3/es not_active Expired - Lifetime
- 1997-09-11 SK SK338-99A patent/SK33899A3/sk unknown
- 1997-09-11 HU HU0000121A patent/HUP0000121A2/hu unknown
- 1997-09-11 IL IL12892897A patent/IL128928A0/xx unknown
- 1997-09-11 DE DE69732120T patent/DE69732120T2/de not_active Expired - Fee Related
- 1997-09-11 JP JP10513765A patent/JP2001500510A/ja not_active Ceased
- 1997-09-11 KR KR1019997002149A patent/KR20000036120A/ko not_active Withdrawn
- 1997-09-11 BR BR9712831-7A patent/BR9712831A/pt unknown
- 1997-09-11 PL PL97332242A patent/PL332242A1/xx unknown
- 1997-09-11 EP EP97941480A patent/EP0929545B1/de not_active Expired - Lifetime
- 1997-09-11 CZ CZ99843A patent/CZ84399A3/cs unknown
- 1997-09-11 CA CA002266016A patent/CA2266016C/en not_active Expired - Fee Related
- 1997-11-09 ID IDW990086A patent/ID21699A/id unknown
-
1999
- 1999-03-12 NO NO991234A patent/NO991234L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR199901276T2 (xx) | 1999-09-21 |
| EP0929545A1 (de) | 1999-07-21 |
| DE69732120D1 (de) | 2005-02-03 |
| AU4337997A (en) | 1998-04-02 |
| CN1237165A (zh) | 1999-12-01 |
| PL332242A1 (en) | 1999-08-30 |
| HUP0000121A2 (hu) | 2001-04-28 |
| NO991234L (no) | 1999-05-12 |
| EP0929545B1 (de) | 2004-12-29 |
| DE69732120T2 (de) | 2005-12-08 |
| JP2001500510A (ja) | 2001-01-16 |
| CZ84399A3 (cs) | 1999-11-17 |
| WO1998011093A1 (en) | 1998-03-19 |
| CA2266016A1 (en) | 1998-03-19 |
| BR9712831A (pt) | 1999-11-16 |
| SK33899A3 (en) | 2000-02-14 |
| CN1104427C (zh) | 2003-04-02 |
| IL128928A0 (en) | 2000-02-17 |
| NZ334453A (en) | 2000-08-25 |
| ES2235252T3 (es) | 2005-07-01 |
| KR20000036120A (ko) | 2000-06-26 |
| ID21699A (id) | 1999-07-15 |
| NO991234D0 (no) | 1999-03-12 |
| CA2266016C (en) | 2004-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69732120D1 (de) | Trizyklische inhibitoren der farnesyl protein transferase | |
| NO991235L (no) | Forbindelser anvendelige for inhibering av farnesylproteintransferase | |
| DE69709774D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren | |
| NO991231D0 (no) | Forbindelser for inhibering av farnesylproteintransferase | |
| DE69724130D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |