ATE227297T1 - 2-pyridylmethylen-polyazamacrocyclophosphonsäur n,ihre komplexe und derivate zur verwendung als kontrastmittel - Google Patents
2-pyridylmethylen-polyazamacrocyclophosphonsäur n,ihre komplexe und derivate zur verwendung als kontrastmittelInfo
- Publication number
- ATE227297T1 ATE227297T1 AT94917922T AT94917922T ATE227297T1 AT E227297 T1 ATE227297 T1 AT E227297T1 AT 94917922 T AT94917922 T AT 94917922T AT 94917922 T AT94917922 T AT 94917922T AT E227297 T1 ATE227297 T1 AT E227297T1
- Authority
- AT
- Austria
- Prior art keywords
- complexes
- derivatives
- contrast agents
- acid
- polyazamacrocyclophosphonic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/057,588 US5462725A (en) | 1993-05-06 | 1993-05-06 | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| PCT/US1994/005009 WO1994026275A1 (en) | 1993-05-06 | 1994-05-05 | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE227297T1 true ATE227297T1 (de) | 2002-11-15 |
Family
ID=22011534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94917922T ATE227297T1 (de) | 1993-05-06 | 1994-05-05 | 2-pyridylmethylen-polyazamacrocyclophosphonsäur n,ihre komplexe und derivate zur verwendung als kontrastmittel |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5462725A (de) |
| EP (1) | EP0711300B1 (de) |
| JP (1) | JPH08510245A (de) |
| CN (1) | CN1125905A (de) |
| AT (1) | ATE227297T1 (de) |
| AU (1) | AU678583B2 (de) |
| BG (1) | BG100192A (de) |
| CA (1) | CA2162174A1 (de) |
| CZ (1) | CZ289595A3 (de) |
| DE (1) | DE69431660T2 (de) |
| FI (1) | FI955319L (de) |
| HU (1) | HUT74565A (de) |
| LV (1) | LV11430B (de) |
| NO (1) | NO301829B1 (de) |
| PL (1) | PL311643A1 (de) |
| SG (1) | SG46458A1 (de) |
| WO (1) | WO1994026275A1 (de) |
Families Citing this family (72)
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| US5409689A (en) * | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| DE19523891C1 (de) * | 1995-06-30 | 1996-11-21 | Hoechst Ag | Chirale Mangan-triazanonankomplexe und Verfahren zu ihrer Herstellung |
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| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| EP1246830B1 (de) * | 1999-09-13 | 2003-11-12 | Bristol-Myers Squibb Pharma Company | Makrozyclische liganden für metallpharmazeutika |
| EP1362861B1 (de) * | 1999-09-13 | 2005-12-14 | Bristol-Myers Squibb Pharma Company | Makrocyclische Chelatbildner für Metallopharmazeutika |
| US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
| US7338651B2 (en) * | 2001-09-04 | 2008-03-04 | Texas Tech University System | Multi-use multimodal imaging chelates |
| JP2005507005A (ja) * | 2001-10-22 | 2005-03-10 | テキサス テック ユニバーシティー | 組織特異的螢光キレート |
| US9031634B2 (en) * | 2002-05-17 | 2015-05-12 | Christopher Flask | Chemical shift markers for improved wireless fiducial marker tracking |
| US20060210479A1 (en) * | 2004-08-10 | 2006-09-21 | Dow Global Technologies Inc. | Targeting chelants and chelates |
| EP1637524A1 (de) * | 2004-09-20 | 2006-03-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | 10-substituierte 1-, 4, 7,-tris (carboxymethyl)-1,4,7,10-tetraazacyclo-dodecanederivate zur Verwendung als Kontrastmittel |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| CA2581639C (en) * | 2004-09-30 | 2016-07-26 | Molecular Devices Corporation | Luminescent lanthanide complexes |
| CL2007001536A1 (es) | 2006-05-30 | 2008-01-25 | Genentech Inc | Anticuerpos anti-cd22; polinucleotidos que los codifica; vector y celula huesped que los comprende; metodo de fabricacion; metodo de deteccion del anticuerpo en una muestra biologica; inmunoconjugado que comprende al anticuerpo; composicion que lo comprende y su uso para tratar trastornos proliferativos de celulas b. |
| EP2061814B1 (de) | 2006-10-27 | 2012-06-06 | Genentech, Inc. | Antikörper und immunkonjugate sowie ihre verwendungen |
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| CL2008002083A1 (es) | 2007-07-16 | 2008-11-21 | Genentech Inc | Anticuerpo humanizado anti-cd79b/igbeta/b29; inmunoconjugado; metodo in vitro para determinar presencia de cd79b, inhibir crecimiento de celula con cd79b, o para detectara celula b; metodo para elaborar dicho anticyerpo humanizado; acido nucleico; celula huesped; composicion; metodo de elaboracion de inmunoconjugado; uso medico |
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| WO2019201901A1 (en) | 2018-04-18 | 2019-10-24 | F. Hoffmann-La Roche Ag | Novel anti-thymidine kinase antibodies |
| ES2983797T3 (es) | 2018-08-31 | 2024-10-24 | Hoffmann La Roche | Timidina cinasa (TK-1) en índices pronóstico para LDLBG |
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| JP7315780B2 (ja) | 2019-07-22 | 2023-07-26 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのサブスタンスｐ |
| CN114144676A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a6作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
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| JP7783809B2 (ja) | 2019-11-15 | 2025-12-10 | エフ． ホフマン－ラ ロシュ アーゲー | 患者試料における質量分析測定のためのβ－ラクタム抗生物質の誘導体化 |
| WO2022089710A1 (en) | 2020-10-30 | 2022-05-05 | F. Hoffmann-La Roche Ag | Timp1 as a marker for cholangiocarcinoma |
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| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| WO2022207685A1 (en) | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis |
| JP7727015B2 (ja) | 2021-05-17 | 2025-08-20 | エフ． ホフマン－ラ ロシュ アーゲー | 腺筋症の非侵襲的診断のための血液バイオマーカーとしてのｓＦＲＰ４ |
| EP4423122A1 (de) | 2021-10-26 | 2024-09-04 | F. Hoffmann-La Roche AG | Für sars-cov-2 rbd spezifische monoklonale antikörper |
| EP4448564A1 (de) | 2021-12-17 | 2024-10-23 | F. Hoffmann-La Roche AG | Neuer antikörper zum nachweis von amyloid beta 42 (a-beta42) |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| CN119404103A (zh) | 2022-06-23 | 2025-02-07 | 豪夫迈·罗氏有限公司 | 用于诊断子宫内膜异位症及用于对子宫内膜异位症的分期进行分类的方法 |
| US20260016487A1 (en) | 2022-07-22 | 2026-01-15 | Roche Diagnostics Operations, Inc. | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| US20260036594A1 (en) | 2022-07-22 | 2026-02-05 | Roche Diagnostics Operations, Inc. | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| JP2025524025A (ja) | 2022-07-22 | 2025-07-25 | エフ． ホフマン－ラ ロシュ アーゲー | 多嚢胞性卵巣症候群の診断のための（血液）バイオマーカーとしてのロイコトリエンａ４ヒドロラーゼ（ｌｔａ４ｈ） |
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-
1993
- 1993-05-06 US US08/057,588 patent/US5462725A/en not_active Expired - Fee Related
-
1994
- 1994-05-05 AU AU69447/94A patent/AU678583B2/en not_active Ceased
- 1994-05-05 CN CN94192527.7A patent/CN1125905A/zh active Pending
- 1994-05-05 WO PCT/US1994/005009 patent/WO1994026275A1/en not_active Ceased
- 1994-05-05 EP EP94917922A patent/EP0711300B1/de not_active Expired - Lifetime
- 1994-05-05 PL PL94311643A patent/PL311643A1/xx unknown
- 1994-05-05 FI FI955319A patent/FI955319L/fi unknown
- 1994-05-05 CA CA002162174A patent/CA2162174A1/en not_active Abandoned
- 1994-05-05 CZ CZ952895A patent/CZ289595A3/cs unknown
- 1994-05-05 DE DE69431660T patent/DE69431660T2/de not_active Expired - Fee Related
- 1994-05-05 HU HU9503174A patent/HUT74565A/hu unknown
- 1994-05-05 SG SG1996004873A patent/SG46458A1/en unknown
- 1994-05-05 AT AT94917922T patent/ATE227297T1/de not_active IP Right Cessation
- 1994-05-05 JP JP6525558A patent/JPH08510245A/ja not_active Ceased
-
1995
- 1995-11-06 NO NO954440A patent/NO301829B1/no unknown
- 1995-12-05 BG BG100192A patent/BG100192A/xx unknown
- 1995-12-06 LV LVP-95-362A patent/LV11430B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9503174D0 (en) | 1996-01-29 |
| CA2162174A1 (en) | 1994-11-24 |
| LV11430B (en) | 1997-04-20 |
| FI955319A0 (fi) | 1995-11-06 |
| PL311643A1 (en) | 1996-03-04 |
| NO954440L (no) | 1996-01-05 |
| BG100192A (en) | 1996-12-31 |
| JPH08510245A (ja) | 1996-10-29 |
| NO301829B1 (no) | 1997-12-15 |
| HUT74565A (en) | 1997-01-28 |
| AU678583B2 (en) | 1997-06-05 |
| AU6944794A (en) | 1994-12-12 |
| US5462725A (en) | 1995-10-31 |
| WO1994026275A1 (en) | 1994-11-24 |
| EP0711300A1 (de) | 1996-05-15 |
| DE69431660D1 (de) | 2002-12-12 |
| DE69431660T2 (de) | 2003-08-21 |
| NO954440D0 (no) | 1995-11-06 |
| SG46458A1 (en) | 1998-02-20 |
| FI955319A7 (fi) | 1995-12-22 |
| LV11430A (lv) | 1996-08-20 |
| CZ289595A3 (en) | 1997-01-15 |
| FI955319L (fi) | 1995-12-22 |
| EP0711300B1 (de) | 2002-11-06 |
| EP0711300A4 (de) | 1996-03-12 |
| CN1125905A (zh) | 1996-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |