ATE277058T1 - Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel - Google Patents

Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel

Info

Publication number
ATE277058T1
ATE277058T1 AT97908699T AT97908699T ATE277058T1 AT E277058 T1 ATE277058 T1 AT E277058T1 AT 97908699 T AT97908699 T AT 97908699T AT 97908699 T AT97908699 T AT 97908699T AT E277058 T1 ATE277058 T1 AT E277058T1
Authority
AT
Austria
Prior art keywords
complexes
contrast agents
acid
polyazomacrocyclofluoromonoalkylphosphenic
polyazamacrocyclofluoromonoalkylphosphonic
Prior art date
Application number
AT97908699T
Other languages
English (en)
Inventor
Garry E Kiefer
A Dean Sherry
Original Assignee
Dow Global Technologies Inc
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Inc, Univ Texas filed Critical Dow Global Technologies Inc
Application granted granted Critical
Publication of ATE277058T1 publication Critical patent/ATE277058T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT97908699T 1996-02-23 1997-02-21 Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel ATE277058T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/606,162 US5834456A (en) 1996-02-23 1996-02-23 Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
PCT/US1997/002799 WO1997031005A1 (en) 1996-02-23 1997-02-21 Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents

Publications (1)

Publication Number Publication Date
ATE277058T1 true ATE277058T1 (de) 2004-10-15

Family

ID=24426818

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97908699T ATE277058T1 (de) 1996-02-23 1997-02-21 Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel

Country Status (6)

Country Link
US (1) US5834456A (de)
EP (1) EP0882055B1 (de)
AT (1) ATE277058T1 (de)
AU (1) AU2054097A (de)
DE (1) DE69730820T2 (de)
WO (1) WO1997031005A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
US6670456B2 (en) * 2001-02-28 2003-12-30 Dow Global Technologies Inc. Actinium-225 complexes and conjugates for targeted radiotherapy
US6911017B2 (en) * 2001-09-19 2005-06-28 Advanced Cardiovascular Systems, Inc. MRI visible catheter balloon
US20040115822A1 (en) * 2002-09-12 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
EP2032606B1 (de) 2006-05-30 2013-11-27 Genentech, Inc. Antikörper und immunkonjugate sowie ihre verwendungen
BRPI0717638A2 (pt) 2006-10-27 2013-11-12 Genentech Inc Anticorpors e imunoconjugados e usos para os mesmos
MX2009008430A (es) 2007-02-09 2009-10-28 Genentech Inc Anticuerpos anti-robo4 y sus usos.
PE20090943A1 (es) 2007-07-16 2009-08-05 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados
EP2176295B1 (de) 2007-07-16 2014-11-19 Genentech, Inc. Humanisierte anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren
KR101607346B1 (ko) 2008-01-31 2016-03-29 제넨테크, 인크. 항-cd79b 항체 및 면역접합체 및 사용 방법
RU2011115820A (ru) * 2008-09-22 2012-10-27 Конинклейке Филипс Электроникс, Н.В. (Nl) Шовные материалы, видимые на магнитно-резонансных изображениях, для минимально инвазивной техники анастомоза с контролем по изображениям
RU2587621C2 (ru) 2009-04-01 2016-06-20 Дженентек, Инк. АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
MX2011012665A (es) 2009-06-04 2012-03-07 Novartis Ag Metodos para identificacion de sitios para conjugacion de igg.
CN102770456B (zh) 2009-12-04 2018-04-06 弗·哈夫曼-拉罗切有限公司 多特异性抗体、抗体类似物、组合物和方法
US8722020B2 (en) 2010-03-31 2014-05-13 General Electric Company Hydroxylated contrast enhancement agents
US8362281B2 (en) 2010-03-31 2013-01-29 General Electric Company Intermediates for hydroxylated contrast enhancement agents
US8765977B2 (en) 2010-03-31 2014-07-01 General Electric Company Hydroxylated contrast enhancement agents and imaging method
NZ701208A (en) 2010-06-03 2016-05-27 Genentech Inc Immuno-pet imaging of antibodies and immunoconjugates and uses thereof
CA2799540A1 (en) 2010-06-08 2011-12-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
EP2870180B1 (de) 2012-07-04 2024-08-28 F. Hoffmann-La Roche AG Anti-biotin-antikörper und verwendungsverfahren
RU2684595C2 (ru) 2012-07-04 2019-04-09 Ф.Хоффманн-Ля Рош Аг Ковалентно связанные конъюгаты антиген-антитело
DK2869837T3 (en) 2012-07-04 2016-09-26 Hoffmann La Roche Anti-theophylline antibodies and methods of use
BR112016014945A2 (pt) 2014-01-03 2018-01-23 F. Hoffmann-La Roche Ag conjugado, formulação farmacêutica e uso
EP3089758B1 (de) 2014-01-03 2021-01-27 F.Hoffmann-La Roche Ag Kovalent verknüpfte helikar-/anti-helikar-antikörperkonjugate und verwendungen davon
CN105899540B (zh) 2014-01-03 2020-02-07 豪夫迈·罗氏有限公司 双特异性抗-半抗原/抗-血脑屏障受体的抗体、其复合物及它们作为血脑屏障穿梭物的应用
SG11201701128YA (en) 2014-09-12 2017-03-30 Genentech Inc Cysteine engineered antibodies and conjugates
CA2966287A1 (en) 2014-12-17 2016-06-23 F. Hoffmann-La Roche Ag Novel methods for enzyme mediated polypeptide conjugation using sortase
CN104945312A (zh) * 2015-06-24 2015-09-30 黄荣辉 一种2,6-二氯甲基吡啶盐酸盐的制备方法
CN108138204B (zh) 2015-09-25 2021-12-31 豪夫迈·罗氏有限公司 使用分选酶a生产硫酯的方法
BR112018003594A2 (pt) 2015-09-25 2018-09-25 Hoffmann La Roche cadeia pesada de imunoglobulina recombinante, anticorpos, método de produção de conjugado e conjugados
WO2017050866A1 (en) 2015-09-25 2017-03-30 F. Hoffmann-La Roche Ag Novel soluble sortase a
CN108026560A (zh) 2015-09-25 2018-05-11 豪夫迈·罗氏有限公司 在低共熔溶剂中使用分选酶的转酰胺反应
EP3436578B1 (de) 2016-03-30 2022-01-19 F. Hoffmann-La Roche AG Verbesserte sortase
WO2018191389A1 (en) 2017-04-12 2018-10-18 Roche Sequencing Solutions, Inc. A method for sequencing reaction with tagged nucleoside obtained via pictet spengler reaction
JP7267253B2 (ja) 2017-07-13 2023-05-01 エフ. ホフマン-ラ ロシュ アーゲー Pivkaに対する新規結合剤およびアッセイ
EP3697813A1 (de) 2017-10-20 2020-08-26 H. Hoffnabb-La Roche Ag Kopierschutz für antikörper
KR102769570B1 (ko) 2017-11-30 2025-02-19 제넨테크, 인크. 항-pd-l1 항체 및 pd-l1 탐지를 위하여 동일한 항체를 이용하는 방법
KR20200131838A (ko) 2018-03-14 2020-11-24 에프. 호프만-라 로슈 아게 항체의 친화성 성숙화를 위한 방법
BR112020017941A2 (pt) 2018-03-14 2021-02-17 F. Hoffmann-La Roche Ag anticorpos, moléculas de ácido nucleico, vetor, composição e método de determinação da troponina t cardíaca humana
EP3781600A1 (de) 2018-04-18 2021-02-24 F. Hoffmann-La Roche AG Neuartige anti-thymidinkinase-antikörper
JP7577647B2 (ja) 2018-08-31 2024-11-05 エフ. ホフマン-ラ ロシュ アーゲー Dlbclについての予後指標におけるチミジンキナーゼ(tk-1)
KR20210087938A (ko) 2018-09-28 2021-07-13 이미지냅 인코포레이티드 Cd8 이미징 구조체 및 이의 사용 방법
JP7692892B2 (ja) 2019-08-09 2025-06-16 エフ. ホフマン-ラ ロシュ アーゲー 新規抗トロポニンt抗体
KR102903735B1 (ko) 2020-10-30 2025-12-23 에프. 호프만-라 로슈 아게 담관암종의 표지자로서의 timp1
CN118382636A (zh) 2021-12-17 2024-07-23 豪夫迈·罗氏有限公司 一种用于检测淀粉样蛋白β42(Aβ42)的新抗体
CN118638117B (zh) * 2024-05-29 2024-12-13 江苏宝东医药科技有限公司 一种绿色制备1,4,7,10-四氮杂-2,6-吡啶环蕃方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5188816A (en) * 1984-10-18 1993-02-23 Board Of Regents, The University Of Texas System Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
US4639364A (en) * 1984-11-14 1987-01-27 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4719313A (en) * 1985-08-21 1988-01-12 Merrell Dow Pharmaceuticals Inc. Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes
US4914240A (en) * 1985-08-21 1990-04-03 Merrell Dow Pharmaceuticals Inc. Gem-dihalo-1, 8-diamino-4-aza-octanes
US4778926A (en) * 1985-08-21 1988-10-18 Merrell Dow Pharmaceuticals Inc. Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes
US4695654A (en) * 1985-08-21 1987-09-22 Merrell Dow Pharmaceuticals Inc. Gem-dihalo-1,8-diamino-4-aza-octanes
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8723438D0 (en) * 1987-10-06 1987-11-11 Amersham Int Plc Cationic complexes of technetium-99m
US5582980A (en) * 1989-07-17 1996-12-10 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5284647A (en) * 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
ATE140869T1 (de) * 1989-11-27 1996-08-15 Concat Ltd Qualitätssteigerung von mr-bildern von knochen und ähnlichem gewebe mittels paramagnetischer kationenkomplexe und polyphosphonatliganden
IT1246380B (it) * 1990-04-12 1994-11-18 Bracco Spa Sali insolubili di lantanidi per la visualizzazione in risonanza magnetica nucleare del tratto gastro-intestinale
NZ237868A (en) * 1990-04-18 1994-04-27 Celltech Ltd Paramagnetic metal complexes of 1,4,7,10-tetracyclododecane derivatives and their use as nmr imaging agents
AU648315B2 (en) * 1990-06-18 1994-04-21 Dow Chemical Company, The The use of macrocyclic aminophosphonic acid complexes as imaging agents
US5248498A (en) * 1991-08-19 1993-09-28 Mallinckrodt Medical, Inc. Fullerene compositions for magnetic resonance spectroscopy and imaging
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
EP0570575B1 (de) * 1991-12-10 1997-12-10 The Dow Chemical Company Bicycloazamakrocyclophosphon-Säure, Komplexe, Konjugate, Kontrastmittel und Herstellung
WO1993018795A1 (fr) * 1992-03-19 1993-09-30 Daikin Industries, Ltd. Milieu de contraste destine a l'imagerie par resonance magnetique et procede de diagnostic
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
GB9216843D0 (en) * 1992-08-07 1992-09-23 Cancer Res Inst Contrast agents for medical imaging
JPH06181890A (ja) * 1992-10-06 1994-07-05 Terumo Corp Mri造影剤
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
JPH08510458A (ja) * 1993-06-02 1996-11-05 ブラッコ エッセ.ピ.ア. 沃素化された常磁性キレートおよびそれらの造影剤としての使用法
JPH0797340A (ja) * 1993-06-03 1995-04-11 Terumo Corp Mri造影剤組成物
HUT72671A (en) * 1993-11-26 1996-05-28 Dow Chemical Co Process for preparing polyazamacrocycles
IT1265440B1 (it) * 1993-12-24 1996-11-22 Bracco Spa Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse

Also Published As

Publication number Publication date
AU2054097A (en) 1997-09-10
EP0882055B1 (de) 2004-09-22
US5834456A (en) 1998-11-10
DE69730820D1 (de) 2004-10-28
EP0882055A1 (de) 1998-12-09
DE69730820T2 (de) 2005-09-29
WO1997031005A1 (en) 1997-08-28

Similar Documents

Publication Publication Date Title
ATE277058T1 (de) Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel
ATE227297T1 (de) 2-pyridylmethylen-polyazamacrocyclophosphonsäur n,ihre komplexe und derivate zur verwendung als kontrastmittel
ATE316377T1 (de) Tricyclopolyazamacrocyclophosphonsäuren, ihre komplexe und derivate, für eine verwendung als kontrastmittel
IL124593A0 (en) Substituted aryl or heteroarylamides having retinoid-like biological activity
DE69106135D1 (de) Quasi-azeotrope Mischungen zur Verwendung als Kältemittel.
BG105784A (en) Triazole compounds with dopamine-d3-receptor affinity
ATE238307T1 (de) Substituierte porphyrinen
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
AU9744298A (en) Substituted tetrahydronaphthaline and analogous compounds
DE69927688D1 (de) Antivirales Mittel in Kombination mit Strahlentherapie zur Verwendung in der Behandlung von Krebs
PT971922E (pt) Compostos de tetra-hidropirido
BR9713176A (pt) Benzotiofenos amorfos,métodos de preparação e métodos de uso
AU2455600A (en) Apoptosis-inducing factor
NZ505085A (en) Pharmaceutical compositions comprising bipapcitide monocarboxylate and/or bipapcitide dicarboxylate for imaging and treating thrombi

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties