ATE277058T1 - Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel - Google Patents
Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittelInfo
- Publication number
- ATE277058T1 ATE277058T1 AT97908699T AT97908699T ATE277058T1 AT E277058 T1 ATE277058 T1 AT E277058T1 AT 97908699 T AT97908699 T AT 97908699T AT 97908699 T AT97908699 T AT 97908699T AT E277058 T1 ATE277058 T1 AT E277058T1
- Authority
- AT
- Austria
- Prior art keywords
- complexes
- contrast agents
- acid
- polyazomacrocyclofluoromonoalkylphosphenic
- polyazamacrocyclofluoromonoalkylphosphonic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title abstract 2
- 229910052688 Gadolinium Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052746 lanthanum Inorganic materials 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/606,162 US5834456A (en) | 1996-02-23 | 1996-02-23 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| PCT/US1997/002799 WO1997031005A1 (en) | 1996-02-23 | 1997-02-21 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277058T1 true ATE277058T1 (de) | 2004-10-15 |
Family
ID=24426818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97908699T ATE277058T1 (de) | 1996-02-23 | 1997-02-21 | Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5834456A (de) |
| EP (1) | EP0882055B1 (de) |
| AT (1) | ATE277058T1 (de) |
| AU (1) | AU2054097A (de) |
| DE (1) | DE69730820T2 (de) |
| WO (1) | WO1997031005A1 (de) |
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| US6019959A (en) * | 1997-07-31 | 2000-02-01 | Schering Aktiengesellschaft | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis |
| US6565828B2 (en) * | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
| US6776977B2 (en) | 2001-01-09 | 2004-08-17 | Bristol-Myers Squibb Pharma Company | Polypodal chelants for metallopharmaceuticals |
| US7048907B2 (en) * | 2001-02-05 | 2006-05-23 | Biophysics Assay Laboratory, Inc. | Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products |
| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
| US6911017B2 (en) * | 2001-09-19 | 2005-06-28 | Advanced Cardiovascular Systems, Inc. | MRI visible catheter balloon |
| US20040115822A1 (en) * | 2002-09-12 | 2004-06-17 | Schapaugh Randal Lee | Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition |
| WO2006020779A2 (en) * | 2004-08-10 | 2006-02-23 | Dow Global Technologies Inc. | Targeting chelants and chelates |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| WO2007140371A2 (en) | 2006-05-30 | 2007-12-06 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| AU2007308792B2 (en) | 2006-10-27 | 2013-01-24 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
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| ATE543835T1 (de) | 2007-07-16 | 2012-02-15 | Genentech Inc | Anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren |
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| RU2011115820A (ru) * | 2008-09-22 | 2012-10-27 | Конинклейке Филипс Электроникс, Н.В. (Nl) | Шовные материалы, видимые на магнитно-резонансных изображениях, для минимально инвазивной техники анастомоза с контролем по изображениям |
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| PT2437785E (pt) | 2009-06-04 | 2015-04-20 | Novartis Ag | Método de identificação de sítios para conjugação de igg |
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| SG185428A1 (en) | 2010-06-08 | 2012-12-28 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| BR112014030844A2 (pt) | 2012-07-04 | 2019-10-15 | Hoffmann La Roche | anticorpo anti-biotina humanizado, formulação farmacêutica e uso do anticorpo |
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| JP6324376B2 (ja) | 2012-07-04 | 2018-05-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗テオフィリン抗体および使用方法 |
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| TW201625688A (zh) | 2014-09-12 | 2016-07-16 | 建南德克公司 | 經半胱胺酸改造之抗體及接合物 |
| JP6618539B2 (ja) | 2014-12-17 | 2019-12-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ソルターゼを使用した酵素媒介性のポリペプチドコンジュゲーションのための方法 |
| CN104945312A (zh) * | 2015-06-24 | 2015-09-30 | 黄荣辉 | 一种2,6-二氯甲基吡啶盐酸盐的制备方法 |
| JP6895953B2 (ja) | 2015-09-25 | 2021-06-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ソルターゼａを利用してチオエステルを作製するための方法 |
| EP3353314A1 (de) | 2015-09-25 | 2018-08-01 | H. Hoffnabb-La Roche Ag | Transamidierung mit sortase a in tiefeutektischen lösungsmitteln |
| JP6998862B2 (ja) | 2015-09-25 | 2022-02-04 | エフ．ホフマン－ラ ロシュ アーゲー | 可溶性ソルターゼａ |
| EP3353201B1 (de) | 2015-09-25 | 2021-09-08 | F. Hoffmann-La Roche AG | Rekombinante schwere immunglobulinketten mit einer sortasekonjugationsschleife und konjugate davon |
| CN109072212B (zh) | 2016-03-30 | 2022-10-04 | 豪夫迈·罗氏有限公司 | 改善的分选酶 |
| WO2018191389A1 (en) | 2017-04-12 | 2018-10-18 | Roche Sequencing Solutions, Inc. | A method for sequencing reaction with tagged nucleoside obtained via pictet spengler reaction |
| EP4707307A2 (de) | 2017-07-13 | 2026-03-11 | Roche Diagnostics GmbH | Neues bindemittel und test für pivka |
| EP3697813A1 (de) | 2017-10-20 | 2020-08-26 | H. Hoffnabb-La Roche Ag | Kopierschutz für antikörper |
| CN111918876B (zh) | 2017-11-30 | 2024-02-02 | 豪夫迈·罗氏有限公司 | 抗pd-l1抗体及使用其检测pd-l1的方法 |
| WO2019175127A1 (en) | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Novel anti-troponint antibodies |
| WO2019175131A1 (en) | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Method for affinity maturation of antibodies |
| WO2019201901A1 (en) | 2018-04-18 | 2019-10-24 | F. Hoffmann-La Roche Ag | Novel anti-thymidine kinase antibodies |
| CN112639475A (zh) | 2018-08-31 | 2021-04-09 | 豪夫迈·罗氏有限公司 | Dlbcl的预后指数中的胸苷激酶(tk-1) |
| CN116271117A (zh) | 2018-09-28 | 2023-06-23 | 伊麦吉纳博公司 | Cd8成像构建体及其使用方法 |
| BR112022002376A2 (pt) | 2019-08-09 | 2022-04-26 | Hoffmann La Roche | Anticorpos que se ligam especificamente à troponina t cardíaca humana, anticorpos, moléculas de ácido nucleico, vetor, composição e método para determinar a troponina t cardíaca humana |
| EP4237855A1 (de) | 2020-10-30 | 2023-09-06 | F. Hoffmann-La Roche AG | Timp1 als marker für cholangiokarzinome |
| CN118382636A (zh) | 2021-12-17 | 2024-07-23 | 豪夫迈·罗氏有限公司 | 一种用于检测淀粉样蛋白β42(Aβ42)的新抗体 |
| CN118638117B (zh) * | 2024-05-29 | 2024-12-13 | 江苏宝东医药科技有限公司 | 一种绿色制备1,4,7,10-四氮杂-2,6-吡啶环蕃方法 |
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|---|---|---|---|---|
| US5059412A (en) * | 1984-06-04 | 1991-10-22 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors |
| US5064633A (en) * | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
| US5342606A (en) * | 1984-10-18 | 1994-08-30 | Board Of Regents, The University Of Texas System | Polyazamacrocyclic compounds for complexation of metal ions |
| US5316757A (en) * | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
| US5188816A (en) * | 1984-10-18 | 1993-02-23 | Board Of Regents, The University Of Texas System | Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS |
| US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
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| DE3713842A1 (de) * | 1987-04-22 | 1988-11-17 | Schering Ag | Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| GB8719041D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| GB8723438D0 (en) * | 1987-10-06 | 1987-11-11 | Amersham Int Plc | Cationic complexes of technetium-99m |
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| AU649001B2 (en) * | 1989-11-27 | 1994-05-12 | Chelator Llc | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| US5236695A (en) * | 1989-11-27 | 1993-08-17 | Concat, Ltd. | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| IT1246380B (it) * | 1990-04-12 | 1994-11-18 | Bracco Spa | Sali insolubili di lantanidi per la visualizzazione in risonanza magnetica nucleare del tratto gastro-intestinale |
| GB2250198B (en) * | 1990-04-18 | 1994-06-22 | Celltech Ltd | Tetra-aza macrocycles,processes for their preparation and their use in magnetic resonance imaging |
| BR9102490A (pt) * | 1990-06-18 | 1992-01-21 | Dow Chemical Co | Metodo para uso diagnostico na formacao de imagens e composicao |
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| DK0570575T3 (da) * | 1991-12-10 | 1998-08-24 | Dow Chemical Co | Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf |
| EP0673655A1 (de) * | 1992-03-19 | 1995-09-27 | Daikin Industries, Limited | Mri kontrastmittel und diagnostikverfahren |
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| GB9216843D0 (en) * | 1992-08-07 | 1992-09-23 | Cancer Res Inst | Contrast agents for medical imaging |
| JPH06181890A (ja) * | 1992-10-06 | 1994-07-05 | Terumo Corp | Ｍｒｉ造影剤 |
| US5385893A (en) * | 1993-05-06 | 1995-01-31 | The Dow Chemical Company | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
| EP0703790B1 (de) * | 1993-06-02 | 2000-08-16 | BRACCO S.p.A. | Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel |
| JPH0797340A (ja) * | 1993-06-03 | 1995-04-11 | Terumo Corp | Ｍｒｉ造影剤組成物 |
| ATE232220T1 (de) * | 1993-11-26 | 2003-02-15 | Dow Global Technologies Inc | Verfahren zur herstellung von polyazamacrocylen |
| IT1265440B1 (it) * | 1993-12-24 | 1996-11-22 | Bracco Spa | Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse |
-
1996
- 1996-02-23 US US08/606,162 patent/US5834456A/en not_active Expired - Fee Related
-
1997
- 1997-02-21 EP EP97908699A patent/EP0882055B1/de not_active Expired - Lifetime
- 1997-02-21 AU AU20540/97A patent/AU2054097A/en not_active Abandoned
- 1997-02-21 WO PCT/US1997/002799 patent/WO1997031005A1/en not_active Ceased
- 1997-02-21 DE DE69730820T patent/DE69730820T2/de not_active Expired - Fee Related
- 1997-02-21 AT AT97908699T patent/ATE277058T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997031005A1 (en) | 1997-08-28 |
| EP0882055A1 (de) | 1998-12-09 |
| DE69730820D1 (de) | 2004-10-28 |
| EP0882055B1 (de) | 2004-09-22 |
| DE69730820T2 (de) | 2005-09-29 |
| US5834456A (en) | 1998-11-10 |
| AU2054097A (en) | 1997-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |