ATE227573T1 - Orale oder intramuskuläre behandlung von pankreaskrebs durch wasserunlösliches s- camptothecin mit geschlossenem lactonring - Google Patents

Orale oder intramuskuläre behandlung von pankreaskrebs durch wasserunlösliches s- camptothecin mit geschlossenem lactonring

Info

Publication number: ATE227573T1
Authority: AT; Austria
Prior art keywords: camptothecin; oral; insoluble; water; lactone ring
Prior art date: 1993-01-15

Application number

AT97101631T

Other languages

English (en)

Inventor

Beppino C Giovanella

Hellmuth R Hinz

Anthony J Kozielski

John S Stehlin

Original Assignee

Stehlin Foundation For Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-15

Filing date

1994-01-14

Publication date

2002-11-15

1994-01-14 Application filed by Stehlin Foundation For Cancer filed Critical Stehlin Foundation For Cancer

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE227573T1 publication Critical patent/ATE227573T1/de

Links

229940127093 camptothecin Drugs 0.000 title abstract 2
238000007918 intramuscular administration Methods 0.000 title abstract 2
150000002596 lactones Chemical group 0.000 title abstract 2
206010061902 Pancreatic neoplasm Diseases 0.000 title 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 title 1
208000008443 pancreatic carcinoma Diseases 0.000 title 1
FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 2
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
206010009944 Colon cancer Diseases 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT97101631T 1993-01-15 1994-01-14 Orale oder intramuskuläre behandlung von pankreaskrebs durch wasserunlösliches s- camptothecin mit geschlossenem lactonring ATE227573T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US284493A	1993-01-15	1993-01-15

Publications (1)

Publication Number	Publication Date
ATE227573T1 true ATE227573T1 (de)	2002-11-15

Family

ID=21702794

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT02015200T ATE388706T1 (de)	1993-01-15	1994-01-14	Die verwendung von wasserunlöslichem s- camptothecin mit geschlossenem lactonring für die herstellung eines medikamentes zur behandlung von darmkrebs
AT94907804T ATE165003T1 (de)	1993-01-15	1994-01-14	Transdermal behandlung von krebs mit wasserunlöslichem s-camtothecin mit geschlossenem lactoring
AT97101631T ATE227573T1 (de)	1993-01-15	1994-01-14	Orale oder intramuskuläre behandlung von pankreaskrebs durch wasserunlösliches s- camptothecin mit geschlossenem lactonring

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT02015200T ATE388706T1 (de)	1993-01-15	1994-01-14	Die verwendung von wasserunlöslichem s- camptothecin mit geschlossenem lactonring für die herstellung eines medikamentes zur behandlung von darmkrebs
AT94907804T ATE165003T1 (de)	1993-01-15	1994-01-14	Transdermal behandlung von krebs mit wasserunlöslichem s-camtothecin mit geschlossenem lactoring

Country Status (9)

Country	Link
EP (3)	EP0678025B1 (de)
JP (1)	JP3099128B2 (de)
AT (3)	ATE388706T1 (de)
CA (1)	CA2148822C (de)
DE (3)	DE69431731T2 (de)
DK (3)	DK1250926T3 (de)
ES (3)	ES2301590T3 (de)
PT (1)	PT1250926E (de)
WO (1)	WO1994015604A1 (de)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5244903A (en) *	1987-03-31	1993-09-14	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
DK0418099T3 (da) *	1989-09-15	2002-04-02	Res Triangle Inst	Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
US5422344A (en) *	1990-05-08	1995-06-06	The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services	Method of treating retroviral infections in mammals
ATE136898T1 (de) *	1991-10-29	1996-05-15	Glaxo Wellcome Inc	Wasserlösliche camptothecinderivate
NZ245112A (en) *	1991-11-15	1995-07-26	Smithkline Beecham Corp	Pharmaceutical composition comprising a camptothecin analog and a platinum coordination compound
AU2394392A (en) *	1991-12-10	1993-07-19	Smithkline Beecham Corporation	Treatment of colorectal cancer

1994
- 1994-01-14 AT AT02015200T patent/ATE388706T1/de not_active IP Right Cessation
- 1994-01-14 AT AT94907804T patent/ATE165003T1/de not_active IP Right Cessation
- 1994-01-14 ES ES02015200T patent/ES2301590T3/es not_active Expired - Lifetime
- 1994-01-14 DE DE69431731T patent/DE69431731T2/de not_active Expired - Fee Related
- 1994-01-14 EP EP94907804A patent/EP0678025B1/de not_active Expired - Lifetime
- 1994-01-14 ES ES97101631T patent/ES2186812T3/es not_active Expired - Lifetime
- 1994-01-14 DE DE69409633T patent/DE69409633T2/de not_active Expired - Fee Related
- 1994-01-14 DK DK02015200T patent/DK1250926T3/da active
- 1994-01-14 DK DK94907804T patent/DK0678025T3/da active
- 1994-01-14 ES ES94907804T patent/ES2114681T3/es not_active Expired - Lifetime
- 1994-01-14 EP EP02015200A patent/EP1250926B1/de not_active Expired - Lifetime
- 1994-01-14 AT AT97101631T patent/ATE227573T1/de not_active IP Right Cessation
- 1994-01-14 DK DK97101631T patent/DK0778024T3/da active
- 1994-01-14 DE DE69435084T patent/DE69435084T2/de not_active Expired - Fee Related
- 1994-01-14 EP EP97101631A patent/EP0778024B1/de not_active Expired - Lifetime
- 1994-01-14 WO PCT/US1994/000403 patent/WO1994015604A1/en not_active Ceased
- 1994-01-14 CA CA002148822A patent/CA2148822C/en not_active Expired - Fee Related
- 1994-01-14 JP JP06516305A patent/JP3099128B2/ja not_active Expired - Fee Related
- 1994-01-14 PT PT02015200T patent/PT1250926E/pt unknown

Also Published As

Publication number	Publication date
ES2301590T3 (es)	2008-07-01
JP3099128B2 (ja)	2000-10-16
DK0778024T3 (da)	2002-12-23
ATE165003T1 (de)	1998-05-15
DE69409633T2 (de)	1998-08-06
EP0778024B1 (de)	2002-11-13
DE69431731D1 (de)	2002-12-19
EP0678025A1 (de)	1995-10-25
ATE388706T1 (de)	2008-03-15
EP1250926A2 (de)	2002-10-23
JPH08505626A (ja)	1996-06-18
WO1994015604A1 (en)	1994-07-21
EP0678025B1 (de)	1998-04-15
DE69435084D1 (de)	2008-04-24
CA2148822C (en)	2001-03-27
PT1250926E (pt)	2008-06-11
CA2148822A1 (en)	1994-07-21
DE69435084T2 (de)	2009-03-19
ES2114681T3 (es)	1998-06-01
DK0678025T3 (da)	1998-10-07
ES2186812T3 (es)	2003-05-16
DK1250926T3 (da)	2008-07-07
DE69409633D1 (de)	1998-05-20
EP1250926A3 (de)	2002-11-20
EP0778024A1 (de)	1997-06-11
EP1250926B1 (de)	2008-03-12
DE69431731T2 (de)	2003-03-13

Legal Events

Date

Code

Title

Description

2003-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0778024

Country of ref document: EP

2009-10-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE105482T1 (de)	1994-05-15	Behandlung von krebs mit somatostatin und mit analogen davon.
ATE72991T1 (de)	1992-03-15	Nasale verabreichung von arzneimitteln.
ATE168560T1 (de)	1998-08-15	Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
EP0449247A3 (en)	1992-03-04	Pharmaceutical composition containing galanthamine for treating alcoholism
DK541189D0 (da)	1989-10-30	Anvendelse af nalmefen eller naltrexon til fremstilling af et laegemiddel til behandling af interstitiel cystitis
DE69201660D1 (de)	1995-04-20	Verwendung von Acetyl L-Carnitin zur therapeutischen Behandlung von Coma.
ES2093357T3 (es)	1996-12-16	Metodo de tratamiento de la alopecia.
DK0458589T3 (da)	1995-04-03	Behandling af okulær hypertension med en okulær synergistisk kombination
ATE227573T1 (de)	2002-11-15	Orale oder intramuskuläre behandlung von pankreaskrebs durch wasserunlösliches s- camptothecin mit geschlossenem lactonring
DE69010523D1 (de)	1994-08-18	Kit oder Zusammensetzung zur Vorbeugung oder Behandlung von HIV-1 Infektionen.
DE68910010D1 (de)	1993-11-25	Verwendung von Dapiprazol zur Herstellung eines Arzneimittels zur Verhinderung des Toleranzentwicklung bei der analgetischen Behandlung mit Morphin.
DE69233773D1 (de)	2009-11-19	Verwendung von topotecan zur herstellung eines medikaments zur verwendung in der behandlung von ovarialkrebs
IL98200A0 (en)	1992-06-21	Pharmaceutical composition containing a derivative of substituted-l-valyl-l-prolinamide
DK0556051T3 (da)	1997-07-28	Anvendelse af bilobalid samt derivater deraf til behandling af en infektion hos et individ og farmaceutiske præparater tilpasset denne anvendelse.
DE69932741D1 (de)	2006-09-21	Verwendung von n-glycolneuraminsäure und deren derivaten zur herstellung eines medikaments zur behandlung von hiv-infektionen
AU628492B2 (en)	1992-09-17	Improvements in chemical compounds