DK0678025T3 - Transdermal behandling af cancer med vand-ouopløslig S-camptothecin af den lukkede lactonringform - Google Patents

Transdermal behandling af cancer med vand-ouopløslig S-camptothecin af den lukkede lactonringform

Info

Publication number: DK0678025T3
Authority: DK; Denmark
Prior art keywords: camptothecin; insoluble; water; lactone ring; cancer
Prior art date: 1993-01-15

Application number

DK94907804T

Other languages

English (en)

Inventor

Beppino C Giovanella

Hellmuth R Hinz

Anthony J Kozielski

John S Stehlin

Original Assignee

Stehlin Foundation For Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-15

Filing date

1994-01-14

Publication date

1998-10-07

1994-01-14 Application filed by Stehlin Foundation For Cancer filed Critical Stehlin Foundation For Cancer

1998-10-07 Application granted granted Critical

1998-10-07 Publication of DK0678025T3 publication Critical patent/DK0678025T3/da

Links

229940127093 camptothecin Drugs 0.000 title abstract 2
150000002596 lactones Chemical group 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 2
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
206010009944 Colon cancer Diseases 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000007918 intramuscular administration Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK94907804T 1993-01-15 1994-01-14 Transdermal behandling af cancer med vand-ouopløslig S-camptothecin af den lukkede lactonringform DK0678025T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US284493A	1993-01-15	1993-01-15
PCT/US1994/000403 WO1994015604A1 (en)	1993-01-15	1994-01-14	Transdermal treatment of cancer with water-insoluble s-camptothecin of the closed lactone ring form

Publications (1)

Publication Number	Publication Date
DK0678025T3 true DK0678025T3 (da)	1998-10-07

Family

ID=21702794

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK94907804T DK0678025T3 (da)	1993-01-15	1994-01-14	Transdermal behandling af cancer med vand-ouopløslig S-camptothecin af den lukkede lactonringform
DK97101631T DK0778024T3 (da)	1993-01-15	1994-01-14	Oral eller intramuskulær behandling af pancreascancer med vanduopløselig S-camptothecin i lukket lactonring-formen
DK02015200T DK1250926T3 (da)	1993-01-15	1994-01-14	Anvendelse af vanduoplöseligt S-camptothecin med en lukket lactonring i fremstilling af et medikament til behandling af coloncancer

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK97101631T DK0778024T3 (da)	1993-01-15	1994-01-14	Oral eller intramuskulær behandling af pancreascancer med vanduopløselig S-camptothecin i lukket lactonring-formen
DK02015200T DK1250926T3 (da)	1993-01-15	1994-01-14	Anvendelse af vanduoplöseligt S-camptothecin med en lukket lactonring i fremstilling af et medikament til behandling af coloncancer

Country Status (9)

Country	Link
EP (3)	EP0678025B1 (da)
JP (1)	JP3099128B2 (da)
AT (3)	ATE165003T1 (da)
CA (1)	CA2148822C (da)
DE (3)	DE69431731T2 (da)
DK (3)	DK0678025T3 (da)
ES (3)	ES2301590T3 (da)
PT (1)	PT1250926E (da)
WO (1)	WO1994015604A1 (da)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5244903A (en) *	1987-03-31	1993-09-14	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
DK0418099T3 (da) *	1989-09-15	2002-04-02	Res Triangle Inst	Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
US5422344A (en) *	1990-05-08	1995-06-06	The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services	Method of treating retroviral infections in mammals
ATE136898T1 (de) *	1991-10-29	1996-05-15	Glaxo Wellcome Inc	Wasserlösliche camptothecinderivate
WO1993009782A1 (en) *	1991-11-15	1993-05-27	Smithkline Beecham Corporation	Combination chemotherapy
AU2394392A (en) *	1991-12-10	1993-07-19	Smithkline Beecham Corporation	Treatment of colorectal cancer

1994
- 1994-01-14 EP EP94907804A patent/EP0678025B1/en not_active Expired - Lifetime
- 1994-01-14 DK DK94907804T patent/DK0678025T3/da active
- 1994-01-14 EP EP02015200A patent/EP1250926B1/en not_active Expired - Lifetime
- 1994-01-14 DE DE69431731T patent/DE69431731T2/de not_active Expired - Fee Related
- 1994-01-14 CA CA002148822A patent/CA2148822C/en not_active Expired - Fee Related
- 1994-01-14 AT AT94907804T patent/ATE165003T1/de not_active IP Right Cessation
- 1994-01-14 WO PCT/US1994/000403 patent/WO1994015604A1/en not_active Ceased
- 1994-01-14 DK DK97101631T patent/DK0778024T3/da active
- 1994-01-14 JP JP06516305A patent/JP3099128B2/ja not_active Expired - Fee Related
- 1994-01-14 DE DE69435084T patent/DE69435084T2/de not_active Expired - Fee Related
- 1994-01-14 PT PT02015200T patent/PT1250926E/pt unknown
- 1994-01-14 DK DK02015200T patent/DK1250926T3/da active
- 1994-01-14 AT AT97101631T patent/ATE227573T1/de not_active IP Right Cessation
- 1994-01-14 ES ES02015200T patent/ES2301590T3/es not_active Expired - Lifetime
- 1994-01-14 DE DE69409633T patent/DE69409633T2/de not_active Expired - Fee Related
- 1994-01-14 EP EP97101631A patent/EP0778024B1/en not_active Expired - Lifetime
- 1994-01-14 AT AT02015200T patent/ATE388706T1/de not_active IP Right Cessation
- 1994-01-14 ES ES94907804T patent/ES2114681T3/es not_active Expired - Lifetime
- 1994-01-14 ES ES97101631T patent/ES2186812T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK1250926T3 (da)	2008-07-07
DK0778024T3 (da)	2002-12-23
EP0678025B1 (en)	1998-04-15
CA2148822A1 (en)	1994-07-21
EP0778024A1 (en)	1997-06-11
DE69409633T2 (de)	1998-08-06
DE69435084T2 (de)	2009-03-19
EP1250926A2 (en)	2002-10-23
ATE165003T1 (de)	1998-05-15
EP0678025A1 (en)	1995-10-25
JP3099128B2 (ja)	2000-10-16
DE69409633D1 (de)	1998-05-20
EP0778024B1 (en)	2002-11-13
JPH08505626A (ja)	1996-06-18
ES2114681T3 (es)	1998-06-01
ATE388706T1 (de)	2008-03-15
EP1250926B1 (en)	2008-03-12
ES2301590T3 (es)	2008-07-01
DE69431731T2 (de)	2003-03-13
CA2148822C (en)	2001-03-27
ES2186812T3 (es)	2003-05-16
PT1250926E (pt)	2008-06-11
ATE227573T1 (de)	2002-11-15
WO1994015604A1 (en)	1994-07-21
DE69431731D1 (de)	2002-12-19
DE69435084D1 (de)	2008-04-24
EP1250926A3 (en)	2002-11-20

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ATE352289T1 (de)	2007-02-15	Mittel zur oralen verabreichung
DK203787D0 (da)	1987-04-22	Praeparat til nasal administrering
DK0668763T3 (da)	2002-06-03	Anvendelse af phenserin til fremstillingen af lægemidler til behandlingen af kognitive sygdomme
DK0735863T3 (da)	2002-12-16	Præparat indeholdende bromocriptin med accelereret frigørelse
DE3873603D1 (de)	1992-09-17	Zusammensetzung gegen coccidiosis.
DK0458589T3 (da)	1995-04-03	Behandling af okulær hypertension med en okulær synergistisk kombination
DE3856052D1 (de)	1997-11-27	Anwendung des N-n-butyl-Derivates von Desoxynojirimycin zur Herstellung eines Arzneimittels zur Inhibierung von HIV-Virus
DK1250926T3 (da)	2008-07-07	Anvendelse af vanduoplöseligt S-camptothecin med en lukket lactonring i fremstilling af et medikament til behandling af coloncancer
ATE108335T1 (de)	1994-07-15	Kit oder zusammensetzung zur vorbeugung oder behandlung von hiv-1 infektionen.
GB9202993D0 (en)	1992-03-25	Novel pharmaceutical uses of bilobalide and derivatives thereof and pharmaceutical compositions adapted for such use
DE69233773D1 (de)	2009-11-19	Verwendung von topotecan zur herstellung eines medikaments zur verwendung in der behandlung von ovarialkrebs
DK0490380T3 (da)	1998-09-23	Anvendelse af N,N'-bis[3-(ethylamino)propyl]-1,7-heptandiamin og et cytotoksisk middel
DK0457336T3 (da)	1995-08-07	Ny anvendelse af 4-carbamoyl-1-beta-D-ribofuranosylimidazolium-5-olat
AU628492B2 (en)	1992-09-17	Improvements in chemical compounds
UA37934A (uk)	2001-05-15	Спосіб профілактики карієсу зубів