ATE240734T1 - Zubereitung von xanthinderivaten als feste dispersion - Google Patents
Zubereitung von xanthinderivaten als feste dispersionInfo
- Publication number
- ATE240734T1 ATE240734T1 AT96916342T AT96916342T ATE240734T1 AT E240734 T1 ATE240734 T1 AT E240734T1 AT 96916342 T AT96916342 T AT 96916342T AT 96916342 T AT96916342 T AT 96916342T AT E240734 T1 ATE240734 T1 AT E240734T1
- Authority
- AT
- Austria
- Prior art keywords
- solid dispersion
- preparation
- xanthinderivates
- hxdrogen
- hxdroxy
- Prior art date
Links
- 239000007962 solid dispersion Substances 0.000 title abstract 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000002605 large molecules Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19005895 | 1995-07-26 | ||
| PCT/JP1996/001555 WO1997004782A1 (en) | 1995-07-26 | 1996-06-07 | Solid dispersion or solid dispersion preparation of xanthine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240734T1 true ATE240734T1 (de) | 2003-06-15 |
Family
ID=16251650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96916342T ATE240734T1 (de) | 1995-07-26 | 1996-06-07 | Zubereitung von xanthinderivaten als feste dispersion |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6254889B1 (de) |
| EP (1) | EP0784974B1 (de) |
| JP (1) | JP3938938B2 (de) |
| AT (1) | ATE240734T1 (de) |
| DE (1) | DE69628276T2 (de) |
| DK (1) | DK0784974T3 (de) |
| ES (1) | ES2199289T3 (de) |
| PT (1) | PT784974E (de) |
| WO (1) | WO1997004782A1 (de) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| US6706283B1 (en) * | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
| ATE400252T1 (de) | 1999-02-10 | 2008-07-15 | Pfizer Prod Inc | Pharmazeutische feste dispersionen |
| EP1239831B1 (de) | 1999-12-23 | 2012-10-31 | Mayne Pharma International Pty Ltd. | Verbesserte pharmazeutische zusammensetzungen für schwerlösliche arzneistoffe |
| CN1402629A (zh) | 1999-12-23 | 2003-03-12 | 辉瑞产品公司 | 提供提高的药物浓度的药物组合物 |
| US20010053791A1 (en) * | 2000-03-16 | 2001-12-20 | Babcock Walter C. | Glycogen phosphorylase inhibitor |
| AU2256702A (en) * | 2000-12-01 | 2002-06-11 | Kyowa Hakko Kogyo Kk | Composition improved in solubility or oral absorbability |
| US20030082231A1 (en) * | 2001-02-02 | 2003-05-01 | Cheryl Kos | Coating for orally administered compositions |
| JP4310605B2 (ja) * | 2001-05-25 | 2009-08-12 | 大塚製薬株式会社 | 医薬用組成物 |
| JP2004534812A (ja) * | 2001-06-22 | 2004-11-18 | ファイザー・プロダクツ・インク | 薬物および中性ポリマーの分散物の医薬組成物 |
| DE60320940D1 (de) | 2002-02-01 | 2008-06-26 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
| EP1479300B1 (de) * | 2002-02-22 | 2009-10-21 | Ajinomoto Co., Inc. | Aminosäurepulver und verfahren zu seiner herstellung |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| CA2522971A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| EP1932529A1 (de) | 2003-04-25 | 2008-06-18 | Novacardia, Inc. | Verfahren zur verbesserten Harnausscheidung bei Personen mit beeinträchtiger Nierenfunktion |
| EP1626049B1 (de) * | 2003-05-09 | 2012-02-22 | Kyowa Hakko Kirin Co., Ltd. | Microkristall of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione |
| BRPI0413277A (pt) | 2003-08-04 | 2006-10-10 | Pfizer Prod Inc | composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas |
| AU2005237466A1 (en) * | 2004-04-16 | 2005-11-10 | Novacardia, Inc. | Combination therapy comprising an adenosine A1 receptor antagonist and an aldosterone inhibitor |
| US20080312587A1 (en) * | 2005-06-10 | 2008-12-18 | Gruenethal Gmbh | System for the Oral Administration of Solids to Persons Suffering from Dementia |
| WO2007069675A1 (ja) | 2005-12-14 | 2007-06-21 | Kyowa Hakko Kogyo Co., Ltd. | キサンチン誘導体の易吸収性経口製剤 |
| JP2007308480A (ja) * | 2006-04-20 | 2007-11-29 | Shin Etsu Chem Co Ltd | 腸溶性固体分散体を含んでなる固形製剤 |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| WO2008121893A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| GB0708258D0 (en) * | 2007-04-27 | 2007-06-06 | Katholleke Universiteit Leuven | New anti-viral nulceoside analogs |
| US8309129B2 (en) | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| US8703204B2 (en) | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
| WO2008149230A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate |
| EP2162120B1 (de) | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer |
| DK2200588T3 (da) * | 2007-09-25 | 2019-07-01 | Solubest Ltd | Sammensætninger, som omfatter lipofile aktive forbindelser, og fremgangsmåde til fremstilling deraf |
| WO2009073216A1 (en) | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer |
| EP2231169B1 (de) | 2007-12-06 | 2016-05-04 | Bend Research, Inc. | Pharmazeutische zusammensetzungen mit nanopartikeln und resuspensionsmaterial |
| AU2009223014A1 (en) * | 2008-03-11 | 2009-09-17 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
| KR20200065093A (ko) | 2012-06-21 | 2020-06-08 | 메인 파마 인터내셔널 프로프라이어터리 리미티드 | 이트라코나졸 조성물 및 투여형, 그리고 이것들의 사용 방법 |
| TWI615157B (zh) * | 2013-02-06 | 2018-02-21 | 大塚製藥股份有限公司 | 包括不定形西洛他唑的固體分散劑 |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| SG11201811491YA (en) | 2016-06-27 | 2019-01-30 | Achillion Pharmaceuticals Inc | Quinazoline and indole compounds to treat medical disorders |
| CN110603252A (zh) | 2017-03-01 | 2019-12-20 | 艾其林医药公司 | 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物 |
| TWI780270B (zh) | 2017-11-28 | 2022-10-11 | 靜岡縣公立大學法人 | 固體分散體 |
| US20230022157A1 (en) | 2018-08-20 | 2023-01-26 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| JP7443375B2 (ja) | 2018-09-06 | 2024-03-05 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 医学的障害の治療のための大環状化合物 |
| EP3866773B1 (de) | 2018-10-16 | 2024-08-28 | Georgia State University Research Foundation, Inc. | Kohlenmonoxid-prodrugs zur behandlung von erkrankungen |
| WO2021127452A1 (en) | 2019-12-19 | 2021-06-24 | Georgia State University Research Foundation, Inc. | Compounds for the treatment of bacterial infections and potentiation of antibiotics |
| CN115362162A (zh) | 2020-02-20 | 2022-11-18 | 艾其林医药公司 | 用于治疗补体因子d介导的障碍的杂芳基化合物 |
| CN116437913A (zh) | 2020-09-23 | 2023-07-14 | 艾其林医药公司 | 用于治疗补体介导的病症的药物化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976071A (en) * | 1974-01-07 | 1976-08-24 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
| US5286489A (en) * | 1985-08-26 | 1994-02-15 | The Procter & Gamble Company | Taste masking compositions |
| CH674148A5 (de) * | 1986-06-24 | 1990-05-15 | Racz Istvan | |
| JP2521461B2 (ja) | 1987-03-10 | 1996-08-07 | エスエス製薬株式会社 | 持続性錠剤 |
| ATE124864T1 (de) * | 1989-03-10 | 1995-07-15 | Yamanouchi Pharma Co Ltd | Die wirkstoffabgabe steuerndes überzugsmaterial für lang wirksame formulierungen. |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| US5290782A (en) | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| WO1992018106A1 (fr) * | 1991-04-16 | 1992-10-29 | Nippon Shinyaku Co., Ltd. | Procede de production d'une dispersion solide |
-
1996
- 1996-06-07 DE DE69628276T patent/DE69628276T2/de not_active Expired - Fee Related
- 1996-06-07 WO PCT/JP1996/001555 patent/WO1997004782A1/ja not_active Ceased
- 1996-06-07 DK DK96916342T patent/DK0784974T3/da active
- 1996-06-07 AT AT96916342T patent/ATE240734T1/de not_active IP Right Cessation
- 1996-06-07 EP EP96916342A patent/EP0784974B1/de not_active Expired - Lifetime
- 1996-06-07 US US08/809,651 patent/US6254889B1/en not_active Expired - Fee Related
- 1996-06-07 PT PT96916342T patent/PT784974E/pt unknown
- 1996-06-07 ES ES96916342T patent/ES2199289T3/es not_active Expired - Lifetime
- 1996-06-07 JP JP50744297A patent/JP3938938B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997004782A1 (en) | 1997-02-13 |
| EP0784974A1 (de) | 1997-07-23 |
| DK0784974T3 (da) | 2003-09-01 |
| EP0784974B1 (de) | 2003-05-21 |
| DE69628276D1 (de) | 2003-06-26 |
| DE69628276T2 (de) | 2004-04-08 |
| JP3938938B2 (ja) | 2007-06-27 |
| EP0784974A4 (de) | 2000-09-27 |
| US6254889B1 (en) | 2001-07-03 |
| PT784974E (pt) | 2003-09-30 |
| ES2199289T3 (es) | 2004-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0784974 Country of ref document: EP |
|
| EEFA | Change of the company name | ||
| REN | Ceased due to non-payment of the annual fee |