ATE229520T1 - Benzothiophenderivate als antithrombotische mitteln und zwischenprodukte - Google Patents
Benzothiophenderivate als antithrombotische mitteln und zwischenprodukteInfo
- Publication number
- ATE229520T1 ATE229520T1 AT99308495T AT99308495T ATE229520T1 AT E229520 T1 ATE229520 T1 AT E229520T1 AT 99308495 T AT99308495 T AT 99308495T AT 99308495 T AT99308495 T AT 99308495T AT E229520 T1 ATE229520 T1 AT E229520T1
- Authority
- AT
- Austria
- Prior art keywords
- direct bond
- hydrogen
- methylene
- formula
- intermediate products
- Prior art date
Links
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229960004676 antithrombotic agent Drugs 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- -1 5-tetrazolyl Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 2
- 229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003868 thrombin inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10604898P | 1998-10-28 | 1998-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229520T1 true ATE229520T1 (de) | 2002-12-15 |
Family
ID=22309199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99308495T ATE229520T1 (de) | 1998-10-28 | 1999-10-27 | Benzothiophenderivate als antithrombotische mitteln und zwischenprodukte |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6133262A (de) |
| EP (1) | EP0997460B1 (de) |
| JP (1) | JP2000136188A (de) |
| AT (1) | ATE229520T1 (de) |
| CA (1) | CA2287549A1 (de) |
| DE (1) | DE69904427T2 (de) |
| DK (1) | DK0997460T3 (de) |
| ES (1) | ES2189355T3 (de) |
| PT (1) | PT997460E (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007096362A1 (en) * | 2006-02-21 | 2007-08-30 | Trigen Limited | Heterocyclic compounds and their use in the treatment of cardiovascular disease |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274213A (en) * | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
| US3293263A (en) * | 1963-12-09 | 1966-12-20 | Upjohn Co | Diphenylbenzocycloalkenes |
| GB1456323A (en) * | 1974-06-06 | 1976-11-24 | Labaz | Benzothiophenes process for preparing them and pharmaceutical compositions containing the same |
| US4001426A (en) * | 1974-10-17 | 1977-01-04 | Smithkline Corporation | Substituted benzofurans and benzothiophenes |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| KR920703558A (ko) * | 1990-11-15 | 1992-12-18 | 원본미기재 | 메타-치환 페닐알라닌 유도체 |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| US5371091A (en) * | 1992-08-31 | 1994-12-06 | Bristol-Myers Squibb Company | Heteroaromatic amine thrombin inhibitors |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5441965A (en) * | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting thrombin |
| JPH09507071A (ja) * | 1993-12-21 | 1997-07-15 | イーライ・リリー・アンド・カンパニー | アミロイド原性ペプチドに関連した状態を治療又は予防する方法 |
| EP0736007A4 (de) * | 1993-12-21 | 1997-03-19 | Lilly Co Eli | Nicht-peptidische tachykinin rezeptor antagonisten |
| IL115582A0 (en) * | 1994-10-14 | 1996-01-19 | Lilly Co Eli | Methods for treating resistant tumors |
| US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| US5523309A (en) * | 1995-03-10 | 1996-06-04 | Eli Lilly And Company | Benzofuran pharmaceutical compounds |
| US5567828A (en) * | 1995-06-07 | 1996-10-22 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side |
| US5532254A (en) * | 1995-06-07 | 1996-07-02 | Eli Lilly And Company | Modulation of calcium channels using benzothiophenes |
| JP2002500618A (ja) * | 1995-10-31 | 2002-01-08 | イーライ・リリー・アンド・カンパニー | 抗血栓性ジアミン |
| CA2214919A1 (en) * | 1996-09-24 | 1998-03-24 | Kenneth Lee Hauser | Benzothiophene compounds, intermediates, processes, compositions, and methods |
-
1999
- 1999-10-27 PT PT99308495T patent/PT997460E/pt unknown
- 1999-10-27 DK DK99308495T patent/DK0997460T3/da active
- 1999-10-27 CA CA002287549A patent/CA2287549A1/en not_active Abandoned
- 1999-10-27 AT AT99308495T patent/ATE229520T1/de not_active IP Right Cessation
- 1999-10-27 DE DE69904427T patent/DE69904427T2/de not_active Expired - Fee Related
- 1999-10-27 ES ES99308495T patent/ES2189355T3/es not_active Expired - Lifetime
- 1999-10-27 EP EP99308495A patent/EP0997460B1/de not_active Expired - Lifetime
- 1999-10-28 US US09/429,459 patent/US6133262A/en not_active Expired - Fee Related
- 1999-10-28 JP JP11306770A patent/JP2000136188A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PT997460E (pt) | 2003-03-31 |
| DE69904427T2 (de) | 2003-07-17 |
| EP0997460B1 (de) | 2002-12-11 |
| DE69904427D1 (de) | 2003-01-23 |
| EP0997460A1 (de) | 2000-05-03 |
| ES2189355T3 (es) | 2003-07-01 |
| CA2287549A1 (en) | 2000-04-28 |
| JP2000136188A (ja) | 2000-05-16 |
| DK0997460T3 (da) | 2003-03-31 |
| US6133262A (en) | 2000-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0997460 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |