DK0997460T3 - Benzothiophenforbindelser som antithrombotiske midler og mellemprodukter - Google Patents
Benzothiophenforbindelser som antithrombotiske midler og mellemprodukterInfo
- Publication number
- DK0997460T3 DK0997460T3 DK99308495T DK99308495T DK0997460T3 DK 0997460 T3 DK0997460 T3 DK 0997460T3 DK 99308495 T DK99308495 T DK 99308495T DK 99308495 T DK99308495 T DK 99308495T DK 0997460 T3 DK0997460 T3 DK 0997460T3
- Authority
- DK
- Denmark
- Prior art keywords
- direct bond
- hydrogen
- intermediates
- methylene
- formula
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229960004676 antithrombotic agent Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- -1 5-tetrazolyl Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 2
- 229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003868 thrombin inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10604898P | 1998-10-28 | 1998-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0997460T3 true DK0997460T3 (da) | 2003-03-31 |
Family
ID=22309199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99308495T DK0997460T3 (da) | 1998-10-28 | 1999-10-27 | Benzothiophenforbindelser som antithrombotiske midler og mellemprodukter |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6133262A (da) |
| EP (1) | EP0997460B1 (da) |
| JP (1) | JP2000136188A (da) |
| AT (1) | ATE229520T1 (da) |
| CA (1) | CA2287549A1 (da) |
| DE (1) | DE69904427T2 (da) |
| DK (1) | DK0997460T3 (da) |
| ES (1) | ES2189355T3 (da) |
| PT (1) | PT997460E (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007217529A1 (en) * | 2006-02-21 | 2007-08-30 | Trigen Limited | Heterocyclic compounds and their use in the treatment of cardiovascular disease |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274213A (en) * | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
| US3293263A (en) * | 1963-12-09 | 1966-12-20 | Upjohn Co | Diphenylbenzocycloalkenes |
| GB1456323A (en) * | 1974-06-06 | 1976-11-24 | Labaz | Benzothiophenes process for preparing them and pharmaceutical compositions containing the same |
| US4001426A (en) * | 1974-10-17 | 1977-01-04 | Smithkline Corporation | Substituted benzofurans and benzothiophenes |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| JPH05503300A (ja) * | 1990-11-15 | 1993-06-03 | ペンタファルム アクチェンゲゼルシャフト | メタ置換フェニルアラニン誘導体 |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| US5371091A (en) * | 1992-08-31 | 1994-12-06 | Bristol-Myers Squibb Company | Heteroaromatic amine thrombin inhibitors |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5441965A (en) * | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting thrombin |
| WO1995017382A1 (en) * | 1993-12-21 | 1995-06-29 | Eli Lilly And Company | Non-peptide tachykinin receptor antagonists |
| JPH09507071A (ja) * | 1993-12-21 | 1997-07-15 | イーライ・リリー・アンド・カンパニー | アミロイド原性ペプチドに関連した状態を治療又は予防する方法 |
| IL115582A0 (en) * | 1994-10-14 | 1996-01-19 | Lilly Co Eli | Methods for treating resistant tumors |
| US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| US5523309A (en) * | 1995-03-10 | 1996-06-04 | Eli Lilly And Company | Benzofuran pharmaceutical compounds |
| US5532254A (en) * | 1995-06-07 | 1996-07-02 | Eli Lilly And Company | Modulation of calcium channels using benzothiophenes |
| US5567828A (en) * | 1995-06-07 | 1996-10-22 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side |
| ATE284690T1 (de) * | 1995-10-31 | 2005-01-15 | Lilly Co Eli | Antithrombotische diamine |
| CA2214919A1 (en) * | 1996-09-24 | 1998-03-24 | Kenneth Lee Hauser | Benzothiophene compounds, intermediates, processes, compositions, and methods |
-
1999
- 1999-10-27 DK DK99308495T patent/DK0997460T3/da active
- 1999-10-27 PT PT99308495T patent/PT997460E/pt unknown
- 1999-10-27 ES ES99308495T patent/ES2189355T3/es not_active Expired - Lifetime
- 1999-10-27 CA CA002287549A patent/CA2287549A1/en not_active Abandoned
- 1999-10-27 DE DE69904427T patent/DE69904427T2/de not_active Expired - Fee Related
- 1999-10-27 EP EP99308495A patent/EP0997460B1/en not_active Expired - Lifetime
- 1999-10-27 AT AT99308495T patent/ATE229520T1/de not_active IP Right Cessation
- 1999-10-28 JP JP11306770A patent/JP2000136188A/ja not_active Withdrawn
- 1999-10-28 US US09/429,459 patent/US6133262A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE229520T1 (de) | 2002-12-15 |
| JP2000136188A (ja) | 2000-05-16 |
| DE69904427D1 (de) | 2003-01-23 |
| EP0997460B1 (en) | 2002-12-11 |
| PT997460E (pt) | 2003-03-31 |
| DE69904427T2 (de) | 2003-07-17 |
| ES2189355T3 (es) | 2003-07-01 |
| EP0997460A1 (en) | 2000-05-03 |
| CA2287549A1 (en) | 2000-04-28 |
| US6133262A (en) | 2000-10-17 |
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