ATE229527T1 - Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung - Google Patents

Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung

Info

Publication number: ATE229527T1
Authority: AT; Austria
Prior art keywords: derivatives; lower alkyl; pyrazolopyridylpyrazinone; production; activity
Prior art date: 1996-10-04

Application number

AT97941255T

Other languages

English (en)

Inventor

Yasushi Kouno

Takenobu Ogata

Katsuya Awano

Kayoko Matsuzawa

Taroh Tooru

Machi

Original Assignee

Kyorin Seiyaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-04

Filing date

1997-09-26

Publication date

2002-12-15

1997-09-26 Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229527T1 publication Critical patent/ATE229527T1/de

Links

BBZZRIPPYOYZOG-UHFFFAOYSA-N N1N=C(C2=C1C=CC=N2)C=2C(NC=CN2)=O Chemical class N1N=C(C2=C1C=CC=N2)C=2C(NC=CN2)=O BBZZRIPPYOYZOG-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
AUSTYKOYMLRNQQ-UHFFFAOYSA-N 5-(1h-pyrazolo[4,3-b]pyridin-3-yl)-1h-pyridazin-6-one Chemical class O=C1NN=CC=C1C1=NNC2=CC=CN=C12 AUSTYKOYMLRNQQ-UHFFFAOYSA-N 0.000 abstract 1
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
230000003182 bronchodilatating effect Effects 0.000 abstract 1
229940124630 bronchodilator Drugs 0.000 abstract 1
239000000168 bronchodilator agent Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
210000002345 respiratory system Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT97941255T 1996-10-04 1997-09-26 Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung ATE229527T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP28314896		1996-10-04
PCT/JP1997/003434 WO1998014448A1 (en)	1996-10-04	1997-09-26	Pyrazolopyridylpyridazinone derivatives and process for the preparation thereof

Publications (1)

Publication Number	Publication Date
ATE229527T1 true ATE229527T1 (de)	2002-12-15

Family

ID=17661845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97941255T ATE229527T1 (de)	1996-10-04	1997-09-26	Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung

Country Status (11)

Country	Link
US (1)	US6265577B1 (de)
EP (1)	EP0989129B1 (de)
KR (1)	KR100517397B1 (de)
CN (1)	CN1083841C (de)
AT (1)	ATE229527T1 (de)
AU (1)	AU733316B2 (de)
CA (1)	CA2267103C (de)
DE (1)	DE69717867T2 (de)
ES (1)	ES2187814T3 (de)
HU (1)	HUP9903018A2 (de)
WO (1)	WO1998014448A1 (de)

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US6187779B1 (en)	1998-11-20	2001-02-13	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
US6369092B1 (en)	1998-11-23	2002-04-09	Cell Pathways, Inc.	Method for treating neoplasia by exposure to substituted benzimidazole derivatives
US6077842A (en) *	1998-11-24	2000-06-20	Cell Pathways, Inc.	Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
US6486155B1 (en)	1998-11-24	2002-11-26	Cell Pathways Inc	Method of inhibiting neoplastic cells with isoquinoline derivatives
US6034099A (en) *	1998-11-24	2000-03-07	Cell Pathways, Inc.	Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6875575B1 (en)	1998-11-25	2005-04-05	Osi Pharmaceuticals, Inc.	Diagnostic methods for neoplasia
US6020379A (en) *	1999-02-19	2000-02-01	Cell Pathways, Inc.	Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
CA2715683A1 (en)	1999-08-21	2001-03-01	Nycomed Gmbh	Synergistic combination
US7276529B2 (en)	2002-03-20	2007-10-02	Celgene Corporation	Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7208516B2 (en)	2002-03-20	2007-04-24	Celgene Corporation	Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7893101B2 (en)	2002-03-20	2011-02-22	Celgene Corporation	Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en)	2002-03-20	2005-11-08	Celgene Corporation	(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
JP4589122B2 (ja) *	2002-12-03	2010-12-01	杏林製薬株式会社	ホスホジエステラーゼ１０ａ阻害剤
EA200501548A1 (ru)	2003-04-01	2006-02-24	Апплайд Резеч Системз Арс Холдинг Н.В.	Ингибиторы фосфодиэстераз при бесплодии
JP4890439B2 (ja) *	2005-03-07	2012-03-07	杏林製薬株式会社	ピラゾロピリジン−４−イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤
US7585875B2 (en) *	2006-06-06	2009-09-08	Avigen, Inc.	Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use
US20100056791A1 (en) *	2006-09-01	2010-03-04	Yasushi Kohno	Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
US20090318385A1 (en) *	2006-09-06	2009-12-24	Yasushi Kohno	Pyrazolopyride derivative and phosphodiesterase ( pde) inhibitors containing the same as active ingredient
JP2010013354A (ja) *	2006-09-07	2010-01-21	Kyorin Pharmaceut Co Ltd	２−アルキル−６−（ピラゾロピリジン−４−イル）ピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤
WO2008129624A1 (ja) *	2007-04-10	2008-10-30	Kyorin Pharmaceutical Co., Ltd.	ピラゾロピリジン－４－イルピラゾロン誘導体とその付加塩及びそれを有効成分とするホスホジエステラーゼ阻害剤
EP2348018A4 (de) *	2008-09-25	2012-04-25	Kyorin Seiyaku Kk	Heterocyclisches biarylderivat und dieses als wirkstoff enthaltender pde-hemmer
US20110224250A1 (en)	2008-10-09	2011-09-15	Yasushi Kohno	Isoquinoline derivative, and pde inhibitor comprising same as active ingredient
KR101946499B1 (ko)	2011-04-08	2019-02-11	얀센 사이언시즈 아일랜드 언리미티드 컴퍼니	바이러스 감염 치료를 위한 피리미딘 유도체
UA116083C2 (uk)	2011-11-09	2018-02-12	ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі	Похідні пурину для лікування вірусних інфекцій
PT2872515T (pt)	2012-07-13	2016-07-27	Janssen Sciences Ireland Uc	Purinas macrocíclicas para o tratamento de infeções virais
EA035327B1 (ru)	2012-10-10	2020-05-28	Янссен Сайенсиз Айрлэнд Юси	Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний
ES2655843T3 (es)	2012-11-16	2018-02-21	Janssen Sciences Ireland Uc	Derivados 2-aminoquinazolínicos sustituidos heterocíclicos para el tratamiento de infecciones víricas
MY191389A (en)	2013-02-21	2022-06-22	Janssen Sciences Ireland Uc	2-aminopyrimidine derivatives for the treatment of viral infections
CN105338983B (zh)	2013-03-29	2019-10-25	爱尔兰詹森科学公司	用于治疗病毒感染的大环脱氮-嘌呤酮
JP6377139B2 (ja)	2013-05-24	2018-08-22	ヤンセン・サイエンシズ・アイルランド・ユーシー	ウイルス感染症およびさらなる疾患の処置のためのピリドン誘導体
JP6763769B2 (ja)	2013-06-27	2020-09-30	ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー	ウイルス感染症および他の疾病の処置のためのピロロ［３，２−ｄ］ピリミジン誘導体
MX368625B (es)	2013-07-30	2019-10-08	Janssen Sciences Ireland Uc	Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales.
JP6687550B2 (ja)	2014-06-23	2020-04-22	セルジーンコーポレイション	肝疾患又は肝機能異常を治療するためのアプレミラスト
SG11201811448RA (en)	2016-07-01	2019-01-30	Janssen Sciences Ireland Unlimited Co	Dihydropyranopyrimidines for the treatment of viral infections
KR102450287B1 (ko)	2016-09-29	2022-09-30	얀센 사이언시즈 아일랜드 언리미티드 컴퍼니	바이러스 감염 및 추가적인 질환의 치료를 위한 피리미딘 프로드러그
TW202415645A (zh)	2018-03-01	2024-04-16	愛爾蘭商健生科學愛爾蘭無限公司	２，４－二胺基喹唑啉衍生物及其醫學用途

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GB8901423D0 (en) *	1989-01-23	1989-03-15	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
GB9015764D0 (en) *	1990-07-18	1990-09-05	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
CA2060138A1 (en) *	1991-01-29	1992-07-30	Youichi Shiokawa	New use of the adenosine antagonist

1997
- 1997-09-26 CA CA002267103A patent/CA2267103C/en not_active Expired - Fee Related
- 1997-09-26 AT AT97941255T patent/ATE229527T1/de not_active IP Right Cessation
- 1997-09-26 AU AU43213/97A patent/AU733316B2/en not_active Ceased
- 1997-09-26 US US09/269,734 patent/US6265577B1/en not_active Expired - Fee Related
- 1997-09-26 DE DE69717867T patent/DE69717867T2/de not_active Expired - Fee Related
- 1997-09-26 EP EP97941255A patent/EP0989129B1/de not_active Expired - Lifetime
- 1997-09-26 HU HU9903018A patent/HUP9903018A2/hu unknown
- 1997-09-26 CN CN97198468A patent/CN1083841C/zh not_active Expired - Fee Related
- 1997-09-26 KR KR10-1999-7002884A patent/KR100517397B1/ko not_active Expired - Fee Related
- 1997-09-26 ES ES97941255T patent/ES2187814T3/es not_active Expired - Lifetime
- 1997-09-26 WO PCT/JP1997/003434 patent/WO1998014448A1/ja not_active Ceased

Also Published As

Publication number	Publication date
DE69717867T2 (de)	2003-10-02
HUP9903018A2 (hu)	2000-03-28
CN1232463A (zh)	1999-10-20
US6265577B1 (en)	2001-07-24
EP0989129A4 (de)	2001-04-11
DE69717867D1 (de)	2003-01-23
WO1998014448A1 (en)	1998-04-09
KR20000048874A (ko)	2000-07-25
CA2267103C (en)	2006-05-30
CA2267103A1 (en)	1998-04-09
AU733316B2 (en)	2001-05-10
KR100517397B1 (ko)	2005-09-29
CN1083841C (zh)	2002-05-01
EP0989129A1 (de)	2000-03-29
AU4321397A (en)	1998-04-24
EP0989129B1 (de)	2002-12-11
ES2187814T3 (es)	2003-06-16

Legal Events

Date	Code	Title	Description
2003-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69717867D1 (de)	2003-01-23	Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung
DE69524251D1 (de)	2002-01-10	Neue verbindung, verfahren zu ihrer herstellung und antitumormittel
ATE210635T1 (de)	2001-12-15	Aromatische hydroxamsäure-verbindungen, ihre herstellung und verwendung
NZ240676A (en)	1993-05-26	Heterocyclic compounds substituted by a (piperidin-4-yl)-1-oxoalkyl group and pharmaceutical compositions thereof
ATE242241T1 (de)	2003-06-15	Imidazopyridinderivate und verfahren zu ihrer herstellung
ATE150462T1 (de)	1997-04-15	Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
ATE254612T1 (de)	2003-12-15	Zuckerderivate, geliermittel, geliermittelzubereitungen, verfahren zu ihrer herstellung und gelzubereitungen
ATE229960T1 (de)	2003-01-15	Verfahren zur herstellung von 13-ether-derivaten von milbemycinen und zwischenprodukte
EP1020434A4 (de)	2000-11-15	3-amidinoanilin-derivate, inhibitoren des aktivierten blutgerinnungsfaktors x und zwischenpodukte zur herstellung beider
ATE38661T1 (de)	1988-12-15	Zwischenprodukt und verfahren zu dessen herstellung.
ATE57699T1 (de)	1990-11-15	Pyridoncarbonsauere-derivate und verfahren zu ihrer herstellung.
ATE164582T1 (de)	1998-04-15	1-methylcarbapenemderivate und verfahren zu ihrer herstellung
EP1123918A4 (de)	2002-08-07	Aromatische aminderivate, verfahren zu ihrer herstellung und mittel, die diese enthalten
EP0997462A4 (de)	2001-07-04	Naphthyridinderivate oder salze davon
ATE141606T1 (de)	1996-09-15	Cephemverbindungen und verfahren zu ihrer herstellung
ATE60060T1 (de)	1991-02-15	Sialosylceramide und verfahren zu deren herstellung.
ATE142213T1 (de)	1996-09-15	Cephalosporinverbindungen und verfahren zu ihrer herstellung
ATE457972T1 (de)	2010-03-15	Verfahren zur herstellung von 7-amino-syn-3,5- dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
DE3864707D1 (de)	1991-10-17	Benzoxazin-derivate und verfahren zu ihrer herstellung.
DE3480839D1 (de)	1990-02-01	Benzimidazol-derivat, verfahren zu seiner herstellung und pharmazeutische zusammensetzung.
ATE148128T1 (de)	1997-02-15	Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
HUT50788A (en)	1990-03-28	Process for producing phenoxyacetic acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HUT49340A (en)	1989-09-28	Process for production of derivatives of tioformamid and medical compositions containing them
DE3884518D1 (de)	1993-11-04	Naphthothiazepin-derivate und verfahren zu ihrer herstellung.
ATE154359T1 (de)	1997-06-15	2'-methylidenpyrimidinnukleosidverbindungen, ihre verwendung und verfahren zu ihrer herstellung