ES2188795T3 - Agentes antimicrobianos benzoxacina. - Google Patents

Agentes antimicrobianos benzoxacina.

Info

Publication number
ES2188795T3
ES2188795T3 ES96936648T ES96936648T ES2188795T3 ES 2188795 T3 ES2188795 T3 ES 2188795T3 ES 96936648 T ES96936648 T ES 96936648T ES 96936648 T ES96936648 T ES 96936648T ES 2188795 T3 ES2188795 T3 ES 2188795T3
Authority
ES
Spain
Prior art keywords
benzoxacine
antimicrobial agents
group
those
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96936648T
Other languages
English (en)
Inventor
Roger Frechette
Michele A Weidner-Wells
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Application granted granted Critical
Publication of ES2188795T3 publication Critical patent/ES2188795T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION ESTA RELACIONADA CON UNOS COMPUESTOS ANTIBACTERIANOS DE BENZOXACINA Y PIRIDOXACINA CON LA FORMULA GENERAL (1), EN LA QUE EL GRUPO Q CORRESPONDE A UN GRUPO FENILO O PIRIDILO UNIDO, TAL COMO SE DESCRIBE MAS ADELANTE, ASI COMO UNAS COMPOSICIONES FARMACEUTICAS QUE CONTENGAN ESTOS COMPUESTOS, UNOS METODOS PARA SU PRODUCCION Y SU USO EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES96936648T 1995-11-07 1996-10-17 Agentes antimicrobianos benzoxacina. Expired - Lifetime ES2188795T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/553,188 US5696117A (en) 1995-11-07 1995-11-07 Benzoxazine antimicrobial agents

Publications (1)

Publication Number Publication Date
ES2188795T3 true ES2188795T3 (es) 2003-07-01

Family

ID=24208465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96936648T Expired - Lifetime ES2188795T3 (es) 1995-11-07 1996-10-17 Agentes antimicrobianos benzoxacina.

Country Status (24)

Country Link
US (2) US5696117A (es)
EP (1) EP0869949B1 (es)
JP (1) JP2000500134A (es)
KR (1) KR100503910B1 (es)
AR (1) AR004706A1 (es)
AT (1) ATE229944T1 (es)
AU (1) AU720743B2 (es)
BR (1) BR9611400A (es)
CZ (1) CZ137998A3 (es)
DE (1) DE69625515T2 (es)
DK (1) DK0869949T3 (es)
ES (1) ES2188795T3 (es)
HU (1) HUP9901184A3 (es)
IL (1) IL124337A (es)
MX (1) MX9803650A (es)
MY (1) MY128650A (es)
NO (1) NO311026B1 (es)
NZ (1) NZ321251A (es)
PL (1) PL189987B1 (es)
RU (1) RU2191179C2 (es)
SK (2) SK283888B6 (es)
TW (1) TW536537B (es)
WO (1) WO1997017333A1 (es)
ZA (1) ZA969326B (es)

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CA2307068C (en) 1997-10-27 2007-04-10 Dr. Reddy's Laboratories Limited Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
US6265401B1 (en) * 1997-10-27 2001-07-24 Reddy-Cheminor, Inc. Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2001012600A1 (en) * 1999-08-12 2001-02-22 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
WO2001087861A2 (en) * 2000-05-12 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators
WO2001087860A2 (en) * 2000-05-12 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Novel benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment
US6908908B2 (en) * 2000-05-12 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4H-benzo [1,4] oxazin-3-ones
AU2001263083A1 (en) 2000-05-12 2001-11-26 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4h-benzo(1,4)oxazin-3-ones
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
AU2004268865B8 (en) * 2003-09-01 2011-01-06 Ono Pharmaceutical Co., Ltd. Condensed ring compound and use thereof
KR20060080197A (ko) * 2003-09-17 2006-07-07 오노 야꾸힝 고교 가부시키가이샤 카르복실산 화합물 및 이들을 유효 성분으로서 함유하는의약 조성물
US20050266575A1 (en) * 2004-05-27 2005-12-01 Mayo Kevin H Pharmacophores for nociceptin, methods of obtaining and using in screening for nociceptin mimics
GB0423405D0 (en) * 2004-10-21 2004-11-24 Novartis Ag Organic compounds
WO2006082495A1 (en) * 2005-02-02 2006-08-10 Ranbaxy Laboratories Limited Peroxisome proliferator activated receptor modulators
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
TWI386207B (zh) * 2005-11-24 2013-02-21 Eisai R&D Man Co Ltd 味啉類型之肉桂醯胺化合物
WO2007086504A1 (ja) * 2006-01-27 2007-08-02 Japan Tobacco Inc. カルボン酸化合物及びその用途
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof
JP5099814B2 (ja) * 2006-02-02 2012-12-19 田辺三菱製薬株式会社 含窒素複素二環式化合物
TWI385161B (zh) 2006-02-02 2013-02-11 Mitsubishi Tanabe Pharma Corp 含氮雜雙環化合物
KR20080103090A (ko) * 2006-03-10 2008-11-26 유조 츠치다 항미생물제 및 항미생물성 조성물
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
TWI410410B (zh) * 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
AU2010237801A1 (en) * 2009-04-14 2011-10-20 Syngenta Participations Ag Haloalkylsulfonanilide derivative
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US9493452B2 (en) 2011-03-24 2016-11-15 Southern Methodist University Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
US8669363B2 (en) 2011-03-24 2014-03-11 Southern Methodist University Quinoxaline compounds and derivatives
WO2013142831A1 (en) 2012-03-23 2013-09-26 Southern Methodist University Methods of making and using thioxothiazolidine and rhodanine derivatives as hiv-1 and jsp-1 inhibitors
GB2533925A (en) * 2014-12-31 2016-07-13 Univ Bath Antimicrobial compounds, compositions and methods
JP7397491B2 (ja) 2018-10-23 2023-12-13 国立研究開発法人科学技術振興機構 ＰＰＡＲδ活性化剤

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US3635956A (en) * 1968-03-01 1972-01-18 Squibb & Sons Inc Benzothiazines related compounds derivatives and salts thereof
US3725403A (en) * 1970-10-20 1973-04-03 Squibb & Sons Inc Benzothiazine derivatives
JPS5547006B2 (es) * 1973-04-04 1980-11-27
FR2588868B1 (fr) * 1985-10-21 1988-11-10 Negma Laboratoires Acyl-7 benzoxazinones et leurs derives, procede pour les obtenir et compositions pharmaceutiques les contenant
EP0233728A1 (en) * 1986-02-11 1987-08-26 Takeda Chemical Industries, Ltd. 1,4-Benzoxazine derivatives their production and use
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
AU5404790A (en) * 1989-04-26 1990-11-16 Upjohn Company, The Antibacterial pyrido(1,2,3-de)-1,4-benzoxazinone agents
NO179912C (no) * 1990-11-28 1997-01-08 Daiichi Seiyaku Co Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat
DE4304806A1 (de) * 1993-02-17 1994-08-18 Kali Chemie Pharma Gmbh 5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2714381B1 (fr) * 1993-12-29 1996-02-02 Pharmascience Lab Dérivés de la benzoxazine, leurs procédés d'obtention et leur utilisation en tant que médicaments .

Also Published As

Publication number Publication date
US5854242A (en) 1998-12-29
WO1997017333A1 (en) 1997-05-15
DE69625515T2 (de) 2003-05-15
SK59798A3 (en) 1999-09-10
RU2191179C2 (ru) 2002-10-20
EP0869949B1 (en) 2002-12-18
JP2000500134A (ja) 2000-01-11
IL124337A (en) 2001-08-08
IL124337A0 (en) 1998-12-06
DE69625515D1 (de) 2003-01-30
NO982071L (no) 1998-06-05
NZ321251A (en) 1999-10-28
PL326704A1 (en) 1998-10-26
EP0869949A1 (en) 1998-10-14
HUP9901184A2 (hu) 1999-10-28
ZA969326B (en) 1998-05-06
MY128650A (en) 2007-02-28
AU7451996A (en) 1997-05-29
DK0869949T3 (da) 2003-03-31
AR004706A1 (es) 1999-03-10
PL189987B1 (pl) 2005-10-31
CZ137998A3 (cs) 1998-10-14
BR9611400A (pt) 1999-08-31
KR19990067395A (ko) 1999-08-16
MX9803650A (es) 1998-11-30
NO311026B1 (no) 2001-10-01
US5696117A (en) 1997-12-09
AU720743B2 (en) 2000-06-08
HUP9901184A3 (en) 2001-11-28
TW536537B (en) 2003-06-11
ATE229944T1 (de) 2003-01-15
KR100503910B1 (ko) 2005-12-29
NO982071D0 (no) 1998-05-06
SK283888B6 (sk) 2004-04-06
SK285388B6 (sk) 2006-12-07

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