ATE230273T1 - Verwendung von deltorphin zur behandlung von zytokin-vermittelter leberschädigung - Google Patents

Verwendung von deltorphin zur behandlung von zytokin-vermittelter leberschädigung

Info

Publication number: ATE230273T1
Authority: AT; Austria
Prior art keywords: deltorphin; seq; liver damage; deltorphins; mediated liver
Prior art date: 1998-05-01

Application number

AT99921558T

Other languages

English (en)

Inventor

Peter R Oeltgen

Craig I Mcclain

Shirish Barve

Paul D Bishop

Original Assignee

Univ Kentucky Res Found

Zymogenetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-01

Filing date

1999-04-30

Publication date

2003-01-15

1999-04-30 Application filed by Univ Kentucky Res Found, Zymogenetics Inc filed Critical Univ Kentucky Res Found

2003-01-15 Application granted granted Critical

2003-01-15 Publication of ATE230273T1 publication Critical patent/ATE230273T1/de

Links

101800005209 Deltorphin Proteins 0.000 title abstract 2
BHSURCCZOBVHJJ-NWOHMYAQSA-N Deltorphin A Chemical compound C([C@H](N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(N)=O)C1=CC=C(O)C=C1 BHSURCCZOBVHJJ-NWOHMYAQSA-N 0.000 title abstract 2
206010067125 Liver injury Diseases 0.000 title 1
231100000234 hepatic damage Toxicity 0.000 title 1
230000008818 liver damage Effects 0.000 title 1
102000004127 Cytokines Human genes 0.000 abstract 3
108090000695 Cytokines Proteins 0.000 abstract 3
231100000753 hepatic injury Toxicity 0.000 abstract 2
230000001404 mediated effect Effects 0.000 abstract 2
108700040992 Ala(2)- deltorphin I Proteins 0.000 abstract 1
108700040991 Ala(2)- deltorphin II Proteins 0.000 abstract 1
NUNBRHVOPFWRRG-RCEFDBTISA-N Deltorphin B Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O)C(C)C)NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 NUNBRHVOPFWRRG-RCEFDBTISA-N 0.000 abstract 1
CJAORFIPPWIGPG-QXYJMILXSA-N Deltorphin C Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O)C(C)C)NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 CJAORFIPPWIGPG-QXYJMILXSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
206010040070 Septic Shock Diseases 0.000 abstract 1
108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
208000014674 injury Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000010172 mouse model Methods 0.000 abstract 1
230000036303 septic shock Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
239000003053 toxin Substances 0.000 abstract 1
231100000765 toxin Toxicity 0.000 abstract 1
108700012359 toxins Proteins 0.000 abstract 1
230000008733 trauma Effects 0.000 abstract 1
102000003390 tumor necrosis factor Human genes 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Compounds Of Unknown Constitution (AREA)

AT99921558T 1998-05-01 1999-04-30 Verwendung von deltorphin zur behandlung von zytokin-vermittelter leberschädigung ATE230273T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7125598A	1998-05-01	1998-05-01
PCT/US1999/009457 WO1999056767A2 (en)	1998-05-01	1999-04-30	Method for treating cytokine mediated hepatic injury

Publications (1)

Publication Number	Publication Date
ATE230273T1 true ATE230273T1 (de)	2003-01-15

Family

ID=22100214

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99921558T ATE230273T1 (de)	1998-05-01	1999-04-30	Verwendung von deltorphin zur behandlung von zytokin-vermittelter leberschädigung

Country Status (10)

Country	Link
EP (1)	EP1073452B1 (de)
JP (1)	JP2002513767A (de)
AT (1)	ATE230273T1 (de)
AU (1)	AU751972B2 (de)
BR (1)	BR9909988A (de)
CA (1)	CA2326065A1 (de)
DE (1)	DE69904712D1 (de)
NZ (1)	NZ507775A (de)
WO (1)	WO1999056767A2 (de)
ZA (1)	ZA200005924B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6900178B2 (en)	2000-09-12	2005-05-31	University Of Kentucky Research Foundation	Protection against ischemia and reperfusion injury
US6875742B2 (en) *	2000-10-10	2005-04-05	Zymogenetics, Inc.	Method for treating cytokine mediated hepatic injury
WO2003065997A2 (en)	2002-02-06	2003-08-14	Vicor Technologies, Inc.	Anti-infarction molecules
US8530515B2 (en)	2010-08-09	2013-09-10	William Brusilow	Use of methionine sulfoximine to treat acute liver failure and other diseases caused by an inflammatory cytokine response

1999
- 1999-04-30 DE DE69904712T patent/DE69904712D1/de not_active Expired - Lifetime
- 1999-04-30 CA CA002326065A patent/CA2326065A1/en not_active Abandoned
- 1999-04-30 BR BR9909988-8A patent/BR9909988A/pt not_active Application Discontinuation
- 1999-04-30 JP JP2000546791A patent/JP2002513767A/ja active Pending
- 1999-04-30 AT AT99921558T patent/ATE230273T1/de not_active IP Right Cessation
- 1999-04-30 WO PCT/US1999/009457 patent/WO1999056767A2/en not_active Ceased
- 1999-04-30 NZ NZ507775A patent/NZ507775A/xx unknown
- 1999-04-30 AU AU38742/99A patent/AU751972B2/en not_active Ceased
- 1999-04-30 EP EP99921558A patent/EP1073452B1/de not_active Expired - Lifetime
2000
- 2000-10-23 ZA ZA200005924A patent/ZA200005924B/en unknown

Also Published As

Publication number	Publication date
DE69904712D1 (de)	2003-02-06
BR9909988A (pt)	2000-12-26
WO1999056767A3 (en)	2000-03-02
WO1999056767A2 (en)	1999-11-11
CA2326065A1 (en)	1999-11-11
EP1073452A2 (de)	2001-02-07
AU3874299A (en)	1999-11-23
NZ507775A (en)	2003-04-29
ZA200005924B (en)	2002-12-23
EP1073452B1 (de)	2003-01-02
AU751972B2 (en)	2002-09-05
JP2002513767A (ja)	2002-05-14

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Legal Events

Date	Code	Title	Description
2003-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties