ATE237330T1 - Verabreichung von nikotin im dickdarm zur behandlung von entzündlicher eingeweidenerkrankung - Google Patents
Verabreichung von nikotin im dickdarm zur behandlung von entzündlicher eingeweidenerkrankungInfo
- Publication number
- ATE237330T1 ATE237330T1 AT97904516T AT97904516T ATE237330T1 AT E237330 T1 ATE237330 T1 AT E237330T1 AT 97904516 T AT97904516 T AT 97904516T AT 97904516 T AT97904516 T AT 97904516T AT E237330 T1 ATE237330 T1 AT E237330T1
- Authority
- AT
- Austria
- Prior art keywords
- nicotine
- colon
- administration
- inflammatory
- treatment
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title abstract 4
- 229960002715 nicotine Drugs 0.000 title abstract 4
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract 4
- 210000001072 colon Anatomy 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/605,319 US5846983A (en) | 1996-02-09 | 1996-02-09 | Colonic delivery of nicotine to treat inflammatory bowel disease |
| PCT/GB1997/000369 WO1997028801A1 (en) | 1996-02-09 | 1997-02-07 | Colonic delivery of nicotine to treat inflammatory bowel disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE237330T1 true ATE237330T1 (de) | 2003-05-15 |
Family
ID=24423169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97904516T ATE237330T1 (de) | 1996-02-09 | 1997-02-07 | Verabreichung von nikotin im dickdarm zur behandlung von entzündlicher eingeweidenerkrankung |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5846983A (de) |
| EP (1) | EP0893998B2 (de) |
| JP (1) | JP4283340B2 (de) |
| KR (1) | KR100458636B1 (de) |
| CN (1) | CN1127340C (de) |
| AT (1) | ATE237330T1 (de) |
| AU (1) | AU718971C (de) |
| CA (1) | CA2246235C (de) |
| CZ (1) | CZ293616B6 (de) |
| DE (1) | DE69720985T3 (de) |
| DK (1) | DK0893998T4 (de) |
| ES (1) | ES2196303T5 (de) |
| HU (1) | HUP9900950A3 (de) |
| MX (1) | MX9806354A (de) |
| MY (1) | MY122023A (de) |
| PL (1) | PL187914B1 (de) |
| PT (1) | PT893998E (de) |
| SK (1) | SK284539B6 (de) |
| WO (1) | WO1997028801A1 (de) |
| ZA (1) | ZA971020B (de) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| GB9614902D0 (en) | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| US6268386B1 (en) * | 1998-06-25 | 2001-07-31 | Marshall Anlauf Thompson | Nicotine beverage |
| EP1105141B1 (de) * | 1998-08-06 | 2003-11-05 | Wolfgang Stremmel | Phosphatidylcholin als arzneimittel mit schleimhautschützender wirkung |
| ATE446767T1 (de) * | 1999-02-12 | 2009-11-15 | Univ Washington | Gm-csf zur behandlung von morbus crohn |
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| WO2001032180A2 (en) * | 1999-11-01 | 2001-05-10 | Rodeva Limited | Composition for treatment of constipation and irritable bowel syndrome |
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| IT1318625B1 (it) | 2000-07-14 | 2003-08-27 | Roberto Valducci | Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente. |
| US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
| US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| CA2418135C (en) * | 2000-08-03 | 2011-09-20 | Antares Pharma Ipl Ag | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
| US20050130990A1 (en) * | 2001-03-23 | 2005-06-16 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
| CA2341952A1 (en) * | 2001-03-23 | 2002-09-23 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases |
| US20030108592A1 (en) * | 2001-12-10 | 2003-06-12 | Thompson Marshall Anlauf | Method of producing a nicotine composition |
| US20060204598A1 (en) * | 2001-12-10 | 2006-09-14 | Thompson Marshall A | Nicotine-alternative compositions and methods of producing such compositions |
| US20100160376A1 (en) * | 2001-12-10 | 2010-06-24 | Marshall Anlauf Thompson | Nicotine-alternative compositions and methods of producing such compositions |
| US20050131031A1 (en) * | 2001-12-10 | 2005-06-16 | Thompson Marshall A. | Method of producing a nicotine composition |
| US7091357B2 (en) | 2001-12-26 | 2006-08-15 | University Of Kentucky Research Foundation | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies |
| US8557804B2 (en) | 2002-03-25 | 2013-10-15 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
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| CA2538856C (en) | 2003-10-10 | 2010-06-29 | Antares Pharma Ipl Ag | Transdermal pharmaceutical formulation for minimizing skin residues |
| US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| JP2008528028A (ja) * | 2005-01-27 | 2008-07-31 | マーシャル アンラーフ トンプソン | ニコチン組成物の製造方法 |
| WO2007124250A2 (en) | 2006-04-21 | 2007-11-01 | Antares Pharma Ipl Ag | Methods of treating hot flashes with formulations for transdermal or transmucosal application |
| WO2006125642A1 (en) | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| WO2008103818A1 (en) * | 2007-02-21 | 2008-08-28 | University Of Louisville Research Foundation | Therapeutic cotinine compositions |
| GB2468424B (en) * | 2007-04-02 | 2011-11-09 | Parkinson S Inst | Methods and compositions for reduction of side effects of therapeutic treatments |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| AU2009205314A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| EP2100598A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2100599A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
| CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| AU2010302350B2 (en) | 2009-10-02 | 2015-06-18 | Journey Medical Corporation | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
| US12661407B2 (en) | 2010-04-08 | 2026-06-23 | Journey Medical Corporation | Compositions, gels and foams with rheology modulators and uses thereof |
| EP2510928A1 (de) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten |
| US20130017259A1 (en) | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
| KR20150021071A (ko) * | 2012-06-15 | 2015-02-27 | 코나리스 리써치 인스티튜트 아게 | 니코틴산 및/또는 니코틴아미드 및/또는 트립토판을 포함하는 장내 세균총에 유익한 효능을 가진 약학 조성물 |
| US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
| KR20160088436A (ko) | 2013-12-13 | 2016-07-25 | 코나리스 리써치 인스티튜트 아게 | 니코틴아미드 및 5-아미노살리실산의 조합을 포함하는, 장내 세균총에 유익한 영향을 미치거나 및/또는 위장 염증을 치료하기 위한 약학 조성물 |
| PT3079675T (pt) | 2013-12-13 | 2020-03-05 | Conaris Res Institute Ag | Uma composição farmacêutica que contém ácido nicotínico e/ou nicotinamida para utilização para influenciar beneficamente os níveis de lípidos no sangue através da modificação da microbiota intestinal |
| GB201400442D0 (en) * | 2014-01-10 | 2014-02-26 | Sigmoid Pharma Ltd | Compositions for use in the treatment of ulcerative colitis |
| JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | 薬剤送達方法及びシステム |
| AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
| MX2020012139A (es) | 2016-09-08 | 2021-01-29 | Vyne Pharmaceuticals Inc | Composiciones y metodos para tratar rosacea y acne. |
| WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| AU2019279884B2 (en) | 2018-05-29 | 2025-01-30 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| JP2022507660A (ja) | 2018-11-16 | 2022-01-18 | モーニングサイド ベンチャー インベストメンツ リミテッド | 温度によって調節される経皮薬剤送達システム |
| US20210046011A1 (en) | 2019-08-12 | 2021-02-18 | Massachusetts Institute Of Technology | Articles and methods for administration of therapeutic agents |
| CN115089641B (zh) * | 2022-05-25 | 2023-07-25 | 西安交通大学医学院第一附属医院 | 一种难治型溃疡性结肠炎灌肠剂及其制备方法 |
| WO2025236078A1 (en) * | 2024-05-09 | 2025-11-20 | Tjp Labs Inc. | Stabilized nicotine particles |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3645036A1 (de) * | 1986-11-18 | 1989-01-05 | Forschungsgesellschaft Rauchen | Nikotinhaltiges mittel |
| US4855142A (en) * | 1987-02-27 | 1989-08-08 | Ciba-Geigy Corporation | Pharmaceutical plaster |
| IE62662B1 (en) * | 1989-01-06 | 1995-02-22 | Elan Corp Plc | Use of nicotine in the treatment of conditions susceptible to said treatment |
| KR100193933B1 (ko) * | 1990-07-20 | 1999-06-15 | 에밀리오 캠포레시, 존 페르구손 | 비스무트와 폴리아크릴레이트와의 수용성 착체, 이의 제조 방법 및 상기 착체 또는 다른 비스무트염을 함유하는 궤양성 대장염 치료용 약제학적 조성물 |
| GEP19971086B (en) * | 1991-02-22 | 1997-12-02 | Tillotts Pharma Ag | Peroral Pharmaceutically Dispensed Form for Selective Introducing of the Medicine into the Intestine |
| GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
| KR0121127B1 (ko) * | 1994-05-09 | 1997-11-13 | 강박광 | 이온성 고분자 네트웍을 갖는 피부약물전달체계 |
| US5604231A (en) * | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
| US5532254A (en) † | 1995-06-07 | 1996-07-02 | Eli Lilly And Company | Modulation of calcium channels using benzothiophenes |
| GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
-
1996
- 1996-02-09 US US08/605,319 patent/US5846983A/en not_active Expired - Fee Related
-
1997
- 1997-02-06 MY MYPI97000462A patent/MY122023A/en unknown
- 1997-02-07 EP EP97904516A patent/EP0893998B2/de not_active Expired - Lifetime
- 1997-02-07 PL PL32843097A patent/PL187914B1/pl not_active IP Right Cessation
- 1997-02-07 CN CN97192177A patent/CN1127340C/zh not_active Expired - Fee Related
- 1997-02-07 CZ CZ19982451A patent/CZ293616B6/cs not_active IP Right Cessation
- 1997-02-07 DK DK97904516T patent/DK0893998T4/da active
- 1997-02-07 AT AT97904516T patent/ATE237330T1/de not_active IP Right Cessation
- 1997-02-07 JP JP52830797A patent/JP4283340B2/ja not_active Expired - Fee Related
- 1997-02-07 KR KR10-1998-0706162A patent/KR100458636B1/ko not_active Expired - Fee Related
- 1997-02-07 AU AU17294/97A patent/AU718971C/en not_active Ceased
- 1997-02-07 WO PCT/GB1997/000369 patent/WO1997028801A1/en not_active Ceased
- 1997-02-07 PT PT97904516T patent/PT893998E/pt unknown
- 1997-02-07 DE DE69720985T patent/DE69720985T3/de not_active Expired - Fee Related
- 1997-02-07 SK SK1068-98A patent/SK284539B6/sk unknown
- 1997-02-07 HU HU9900950A patent/HUP9900950A3/hu unknown
- 1997-02-07 ZA ZA9701020A patent/ZA971020B/xx unknown
- 1997-02-07 CA CA002246235A patent/CA2246235C/en not_active Expired - Fee Related
- 1997-02-07 ES ES97904516T patent/ES2196303T5/es not_active Expired - Lifetime
-
1998
- 1998-08-06 MX MX9806354A patent/MX9806354A/es unknown
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