ATE230749T1 - Glucocorticoid selektive entzündungshemmende mittel - Google Patents

Glucocorticoid selektive entzündungshemmende mittel

Info

Publication number: ATE230749T1
Authority: AT; Austria
Prior art keywords: glucocorticoid; inflammatory agents; selective anti; mammal; compounds
Prior art date: 1998-02-13

Application number

AT99906996T

Other languages

English (en)

Inventor

Michael J Coughlan

Steven W Elmore

Michael E Kort

Philip R Kym

Jimmie L Moore

John K Pratt

Alan X Wang

James P Edwards

Todd K Jones

Original Assignee

Abbott Lab

Ligand Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-13

Filing date

1999-02-12

Publication date

2003-01-15

1999-02-12 Application filed by Abbott Lab, Ligand Pharm Inc filed Critical Abbott Lab

2003-01-15 Application granted granted Critical

2003-01-15 Publication of ATE230749T1 publication Critical patent/ATE230749T1/de

Links

229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
239000003862 glucocorticoid Substances 0.000 title 1
208000023275 Autoimmune disease Diseases 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000026278 immune system disease Diseases 0.000 abstract 2
102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
230000001363 autoimmune Effects 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000754 repressing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99906996T 1998-02-13 1999-02-12 Glucocorticoid selektive entzündungshemmende mittel ATE230749T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2394798A	1998-02-13	1998-02-13
US24783199A	1999-02-10	1999-02-10
PCT/US1999/003127 WO1999041256A1 (en)	1998-02-13	1999-02-12	Glucocorticoid-selective anti-inflammatory agents

Publications (1)

Publication Number	Publication Date
ATE230749T1 true ATE230749T1 (de)	2003-01-15

Family

ID=26697833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99906996T ATE230749T1 (de)	1998-02-13	1999-02-12	Glucocorticoid selektive entzündungshemmende mittel

Country Status (20)

Country	Link
EP (1)	EP1053239B1 (de)
JP (1)	JP2002503665A (de)
KR (1)	KR20010040935A (de)
CN (1)	CN1119348C (de)
AT (1)	ATE230749T1 (de)
AU (1)	AU766441B2 (de)
BG (1)	BG64317B1 (de)
BR (1)	BR9907788A (de)
CA (1)	CA2320943A1 (de)
DE (1)	DE69904804T2 (de)
DK (1)	DK1053239T3 (de)
ES (1)	ES2192035T3 (de)
HU (1)	HUP0100460A3 (de)
IL (1)	IL137508A0 (de)
NO (1)	NO20004053L (de)
NZ (1)	NZ506013A (de)
PL (1)	PL193323B1 (de)
SK (1)	SK284689B6 (de)
TR (1)	TR200003094T2 (de)
WO (1)	WO1999041256A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6506766B1 (en)	1998-02-13	2003-01-14	Abbott Laboratories	Glucocortiocoid-selective antinflammatory agents
US6329534B1 (en)	1999-09-01	2001-12-11	Abbott Laboratories	Glucocorticoid receptor antagonists for treatment of diabetes
US6593480B2 (en) *	1999-09-01	2003-07-15	Abbott Laboratories	Glucocorticoid receptor antagonists for treatment of diabetes
CO5180649A1 (es) *	1999-09-01	2002-07-30	Abbott Lab	Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes
US6436986B1 (en)	1999-09-01	2002-08-20	Abbott Laboratories	Glucocorticoid receptor antagonists for treatment of diabetes
ES2246292T3 (es)	2000-10-30	2006-02-16	Pfizer Products Inc.	Moduladores de receptor glucocorticoide.
US6608216B2 (en)	2001-06-29	2003-08-19	Abbott Laboratories	Process for the preparation of chiral glucocorticoid receptor agents
WO2003002548A1 (en) *	2001-06-29	2003-01-09	Abbott Laboratories	A process for the preparation of chiral glucocorticoid receptor agents
US6518430B1 (en) *	2001-09-21	2003-02-11	Abbott Laboratories	Process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-F]quinolines and derivatives thereof
WO2003059899A1 (en)	2002-01-14	2003-07-24	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
AU2003230700A1 (en)	2002-03-26	2003-10-13	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
PL373043A1 (en)	2002-03-26	2005-08-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AU2003221706B2 (en)	2002-04-11	2008-02-28	Merck Sharp & Dohme Corp.	1H-Benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators
US7186864B2 (en)	2002-05-29	2007-03-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en)	2002-06-06	2006-07-11	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE60322713D1 (de)	2002-08-21	2008-09-18	Boehringer Ingelheim Pharma	Substituierte dihydrochinoline als glucocorticoid-mmimetika,verfahren zu deren herstellung, pharmazeutische zubereitungen und deren verwendung
EP1551845A1 (de) *	2002-10-11	2005-07-13	Ligand Pharmaceuticals, Inc.	5-CYCLOALKENYLç5H!CHROMENOç3,4-F!CHINOLINDERIVATE ALS SELEKTIVE, DEN PROGESTERONREZEPTOR MODULIERENDE VERBINDUNGEN
DE20301728U1 (de)	2002-10-11	2004-03-11	Ligand Pharmaceuticals, Inc., San Diego	5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen
AU2003258047A1 (en)	2002-10-11	2004-05-04	Ligand Pharmaceuticals Incorporated	5-(1',1'-CYCLOALKYL/ALKENYL)METHYLIDENE 1,2-DIHYDRO-5H-CHROMENO(3,4-f)QUINOLINES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS
AU2003297471A1 (en)	2003-01-03	2004-08-10	Boehringer Ingelheim Pharmaceuticals, Inc.	1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
US20070088042A1 (en)	2004-09-09	2007-04-19	Meissner Robert S	Fluorinated 4-azasteroid derivatives as androgen receptor modulators
US7235662B2 (en)	2003-06-11	2007-06-26	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US8097606B2 (en)	2003-07-23	2012-01-17	Corcept Therapeutics, Inc.	Antiglucocorticoids for the treatment of catatonia
UY28526A1 (es)	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
EP1675839B1 (de)	2003-10-16	2007-07-11	Boehringer Ingelheim Pharmaceuticals Inc.	Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole
US7795272B2 (en)	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US7635711B2 (en)	2004-12-27	2009-12-22	Boehringer-Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EP1944290B1 (de) *	2005-09-14	2013-12-04	Santen Pharmaceutical Co., Ltd.	Neues 1,2-dihydrochinolinderivat mit glucocorticoidrezeptorbindender aktivität
EP2443134A2 (de)	2009-06-16	2012-04-25	Schering Corporation	Neue [3,2-c]heteroarylsteroide als glucocorticoidrezeptoragonisten, zusammensetzungen und verwendung
JP2013500962A (ja)	2009-07-31	2013-01-10	カディラヘルスケアリミティド	グルココルチコイド受容体のモジュレーターとしての新規化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996019458A2 (en) *	1994-12-22	1996-06-27	Ligand Pharmaceuticals Incorporated	Steroid receptor modulator compounds and methods

1999
- 1999-02-12 SK SK1197-2000A patent/SK284689B6/sk unknown
- 1999-02-12 AT AT99906996T patent/ATE230749T1/de active
- 1999-02-12 JP JP2000531449A patent/JP2002503665A/ja active Pending
- 1999-02-12 KR KR1020007008850A patent/KR20010040935A/ko not_active Ceased
- 1999-02-12 CN CN99804902A patent/CN1119348C/zh not_active Expired - Fee Related
- 1999-02-12 NZ NZ506013A patent/NZ506013A/xx unknown
- 1999-02-12 IL IL13750899A patent/IL137508A0/xx unknown
- 1999-02-12 PL PL343018A patent/PL193323B1/pl not_active IP Right Cessation
- 1999-02-12 CA CA002320943A patent/CA2320943A1/en not_active Abandoned
- 1999-02-12 EP EP99906996A patent/EP1053239B1/de not_active Expired - Lifetime
- 1999-02-12 AU AU26773/99A patent/AU766441B2/en not_active Ceased
- 1999-02-12 WO PCT/US1999/003127 patent/WO1999041256A1/en not_active Ceased
- 1999-02-12 TR TR2000/03094T patent/TR200003094T2/xx unknown
- 1999-02-12 DK DK99906996T patent/DK1053239T3/da active
- 1999-02-12 DE DE69904804T patent/DE69904804T2/de not_active Expired - Lifetime
- 1999-02-12 HU HU0100460A patent/HUP0100460A3/hu unknown
- 1999-02-12 BR BR9907788-4A patent/BR9907788A/pt not_active Application Discontinuation
- 1999-02-12 ES ES99906996T patent/ES2192035T3/es not_active Expired - Lifetime
2000
- 2000-08-11 NO NO20004053A patent/NO20004053L/no not_active Application Discontinuation
- 2000-08-28 BG BG104719A patent/BG64317B1/bg unknown

Also Published As

Publication number	Publication date
EP1053239B1 (de)	2003-01-08
BR9907788A (pt)	2001-10-30
PL343018A1 (en)	2001-07-30
IL137508A0 (en)	2001-07-24
NZ506013A (en)	2003-03-28
HUP0100460A3 (en)	2003-03-28
DK1053239T3 (da)	2003-04-22
CA2320943A1 (en)	1999-09-19
NO20004053L (no)	2000-09-11
SK11972000A3 (sk)	2001-08-06
WO1999041256A1 (en)	1999-08-19
NO20004053D0 (no)	2000-08-11
SK284689B6 (sk)	2005-09-08
BG104719A (en)	2001-05-31
AU2677399A (en)	1999-08-30
CN1296486A (zh)	2001-05-23
TR200003094T2 (tr)	2001-01-22
KR20010040935A (ko)	2001-05-15
AU766441B2 (en)	2003-10-16
HUP0100460A2 (hu)	2001-09-28
DE69904804T2 (de)	2003-11-06
EP1053239A1 (de)	2000-11-22
HK1033308A1 (en)	2001-08-24
CN1119348C (zh)	2003-08-27
DE69904804D1 (de)	2003-02-13
ES2192035T3 (es)	2003-09-16
PL193323B1 (pl)	2007-02-28
JP2002503665A (ja)	2002-02-05
BG64317B1 (bg)	2004-09-30

Legal Events

Date

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Title

Description

2003-08-15

UEP

Publication of translation of european patent specification

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