ATE231496T1 - Saccharinderivate als proteolytische enzyminhibitoren - Google Patents

Saccharinderivate als proteolytische enzyminhibitoren

Info

Publication number: ATE231496T1
Authority: AT; Austria
Prior art keywords: proteolytic; enzymin; hibitors; saccharine derivatives; saccharine
Prior art date: 1993-05-25

Application number

AT94201437T

Other languages

English (en)

Inventor

Dennis John Hlasta

James H Ackerman

Albert J Mura

Ranjit Ch Desai

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-25

Filing date

1994-05-21

Publication date

2003-02-15

1994-05-21 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE231496T1 publication Critical patent/ATE231496T1/de

Links

230000002797 proteolythic effect Effects 0.000 title 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical class C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 abstract 2
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Cosmetics (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94201437T 1993-05-25 1994-05-21 Saccharinderivate als proteolytische enzyminhibitoren ATE231496T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/066,805 US5378720A (en)	1991-12-19	1993-05-25	Saccharin derivative proteolytic enzyme inhibitors

Publications (1)

Publication Number	Publication Date
ATE231496T1 true ATE231496T1 (de)	2003-02-15

Family

ID=22071832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94201437T ATE231496T1 (de)	1993-05-25	1994-05-21	Saccharinderivate als proteolytische enzyminhibitoren

Country Status (21)

Country	Link
US (2)	US5378720A (de)
EP (1)	EP0626378B1 (de)
JP (1)	JPH0770094A (de)
KR (1)	KR100334345B1 (de)
AT (1)	ATE231496T1 (de)
AU (1)	AU685785B2 (de)
CA (1)	CA2122886A1 (de)
CZ (1)	CZ289573B6 (de)
DE (1)	DE69432035D1 (de)
FI (1)	FI942423A7 (de)
HU (1)	HUT70760A (de)
IL (1)	IL109780A (de)
MY (1)	MY129998A (de)
NO (1)	NO302474B1 (de)
NZ (1)	NZ260585A (de)
PH (1)	PH31435A (de)
RU (1)	RU2126798C1 (de)
SG (1)	SG55137A1 (de)
SK (1)	SK281020B6 (de)
TW (1)	TW420679B (de)
UA (1)	UA44682C2 (de)

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US5494925A (en) *	1994-12-02	1996-02-27	Sterling Winthrop Inc.	2-heterocyclyloxymethyl and 2-heterocyclylthiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5512576A (en) *	1994-12-02	1996-04-30	Sterling Winthrop Inc.	2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5541168A (en) *	1994-12-02	1996-07-30	Sterling Winthrop Inc.	Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5556909A (en) *	1994-12-02	1996-09-17	Sanofi Winthrop Inc.	Substituted 2-arylcarbonyloxymethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives and compositions and method of use thereof
US5780014A (en) *	1995-04-14	1998-07-14	Inhale Therapeutic Systems	Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5750550A (en) *	1995-09-15	1998-05-12	Sanofi	2-(pyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3 (2H)-One 1, 1-dioxides and compositions and method of use thereof
HUP9904624A2 (hu) *	1999-12-17	2002-01-28	Sanofi-Synthelabo	Szacharinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és intermedierjeik
US7998986B2 (en) *	2001-12-21	2011-08-16	Exelixis Patent Company Llc	Modulators of LXR
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
ES2334990T3 (es) *	2002-02-14	2010-03-18	Pharmacia Corporation	Piridinonas sustituidas como moduladores de p38 map quinasa.
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) *	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
SI2203439T1 (sl)	2007-09-14	2011-05-31	Ortho Mcneil Janssen Pharm	1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
BRPI0817101A2 (pt)	2007-09-14	2017-05-09	Addex Pharmaceuticals Sa	4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
ES2409215T3 (es) *	2007-09-14	2013-06-25	Janssen Pharmaceuticals, Inc.	4-fenil-1H-piridin-2-onas 1-3-disustituidas
ES2637794T3 (es) *	2007-11-14	2017-10-17	Janssen Pharmaceuticals, Inc.	Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
US8324405B2 (en)	2008-02-05	2012-12-04	Fibrogen, Inc.	Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
ES2439291T3 (es)	2008-09-02	2014-01-22	Janssen Pharmaceuticals, Inc.	Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
CA2738849C (en)	2008-10-16	2016-06-28	Addex Pharma S.A.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
CN102272117B (zh)	2008-11-14	2015-06-17	菲布罗根有限公司	作为hif羟化酶抑制剂的苯并噻喃衍生物
ES2401691T3 (es)	2008-11-28	2013-04-23	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato
ES2440001T3 (es)	2009-05-12	2014-01-27	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos
SG176018A1 (en)	2009-05-12	2011-12-29	Janssen Pharmaceuticals Inc	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103298809B (zh)	2010-11-08	2016-08-31	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
CA2814998C (en)	2010-11-08	2019-10-29	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552455T3 (es)	2010-11-08	2015-11-30	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
IL279202B2 (en)	2014-01-21	2023-09-01	Janssen Pharmaceutica Nv	Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
US10537573B2 (en)	2014-01-21	2020-01-21	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
MX2023009059A (es)	2021-02-02	2023-09-15	Liminal Biosciences Ltd	Antagonistas de gpr84 y usos de estos.

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US4276298A (en) *	1978-03-24	1981-06-30	Merck & Co., Inc.	2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
DE3617976A1 (de) *	1986-05-28	1988-01-14	Alter Sa	1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
ES2110414T3 (es) *	1989-05-04	1998-02-16	Sanofi Sa	Derivados de sacarina utiles como inhibidores de enzimas proteoliticas y su preparacion.
US5236917A (en) *	1989-05-04	1993-08-17	Sterling Winthrop Inc.	Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5128339A (en) *	1990-11-01	1992-07-07	Sterling Winthrop Inc.	Proteolytic enzyme inhibition method
AU642537B2 (en) *	1990-11-01	1993-10-21	Sanofi	2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
TW282463B (de) *	1991-11-15	1996-08-01	Sterling Winthrop Inc
AU668694B2 (en) *	1991-12-19	1996-05-16	Sanofi-Synthelabo	Saccharin derivative proteolytic enzyme inhibitors

1993
- 1993-05-25 US US08/066,805 patent/US5378720A/en not_active Expired - Fee Related
1994
- 1994-03-30 TW TW083102772A patent/TW420679B/zh not_active IP Right Cessation
- 1994-04-25 IL IL10978094A patent/IL109780A/en not_active IP Right Cessation
- 1994-05-04 CA CA002122886A patent/CA2122886A1/en not_active Abandoned
- 1994-05-21 EP EP94201437A patent/EP0626378B1/de not_active Expired - Lifetime
- 1994-05-21 SG SG1996007480A patent/SG55137A1/en unknown
- 1994-05-21 AT AT94201437T patent/ATE231496T1/de not_active IP Right Cessation
- 1994-05-21 DE DE69432035T patent/DE69432035D1/de not_active Expired - Lifetime
- 1994-05-24 NZ NZ260585A patent/NZ260585A/en unknown
- 1994-05-24 MY MYPI94001318A patent/MY129998A/en unknown
- 1994-05-24 UA UA94005229A patent/UA44682C2/uk unknown
- 1994-05-24 AU AU63280/94A patent/AU685785B2/en not_active Ceased
- 1994-05-24 KR KR1019940011321A patent/KR100334345B1/ko not_active Expired - Fee Related
- 1994-05-24 RU RU94017851/04A patent/RU2126798C1/ru not_active IP Right Cessation
- 1994-05-24 PH PH48322A patent/PH31435A/en unknown
- 1994-05-24 JP JP6109826A patent/JPH0770094A/ja active Pending
- 1994-05-24 CZ CZ19941268A patent/CZ289573B6/cs not_active IP Right Cessation
- 1994-05-25 FI FI942423A patent/FI942423A7/fi unknown
- 1994-05-25 HU HU9401571A patent/HUT70760A/hu unknown
- 1994-05-25 NO NO941937A patent/NO302474B1/no not_active IP Right Cessation
- 1994-05-25 SK SK615-94A patent/SK281020B6/sk unknown
- 1994-06-22 US US08/263,643 patent/US5466701A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SG55137A1 (en)	1998-12-21
NO302474B1 (no)	1998-03-09
US5378720A (en)	1995-01-03
FI942423A7 (fi)	1994-11-26
JPH0770094A (ja)	1995-03-14
EP0626378B1 (de)	2003-01-22
NO941937L (no)	1994-11-28
EP0626378A1 (de)	1994-11-30
CZ289573B6 (cs)	2002-02-13
HUT70760A (en)	1995-10-30
CZ126894A3 (en)	1994-12-15
KR100334345B1 (ko)	2002-08-27
NO941937D0 (no)	1994-05-25
SK61594A3 (en)	1995-02-08
AU685785B2 (en)	1998-01-29
FI942423A0 (fi)	1994-05-25
MY129998A (en)	2007-05-31
HU9401571D0 (en)	1994-08-29
CA2122886A1 (en)	1994-11-26
IL109780A (en)	1998-08-15
AU6328094A (en)	1994-12-01
UA44682C2 (uk)	2002-03-15
DE69432035D1 (de)	2003-02-27
SK281020B6 (sk)	2000-11-07
NZ260585A (en)	1996-01-26
TW420679B (en)	2001-02-01
US5466701A (en)	1995-11-14
PH31435A (en)	1998-11-03
IL109780A0 (en)	1994-08-26
RU2126798C1 (ru)	1999-02-27

Legal Events

Date	Code	Title	Description
2003-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE231496T1 (de)	2003-02-15	Saccharinderivate als proteolytische enzyminhibitoren
ATE233250T1 (de)	2003-03-15	Saccharinderivate als proteolytische enzyminhibitoren
MX9206008A (es)	1993-11-01	Inhibidores de enzima proteolitica, derivados de sacarina 2-substituida.
AU7725596A (en)	1997-08-01	Antithrombotic diamines
EP0471756A4 (en)	1992-04-08	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof
DE69728869D1 (de)	2004-06-03	Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien
AU667593B2 (en)	1996-03-28	Inhibitors of HIV protease useful for the treatment of AIDS
KR0148213B1 (en)	1998-08-17	Phenyla lkan(en)oic acid and pharmaceutical composition comprising the same
CA2266759A1 (en)	1998-03-26	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
AU6415994A (en)	1994-10-24	Substituted caprolactams and derivatives thereof useful for treatment of hiv disease
GR3022604T3 (en)	1997-05-31	Inhibitors of hiv protease useful for the treatment of aids.
ATE258229T1 (de)	2004-02-15	Substanz fa-70d, herstellungsverfahren und verwendungen
EP0332999A3 (en)	1990-11-28	Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them
AU6029090A (en)	1991-02-14	Improvements in or relating to organic compounds
GEP20022764B (en)	2002-08-26	HIV Protease Inhibitors, Pharmaceutical Compositions and Methods for Inhibiting HIV Protease
WO1998009951A3 (en)	1998-07-09	Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors