NO941937L - Sakarinderivater som inhiberer proteolytiske enzymer - Google Patents

Sakarinderivater som inhiberer proteolytiske enzymer

Info

Publication number: NO941937L
Authority: NO; Norway
Prior art keywords: proteolytic enzymes; inhibit proteolytic; saccharin derivatives; inhibit; saccharin
Prior art date: 1993-05-25

Application number

NO941937A

Other languages

English (en)

Other versions

NO302474B1 (no

NO941937D0 (no

Inventor

Dennis John Hlasta

James Howard Ackerman

Albert Joseph Mura

Ranjit Chimanlal Desai

Original Assignee

Sterling Winthrop Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-25

Filing date

1994-05-25

Publication date

1994-11-28

1994-05-25 Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc

1994-05-25 Publication of NO941937D0 publication Critical patent/NO941937D0/no

1994-11-28 Publication of NO941937L publication Critical patent/NO941937L/no

1998-03-09 Publication of NO302474B1 publication Critical patent/NO302474B1/no

Links

102000035195 Peptidases Human genes 0.000 title abstract 2
108091005804 Peptidases Proteins 0.000 title abstract 2
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 title abstract 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical class C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Cosmetics (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO941937A 1993-05-25 1994-05-25 Sakarinderivater, farmasöytisk sammensetning og anvendelse derav NO302474B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/066,805 US5378720A (en)	1991-12-19	1993-05-25	Saccharin derivative proteolytic enzyme inhibitors

Publications (3)

Publication Number	Publication Date
NO941937D0 NO941937D0 (no)	1994-05-25
NO941937L true NO941937L (no)	1994-11-28
NO302474B1 NO302474B1 (no)	1998-03-09

Family

ID=22071832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO941937A NO302474B1 (no)	1993-05-25	1994-05-25	Sakarinderivater, farmasöytisk sammensetning og anvendelse derav

Country Status (21)

Country	Link
US (2)	US5378720A (no)
EP (1)	EP0626378B1 (no)
JP (1)	JPH0770094A (no)
KR (1)	KR100334345B1 (no)
AT (1)	ATE231496T1 (no)
AU (1)	AU685785B2 (no)
CA (1)	CA2122886A1 (no)
CZ (1)	CZ289573B6 (no)
DE (1)	DE69432035D1 (no)
FI (1)	FI942423A7 (no)
HU (1)	HUT70760A (no)
IL (1)	IL109780A (no)
MY (1)	MY129998A (no)
NO (1)	NO302474B1 (no)
NZ (1)	NZ260585A (no)
PH (1)	PH31435A (no)
RU (1)	RU2126798C1 (no)
SG (1)	SG55137A1 (no)
SK (1)	SK281020B6 (no)
TW (1)	TW420679B (no)
UA (1)	UA44682C2 (no)

Families Citing this family (38)

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US6509006B1 (en)	1992-07-08	2003-01-21	Inhale Therapeutic Systems, Inc.	Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6582728B1 (en)	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
AU1090795A (en) *	1993-11-12	1995-05-29	Cell Therapeutics, Inc.	Method for preventing tissue injury from hypoxia
US6290991B1 (en)	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
US5541168A (en) *	1994-12-02	1996-07-30	Sterling Winthrop Inc.	Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5556909A (en) *	1994-12-02	1996-09-17	Sanofi Winthrop Inc.	Substituted 2-arylcarbonyloxymethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives and compositions and method of use thereof
US5512576A (en) *	1994-12-02	1996-04-30	Sterling Winthrop Inc.	2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5494925A (en) *	1994-12-02	1996-02-27	Sterling Winthrop Inc.	2-heterocyclyloxymethyl and 2-heterocyclylthiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5780014A (en) *	1995-04-14	1998-07-14	Inhale Therapeutic Systems	Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5750550A (en) *	1995-09-15	1998-05-12	Sanofi	2-(pyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3 (2H)-One 1, 1-dioxides and compositions and method of use thereof
HUP9904624A2 (hu) *	1999-12-17	2002-01-28	Sanofi-Synthelabo	Szacharinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és intermedierjeik
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
AU2002351412B2 (en) *	2001-12-21	2010-05-20	Exelixis Patent Company Llc	Modulators of LXR
ES2334990T3 (es) *	2002-02-14	2010-03-18	Pharmacia Corporation	Piridinonas sustituidas como moduladores de p38 map quinasa.
TWI417095B (zh) *	2006-03-15	2013-12-01	Janssen Pharmaceuticals Inc	１，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) *	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
CA2696948C (en) *	2007-09-14	2013-04-30	Jose Maria Cid-Nunez	1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
KR20100065191A (ko)	2007-09-14	2010-06-15	오르토-맥닐-얀센 파마슈티칼스 인코포레이티드	１,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온
KR20100080597A (ko) *	2007-09-14	2010-07-09	오르토-맥닐-얀센 파마슈티칼스 인코포레이티드	１,３-이치환된-４-페닐-1ｈ-피리딘-2-온
EP2220083B1 (en) *	2007-11-14	2017-07-19	Janssen Pharmaceuticals, Inc.	Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US8324405B2 (en)	2008-02-05	2012-12-04	Fibrogen, Inc.	Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
CA2735764C (en)	2008-09-02	2016-06-14	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
AU2009304293B2 (en)	2008-10-16	2012-04-26	Addex Pharma S.A.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
CN102272117B (zh)	2008-11-14	2015-06-17	菲布罗根有限公司	作为hif羟化酶抑制剂的苯并噻喃衍生物
BRPI0921333A2 (pt)	2008-11-28	2015-12-29	Addex Pharmaceuticals Sa	derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
NZ596078A (en)	2009-05-12	2013-06-28	Janssen Pharmaceuticals Inc	1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
EA020671B1 (ru)	2009-05-12	2014-12-30	Янссен Фармасьютикалз, Инк.	ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
CA2815002C (en)	2010-11-08	2019-10-22	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103298810B (zh)	2010-11-08	2016-03-16	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2643320B1 (en)	2010-11-08	2015-03-04	Janssen Pharmaceuticals, Inc.	1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR102414246B1 (ko)	2014-01-21	2022-06-27	얀센 파마슈티카 엔.브이.	대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
LT3431106T (lt)	2014-01-21	2021-02-10	Janssen Pharmaceutica Nv	Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
KR20230153387A (ko)	2021-02-02	2023-11-06	리미널 바이오사이언시스 리미티드	Gpr84 길항제 및 이의 용도
JP2024506858A (ja)	2021-02-02	2024-02-15	リミナル・バイオサイエンシーズ・リミテッド	Ｇｐｒ８４アンタゴニストおよびその使用

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Publication number	Priority date	Publication date	Assignee	Title
US2855401A (en) *	1954-04-30	1958-10-07	May & Baker Ltd	Certain n-(aminophenoxy pentyl) sulfonamide or saccharine compounds and higher homologues
US3220940A (en) *	1962-02-07	1965-11-30	Udylite Res Corp	Electrodeposition of nickel
US4195023A (en) *	1975-08-20	1980-03-25	Merck & Co., Inc.	2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) *	1978-03-24	1981-06-30	Merck & Co., Inc.	2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
DE3617976A1 (de) *	1986-05-28	1988-01-14	Alter Sa	1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
AU637614B2 (en) *	1989-05-04	1993-06-03	Sanofi	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof
US5236917A (en) *	1989-05-04	1993-08-17	Sterling Winthrop Inc.	Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5128339A (en) *	1990-11-01	1992-07-07	Sterling Winthrop Inc.	Proteolytic enzyme inhibition method
AU642537B2 (en) *	1990-11-01	1993-10-21	Sanofi	2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU656027B2 (en) *	1991-11-15	1995-01-19	Sanofi	Saccharin derivative proteolytic enzime inhibitors
AU668694B2 (en) *	1991-12-19	1996-05-16	Sanofi-Synthelabo	Saccharin derivative proteolytic enzyme inhibitors

1993
- 1993-05-25 US US08/066,805 patent/US5378720A/en not_active Expired - Fee Related
1994
- 1994-03-30 TW TW083102772A patent/TW420679B/zh not_active IP Right Cessation
- 1994-04-25 IL IL10978094A patent/IL109780A/en not_active IP Right Cessation
- 1994-05-04 CA CA002122886A patent/CA2122886A1/en not_active Abandoned
- 1994-05-21 DE DE69432035T patent/DE69432035D1/de not_active Expired - Lifetime
- 1994-05-21 EP EP94201437A patent/EP0626378B1/en not_active Expired - Lifetime
- 1994-05-21 AT AT94201437T patent/ATE231496T1/de not_active IP Right Cessation
- 1994-05-21 SG SG1996007480A patent/SG55137A1/en unknown
- 1994-05-24 KR KR1019940011321A patent/KR100334345B1/ko not_active Expired - Fee Related
- 1994-05-24 AU AU63280/94A patent/AU685785B2/en not_active Ceased
- 1994-05-24 UA UA94005229A patent/UA44682C2/uk unknown
- 1994-05-24 MY MYPI94001318A patent/MY129998A/en unknown
- 1994-05-24 JP JP6109826A patent/JPH0770094A/ja active Pending
- 1994-05-24 NZ NZ260585A patent/NZ260585A/en unknown
- 1994-05-24 PH PH48322A patent/PH31435A/en unknown
- 1994-05-24 CZ CZ19941268A patent/CZ289573B6/cs not_active IP Right Cessation
- 1994-05-24 RU RU94017851/04A patent/RU2126798C1/ru not_active IP Right Cessation
- 1994-05-25 FI FI942423A patent/FI942423A7/fi unknown
- 1994-05-25 NO NO941937A patent/NO302474B1/no not_active IP Right Cessation
- 1994-05-25 SK SK615-94A patent/SK281020B6/sk unknown
- 1994-05-25 HU HU9401571A patent/HUT70760A/hu unknown
- 1994-06-22 US US08/263,643 patent/US5466701A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0626378A1 (en)	1994-11-30
IL109780A0 (en)	1994-08-26
JPH0770094A (ja)	1995-03-14
CA2122886A1 (en)	1994-11-26
TW420679B (en)	2001-02-01
MY129998A (en)	2007-05-31
CZ289573B6 (cs)	2002-02-13
HUT70760A (en)	1995-10-30
US5378720A (en)	1995-01-03
UA44682C2 (uk)	2002-03-15
CZ126894A3 (en)	1994-12-15
SK61594A3 (en)	1995-02-08
FI942423A0 (fi)	1994-05-25
HU9401571D0 (en)	1994-08-29
SG55137A1 (en)	1998-12-21
AU6328094A (en)	1994-12-01
NZ260585A (en)	1996-01-26
US5466701A (en)	1995-11-14
NO302474B1 (no)	1998-03-09
ATE231496T1 (de)	2003-02-15
EP0626378B1 (en)	2003-01-22
IL109780A (en)	1998-08-15
SK281020B6 (sk)	2000-11-07
AU685785B2 (en)	1998-01-29
NO941937D0 (no)	1994-05-25
KR100334345B1 (ko)	2002-08-27
RU2126798C1 (ru)	1999-02-27
FI942423A7 (fi)	1994-11-26
PH31435A (en)	1998-11-03
DE69432035D1 (de)	2003-02-27

Legal Events

Date	Code	Title	Description
2003-12-29	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN NOVEMBER 2003

Publication	Publication Date	Title
NO941937D0 (no)	1994-05-25	Sakarinderivater som inhiberer proteolytiske enzymer
DE69232929D1 (de)	2003-04-03	Saccharinderivate als proteolytische Enzyminhibitoren
MY107740A (en)	1996-05-30	Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
RU94017851A (ru)	1996-01-10	Ингибиторы протеолитических ферментов на основе производных сахарина, фармацевтическая композиция для лечения дегеративных заболеваний
EP0471756A4 (en)	1992-04-08	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof
ATE253359T1 (de)	2003-11-15	Antithrombotische mittel
AU588929B2 (en)	1989-09-28	Amino acid derivatives
DE69828522D1 (de)	2005-02-10	Antithrombotische mittel
EP0333000A3 (en)	1990-11-28	Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them
ATE258229T1 (de)	2004-02-15	Substanz fa-70d, herstellungsverfahren und verwendungen
DK0673913T3 (da)	1999-09-20	Calcium-alkalimetalcitratforbindelser samt deres anvendelse som lægemidler
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