ATE231919T1 - Verfahren für die fermentative produktion von deazylierten cephalosporinen. - Google Patents

Verfahren für die fermentative produktion von deazylierten cephalosporinen.

Info

Publication number: ATE231919T1
Authority: AT; Austria
Prior art keywords: deazylated; cephalosporins; fermentative production; production; fermentative
Prior art date: 1997-04-22

Application number

AT98929264T

Other languages

English (en)

Inventor

Maarten Nieboer

Vroom Erik De

Johannis Lugtenburg

Dirk Schipper

Adrianus Wilhelmus Vollebregt

Roelof Ary Lans Bovenberg

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-22

Filing date

1998-04-22

Publication date

2003-02-15

1998-04-22 Application filed by Dsm Nv filed Critical Dsm Nv

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE231919T1 publication Critical patent/ATE231919T1/de

Links

229930186147 Cephalosporin Natural products 0.000 title abstract 2
229940124587 cephalosporin Drugs 0.000 title abstract 2
238000012262 fermentative production Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 1
-1 cephalosporin compounds Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium
- Y10S435/935—Penicillium chrysogenum

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Cephalosporin Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT98929264T 1997-04-22 1998-04-22 Verfahren für die fermentative produktion von deazylierten cephalosporinen. ATE231919T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97201197		1997-04-22
PCT/EP1998/002461 WO1998048035A1 (en)	1997-04-22	1998-04-22	Process for the fermentative production of deacylated cephalosporins

Publications (1)

Publication Number	Publication Date
ATE231919T1 true ATE231919T1 (de)	2003-02-15

Family

ID=8228237

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98929264T ATE231919T1 (de)	1997-04-22	1998-04-22	Verfahren für die fermentative produktion von deazylierten cephalosporinen.

Country Status (17)

Country	Link
US (1)	US6410259B1 (de)
EP (1)	EP0915988B1 (de)
JP (1)	JP2000512512A (de)
KR (1)	KR20000022109A (de)
CN (1)	CN1145703C (de)
AT (1)	ATE231919T1 (de)
AU (1)	AU7909498A (de)
BR (1)	BR9804854A (de)
DE (1)	DE69811039T2 (de)
ES (1)	ES2191313T3 (de)
ID (1)	ID21520A (de)
PL (1)	PL330760A1 (de)
PT (1)	PT915988E (de)
RU (1)	RU2208643C2 (de)
SI (1)	SI0915988T1 (de)
WO (1)	WO1998048035A1 (de)
ZA (1)	ZA983395B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1331751A (zh) *	1998-12-22	2002-01-16	Dsm公司	改进的头孢菌素的体内生产方法
EP2123772A1 (de)	2008-04-29	2009-11-25	DSM IP Assets B.V.	Beta-Lactamantibiotikum produzierende Stämme
EP2310487A2 (de)	2008-08-05	2011-04-20	DSM IP Assets B.V.	Adipoyl-7-adca produzierende stämme
EP2310488B1 (de)	2008-08-05	2012-09-19	DSM Sinochem Pharmaceuticals Netherlands B.V.	Adipoyl-7-adca produzierende stämme
CN102369290A (zh)	2009-04-03	2012-03-07	帝斯曼知识产权资产管理有限公司	发酵工艺
WO2011161004A1 (en)	2010-06-22	2011-12-29	Dsm Ip Assets B.V.	Air bubble fermentation process
WO2012117038A1 (en)	2011-03-03	2012-09-07	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Degradation of penicillin compounds
CN102757999A (zh) *	2011-04-29	2012-10-31	上海医药工业研究院	一种用于生产7-氨基头孢烷酸的发酵培养基及其发酵方法
WO2015091455A1 (en)	2013-12-17	2015-06-25	Dpx Holdings B.V.	Bioreactor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5671092A (en) *	1979-11-14	1981-06-13	Kyowa Hakko Kogyo Co Ltd	Optical active cephalosporin analogous derivative
EP0045717B1 (de) *	1980-08-01	1985-09-25	BIOCHEMIE Gesellschaft m.b.H.	Cephalosporinderivate, ihre Herstellung und Anwendung
PT83746B (pt)	1985-11-15	1988-08-17	Gist Brocades Nv	Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
PT97116B (pt)	1990-03-23	1998-10-30	Gist Brocades Nv	Processo para modular a producao de metabolitos secundarios nomeadamente derivados de beta-lactama
US5318896A (en) *	1991-09-11	1994-06-07	Merck & Co., Inc.	Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) *	1991-10-15	1999-12-01	한스 발터 라벤	7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
ES2194873T3 (es)	1993-07-30	2003-12-01	Dsm Ip Assets Bv	Procedimiento para la produccion eficaz de 7-adca a traves de 3-(carboxietil)propionil-7-adca.
BR9407108A (pt) *	1993-07-30	1996-08-27	Gist Brocades Nv	Processo para a preparação e recuperação de ácido 7-amino desacetoxi cefalosporânico (7-adca) vetor de ADN recombinante e célula hospedeira transformada com um vetor definido

1998
- 1998-04-22 PL PL98330760A patent/PL330760A1/xx unknown
- 1998-04-22 JP JP10545046A patent/JP2000512512A/ja active Pending
- 1998-04-22 PT PT98929264T patent/PT915988E/pt unknown
- 1998-04-22 DE DE69811039T patent/DE69811039T2/de not_active Expired - Fee Related
- 1998-04-22 AT AT98929264T patent/ATE231919T1/de not_active IP Right Cessation
- 1998-04-22 KR KR1019980710519A patent/KR20000022109A/ko not_active Ceased
- 1998-04-22 RU RU99101109/13A patent/RU2208643C2/ru not_active IP Right Cessation
- 1998-04-22 EP EP98929264A patent/EP0915988B1/de not_active Expired - Lifetime
- 1998-04-22 CN CNB988005247A patent/CN1145703C/zh not_active Expired - Fee Related
- 1998-04-22 ES ES98929264T patent/ES2191313T3/es not_active Expired - Lifetime
- 1998-04-22 BR BR9804854-6A patent/BR9804854A/pt not_active IP Right Cessation
- 1998-04-22 ID IDW980130A patent/ID21520A/id unknown
- 1998-04-22 WO PCT/EP1998/002461 patent/WO1998048035A1/en not_active Ceased
- 1998-04-22 ZA ZA983395A patent/ZA983395B/xx unknown
- 1998-04-22 SI SI9830380T patent/SI0915988T1/xx unknown
- 1998-04-22 AU AU79094/98A patent/AU7909498A/en not_active Abandoned
- 1998-04-22 US US09/202,797 patent/US6410259B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0915988A1 (de)	1999-05-19
DE69811039T2 (de)	2004-01-22
CN1224469A (zh)	1999-07-28
AU7909498A (en)	1998-11-13
ES2191313T3 (es)	2003-09-01
PL330760A1 (en)	1999-05-24
BR9804854A (pt)	1999-09-08
CN1145703C (zh)	2004-04-14
WO1998048035A1 (en)	1998-10-29
EP0915988B1 (de)	2003-01-29
RU2208643C2 (ru)	2003-07-20
KR20000022109A (ko)	2000-04-25
PT915988E (pt)	2003-06-30
SI0915988T1 (en)	2003-06-30
US6410259B1 (en)	2002-06-25
JP2000512512A (ja)	2000-09-26
DE69811039D1 (de)	2003-03-06
ID21520A (id)	1999-06-24
ZA983395B (en)	1999-01-27

Legal Events

Date

Code

Title

Description

2003-08-15

UEP

Publication of translation of european patent specification

Ref document number: 0915988

Country of ref document: EP

2006-01-15

REN

Ceased due to non-payment of the annual fee

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