ES2191313T3 - Procedimiento para la produccion fermentativa de cefalosporinas desaciladas. - Google Patents

Procedimiento para la produccion fermentativa de cefalosporinas desaciladas.

Info

Publication number
ES2191313T3
ES2191313T3 ES98929264T ES98929264T ES2191313T3 ES 2191313 T3 ES2191313 T3 ES 2191313T3 ES 98929264 T ES98929264 T ES 98929264T ES 98929264 T ES98929264 T ES 98929264T ES 2191313 T3 ES2191313 T3 ES 2191313T3
Authority
ES
Spain
Prior art keywords
cephalosporins
disabled
procedure
fermentative production
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98929264T
Other languages
English (en)
Inventor
Maarten Nieboer
Vroom Erik De
Johannis Lugtenburg
Dirk Schipper
Adrianus Wilhelmus Vollebregt
Roelof Ary Lans Bovenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of ES2191313T3 publication Critical patent/ES2191313T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PRESENTE INVENCION DESCRIBE UN PROCEDIMIENTO DE PRODUCCION DE COMPUESTOS DE CEFALOSPORINA N - DESACILADOS, A TRAVES DE LA PRODUCCION FERMENTATIVA DE LOS DERIVADOS 7 - ACILADOS DE DICHOS COMPUESTOS.
ES98929264T 1997-04-22 1998-04-22 Procedimiento para la produccion fermentativa de cefalosporinas desaciladas. Expired - Lifetime ES2191313T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201197 1997-04-22

Publications (1)

Publication Number Publication Date
ES2191313T3 true ES2191313T3 (es) 2003-09-01

Family

ID=8228237

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98929264T Expired - Lifetime ES2191313T3 (es) 1997-04-22 1998-04-22 Procedimiento para la produccion fermentativa de cefalosporinas desaciladas.

Country Status (17)

Country Link
US (1) US6410259B1 (es)
EP (1) EP0915988B1 (es)
JP (1) JP2000512512A (es)
KR (1) KR20000022109A (es)
CN (1) CN1145703C (es)
AT (1) ATE231919T1 (es)
AU (1) AU7909498A (es)
BR (1) BR9804854A (es)
DE (1) DE69811039T2 (es)
ES (1) ES2191313T3 (es)
ID (1) ID21520A (es)
PL (1) PL330760A1 (es)
PT (1) PT915988E (es)
RU (1) RU2208643C2 (es)
SI (1) SI0915988T1 (es)
WO (1) WO1998048035A1 (es)
ZA (1) ZA983395B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1141372A2 (en) * 1998-12-22 2001-10-10 Dsm N.V. Improved in vivo production of cephalosporins
EP2123772A1 (en) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-lactam antibiotic producing strains
CN102131921A (zh) 2008-08-05 2011-07-20 帝斯曼知识产权资产管理有限公司 生产己二酰基-7-adca的菌株
CN102119213A (zh) 2008-08-05 2011-07-06 帝斯曼知识产权资产管理有限公司 生产己二酰基-7-adca的菌株
WO2010115838A1 (en) 2009-04-03 2010-10-14 Dsm Ip Assets B.V. Fermentation process
HUE035540T2 (en) 2010-06-22 2018-05-02 Dsm Sinochem Pharm Nl Bv Air bubble fermentation process
EA023822B1 (ru) 2011-03-03 2016-07-29 Дсм Синокем Фармасьютикалз Нидерландз Б.В. Разложение соединений пенициллина
CN102757999A (zh) * 2011-04-29 2012-10-31 上海医药工业研究院 一种用于生产7-氨基头孢烷酸的发酵培养基及其发酵方法
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671092A (en) * 1979-11-14 1981-06-13 Kyowa Hakko Kogyo Co Ltd Optical active cephalosporin analogous derivative
DE3172432D1 (en) * 1980-08-01 1985-10-31 Biochemie Gmbh New cephalosporin derivatives, their production and their use
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
IE910956A1 (en) 1990-03-23 1991-09-25 Gist Brocades Nv A method of modulating the production of secondary¹metabolites
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
SK280569B6 (sk) * 1991-10-15 2000-03-13 Gist-Brocades B.V. Biologický spôsob výroby kyseliny7-aminodeacetylce
KR100336174B1 (ko) * 1993-07-30 2002-11-01 디에스엠 기스트 베.파우. 2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법
PT711348E (pt) 1993-07-30 2003-08-29 Dsm Nv Processo para a eficiente producao de 7-adca por via de 3-(carboxietiltio)propionil-7-adca

Also Published As

Publication number Publication date
DE69811039D1 (de) 2003-03-06
KR20000022109A (ko) 2000-04-25
ID21520A (id) 1999-06-24
SI0915988T1 (en) 2003-06-30
JP2000512512A (ja) 2000-09-26
RU2208643C2 (ru) 2003-07-20
CN1224469A (zh) 1999-07-28
PL330760A1 (en) 1999-05-24
WO1998048035A1 (en) 1998-10-29
AU7909498A (en) 1998-11-13
ZA983395B (en) 1999-01-27
EP0915988B1 (en) 2003-01-29
DE69811039T2 (de) 2004-01-22
ATE231919T1 (de) 2003-02-15
BR9804854A (pt) 1999-09-08
US6410259B1 (en) 2002-06-25
CN1145703C (zh) 2004-04-14
EP0915988A1 (en) 1999-05-19
PT915988E (pt) 2003-06-30

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