ATE232202T1 - Verfahren zur herstellung von n-(2- (dimethylamino)ethyl)akridin-4-carbonsäureamide - Google Patents

Verfahren zur herstellung von n-(2- (dimethylamino)ethyl)akridin-4-carbonsäureamide

Info

Publication number: ATE232202T1
Authority: AT; Austria
Prior art keywords: producing; acridine; pct; dimethylamino; ethyl
Prior art date: 1996-10-18

Application number

AT97909455T

Other languages

English (en)

Inventor

William A Denny

Swarnalatha Gamage

Julie Ann Spicer

Michael Wright

David Frank Hayman

Original Assignee

Xenova Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-18

Filing date

1997-10-17

Publication date

2003-02-15

1996-10-18 Priority claimed from GBGB9621795.5A external-priority patent/GB9621795D0/en

1996-12-20 Priority claimed from GBGB9626457.7A external-priority patent/GB9626457D0/en

1997-10-17 Application filed by Xenova Ltd filed Critical Xenova Ltd

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE232202T1 publication Critical patent/ATE232202T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
229940125665 acridine carboxamide Drugs 0.000 abstract 1
XBGNERSKEKDZDS-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]acridine-4-carboxamide Chemical compound C1=CC=C2N=C3C(C(=O)NCCN(C)C)=CC=CC3=CC2=C1 XBGNERSKEKDZDS-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Glass Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Wire Bonding (AREA)
Adhesives Or Adhesive Processes (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT97909455T 1996-10-18 1997-10-17 Verfahren zur herstellung von n-(2- (dimethylamino)ethyl)akridin-4-carbonsäureamide ATE232202T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9621795.5A GB9621795D0 (en)	1996-10-18	1996-10-18	Pharmaceutical compounds
GBGB9626457.7A GB9626457D0 (en)	1996-12-20	1996-12-20	Process
PCT/GB1997/002884 WO1998017649A1 (en)	1996-10-18	1997-10-17	Process for the preparation of n-[2-(dimethylamino)ethyl]acridine-4-carboxamide

Publications (1)

Publication Number	Publication Date
ATE232202T1 true ATE232202T1 (de)	2003-02-15

Family

ID=26310257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97909455T ATE232202T1 (de)	1996-10-18	1997-10-17	Verfahren zur herstellung von n-(2- (dimethylamino)ethyl)akridin-4-carbonsäureamide

Country Status (20)

Country	Link
US (1)	US6111109A (de)
EP (1)	EP0934277B1 (de)
JP (1)	JP2001502682A (de)
KR (1)	KR20000049239A (de)
AT (1)	ATE232202T1 (de)
AU (1)	AU741305B2 (de)
BG (1)	BG103328A (de)
BR (1)	BR9711945A (de)
CA (1)	CA2268413A1 (de)
CZ (1)	CZ135199A3 (de)
DE (1)	DE69718925D1 (de)
GB (1)	GB2333293B (de)
ID (1)	ID21677A (de)
NO (1)	NO313382B1 (de)
NZ (1)	NZ334951A (de)
PL (1)	PL332728A1 (de)
RU (1)	RU2178785C2 (de)
SK (1)	SK50599A3 (de)
TW (1)	TW430658B (de)
WO (1)	WO1998017649A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1853594A2 (de) *	2005-01-27	2007-11-14	Alma Mater Studiorum -Universita' di Bologna	Zur behandlung von alzheimer-krankheit geeignete organische verbindungen, ihre verwendung und herstellungsverfahren
US20070299093A1 (en) *	2005-01-27	2007-12-27	Alma Mater Studiorum-Universitá Di Bologna	Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
FR2904317A1 (fr)	2006-07-27	2008-02-01	Inst Nat Sante Rech Med	Analogues d'halogenobenzamides marques a titre de radiopharmaceutiques
EP2085390A1 (de)	2008-01-31	2009-08-05	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Markierte Analoge von Halobenzamiden als multimodale Radiopharmazeutika und ihre Vorläufer
CN105315205B (zh) *	2015-01-19	2018-03-23	威海惠安康生物科技有限公司	一种以邻硝基苯甲醛和环己醇为原料制备吖啶的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3686180A (en) *	1970-11-04	1972-08-22	Smith Kline French Lab	Substituted 9-lower alkylacridine-4-carboxylic acids
NZ201084A (en) *	1982-06-25	1985-10-11	New Zealand Dev Finance	4-carboxamidoacridine derivatives and pharmaceutical compositions containing such
SG45403A1 (en) *	1991-01-11	1998-01-16	Glaxo Lab Sa	Acridine derivatives
US5696131A (en) *	1993-01-22	1997-12-09	Xenova Limited	Treatment of cancers
NZ295546A (en) *	1994-10-05	1999-01-28	Glaxo Wellcome Inc	Parenteral medicament containing n-{4-[2-1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-phenyl}- 9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide, surfactant, and buffer

1997
- 1997-10-17 GB GB9908188A patent/GB2333293B/en not_active Expired - Fee Related
- 1997-10-17 KR KR1019990703343A patent/KR20000049239A/ko not_active Ceased
- 1997-10-17 DE DE69718925T patent/DE69718925D1/de not_active Expired - Lifetime
- 1997-10-17 JP JP10519107A patent/JP2001502682A/ja active Pending
- 1997-10-17 PL PL97332728A patent/PL332728A1/xx unknown
- 1997-10-17 US US09/284,570 patent/US6111109A/en not_active Expired - Fee Related
- 1997-10-17 WO PCT/GB1997/002884 patent/WO1998017649A1/en not_active Ceased
- 1997-10-17 SK SK505-99A patent/SK50599A3/sk unknown
- 1997-10-17 BR BR9711945A patent/BR9711945A/pt unknown
- 1997-10-17 CA CA002268413A patent/CA2268413A1/en not_active Abandoned
- 1997-10-17 RU RU99109986/04A patent/RU2178785C2/ru not_active IP Right Cessation
- 1997-10-17 NZ NZ334951A patent/NZ334951A/xx unknown
- 1997-10-17 ID IDW990202A patent/ID21677A/id unknown
- 1997-10-17 CZ CZ991351A patent/CZ135199A3/cs unknown
- 1997-10-17 AT AT97909455T patent/ATE232202T1/de not_active IP Right Cessation
- 1997-10-17 AU AU47136/97A patent/AU741305B2/en not_active Ceased
- 1997-10-17 EP EP97909455A patent/EP0934277B1/de not_active Expired - Lifetime
- 1997-10-17 TW TW086115308A patent/TW430658B/zh active
1999
- 1999-04-13 BG BG103328A patent/BG103328A/xx unknown
- 1999-04-16 NO NO19991835A patent/NO313382B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB2333293A (en)	1999-07-21
CA2268413A1 (en)	1998-04-30
EP0934277A1 (de)	1999-08-11
BG103328A (en)	2000-07-31
EP0934277B1 (de)	2003-02-05
NO991835L (no)	1999-06-16
TW430658B (en)	2001-04-21
GB9908188D0 (en)	1999-06-02
RU2178785C2 (ru)	2002-01-27
AU741305B2 (en)	2001-11-29
HK1018456A1 (en)	1999-12-24
CZ135199A3 (cs)	1999-09-15
NZ334951A (en)	2000-12-22
ID21677A (id)	1999-07-08
WO1998017649A1 (en)	1998-04-30
NO313382B1 (no)	2002-09-23
SK50599A3 (en)	2000-05-16
GB2333293B (en)	2000-07-12
DE69718925D1 (de)	2003-03-13
AU4713697A (en)	1998-05-15
PL332728A1 (en)	1999-10-11
JP2001502682A (ja)	2001-02-27
KR20000049239A (ko)	2000-07-25
BR9711945A (pt)	1999-08-24
NO991835D0 (no)	1999-04-16
US6111109A (en)	2000-08-29

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Legal Events

Date	Code	Title	Description
2003-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties