ATE204840T1 - Verfahren zur herstellung von galanthaminderivate durch asymmetrische reduktion - Google Patents

Verfahren zur herstellung von galanthaminderivate durch asymmetrische reduktion

Info

Publication number: ATE204840T1
Authority: AT; Austria
Prior art keywords: pct; galanthamin; derivatives; producing; asymmetric reduction
Prior art date: 1995-04-06

Application number

AT96909250T

Other languages

English (en)

Inventor

Ulrich Conrad Dyer

Jane Marie Paul

Raymond Mccague

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-06

Filing date

1996-04-04

Publication date

2001-09-15

1995-04-06 Priority claimed from GBGB9507100.7A external-priority patent/GB9507100D0/en

1996-01-22 Priority claimed from GBGB9601227.3A external-priority patent/GB9601227D0/en

1996-04-04 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE204840T1 publication Critical patent/ATE204840T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title 1
125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT96909250T 1995-04-06 1996-04-04 Verfahren zur herstellung von galanthaminderivate durch asymmetrische reduktion ATE204840T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9507100.7A GB9507100D0 (en)	1995-04-06	1995-04-06	Asymmetric reduction and products thereof
GBGB9601227.3A GB9601227D0 (en)	1996-01-22	1996-01-22	Reduction
PCT/GB1996/000843 WO1996031453A1 (en)	1995-04-06	1996-04-04	Process for preparing galanthamine derivatives by asymmetric reduction

Publications (1)

Publication Number	Publication Date
ATE204840T1 true ATE204840T1 (de)	2001-09-15

Family

ID=26306827

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96909250T ATE204840T1 (de)	1995-04-06	1996-04-04	Verfahren zur herstellung von galanthaminderivate durch asymmetrische reduktion

Country Status (12)

Country	Link
US (1)	US6018043A (de)
EP (1)	EP0819108B1 (de)
AT (1)	ATE204840T1 (de)
AU (1)	AU709080B2 (de)
CA (1)	CA2215518C (de)
CY (1)	CY2257B1 (de)
DE (1)	DE69614841T2 (de)
DK (1)	DK0819108T3 (de)
ES (1)	ES2162042T3 (de)
PT (1)	PT819108E (de)
TW (1)	TW448177B (de)
WO (1)	WO1996031453A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9506843D0 (en) *	1995-04-03	1995-05-24	Chiroscience Ltd	Oxidative process and products thereof
EP1670767B2 (de) *	2003-09-26	2014-10-29	ScinoPharm Taiwan, Ltd.	Optische trennung eines narwedinamidderivats
US20050142193A1 (en) *	2003-12-31	2005-06-30	Lijuan Tang	Galantamine formulations
CA2551946A1 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Immediate, controlled and sustained release formulations of galantamine
DE602006016441D1 (de) *	2005-05-13	2010-10-07	Alza Corp	Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss
WO2007035941A2 (en) *	2005-09-23	2007-03-29	Alza Corporation	Transdermal galantamine delivery system
CN100364995C (zh) *	2006-01-12	2008-01-30	兰州大学	加兰它敏制备方法
EP2009015B1 (de)	2007-06-18	2012-01-11	Aurobindo Pharma Limited	Herstellungsprozess für Galantaminhydrobromid
AT507039A1 (de) *	2008-06-26	2010-01-15	Sanochemia Pharmazeutika Ag	Verfahren zum herstellen von hochreinen benzazepinderivaten
CN102180886B (zh) *	2011-03-05	2015-01-21	兰州大学	加兰他敏不对称催化合成方法

1996
- 1996-04-04 US US08/930,211 patent/US6018043A/en not_active Expired - Lifetime
- 1996-04-04 AU AU52819/96A patent/AU709080B2/en not_active Expired
- 1996-04-04 CA CA002215518A patent/CA2215518C/en not_active Expired - Lifetime
- 1996-04-04 DE DE69614841T patent/DE69614841T2/de not_active Expired - Lifetime
- 1996-04-04 WO PCT/GB1996/000843 patent/WO1996031453A1/en not_active Ceased
- 1996-04-04 ES ES96909250T patent/ES2162042T3/es not_active Expired - Lifetime
- 1996-04-04 EP EP96909250A patent/EP0819108B1/de not_active Expired - Lifetime
- 1996-04-04 AT AT96909250T patent/ATE204840T1/de active
- 1996-04-04 PT PT96909250T patent/PT819108E/pt unknown
- 1996-04-04 DK DK96909250T patent/DK0819108T3/da active
- 1996-04-19 TW TW085104664A patent/TW448177B/zh not_active IP Right Cessation
2002
- 2002-01-04 CY CY0200005A patent/CY2257B1/xx unknown

Also Published As

Publication number	Publication date
AU5281996A (en)	1996-10-23
DE69614841D1 (de)	2001-10-04
DE69614841T2 (de)	2002-04-11
CA2215518A1 (en)	1996-10-10
CA2215518C (en)	2006-11-28
PT819108E (pt)	2002-02-28
CY2257B1 (en)	2003-07-04
TW448177B (en)	2001-08-01
EP0819108B1 (de)	2001-08-29
AU709080B2 (en)	1999-08-19
DK0819108T3 (da)	2001-11-26
WO1996031453A1 (en)	1996-10-10
US6018043A (en)	2000-01-25
ES2162042T3 (es)	2001-12-16
EP0819108A1 (de)	1998-01-21

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Legal Events

Date	Code	Title	Description
2002-01-15	UEP	Publication of translation of european patent specification