ATE232210T1 - Verfahren zur herstellung von erythromicin a-oxim - Google Patents

Verfahren zur herstellung von erythromicin a-oxim

Info

Publication number: ATE232210T1
Authority: AT; Austria
Prior art keywords: oxime; erythromicin; producing; erythromycin; isopropanol
Prior art date: 1996-04-10

Application number

AT97907949T

Other languages

English (en)

Inventor

Sou-Jen Chang

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-10

Filing date

1997-02-27

Publication date

2003-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24526649&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE232210(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-02-27 Application filed by Abbott Lab filed Critical Abbott Lab

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE232210T1 publication Critical patent/ATE232210T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 3
229930006677 Erythromycin A Natural products 0.000 abstract 3
229960003276 erythromycin Drugs 0.000 abstract 3
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
239000003377 acid catalyst Substances 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97907949T 1996-04-10 1997-02-27 Verfahren zur herstellung von erythromicin a-oxim ATE232210T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/630,306 US5808017A (en)	1996-04-10	1996-04-10	Process for preparing erythromycin A oxime
PCT/US1997/003177 WO1997038000A1 (en)	1996-04-10	1997-02-27	Process for preparing erythromycin a oxime

Publications (1)

Publication Number	Publication Date
ATE232210T1 true ATE232210T1 (de)	2003-02-15

Family

ID=24526649

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97907949T ATE232210T1 (de)	1996-04-10	1997-02-27	Verfahren zur herstellung von erythromicin a-oxim

Country Status (8)

Country	Link
US (1)	US5808017A (de)
EP (1)	EP0970099B1 (de)
JP (1)	JP4004068B2 (de)
AT (1)	ATE232210T1 (de)
DE (1)	DE69718942T2 (de)
DK (1)	DK0970099T3 (de)
ES (1)	ES2191821T3 (de)
WO (1)	WO1997038000A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69824590T2 (de) *	1997-07-08	2005-06-30	Sandoz Industrial Products S.A., Granollers	Solvate von erythromycin a oxim
US6245903B1 (en) *	1998-08-21	2001-06-12	Apotex, Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
IN190782B (de) *	1998-09-30	2003-08-23	Max India Ltd
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
AU783055B2 (en) *	1999-12-16	2005-09-22	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs and novel polymorph IV
US6590084B2 (en)	1999-12-20	2003-07-08	Merial	Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
FR2802534B1 (fr) *	1999-12-20	2002-02-01	Merial Sas	Procede pour preparer et isoler la 9-deoxo-9 (z)- hydroxyiminoerythromycine a
RU2002118308A (ru)	2000-01-11	2004-02-20	Тева Фамэситикл Индастрис Лтд. (Il)	Способы получения полиморфных модификаций кларитромицина
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
HUP0302466A2 (hu) *	2000-02-29	2003-11-28	Teva Pharmaceutical Industries Ltd.	Eljárások clarithromycin, clarithromycin intermedier, gyakorlatilag oximmentes clarithromycin és ezt tartalmazó gyógyszerkészítmény előállítására
BR0109544A (pt) *	2000-03-28	2003-06-10	Biochemie Gmbh	Partìculas granuladas com sabor ocultado
WO2002015842A2 (en)	2000-08-23	2002-02-28	Wockhardt Limited	Process for preparation of anhydrous azithromycin
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
RU2199546C2 (ru) *	2001-03-27	2003-02-27	Открытое акционерное общество "Биосинтез"	Способ получения гидрохлорида оксима эритромицина а
JP4344243B2 (ja) *	2001-11-07	2009-10-14	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	デスクラリスロマイシンの製造方法、及び中間体生成物
AU2004258953B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
WO2005009365A2 (en)	2003-07-21	2005-02-03	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
CA2533358C (en)	2003-07-21	2014-03-11	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
US8758820B2 (en)	2003-08-11	2014-06-24	Shionogi Inc.	Robust pellet
JP2007502294A (ja)	2003-08-12	2007-02-08	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
US8246996B2 (en) *	2003-08-29	2012-08-21	Shionogi Inc.	Antibiotic product, use and formulation thereof
JP2007513869A (ja)	2003-09-15	2007-05-31	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
US8715727B2 (en)	2004-07-02	2014-05-06	Shionogi Inc.	Tablet for pulsed delivery
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US7595300B2 (en)	2005-12-13	2009-09-29	Kosan Biosciences Incorporated	7-quinolyl ketolide antibacterial agents
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
WO2009023191A2 (en) *	2007-08-09	2009-02-19	Teva Pharmaceutical Industries Ltd.	An improved process for the preparation of clarithromycin
CN101362783B (zh) *	2008-10-06	2011-12-07	浙江国邦药业有限公司	一种红霉素a(e)肟的制备方法
CN102911225A (zh) *	2011-08-04	2013-02-06	山东方明药业集团股份有限公司	红霉素a肟的清洁化合成方法及其特别组合的反应设备
CN103897002A (zh) *	2012-12-31	2014-07-02	菏泽市方明制药有限公司	一种粗品硫氰酸红霉素制备红霉素a9-肟的方法
CN103923142B (zh) *	2014-04-30	2017-01-11	浙江震元制药有限公司	一种罗红霉素中间体的制备方法
CN115724896A (zh) *	2022-11-18	2023-03-03	枣庄市润安制药新材料有限公司	E/z式两种构型红霉素a肟的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en) *	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4150220A (en) *	1977-02-04	1979-04-17	Pfizer Inc.	Semi-synthetic 4"-erythromycin A derivatives
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法

1996
- 1996-04-10 US US08/630,306 patent/US5808017A/en not_active Expired - Lifetime
1997
- 1997-02-27 DE DE69718942T patent/DE69718942T2/de not_active Expired - Fee Related
- 1997-02-27 AT AT97907949T patent/ATE232210T1/de not_active IP Right Cessation
- 1997-02-27 DK DK97907949T patent/DK0970099T3/da active
- 1997-02-27 ES ES97907949T patent/ES2191821T3/es not_active Expired - Lifetime
- 1997-02-27 WO PCT/US1997/003177 patent/WO1997038000A1/en not_active Ceased
- 1997-02-27 EP EP97907949A patent/EP0970099B1/de not_active Expired - Lifetime
- 1997-02-27 JP JP53618597A patent/JP4004068B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0970099B1 (de)	2003-02-05
WO1997038000A1 (en)	1997-10-16
JP4004068B2 (ja)	2007-11-07
DE69718942D1 (de)	2003-03-13
JP2000508311A (ja)	2000-07-04
DK0970099T3 (da)	2003-05-26
US5808017A (en)	1998-09-15
DE69718942T2 (de)	2003-12-11
EP0970099A1 (de)	2000-01-12
ES2191821T3 (es)	2003-09-16

Legal Events

Date

Code

Title

Description

2003-08-15

UEP

Publication of translation of european patent specification

Ref document number: 0970099

Country of ref document: EP

2010-11-15

REN

Ceased due to non-payment of the annual fee

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