DK0970099T3 - Fremgangsmåde til fremstilling af erythromycin A-oxim - Google Patents

Fremgangsmåde til fremstilling af erythromycin A-oxim

Info

Publication number: DK0970099T3
Authority: DK; Denmark
Prior art keywords: erythromycin; oxime; preparation; isopropanol; acetic acid
Prior art date: 1996-04-10

Application number

DK97907949T

Other languages

English (en)

Inventor

Sou-Jen Chang

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-10

Filing date

1997-02-27

Publication date

2003-05-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24526649&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0970099(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-02-27 Application filed by Abbott Lab filed Critical Abbott Lab

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK0970099T3 publication Critical patent/DK0970099T3/da

Links

KYTWXIARANQMCA-PGYIPVOXSA-N (3r,4s,5s,6r,7r,9r,10z,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-10-hydroxyimino-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradec Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N\O)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 KYTWXIARANQMCA-PGYIPVOXSA-N 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 3
229930006677 Erythromycin A Natural products 0.000 abstract 3
229960003276 erythromycin Drugs 0.000 abstract 3
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
239000003377 acid catalyst Substances 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK97907949T 1996-04-10 1997-02-27 Fremgangsmåde til fremstilling af erythromycin A-oxim DK0970099T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/630,306 US5808017A (en)	1996-04-10	1996-04-10	Process for preparing erythromycin A oxime
PCT/US1997/003177 WO1997038000A1 (en)	1996-04-10	1997-02-27	Process for preparing erythromycin a oxime

Publications (1)

Publication Number	Publication Date
DK0970099T3 true DK0970099T3 (da)	2003-05-26

Family

ID=24526649

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97907949T DK0970099T3 (da)	1996-04-10	1997-02-27	Fremgangsmåde til fremstilling af erythromycin A-oxim

Country Status (8)

Country	Link
US (1)	US5808017A (da)
EP (1)	EP0970099B1 (da)
JP (1)	JP4004068B2 (da)
AT (1)	ATE232210T1 (da)
DE (1)	DE69718942T2 (da)
DK (1)	DK0970099T3 (da)
ES (1)	ES2191821T3 (da)
WO (1)	WO1997038000A1 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK142000A3 (en) *	1997-07-08	2000-06-12	Biochemie Sa	Erythromycin a oxime solvates
CA2245398C (en) *	1998-08-21	2002-01-29	Apotex Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
IN190782B (da) *	1998-09-30	2003-08-23	Max India Ltd
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
WO2001044262A1 (en)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs and novel polymorph iv
FR2802534B1 (fr) *	1999-12-20	2002-02-01	Merial Sas	Procede pour preparer et isoler la 9-deoxo-9 (z)- hydroxyiminoerythromycine a
US6590084B2 (en)	1999-12-20	2003-07-08	Merial	Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
AU2261901A (en)	2000-01-11	2001-07-24	Teva Pharma	Processes for preparing clarithromycin polymorphs
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
KR20030047873A (ko) *	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
AU2001263812B2 (en) *	2000-03-28	2004-09-23	Sandoz Ag	Granulated particles with masked taste
JP2004506664A (ja) *	2000-08-23	2004-03-04	ウォックハート・リミテッド	無水アジトロマイシンの製造法
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
RU2199546C2 (ru) *	2001-03-27	2003-02-27	Открытое акционерное общество "Биосинтез"	Способ получения гидрохлорида оксима эритромицина а
AU2002357482B2 (en) *	2001-11-07	2009-03-26	Sanofi-Aventis Deutschland Gmbh	Method for the production of desclarithromycin, and intermediate products
AU2004258953B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
AU2004258949B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
CA2535177A1 (en)	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
US8062672B2 (en)	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en) *	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (en)	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
CA2572292A1 (en)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US7595300B2 (en)	2005-12-13	2009-09-29	Kosan Biosciences Incorporated	7-quinolyl ketolide antibacterial agents
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin
CN101362783B (zh) *	2008-10-06	2011-12-07	浙江国邦药业有限公司	一种红霉素a(e)肟的制备方法
CN102911225A (zh) *	2011-08-04	2013-02-06	山东方明药业集团股份有限公司	红霉素a肟的清洁化合成方法及其特别组合的反应设备
CN103897002A (zh) *	2012-12-31	2014-07-02	菏泽市方明制药有限公司	一种粗品硫氰酸红霉素制备红霉素a9-肟的方法
CN103923142B (zh) *	2014-04-30	2017-01-11	浙江震元制药有限公司	一种罗红霉素中间体的制备方法
CN115724896A (zh) *	2022-11-18	2023-03-03	枣庄市润安制药新材料有限公司	E/z式两种构型红霉素a肟的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en) *	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4150220A (en) *	1977-02-04	1979-04-17	Pfizer Inc.	Semi-synthetic 4"-erythromycin A derivatives
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法

1996
- 1996-04-10 US US08/630,306 patent/US5808017A/en not_active Expired - Lifetime
1997
- 1997-02-27 DE DE69718942T patent/DE69718942T2/de not_active Expired - Fee Related
- 1997-02-27 WO PCT/US1997/003177 patent/WO1997038000A1/en not_active Ceased
- 1997-02-27 EP EP97907949A patent/EP0970099B1/en not_active Expired - Lifetime
- 1997-02-27 JP JP53618597A patent/JP4004068B2/ja not_active Expired - Fee Related
- 1997-02-27 DK DK97907949T patent/DK0970099T3/da active
- 1997-02-27 ES ES97907949T patent/ES2191821T3/es not_active Expired - Lifetime
- 1997-02-27 AT AT97907949T patent/ATE232210T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP4004068B2 (ja)	2007-11-07
US5808017A (en)	1998-09-15
ES2191821T3 (es)	2003-09-16
EP0970099A1 (en)	2000-01-12
DE69718942D1 (de)	2003-03-13
ATE232210T1 (de)	2003-02-15
DE69718942T2 (de)	2003-12-11
JP2000508311A (ja)	2000-07-04
WO1997038000A1 (en)	1997-10-16
EP0970099B1 (en)	2003-02-05

Publication	Publication Date	Title
DK0970099T3 (da)	2003-05-26	Fremgangsmåde til fremstilling af erythromycin A-oxim
ES2124373T3 (es)	1999-02-01	Procedimiento para la preparacion de derivados del acido n-acil-n,n',n'-etilendiamintriacetico.
TR199902326T2 (xx)	2000-05-22	Anti-hiperkolesterinemikler olarak ikameli piridinler ve bifeniller.
RU95102329A (ru)	1997-01-10	Способ и стабилизированная каталитическая система для получения олефинов
MX9205462A (es)	1993-05-01	Proceso y equipo para teñido de cabello
IE44749L (en)	1977-05-04	Cyclopeptide
AU6337999A (en)	2000-05-08	Core-extended perylene bisimides
BR9809109A (pt)	2000-08-01	Composição aglutinante de tinta em pó
EA199800811A1 (ru)	1999-02-25	Способ получения нитробифенилов
DK0749305T3 (da)	2002-06-17	Fremgangsmåde til fremstilling af avermectin/zein-sammensætninger
CA2204184A1 (en)	1997-03-27	End sections of connections for mineral wool conduits of the "climaver plus" type
JPS53121710A (en)	1978-10-24	Preparation of isomerized chlorofluorohydrocarbon containing hydrogne
ID27440A (id)	2001-04-12	Proses untuk menyiapkan penengah-penengah
JPS529757A (en)	1977-01-25	Clamping method of bolt and its washer
TR200202167T2 (tr)	2002-12-23	Sitalopram hazırlamak için yöntem
JPS5242015A (en)	1977-04-01	Run length code processing method for facsimile signal
UA42797C2 (uk)	2001-11-15	Похідні хінолон- і нафтиридонкарбонової кислоти та похідні ізоіндолу для їх одержання
ES2138215T3 (es)	2000-01-01	Metodo para eliminar un color no deseado de acido clorhidrico.
JPS5419966A (en)	1979-02-15	Production of pyroglutamine peptide
BR9807726A (pt)	2000-02-15	Processo para a preparação de um composto
JPS5386094A (en)	1978-07-29	Preparation of 7-amino-cephem derivatives
ES2049630B1 (es)	1994-12-16	Nuevo procedimiento de obtencion del acido 1-etil-6-fluoro-1,4-dihidro-4-oxo-7-(1-piperacinil)-3-quinolin carboxilico.
JPS51122043A (en)	1976-10-25	Process for preparation of 3-hydroxy-5- cycloxycyclopento-1-ene deriva tives
JPS5272315A (en)	1977-06-16	Aluminum alloy for conductor
JPS52116433A (en)	1977-09-29	Preparation of benzanilide derivatives