ATE232869T1 - Tricyclische delta3-piperidine als alpha2- antagonisten - Google Patents

Tricyclische delta3-piperidine als alpha2- antagonisten

Info

Publication number: ATE232869T1
Authority: AT; Austria
Prior art keywords: piperidines; alpha2 antagonists; delta3; tricyclic; tricyclic delta3
Prior art date: 1998-10-06

Application number

AT99950627T

Other languages

English (en)

Inventor

Ludo Edmond J Kennis

Den Keybus F M A Van

Josephus C Mertens

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-06

Filing date

1999-10-01

Publication date

2003-03-15

1999-10-01 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE232869T1 publication Critical patent/ATE232869T1/de

Links

239000000670 adrenergic alpha-2 receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Gynecology & Obstetrics (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)

AT99950627T 1998-10-06 1999-10-01 Tricyclische delta3-piperidine als alpha2- antagonisten ATE232869T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98203370		1998-10-06
PCT/EP1999/007419 WO2000020421A2 (en)	1998-10-06	1999-10-01	TRICYCLIC Δ3-PIPERIDINES AS α2-ANTAGONISTS

Publications (1)

Publication Number	Publication Date
ATE232869T1 true ATE232869T1 (de)	2003-03-15

Family

ID=8234191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99950627T ATE232869T1 (de)	1998-10-06	1999-10-01	Tricyclische delta3-piperidine als alpha2- antagonisten

Country Status (30)

Country	Link
US (1)	US6495555B1 (de)
EP (1)	EP1119571B1 (de)
JP (1)	JP4590101B2 (de)
KR (1)	KR20010071843A (de)
CN (1)	CN1131230C (de)
AR (1)	AR024216A1 (de)
AT (1)	ATE232869T1 (de)
AU (1)	AU760502B2 (de)
BG (1)	BG64872B1 (de)
BR (1)	BR9913507A (de)
CA (1)	CA2345622C (de)
CZ (1)	CZ20011104A3 (de)
DE (1)	DE69905478T2 (de)
DK (1)	DK1119571T3 (de)
EE (1)	EE04770B1 (de)
ES (1)	ES2193751T3 (de)
HU (1)	HUP0104002A3 (de)
ID (1)	ID28032A (de)
IL (1)	IL142443A0 (de)
NO (1)	NO20011270L (de)
NZ (1)	NZ510115A (de)
PL (1)	PL347894A1 (de)
PT (1)	PT1119571E (de)
RU (1)	RU2230744C2 (de)
SI (1)	SI1119571T1 (de)
SK (1)	SK285585B6 (de)
TR (1)	TR200100952T2 (de)
TW (1)	TWI248441B (de)
UA (1)	UA69420C2 (de)
WO (1)	WO2000020421A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2346082C (en) *	1998-10-06	2010-02-16	Janssen Pharmaceutica N.V.	Tricyclic .delta.3-piperidines as pharmaceuticals
CA2480266C (en) *	2002-04-03	2011-07-12	Orion Corporation	Use of an alpha2-adrenoreceptor antagonist for cns-related diseases
AU2005233456A1 (en)	2004-04-12	2005-10-27	Taisho Pharmaceutical Co., Ltd.	Cyclic amine compound
EP1775283A4 (de) *	2004-07-14	2008-12-10	Japan Tobacco Inc	3-aminobenzamid-verbindung und hemmer der aktivität des vanilloid-rezeptors 1 (vr1)
KR101042490B1 (ko) *	2004-07-15	2011-06-16	니뽄 다바코 산교 가부시키가이샤	축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(ｖｒ1)활성 저해제
US7906508B2 (en) *	2005-12-28	2011-03-15	Japan Tobacco Inc.	3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
CN102459251B (zh)	2009-05-14	2015-05-20	詹森药业有限公司	作为白三烯a4水解酶的调节剂的具有两个稠合双环杂芳基部分的化合物
WO2015091420A1 (de)	2013-12-19	2015-06-25	Bayer Pharma Aktiengesellschaft	Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten
SG11201604949XA (en)	2013-12-19	2016-07-28	Bayer Pharma AG	Substituted piperidinyl-tetrahydroquinolines
AP2016009276A0 (en) *	2013-12-19	2016-06-30	Bayer Pharma AG	Substituted piperidinyl-tetrahydroquinolines and their use as alpha-2c adrenoreceptor antagonists
CN114276359B (zh) *	2022-01-05	2023-05-05	浙江大学	一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU926914A1 (ru) *	1980-05-26	1992-04-23	Научно-исследовательский институт фармакологии АМН СССР	Производные 1,2,3,4-тетрагидробензофуро[3,2-с]-пиридина или хлоргидрат, обладающие р дом свойств анальгетиков и антагонистов морфина
DE3522959A1 (de) *	1985-06-27	1987-01-08	Merck Patent Gmbh	Indolderivate
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US4985422A (en) *	1988-04-27	1991-01-15	Glaxo Group Limited	Lactam derivatives
US4971974A (en) *	1988-06-16	1990-11-20	Neurex Corporation	Benzothiophenes as appetite suppressants
US5100891A (en) *	1991-01-18	1992-03-31	Hoechst-Roussel Pharmaceuticals Inc.	Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
CA2272330A1 (en) *	1996-12-06	1998-06-11	Irene Drizin	Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic compounds
US6498251B1 (en) *	1997-12-25	2002-12-24	Meiji Seika Kaisha, Ltd.	Tetrahydrobenzindole derivatives
CA2346082C (en) *	1998-10-06	2010-02-16	Janssen Pharmaceutica N.V.	Tricyclic .delta.3-piperidines as pharmaceuticals

1999
- 1999-01-10 UA UA2001031999A patent/UA69420C2/uk unknown
- 1999-10-01 CA CA002345622A patent/CA2345622C/en not_active Expired - Fee Related
- 1999-10-01 EE EEP200100209A patent/EE04770B1/xx not_active IP Right Cessation
- 1999-10-01 HU HU0104002A patent/HUP0104002A3/hu unknown
- 1999-10-01 TR TR2001/00952T patent/TR200100952T2/xx unknown
- 1999-10-01 JP JP2000574533A patent/JP4590101B2/ja not_active Expired - Fee Related
- 1999-10-01 IL IL14244399A patent/IL142443A0/xx not_active IP Right Cessation
- 1999-10-01 BR BR9913507-8A patent/BR9913507A/pt not_active IP Right Cessation
- 1999-10-01 NZ NZ510115A patent/NZ510115A/xx unknown
- 1999-10-01 EP EP99950627A patent/EP1119571B1/de not_active Expired - Lifetime
- 1999-10-01 SK SK432-2001A patent/SK285585B6/sk unknown
- 1999-10-01 CN CN99811682A patent/CN1131230C/zh not_active Expired - Fee Related
- 1999-10-01 WO PCT/EP1999/007419 patent/WO2000020421A2/en not_active Ceased
- 1999-10-01 RU RU2001111812/04A patent/RU2230744C2/ru not_active IP Right Cessation
- 1999-10-01 PT PT99950627T patent/PT1119571E/pt unknown
- 1999-10-01 CZ CZ20011104A patent/CZ20011104A3/cs unknown
- 1999-10-01 SI SI9930264T patent/SI1119571T1/xx unknown
- 1999-10-01 US US09/806,547 patent/US6495555B1/en not_active Expired - Lifetime
- 1999-10-01 AT AT99950627T patent/ATE232869T1/de not_active IP Right Cessation
- 1999-10-01 KR KR1020017000442A patent/KR20010071843A/ko not_active Ceased
- 1999-10-01 AU AU63341/99A patent/AU760502B2/en not_active Ceased
- 1999-10-01 DE DE69905478T patent/DE69905478T2/de not_active Expired - Lifetime
- 1999-10-01 ID IDW20010780A patent/ID28032A/id unknown
- 1999-10-01 PL PL99347894A patent/PL347894A1/xx not_active Application Discontinuation
- 1999-10-01 DK DK99950627T patent/DK1119571T3/da active
- 1999-10-01 TW TW088116898A patent/TWI248441B/zh not_active IP Right Cessation
- 1999-10-01 ES ES99950627T patent/ES2193751T3/es not_active Expired - Lifetime
- 1999-10-05 AR ARP990105038A patent/AR024216A1/es not_active Application Discontinuation
2001
- 2001-03-12 BG BG105332A patent/BG64872B1/bg unknown
- 2001-03-13 NO NO20011270A patent/NO20011270L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TR200100952T2 (tr)	2001-10-22
UA69420C2 (uk)	2004-09-15
SK4322001A3 (en)	2002-01-07
BR9913507A (pt)	2001-06-05
PT1119571E (pt)	2003-06-30
BG64872B1 (bg)	2006-07-31
KR20010071843A (ko)	2001-07-31
HUP0104002A2 (hu)	2002-03-28
HUP0104002A3 (en)	2003-12-29
CN1131230C (zh)	2003-12-17
EP1119571B1 (de)	2003-02-19
DE69905478T2 (de)	2004-03-18
NO20011270D0 (no)	2001-03-13
HK1038010A1 (en)	2002-03-01
NO20011270L (no)	2001-03-13
ES2193751T3 (es)	2003-11-01
AU760502B2 (en)	2003-05-15
SI1119571T1 (en)	2003-08-31
DE69905478D1 (de)	2003-03-27
WO2000020421A2 (en)	2000-04-13
TWI248441B (en)	2006-02-01
IL142443A0 (en)	2002-03-10
RU2230744C2 (ru)	2004-06-20
AR024216A1 (es)	2002-09-25
US6495555B1 (en)	2002-12-17
AU6334199A (en)	2000-04-26
EE200100209A (et)	2002-06-17
SK285585B6 (sk)	2007-04-05
CA2345622C (en)	2007-12-04
PL347894A1 (en)	2002-04-22
CZ20011104A3 (cs)	2001-12-12
NZ510115A (en)	2002-11-26
CA2345622A1 (en)	2000-04-13
CN1332744A (zh)	2002-01-23
EP1119571A2 (de)	2001-08-01
JP4590101B2 (ja)	2010-12-01
WO2000020421A3 (en)	2000-08-03
EE04770B1 (et)	2007-02-15
BG105332A (en)	2001-11-30
DK1119571T3 (da)	2003-05-26
JP2002526545A (ja)	2002-08-20
ID28032A (id)	2001-05-03

Legal Events

Date

Code

Title

Description

2003-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1119571

Country of ref document: EP

2008-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
IS6267A (is)	2002-02-13	Ný spíróefnasambönd
NO20003706L (no)	2000-09-14	Ny tricyklisk forbindelse
EP0986385A4 (de)	2001-05-16	Antagonisten des gonadorelins
DE69719354D1 (de)	2003-04-03	Muscarin-antagonisten
ID30132A (id)	2001-11-08	Turunan-turunan pirazol trisiklik
DE69911259D1 (de)	2003-10-16	Tricyclische benzodiazepine als vasopressin antagonisten
NO991821D0 (no)	1999-04-16	Substituerte tricykliske forbindelser
PT1131291E (pt)	2005-01-31	Antagonistas iii do receptor 4-aroil-piperidin-ccr-3
DK0804440T3 (da)	2008-03-31	Tricykliske benzazapin-vasopressionantagonister
EE200000171A (et)	2001-04-16	Uued NPY antagonistid
DK0839806T3 (da)	2003-10-27	Substituerede tricykliske forbindelser
DE69714265D1 (de)	2002-08-29	Tetrahydrochinolinderivate als eaa antagonisten
DE59813430D1 (de)	2006-05-04	Perylenhydrazidimide als Carbonylderivatisierungsreagenzien
DE69718786D1 (de)	2003-03-06	Benzoxazinone als dopamine -d4- rezeptor-antagonisten
DE69626220D1 (de)	2003-03-20	3-azetidinylalkylpiperidine oder -pyrrolidine als tachykinin antagonisten
PT1144411E (pt)	2005-09-30	Compostos espiro anti-histaminicos
ATE286022T1 (de)	2005-01-15	Naphthalin-carboxamide als tachykinin rezeptorantagonisten
ATE232869T1 (de)	2003-03-15	Tricyclische delta3-piperidine als alpha2- antagonisten
NO991823D0 (no)	1999-04-16	Substituerte tricykliske forbindelser
ATE240954T1 (de)	2003-06-15	Oxazolidinone als 5-ht2a-antagonisten
NO20022847D0 (no)	2002-06-14	Nye substituerte tricykliske forbindelser
DE69735811D1 (de)	2006-06-08	Piperazinoderivate als neurokinin-antagonisten
DE60009931D1 (de)	2004-05-19	Muscarin-antagonisten
ATE280161T1 (de)	2004-11-15	Imidazolverbindungen als alpha2-adrenorezeptoren antagonisten
DE60012953D1 (de)	2004-09-16	3-amino-2-phenylpiperidinderivate als substanz p antagonisten