IL142996A0 - New derivatives of erythromycin, their preparation process and their use as medicaments - Google Patents

New derivatives of erythromycin, their preparation process and their use as medicaments

Info

Publication number: IL142996A0
Authority: IL; Israel
Prior art keywords: erythromycin; medicaments; preparation process; new derivatives; derivatives
Prior art date: 1998-11-10

Application number

IL14299699A

Other languages

English (en)

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-10

Filing date

1999-11-09

Publication date

2002-04-21

1999-11-09 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2002-04-21 Publication of IL142996A0 publication Critical patent/IL142996A0/xx

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

IL14299699A 1998-11-10 1999-11-09 New derivatives of erythromycin, their preparation process and their use as medicaments IL142996A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9814145A FR2785612A1 (fr)	1998-11-10	1998-11-10	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
PCT/FR1999/002718 WO2000027857A2 (fr)	1998-11-10	1999-11-09	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number	Publication Date
IL142996A0 true IL142996A0 (en)	2002-04-21

Family

ID=9532584

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14299699A IL142996A0 (en)	1998-11-10	1999-11-09	New derivatives of erythromycin, their preparation process and their use as medicaments
IL142996A IL142996A (en)	1998-11-10	2001-05-06	Derivatives of erythromycin, method of preparation and their use as drugs

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL142996A IL142996A (en)	1998-11-10	2001-05-06	Derivatives of erythromycin, method of preparation and their use as drugs

Country Status (28)

Country	Link
US (2)	US6455505B2 (de)
EP (1)	EP1016669B1 (de)
JP (1)	JP4698783B2 (de)
KR (1)	KR100567695B1 (de)
CN (2)	CN100351238C (de)
AR (1)	AR025814A1 (de)
AT (1)	ATE232879T1 (de)
AU (1)	AU766138B2 (de)
BR (1)	BR9915236A (de)
CA (1)	CA2350651C (de)
CZ (1)	CZ20011622A3 (de)
DE (1)	DE69905447T2 (de)
DK (1)	DK1016669T3 (de)
EA (1)	EA200100533A1 (de)
ES (1)	ES2189365T3 (de)
FR (1)	FR2785612A1 (de)
HR (1)	HRP20010335B1 (de)
HU (1)	HUP0104035A3 (de)
IL (2)	IL142996A0 (de)
NO (1)	NO20012272L (de)
NZ (1)	NZ511609A (de)
PL (1)	PL348098A1 (de)
PT (1)	PT1016669E (de)
SI (1)	SI20640A (de)
TR (1)	TR200101286T2 (de)
TW (1)	TWI237027B (de)
WO (1)	WO2000027857A2 (de)
ZA (1)	ZA200103801B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP2001002222A0 (en)	1999-01-27	2001-09-30	Pfizer Prod Inc	Ketolide antibiotics.
IL145739A0 (en)	1999-05-24	2002-07-25	Pfizer Prod Inc	13-methyl-erythromycin derivatives
TR200401847T4 (tr)	2000-06-30	2004-09-21	Pfizer Products Inc.	Makrolit antibiyotikler.
JP2004017020A (ja) *	2002-06-20	2004-01-22	Sony Corp	コーティング方法および被コーティング粒子
EP1638549A4 (de)	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	Neue antibakterielle mittel
RU2397987C2 (ru) *	2004-07-28	2010-08-27	Рэнбакси Лабораториз Лимитед	Кетолидные производные в качестве антибактериальных агентов
US20090170790A1 (en) *	2004-10-25	2009-07-02	Biswajit Das	Ketolide derivatives as antibacterial agents
CA2703475A1 (en) *	2007-10-25	2009-04-30	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) *	2008-10-24	2014-08-05	Cempra Pharmaceuticals, Inc.	Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja)	2009-09-10	2016-05-11	センプラファーマシューティカルズ，インコーポレイテッド	マラリア、結核、及びｍａｃ病の治療方法
CN103080122A (zh)	2010-03-22	2013-05-01	森普拉制药公司	大环内脂的结晶形式及其用途
WO2011146829A1 (en)	2010-05-20	2011-11-24	Cempra Pharmaceuticals, Inc.	Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (ja)	2010-09-10	2016-12-14	センプラファーマシューティカルズ，インコーポレイテッド	疾患治療のための水素結合形成フルオロケトライド
CN104470527B (zh)	2012-03-27	2019-05-28	森普拉制药公司	用于施用大环内酯抗生素的肠胃外制剂
RU2015138796A (ru)	2013-03-14	2017-04-19	Семпра Фармасьютикалс, Инк.	Способы и составы для лечения респираторных заболеваний
WO2014145210A1 (en)	2013-03-15	2014-09-18	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents
JP6437523B2 (ja)	2013-04-04	2018-12-12	プレジデントアンドフェローズオブハーバードカレッジ	マクロライドならびにそれらの調製および使用の方法
US10633407B2 (en)	2014-10-08	2020-04-28	President And Fellows Of Harvard College	14-membered ketolides and methods of their preparation and use
EP3273969A4 (de)	2015-03-25	2018-11-21	President and Fellows of Harvard College	Makrolide mit modifizierten desosaminzuckern und verwendungen davon
EP3190122A1 (de) *	2016-01-08	2017-07-12	LEK Pharmaceuticals d.d.	Neuartiger syntheseweg zu solithromycin und reinigung davon
CN106432383A (zh) *	2016-09-14	2017-02-22	重庆两江药物研发中心有限公司	索利霉素及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5671074A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2669337B1 (fr) *	1990-11-21	1995-03-24	Roussel Uclaf	Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
FR2697524B1 (fr) *	1992-11-05	1994-12-23	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) *	1994-05-03	1996-07-12	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) *	1994-12-09	1997-01-17	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) *	1995-12-22	1998-01-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
SK285534B6 (sk) *	1996-09-04	2007-03-01	Abbott Laboratories	6-O-substituované ketolidy s antibakteriálnou aktivitou, farmaceutická kompozícia s ich obsahom, ich použitie a spôsob ich prípravy
WO1998040392A1 (fr) *	1997-03-10	1998-09-17	Taisho Pharmaceutical Co., Ltd.	Derives d'erythromycine a

1998
- 1998-11-10 FR FR9814145A patent/FR2785612A1/fr active Pending
1999
- 1999-11-03 US US09/433,146 patent/US6455505B2/en not_active Expired - Lifetime
- 1999-11-08 TW TW088119491A patent/TWI237027B/zh not_active IP Right Cessation
- 1999-11-09 PL PL99348098A patent/PL348098A1/xx not_active Application Discontinuation
- 1999-11-09 TR TR2001/01286T patent/TR200101286T2/xx unknown
- 1999-11-09 CN CNB200510128838XA patent/CN100351238C/zh not_active Expired - Lifetime
- 1999-11-09 WO PCT/FR1999/002718 patent/WO2000027857A2/fr not_active Ceased
- 1999-11-09 NZ NZ511609A patent/NZ511609A/en unknown
- 1999-11-09 AT AT99402783T patent/ATE232879T1/de active
- 1999-11-09 EP EP99402783A patent/EP1016669B1/de not_active Expired - Lifetime
- 1999-11-09 KR KR1020017005854A patent/KR100567695B1/ko not_active Expired - Lifetime
- 1999-11-09 EA EA200100533A patent/EA200100533A1/ru unknown
- 1999-11-09 AU AU10526/00A patent/AU766138B2/en not_active Expired
- 1999-11-09 DK DK99402783T patent/DK1016669T3/da active
- 1999-11-09 SI SI9920091A patent/SI20640A/sl not_active IP Right Cessation
- 1999-11-09 CZ CZ20011622A patent/CZ20011622A3/cs unknown
- 1999-11-09 HU HU0104035A patent/HUP0104035A3/hu unknown
- 1999-11-09 IL IL14299699A patent/IL142996A0/xx active IP Right Grant
- 1999-11-09 CA CA2350651A patent/CA2350651C/fr not_active Expired - Lifetime
- 1999-11-09 JP JP31801599A patent/JP4698783B2/ja not_active Expired - Lifetime
- 1999-11-09 CN CNB998154393A patent/CN1240708C/zh not_active Expired - Lifetime
- 1999-11-09 HR HR990077A patent/HRP20010335B1/xx not_active IP Right Cessation
- 1999-11-09 ES ES99402783T patent/ES2189365T3/es not_active Expired - Lifetime
- 1999-11-09 PT PT99402783T patent/PT1016669E/pt unknown
- 1999-11-09 BR BR9915236-3A patent/BR9915236A/pt active Search and Examination
- 1999-11-09 DE DE69905447T patent/DE69905447T2/de not_active Expired - Lifetime
- 1999-11-10 AR ARP990105702A patent/AR025814A1/es not_active Application Discontinuation
2000
- 2000-12-11 US US09/734,162 patent/US6407257B1/en not_active Expired - Lifetime
2001
- 2001-05-06 IL IL142996A patent/IL142996A/en not_active IP Right Cessation
- 2001-05-09 NO NO20012272A patent/NO20012272L/no not_active Application Discontinuation
- 2001-05-10 ZA ZA200103801A patent/ZA200103801B/en unknown

Also Published As

Publication number	Publication date
EP1016669A1 (de)	2000-07-05
HRP20010335A2 (en)	2002-06-30
DE69905447D1 (de)	2003-03-27
CN1814592A (zh)	2006-08-09
HUP0104035A2 (hu)	2002-02-28
HRP20010335B1 (en)	2003-08-31
ZA200103801B (en)	2002-05-10
AU766138B2 (en)	2003-10-09
ATE232879T1 (de)	2003-03-15
TWI237027B (en)	2005-08-01
JP2000143689A (ja)	2000-05-26
WO2000027857A2 (fr)	2000-05-18
PT1016669E (pt)	2003-07-31
JP4698783B2 (ja)	2011-06-08
DK1016669T3 (da)	2003-05-26
NO20012272D0 (no)	2001-05-09
CZ20011622A3 (cs)	2001-09-12
KR20010080970A (ko)	2001-08-25
CN1240708C (zh)	2006-02-08
US20020013281A1 (en)	2002-01-31
ES2189365T3 (es)	2003-07-01
CA2350651C (fr)	2010-07-20
BR9915236A (pt)	2002-01-08
WO2000027857A3 (fr)	2000-08-17
EA200100533A1 (ru)	2001-10-22
NO20012272L (no)	2001-07-10
TR200101286T2 (tr)	2001-09-21
IL142996A (en)	2006-12-10
CN100351238C (zh)	2007-11-28
US20020028781A1 (en)	2002-03-07
HUP0104035A3 (en)	2003-12-29
US6407257B1 (en)	2002-06-18
CN1333782A (zh)	2002-01-30
EP1016669B1 (de)	2003-02-19
PL348098A1 (en)	2002-05-06
KR100567695B1 (ko)	2006-04-05
DE69905447T2 (de)	2003-07-24
SI20640A (sl)	2002-02-28
AU1052600A (en)	2000-05-29
AR025814A1 (es)	2002-12-18
US6455505B2 (en)	2002-09-24
FR2785612A1 (fr)	2000-05-12
CA2350651A1 (fr)	2000-05-18
NZ511609A (en)	2003-07-25

Legal Events

Date	Code	Title
2007-07-06	KB	Patent renewed
2007-07-24	FF	Patent granted
2010-05-17	KB	Patent renewed

Publication	Publication Date	Title
SI0680967T1 (en)	1999-02-28	Erythromycin derivatives, their process of preparation and their use as medicaments
AP9500743A0 (en)	1995-07-31	New erythromycin derivatives, their preparation process and their use as medicaments
CZ20011622A3 (cs)	2001-09-12	Nové deriváty erythromycinu, způsob jejich přípravy a jejich použití jako léčiv
HUP0000658A3 (en)	2001-03-28	Sulphonamide derivatives, process for their preparation, and their use as medicaments
PL344412A1 (en)	2001-11-05	Pyrazoline derivatives, their preparation and application as medicaments
HUP0105136A3 (en)	2002-05-28	Amide derivatives, process for their preparation and medicaments containing them
HUP0104167A3 (en)	2003-12-29	2-ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents
HUP0203548A3 (en)	2003-04-28	New spirooxindole derivatives, process for their preparation, pharmaceutical compositions containing them and their use
ZA971659B (en)	1998-02-26	Erythromycin derivatives, their preparation process and their use as medicaments.
HUP9900958A3 (en)	2000-04-28	New derivatives of 2-fluoro-3-de[(2,6-dideoxy-3-c-methyl-3-0-methyl-alfa-l-ribohexopyranosyl)-oxy]-6-0-methyl-3-oxo-erytromycin, and their preparation process
ZA997176B (en)	2000-11-20	Derivatives of erythromycin, their preparation process and their use as medicaments.
LT2000004A (en)	2000-07-25	Derivatives of acyl-piperazinil-pyrimidins, preparation thereof and application as medicaments
PL343512A1 (en)	2001-08-27	Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
HUP0100978A3 (en)	2003-08-28	Benzothiadiazoles and derivatives, process for their preparation and medicaments containing them
HUP0100927A3 (en)	2002-03-28	Antitumor substituted indene-derivatives, process for their preparation, medicaments containing them and their use
HUP0104033A3 (en)	2002-08-28	1-benzoyl-tetrahydropyridazine derivatives, process for their preparation, their use and medicaments containing the compounds
HUP0104620A3 (en)	2003-01-28	2-phenylpyran-4-one derivatives, process for their preparation and medicaments containing them
HUP0101234A3 (en)	2002-12-28	Betha-carboline derivatives, process for their preparation and pharmaceutical compositions thereof
AU3853597A (en)	1998-02-10	New derivatives of erythromycin, their preparation process and their use as medicaments
AU5487798A (en)	1998-07-03	New derivatives of erythromycin, their preparation process and their use as medicaments
HUP0001245A3 (en)	2003-05-28	Novel erythromycin derivatives, method of preparation and application as medicines
HUP0204572A3 (en)	2004-07-28	Substituierte bisindolylmaleinimide derivatives, process for their preparation and use and pharmaceutcial compositions containing them
SI0863139T1 (en)	2001-06-30	Benzoxazindione derivatives, process for their preparation and their use
HUP0001452A3 (en)	2000-10-30	Novel erythromycin derivatives, method of preparation and application as medicines
HUP0102854A3 (en)	2002-07-29	Cyanoiminoquinoxaline derivatives, process for their preparation, pharmaceutical compositions containing them and their use