ATE233251T1 - Mmp-hemmende thiadiazolylamide - Google Patents

Mmp-hemmende thiadiazolylamide

Info

Publication number
ATE233251T1
ATE233251T1 AT97931009T AT97931009T ATE233251T1 AT E233251 T1 ATE233251 T1 AT E233251T1 AT 97931009 T AT97931009 T AT 97931009T AT 97931009 T AT97931009 T AT 97931009T AT E233251 T1 ATE233251 T1 AT E233251T1
Authority
AT
Austria
Prior art keywords
ulceration
present
thiadiazolylamides
mmp
inhibiting
Prior art date
Application number
AT97931009T
Other languages
English (en)
Inventor
Mark A Mitchell
Heinrich J Schostarez
Linda L Maggiora
Thomas J Lindberg
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE233251T1 publication Critical patent/ATE233251T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT97931009T 1996-06-21 1997-06-18 Mmp-hemmende thiadiazolylamide ATE233251T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2018896P 1996-06-21 1996-06-21
PCT/US1997/009204 WO1997048688A1 (en) 1996-06-21 1997-06-18 Thiadiazole amide mmp inhibitors

Publications (1)

Publication Number Publication Date
ATE233251T1 true ATE233251T1 (de) 2003-03-15

Family

ID=21797214

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931009T ATE233251T1 (de) 1996-06-21 1997-06-18 Mmp-hemmende thiadiazolylamide

Country Status (10)

Country Link
US (1) US5830869A (de)
EP (1) EP1021424B1 (de)
JP (1) JP2000514787A (de)
AT (1) ATE233251T1 (de)
AU (1) AU3474797A (de)
DE (1) DE69719385T2 (de)
DK (1) DK1021424T3 (de)
ES (1) ES2193385T3 (de)
PT (1) PT1021424E (de)
WO (1) WO1997048688A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9702088D0 (en) 1997-01-31 1997-03-19 Pharmacia & Upjohn Spa Matrix metalloproteinase inhibitors
KR20040028769A (ko) * 2001-06-04 2004-04-03 액시스 파마슈티컬스 인코포레이티드 카텝신 억제제로서의 화합물 및 조성물
JP4825375B2 (ja) * 2001-08-28 2011-11-30 株式会社 資生堂 ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤
JP2005531506A (ja) * 2002-03-01 2005-10-20 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体作動薬としてのアミノアルキルホスホネートおよび関連化合物
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
MXPA06001845A (es) * 2003-08-21 2006-05-04 Pfizer Prod Inc Compuestos para el tratamiento de trastornos neurodegenerativos.
CN117417272B (zh) * 2023-10-19 2024-08-13 上海海皋科技有限公司 一种Boc-D-异亮氨酸的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63142351A (ja) * 1986-12-04 1988-06-14 Fuji Photo Film Co Ltd 直接ポジカラ−画像形成方法
IT1224860B (it) * 1988-07-29 1990-10-24 Istituto Chimico Internazional Composti correlati all'acetozolammi de con attivita' inibitrice dell'anidrasi carbonica, utili in particolare nel trattamento del glaucoma
AU641157B2 (en) * 1989-05-02 1993-09-16 G. Michael Blackburn 2-imino-thiadiazoline-5-sulphonamides and their use in the treatment of glaucoma
AU4267293A (en) * 1992-05-01 1993-11-29 British Biotech Pharmaceuticals Limited Use of MMP inhibitors
US5318964A (en) * 1992-06-11 1994-06-07 Hoffmann-La Roche Inc. Hydroxamic derivatives and pharmaceutical compositions
WO1995004033A1 (en) * 1993-08-02 1995-02-09 Celltech Limited Succinamide derivatives, processes for their preparation and their use as gelatinase and collagenase inhibitors
GB9320660D0 (en) * 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
US5403952A (en) * 1993-10-08 1995-04-04 Merck & Co., Inc. Substituted cyclic derivatives as novel antidegenerative agents
DK0822186T3 (da) * 1994-01-20 2000-06-26 British Biotech Pharm L-tert-leucin-2-pyridylamid
US5677282A (en) * 1995-06-07 1997-10-14 Proscript, Inc. Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase
TW448172B (en) * 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
DK0900211T3 (da) * 1996-04-23 2003-10-27 Upjohn Co Thiadiazolyl(thio)urinstoffer, der er nyttige som matrixmetalloproteaseinhibitorer

Also Published As

Publication number Publication date
AU3474797A (en) 1998-01-07
PT1021424E (pt) 2003-06-30
DE69719385D1 (de) 2003-04-03
DK1021424T3 (da) 2003-06-02
EP1021424A1 (de) 2000-07-26
EP1021424B1 (de) 2003-02-26
DE69719385T2 (de) 2003-12-18
ES2193385T3 (es) 2003-11-01
WO1997048688A1 (en) 1997-12-24
US5830869A (en) 1998-11-03
JP2000514787A (ja) 2000-11-07

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