ES2193385T3 - Inhibidores tiadiazol amida de la metaloproteasa. - Google Patents
Inhibidores tiadiazol amida de la metaloproteasa.Info
- Publication number
- ES2193385T3 ES2193385T3 ES97931009T ES97931009T ES2193385T3 ES 2193385 T3 ES2193385 T3 ES 2193385T3 ES 97931009 T ES97931009 T ES 97931009T ES 97931009 T ES97931009 T ES 97931009T ES 2193385 T3 ES2193385 T3 ES 2193385T3
- Authority
- ES
- Spain
- Prior art keywords
- tiadiazol
- metaloprotease
- amida
- inhibitors
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000670727 Amida Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 101100277337 Arabidopsis thaliana DDM1 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005275 alkylenearyl group Chemical group 0.000 abstract 1
- 101150113676 chr1 gene Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Un compuesto de fórmula I **fórmula** o sales farmacéuticamente aceptables del mismo, donde: Q es a) -(CHR1)n-, o H, b) alquilo C2-8, c) fenilo, d) alquil C1-8 arilo, e) -(CH2)i-X-(CH2)j-arilo, f) -(CH2)I-Het, g) alquileno C3-6, h) alquileno C3-6 arilo, i) -(CH2)j-cicloalquilo, j) -C(CH3)2-S-CH2-NHC(=O)R3, o k) -(CH2)I-NHC(=O)OR3;
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2018896P | 1996-06-21 | 1996-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2193385T3 true ES2193385T3 (es) | 2003-11-01 |
Family
ID=21797214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97931009T Expired - Lifetime ES2193385T3 (es) | 1996-06-21 | 1997-06-18 | Inhibidores tiadiazol amida de la metaloproteasa. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5830869A (es) |
| EP (1) | EP1021424B1 (es) |
| JP (1) | JP2000514787A (es) |
| AT (1) | ATE233251T1 (es) |
| AU (1) | AU3474797A (es) |
| DE (1) | DE69719385T2 (es) |
| DK (1) | DK1021424T3 (es) |
| ES (1) | ES2193385T3 (es) |
| PT (1) | PT1021424E (es) |
| WO (1) | WO1997048688A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9702088D0 (en) | 1997-01-31 | 1997-03-19 | Pharmacia & Upjohn Spa | Matrix metalloproteinase inhibitors |
| IL159135A0 (en) * | 2001-06-04 | 2004-05-12 | Axys Pharm Inc | Novel compounds and compositions as cathepsin inhibitors |
| JP4825375B2 (ja) * | 2001-08-28 | 2011-11-30 | 株式会社 資生堂 | ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤 |
| JP2005531506A (ja) * | 2002-03-01 | 2005-10-20 | メルク エンド カムパニー インコーポレーテッド | Ｅｄｇ受容体作動薬としてのアミノアルキルホスホネートおよび関連化合物 |
| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| CA2534532A1 (en) * | 2003-08-21 | 2005-03-10 | Pfizer Products, Inc. | Compounds for the treatment of neurodegenerative disorders |
| CN117417272B (zh) * | 2023-10-19 | 2024-08-13 | 上海海皋科技有限公司 | 一种Boc-D-异亮氨酸的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63142351A (ja) * | 1986-12-04 | 1988-06-14 | Fuji Photo Film Co Ltd | 直接ポジカラ−画像形成方法 |
| IT1224860B (it) * | 1988-07-29 | 1990-10-24 | Istituto Chimico Internazional | Composti correlati all'acetozolammi de con attivita' inibitrice dell'anidrasi carbonica, utili in particolare nel trattamento del glaucoma |
| AU641157B2 (en) * | 1989-05-02 | 1993-09-16 | G. Michael Blackburn | 2-imino-thiadiazoline-5-sulphonamides and their use in the treatment of glaucoma |
| EP1002556A3 (en) * | 1992-05-01 | 2001-01-10 | British Biotech Pharmaceuticals Limited | Use of MMP inhibitors |
| US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| JPH09503492A (ja) * | 1993-08-02 | 1997-04-08 | セルテック・セラピューティクス・リミテッド | スクシンアミド誘導体、それらの調製法及びそれらのゼラチナーゼ及びコラゲナーゼ阻害剤としての使用 |
| GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
| BR9506535A (pt) * | 1994-01-20 | 1997-09-16 | British Biotech Pharm | Inibidores de metaloproteinases |
| US5677282A (en) * | 1995-06-07 | 1997-10-14 | Proscript, Inc. | Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase |
| TW448172B (en) * | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| JP2000509039A (ja) * | 1996-04-23 | 2000-07-18 | ファルマシア・アンド・アップジョン・カンパニー | マトリックスメタロプロテイナーゼ・インヒビターとして有用なチアジアゾリル（チオ）尿素 |
-
1997
- 1997-06-18 DE DE69719385T patent/DE69719385T2/de not_active Expired - Fee Related
- 1997-06-18 AT AT97931009T patent/ATE233251T1/de not_active IP Right Cessation
- 1997-06-18 ES ES97931009T patent/ES2193385T3/es not_active Expired - Lifetime
- 1997-06-18 US US08/878,266 patent/US5830869A/en not_active Expired - Fee Related
- 1997-06-18 DK DK97931009T patent/DK1021424T3/da active
- 1997-06-18 EP EP97931009A patent/EP1021424B1/en not_active Expired - Lifetime
- 1997-06-18 AU AU34747/97A patent/AU3474797A/en not_active Abandoned
- 1997-06-18 WO PCT/US1997/009204 patent/WO1997048688A1/en not_active Ceased
- 1997-06-18 PT PT97931009T patent/PT1021424E/pt unknown
- 1997-06-18 JP JP10503000A patent/JP2000514787A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ATE233251T1 (de) | 2003-03-15 |
| JP2000514787A (ja) | 2000-11-07 |
| DK1021424T3 (da) | 2003-06-02 |
| PT1021424E (pt) | 2003-06-30 |
| DE69719385D1 (de) | 2003-04-03 |
| WO1997048688A1 (en) | 1997-12-24 |
| DE69719385T2 (de) | 2003-12-18 |
| AU3474797A (en) | 1998-01-07 |
| EP1021424A1 (en) | 2000-07-26 |
| EP1021424B1 (en) | 2003-02-26 |
| US5830869A (en) | 1998-11-03 |
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