ATE233252T1 - Substituierte dihydrobenzofurane als pde- hemmstoffe - Google Patents
Substituierte dihydrobenzofurane als pde- hemmstoffeInfo
- Publication number
- ATE233252T1 ATE233252T1 AT97950157T AT97950157T ATE233252T1 AT E233252 T1 ATE233252 T1 AT E233252T1 AT 97950157 T AT97950157 T AT 97950157T AT 97950157 T AT97950157 T AT 97950157T AT E233252 T1 ATE233252 T1 AT E233252T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- pde inhibitors
- dihydrobenzofuranes
- substituted
- substituted dihydrobenzofuranes
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19647881 | 1996-11-20 | ||
| EP96118743 | 1996-11-22 | ||
| PCT/EP1997/006248 WO1998022453A1 (en) | 1996-11-20 | 1997-11-11 | Substituted dihydrobenzofurans as pde inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE233252T1 true ATE233252T1 (de) | 2003-03-15 |
Family
ID=26031440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97950157T ATE233252T1 (de) | 1996-11-20 | 1997-11-11 | Substituierte dihydrobenzofurane als pde- hemmstoffe |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6054475A (de) |
| EP (1) | EP0941221B1 (de) |
| JP (1) | JP2001505198A (de) |
| AT (1) | ATE233252T1 (de) |
| AU (1) | AU5320698A (de) |
| CY (1) | CY2472B1 (de) |
| DE (1) | DE69719358T2 (de) |
| DK (1) | DK0941221T3 (de) |
| ES (1) | ES2193414T3 (de) |
| PT (1) | PT941221E (de) |
| SI (1) | SI0941221T1 (de) |
| WO (1) | WO1998022453A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU734734B2 (en) * | 1997-10-28 | 2001-06-21 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| PL200923B1 (pl) | 1999-08-21 | 2009-02-27 | Nycomed Gmbh | Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu |
| KR20030007575A (ko) * | 2000-05-03 | 2003-01-23 | 수캄포 아게 | 안압 강하제 |
| SE0004780D0 (sv) * | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
| JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
| DE60208630T2 (de) * | 2001-05-11 | 2006-08-17 | Pfizer Products Inc., Groton | Thiazolderivate und ihre Verwendung als cdk-Inhibitoren |
| AU2002358772B2 (en) | 2001-12-20 | 2008-11-20 | Merck Serono Sa | Pyrrolidine derivatives as prostaglandin modulators |
| US6723755B2 (en) | 2002-06-12 | 2004-04-20 | Piotr Chomczynski | Method of treating rosacea |
| JP2006522151A (ja) | 2003-04-01 | 2006-09-28 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症におけるホスホジエステラーゼ阻害剤 |
| DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| US7812057B2 (en) * | 2004-08-25 | 2010-10-12 | Molecular Research Center, Inc. | Cosmetic compositions |
| EP2275096A3 (de) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenese durch modulation des Muscarinrezeptors |
| EP2258357A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP2314289A1 (de) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| EP2021000A2 (de) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenese mittels angiotensin-modulation |
| WO2008030651A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI944549L (fi) * | 1992-04-02 | 1994-11-30 | Smithkline Beecham Corp | Allergisten ja tulehdussairauksien hoidossa käyttökelpoiset yhdisteet |
| ES2152414T3 (es) * | 1994-07-22 | 2001-02-01 | Byk Gulden Lomberg Chem Fab | Dihidrobenzofuranos. |
| PT828728E (pt) * | 1995-05-18 | 2003-06-30 | Altana Pharma Ag | Di-hidrobenzofuranos de fenilo |
| ATE230404T1 (de) * | 1995-05-18 | 2003-01-15 | Altana Pharma Ag | Cyclohexyldihydrobenzofurane |
-
1997
- 1997-11-11 JP JP52316498A patent/JP2001505198A/ja not_active Ceased
- 1997-11-11 SI SI9730523T patent/SI0941221T1/xx unknown
- 1997-11-11 DK DK97950157T patent/DK0941221T3/da active
- 1997-11-11 WO PCT/EP1997/006248 patent/WO1998022453A1/en not_active Ceased
- 1997-11-11 AU AU53206/98A patent/AU5320698A/en not_active Abandoned
- 1997-11-11 PT PT97950157T patent/PT941221E/pt unknown
- 1997-11-11 AT AT97950157T patent/ATE233252T1/de not_active IP Right Cessation
- 1997-11-11 US US09/284,459 patent/US6054475A/en not_active Expired - Fee Related
- 1997-11-11 ES ES97950157T patent/ES2193414T3/es not_active Expired - Lifetime
- 1997-11-11 DE DE69719358T patent/DE69719358T2/de not_active Expired - Fee Related
- 1997-11-11 EP EP97950157A patent/EP0941221B1/de not_active Expired - Lifetime
-
2004
- 2004-08-11 CY CY0400063A patent/CY2472B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5320698A (en) | 1998-06-10 |
| EP0941221B1 (de) | 2003-02-26 |
| DK0941221T3 (da) | 2003-06-10 |
| JP2001505198A (ja) | 2001-04-17 |
| CY2472B1 (en) | 2005-06-03 |
| EP0941221A1 (de) | 1999-09-15 |
| PT941221E (pt) | 2003-07-31 |
| WO1998022453A1 (en) | 1998-05-28 |
| DE69719358D1 (de) | 2003-04-03 |
| US6054475A (en) | 2000-04-25 |
| SI0941221T1 (en) | 2003-10-31 |
| ES2193414T3 (es) | 2003-11-01 |
| DE69719358T2 (de) | 2003-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0941221 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |