DK0941221T3 - Substituerede dihydrobenzofuraner som PDE-inhibitorer - Google Patents
Substituerede dihydrobenzofuraner som PDE-inhibitorerInfo
- Publication number
- DK0941221T3 DK0941221T3 DK97950157T DK97950157T DK0941221T3 DK 0941221 T3 DK0941221 T3 DK 0941221T3 DK 97950157 T DK97950157 T DK 97950157T DK 97950157 T DK97950157 T DK 97950157T DK 0941221 T3 DK0941221 T3 DK 0941221T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- pde inhibitors
- substituted dihydrobenzofurans
- dihydrobenzofurans
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19647881 | 1996-11-20 | ||
| EP96118743 | 1996-11-22 | ||
| PCT/EP1997/006248 WO1998022453A1 (en) | 1996-11-20 | 1997-11-11 | Substituted dihydrobenzofurans as pde inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0941221T3 true DK0941221T3 (da) | 2003-06-10 |
Family
ID=26031440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97950157T DK0941221T3 (da) | 1996-11-20 | 1997-11-11 | Substituerede dihydrobenzofuraner som PDE-inhibitorer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6054475A (de) |
| EP (1) | EP0941221B1 (de) |
| JP (1) | JP2001505198A (de) |
| AT (1) | ATE233252T1 (de) |
| AU (1) | AU5320698A (de) |
| CY (1) | CY2472B1 (de) |
| DE (1) | DE69719358T2 (de) |
| DK (1) | DK0941221T3 (de) |
| ES (1) | ES2193414T3 (de) |
| PT (1) | PT941221E (de) |
| SI (1) | SI0941221T1 (de) |
| WO (1) | WO1998022453A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003525845A (ja) * | 1997-10-28 | 2003-09-02 | ヴィヴァス・インコーポレイテッド | 勃起機能不全の処置のためのホスホジエステラーゼインヒビターの局所投与 |
| CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
| KR20030007575A (ko) * | 2000-05-03 | 2003-01-23 | 수캄포 아게 | 안압 강하제 |
| SE0004780D0 (sv) * | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
| JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
| DE60208630T2 (de) * | 2001-05-11 | 2006-08-17 | Pfizer Products Inc., Groton | Thiazolderivate und ihre Verwendung als cdk-Inhibitoren |
| ES2337887T3 (es) * | 2001-12-20 | 2010-04-30 | Merck Serono Sa | Derivados de pirrolidina en calidad de moduladores de prostaglandina. |
| US6723755B2 (en) | 2002-06-12 | 2004-04-20 | Piotr Chomczynski | Method of treating rosacea |
| EA200501548A1 (ru) | 2003-04-01 | 2006-02-24 | Апплайд Резеч Системз Арс Холдинг Н.В. | Ингибиторы фосфодиэстераз при бесплодии |
| DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| US7812057B2 (en) * | 2004-08-25 | 2010-10-12 | Molecular Research Center, Inc. | Cosmetic compositions |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2068872A1 (de) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Kombinationen mit einem 4-acylaminopyridin-derivat |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2804603A1 (de) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Betazellen-replikation für promoterverbindungen und verwendungsverfahren dafür |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU225869B1 (en) * | 1992-04-02 | 2007-11-28 | Smithkline Beecham Corp | Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them |
| NZ290420A (en) * | 1994-07-22 | 1999-01-28 | Byk Gulden Lomberg Chem Fab | Phenyl or pyridyl-amide substituted dihydro benzofurans; medicaments |
| DE59610031D1 (de) * | 1995-05-18 | 2003-02-06 | Altana Pharma Ag | Cyclohexyldihydrobenzofurane |
| AU698028B2 (en) * | 1995-05-18 | 1998-10-22 | Altana Pharma Ag | Phenyldihydrobenzofurans |
-
1997
- 1997-11-11 SI SI9730523T patent/SI0941221T1/xx unknown
- 1997-11-11 AU AU53206/98A patent/AU5320698A/en not_active Abandoned
- 1997-11-11 AT AT97950157T patent/ATE233252T1/de not_active IP Right Cessation
- 1997-11-11 DE DE69719358T patent/DE69719358T2/de not_active Expired - Fee Related
- 1997-11-11 JP JP52316498A patent/JP2001505198A/ja not_active Ceased
- 1997-11-11 US US09/284,459 patent/US6054475A/en not_active Expired - Fee Related
- 1997-11-11 DK DK97950157T patent/DK0941221T3/da active
- 1997-11-11 ES ES97950157T patent/ES2193414T3/es not_active Expired - Lifetime
- 1997-11-11 PT PT97950157T patent/PT941221E/pt unknown
- 1997-11-11 WO PCT/EP1997/006248 patent/WO1998022453A1/en not_active Ceased
- 1997-11-11 EP EP97950157A patent/EP0941221B1/de not_active Expired - Lifetime
-
2004
- 2004-08-11 CY CY0400063A patent/CY2472B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69719358D1 (de) | 2003-04-03 |
| ATE233252T1 (de) | 2003-03-15 |
| WO1998022453A1 (en) | 1998-05-28 |
| EP0941221B1 (de) | 2003-02-26 |
| AU5320698A (en) | 1998-06-10 |
| JP2001505198A (ja) | 2001-04-17 |
| ES2193414T3 (es) | 2003-11-01 |
| PT941221E (pt) | 2003-07-31 |
| CY2472B1 (en) | 2005-06-03 |
| US6054475A (en) | 2000-04-25 |
| DE69719358T2 (de) | 2003-12-24 |
| SI0941221T1 (en) | 2003-10-31 |
| EP0941221A1 (de) | 1999-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE233252T1 (de) | Substituierte dihydrobenzofurane als pde- hemmstoffe | |
| DE69831937D1 (de) | Bicyclische protein-farnesyl-transferase inhibitoren | |
| DK0544819T3 (da) | Indolderivater, som inhiberer leukotrienbiosyntese | |
| DK0937074T3 (da) | Benzonaphthyridiner som bronkiale terapeutiske midler | |
| DK1070056T3 (da) | Phthalazinon-PDE III/IV-inhibitorer | |
| NO971538L (no) | Purin- og guaninforbindelser som inhibitorer for PNP | |
| GB0124933D0 (en) | Chemical compounds | |
| PT920426E (pt) | Novos derivados de tiazole com efeito inibidor de fosfodiesterase | |
| TR200001452T2 (tr) | Bifenilamidin türevleri. | |
| ATE219481T1 (de) | 1,7,7-trimethyl-bicyclo(2.2.1)heptane derivative | |
| AU2001263278A1 (en) | Cyclic gmp-specific phosphodiesterase inhibitors | |
| TR200001909T2 (tr) | Matris metaloprotez inhibitörleri. | |
| PT1003724E (pt) | Derivados substituidos com accao antiviral | |
| ATE374189T1 (de) | Phthalazinon-derivate als pde 4 hemmer | |
| ATE337320T1 (de) | Indolderivate als pde5-inhibitoren | |
| AP2001002045A0 (en) | FKBP inhibitors. | |
| MX207081B (de) | ||
| PT100001A (pt) | Novos derivados glicosilicos inibidores da gluco-hidrolase uteis como agentes antidiabeticos | |
| DK0687257T3 (da) | 4-amino-2-(hetero)aryl-butanamider anvendelige som 5HT1A-antagonister | |
| DK0937075T3 (da) | Hidtil ukendte imidazo- og oxazolopyridiner som phosphodiesteraseinhibitorer | |
| PT914129E (pt) | Utilizacao de aspirocloro ou derivados seus como agentes imunossupresivos |