ATE233268T1 - Antibakterielle cephalosporinverbindungen - Google Patents

Antibakterielle cephalosporinverbindungen

Info

Publication number
ATE233268T1
ATE233268T1 AT96919770T AT96919770T ATE233268T1 AT E233268 T1 ATE233268 T1 AT E233268T1 AT 96919770 T AT96919770 T AT 96919770T AT 96919770 T AT96919770 T AT 96919770T AT E233268 T1 ATE233268 T1 AT E233268T1
Authority
AT
Austria
Prior art keywords
cephalosporin compounds
antibacterial cephalosporin
antibacterial
compounds
cephalosporin
Prior art date
Application number
AT96919770T
Other languages
English (en)
Inventor
Gerd Ascher
Johannes Ludescher
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT79495A external-priority patent/AT402820B/de
Priority claimed from AT99295A external-priority patent/AT402821B/de
Priority claimed from AT69896A external-priority patent/AT403283B/de
Priority claimed from AT73396A external-priority patent/AT403284B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Application granted granted Critical
Publication of ATE233268T1 publication Critical patent/ATE233268T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N3/00—Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves or protection against physical influences such as UV radiation using chemical compositions; Grafting wax
    • A01N3/02—Keeping cut flowers fresh chemically
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C05F11/10—Fertilisers containing plant vitamins or hormones
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G3/00—Mixtures of one or more fertilisers with additives not having a specially fertilising activity
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G5/00—Fertilisers characterised by their form
    • C05G5/20—Liquid fertilisers
    • C05G5/23—Solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/40—Bio-organic fraction processing; Production of fertilisers from the organic fraction of waste or refuse

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT96919770T 1995-05-11 1996-05-10 Antibakterielle cephalosporinverbindungen ATE233268T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AT79495A AT402820B (de) 1995-05-11 1995-05-11 Organische verbindungen
AT99295A AT402821B (de) 1995-06-12 1995-06-12 Organische verbindungen
AT69896A AT403283B (de) 1996-04-17 1996-04-17 3-methylimino-3-cephemderivate
AT73396A AT403284B (de) 1996-04-23 1996-04-23 3-methylimino-3-cephemderivate
PCT/EP1996/002023 WO1996035692A1 (en) 1995-05-11 1996-05-10 Antibacterial cephalosporins

Publications (1)

Publication Number Publication Date
ATE233268T1 true ATE233268T1 (de) 2003-03-15

Family

ID=27421316

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96919770T ATE233268T1 (de) 1995-05-11 1996-05-10 Antibakterielle cephalosporinverbindungen
AT02008065T ATE292637T1 (de) 1995-05-11 1996-05-10 Antibakterielle cephalosporine

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02008065T ATE292637T1 (de) 1995-05-11 1996-05-10 Antibakterielle cephalosporine

Country Status (29)

Country Link
US (2) US6531465B1 (de)
EP (2) EP1221446B1 (de)
JP (2) JPH11506429A (de)
KR (1) KR100451336B1 (de)
CN (1) CN1142937C (de)
AR (1) AR001931A1 (de)
AT (2) ATE233268T1 (de)
AU (1) AU712814B2 (de)
BR (1) BR9608517A (de)
CA (1) CA2219656C (de)
CO (1) CO4750666A1 (de)
CY (1) CY2445B1 (de)
CZ (1) CZ352997A3 (de)
DE (2) DE69626389T2 (de)
DK (1) DK0824535T3 (de)
ES (1) ES2193246T3 (de)
HU (1) HUP9801387A3 (de)
IL (2) IL132532A (de)
MX (1) MX9708696A (de)
NO (1) NO326126B1 (de)
NZ (1) NZ308518A (de)
PE (1) PE8398A1 (de)
PL (1) PL193133B1 (de)
PT (1) PT824535E (de)
RU (1) RU2183212C2 (de)
SK (1) SK284962B6 (de)
TW (1) TW452579B (de)
WO (1) WO1996035692A1 (de)
ZA (1) ZA963758B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693095B2 (en) * 1997-04-01 2004-02-17 Biochemie Gesellschaft M.B.H. Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
AT405180B (de) * 1997-04-01 1999-06-25 Biochemie Gmbh Neue derivate von substituierten 3-cephem-4-carbonsäurederivaten und verfahren zu deren herstellung
DE69816057T2 (de) * 1997-04-01 2004-04-15 Biochemie Gesellschaft M.B.H. Antibakterielle substituierte 7-acylamino-3-(methylhydrazono)methyl-cephalosporine und zwischenprodukte
AT406772B (de) * 1998-03-23 2000-08-25 Biochemie Gmbh Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung
ECSP003699A (es) * 1999-10-08 2002-04-23 Smithkline Beecham Corp Inhibidores de fab i
KR100739830B1 (ko) * 2001-03-23 2007-07-13 주식회사 하원제약 세파로스포린 유도체의 제조방법
DE60230934D1 (de) * 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
PE20040657A1 (es) * 2002-07-15 2004-11-08 Sandoz Ag Cefalosporinas
EP1575951B1 (de) 2002-12-06 2014-06-25 Debiopharm International SA Heterozyclische verbindungen, verfahren zu deren herstellung und ihre verwendung als heilmittel
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
US8450307B2 (en) 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
CA2632476A1 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2687533B1 (de) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamidderivate als FAB-I-Hemmer
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
KR101720885B1 (ko) 2012-06-19 2017-03-28 데비오팜 인터네셔날 에스 에이 (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체
RS61312B1 (sr) 2016-02-26 2021-02-26 Debiopharm Int Sa Lek za lečenje infekcija dijabetskog stopala
MY203711A (en) 2019-02-14 2024-07-15 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
JP7418475B2 (ja) 2019-06-14 2024-01-19 デバイオファーム インターナショナル エス．エー． バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用
KR20220061163A (ko) 2019-09-06 2022-05-12 나브리바 테라퓨틱스 게엠베하 사이드로포어 세팔로스포린 접합체 및 이의 용도
CN110590814A (zh) * 2019-09-29 2019-12-20 天津力生制药股份有限公司 一种生产头孢唑林钠产生的二聚体杂质的合成方法

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Publication number Priority date Publication date Assignee Title
DE2333263A1 (de) * 1972-07-07 1974-01-24 Ciba Geigy Ag 7 beta-amino-3-oximinomethyl-cephem-4carbonsaeureverbindungen und verfahren zu ihrer herstellung
JPS5417030B2 (de) 1972-12-06 1979-06-27
DE2262500A1 (de) * 1972-12-20 1973-07-05 Lilly Co Eli 3-oxyiminomethylcephalosporinverbindungen
US4053469A (en) 1973-02-28 1977-10-11 Shionogi & Co., Ltd. Intermediates for the preparation of 7-acylamino-3-oxyiminomethyl-3-cephem-4-carboxylic acids
JPS49109391A (de) * 1973-02-28 1974-10-17
JPS49124091A (de) * 1973-03-30 1974-11-27
JPS5013389A (de) * 1973-06-08 1975-02-12
JPS5093989A (de) 1973-10-25 1975-07-26
JPS5076085A (de) * 1973-10-31 1975-06-21
JPS5083391A (de) * 1973-11-28 1975-07-05
JPS5715597B2 (de) * 1973-12-20 1982-03-31
JPS50131982A (de) * 1974-04-05 1975-10-18
US4101658A (en) 1975-06-04 1978-07-18 Shionogi & Co., Ltd. Antibacterial hydrazono cephalosporins
JPS5283865A (en) * 1976-01-01 1977-07-13 Takeda Chem Ind Ltd Cephalosporin derivatives
JPS5470294A (en) * 1977-11-09 1979-06-05 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
US4258181A (en) * 1978-09-05 1981-03-24 American Cyanamid Company Substituted 9,10-anthracenebishydrazones
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
RU1831484C (ru) * 1988-06-06 1993-07-30 Фудзисава Фармасьютикал Ко, ЛтД Способ получени цефемовых соединений или их солей
US6693095B2 (en) * 1997-04-01 2004-02-17 Biochemie Gesellschaft M.B.H. Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates

Also Published As

Publication number Publication date
ATE292637T1 (de) 2005-04-15
PL193133B1 (pl) 2007-01-31
DE69626389D1 (de) 2003-04-03
HUP9801387A3 (en) 2000-12-28
CN1186494A (zh) 1998-07-01
DE69626389T2 (de) 2003-10-09
KR100451336B1 (ko) 2005-01-17
CO4750666A1 (es) 1999-03-31
EP1221446B1 (de) 2005-04-06
RU2183212C2 (ru) 2002-06-10
MX9708696A (es) 1998-08-30
NO326126B1 (no) 2008-09-29
NO975151D0 (no) 1997-11-10
DE69634581T2 (de) 2006-02-09
CA2219656C (en) 2008-08-19
PT824535E (pt) 2003-07-31
CN1142937C (zh) 2004-03-24
US6531465B1 (en) 2003-03-11
US20030191105A1 (en) 2003-10-09
AU5818496A (en) 1996-11-29
CA2219656A1 (en) 1996-11-14
AR001931A1 (es) 1997-12-10
ZA963758B (en) 1997-11-10
SK284962B6 (sk) 2006-03-02
CY2445B1 (en) 2004-11-12
JPH11506429A (ja) 1999-06-08
IL118221A (en) 2004-06-01
PE8398A1 (es) 1998-03-13
SK150397A3 (en) 1998-03-04
BR9608517A (pt) 1999-06-08
HK1008993A1 (en) 1999-05-21
WO1996035692A1 (en) 1996-11-14
HUP9801387A2 (hu) 1999-01-28
IL118221A0 (en) 1996-09-12
AU712814B2 (en) 1999-11-18
EP1221446A1 (de) 2002-07-10
TW452579B (en) 2001-09-01
NZ308518A (en) 2000-01-28
DK0824535T3 (da) 2003-06-02
NO975151L (no) 1997-11-10
EP0824535A1 (de) 1998-02-25
JP2007023046A (ja) 2007-02-01
PL323233A1 (en) 1998-03-16
KR19990014669A (ko) 1999-02-25
CZ352997A3 (cs) 1998-02-18
IL132532A (en) 2003-06-24
DE69634581D1 (de) 2005-05-12
ES2193246T3 (es) 2003-11-01
US7317101B2 (en) 2008-01-08
EP0824535B1 (de) 2003-02-26

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