ATE233277T1 - Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden - Google Patents
Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor bindenInfo
- Publication number
- ATE233277T1 ATE233277T1 AT97912822T AT97912822T ATE233277T1 AT E233277 T1 ATE233277 T1 AT E233277T1 AT 97912822 T AT97912822 T AT 97912822T AT 97912822 T AT97912822 T AT 97912822T AT E233277 T1 ATE233277 T1 AT E233277T1
- Authority
- AT
- Austria
- Prior art keywords
- urokinase
- bind
- plasminogen activator
- cyclic peptides
- type plasminogen
- Prior art date
Links
- 102000001189 Cyclic Peptides Human genes 0.000 title abstract 3
- 108010069514 Cyclic Peptides Proteins 0.000 title abstract 3
- 102000004504 Urokinase Plasminogen Activator Receptors Human genes 0.000 title abstract 2
- 108010042352 Urokinase Plasminogen Activator Receptors Proteins 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/747,915 US5942492A (en) | 1996-11-12 | 1996-11-12 | Cyclic peptides that bind to urokinase-type plasminogen activator receptor |
| PCT/US1997/018967 WO1998021230A1 (en) | 1996-11-12 | 1997-10-21 | Cyclic peptides that bind to urokinase-type plasminogen activator receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE233277T1 true ATE233277T1 (de) | 2003-03-15 |
Family
ID=25007232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97912822T ATE233277T1 (de) | 1996-11-12 | 1997-10-21 | Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5942492A (de) |
| EP (1) | EP0941235B1 (de) |
| JP (2) | JP2001504819A (de) |
| AT (1) | ATE233277T1 (de) |
| AU (1) | AU751146B2 (de) |
| CA (1) | CA2277832C (de) |
| DE (1) | DE69719359T2 (de) |
| DK (1) | DK0941235T3 (de) |
| ES (1) | ES2193363T3 (de) |
| WO (1) | WO1998021230A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277818B1 (en) * | 1998-10-29 | 2001-08-21 | Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
| US20040204348A1 (en) * | 1996-11-12 | 2004-10-14 | The Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
| DE19933701A1 (de) | 1999-07-19 | 2001-01-25 | Wilex Biotechnology Gmbh | Zyklische peptidomimetische Urokinaserezeptorantagonisten |
| CA2406882A1 (en) * | 1999-10-01 | 2001-04-12 | Angstrom Pharmaceuticals, Inc. | Diagnostic probes and therapeutics targeting upa and upar |
| US6896870B1 (en) | 1999-10-01 | 2005-05-24 | Angstrom Pharmaceuticals, Inc. | Diagnostic probes and therapeutics targeting uPA and uPAR |
| US6649597B1 (en) * | 2000-06-22 | 2003-11-18 | The University Of Iowa Research Foundation | Targeting vector to the urokinase plasminogen activator receptor |
| AU2002212145A1 (en) * | 2000-08-23 | 2002-03-04 | Wilex Ag | Urokinase peptide structure mimetics |
| JP2004137151A (ja) * | 2002-10-15 | 2004-05-13 | Keio Gijuku | 脳腫瘍の治療・診断薬 |
| WO2006036071A2 (en) * | 2004-09-29 | 2006-04-06 | Ge Healthcare As | Urokinase plasminogen activator receptor targeted contrast agent |
| US7173110B2 (en) * | 2004-11-08 | 2007-02-06 | New York University | Peptide anti-tumor agent |
| EP2730282A1 (de) | 2007-11-08 | 2014-05-14 | The General Hospital Corporation | Verfahren und Zusammensetzung zur Behandlung von Proteinurie-Erkrankungen |
| CA2984218C (en) * | 2007-12-13 | 2019-12-31 | Cytogel Pharma, Llc | Advantageous salts of mu-opiate receptor peptides |
| US20110212083A1 (en) | 2008-11-06 | 2011-09-01 | University Of Miami Office Of Technology Transfer | Role of soluble upar in the pathogenesis of proteinuric kidney disease |
| WO2010129609A2 (en) | 2009-05-07 | 2010-11-11 | The Regents Of The University Of California | Antibodies and methods of use thereof |
| EP2574172A4 (de) * | 2010-05-21 | 2013-10-30 | Cytogel Pharma Llc | Materialien und verfahren zur behandlung von entzündungen |
| WO2012154218A2 (en) | 2011-05-09 | 2012-11-15 | The University Of Miami | Reducing soluble urokinase receptor in the circulation |
| CA2905172C (en) | 2012-05-08 | 2021-07-20 | Andreas Kjaer | 177-lu labeled peptide for site-specific upar-targeting |
| ES2972124T3 (es) | 2012-12-03 | 2024-06-11 | Curasight As | Péptidos marcados con un radionúclido que emite positrones para obtención de imágenes de PET del uPAR humana |
| US9255155B2 (en) | 2013-01-31 | 2016-02-09 | The Regents Of The University Of California | Antibodies specific for urokinase-type plasminogen activator and methods of treating cancer |
| EP4091624A1 (de) | 2013-03-15 | 2022-11-23 | Protagonist Therapeutics, Inc. | Hepcidin-analoga und verwendungen davon |
| US9308236B2 (en) * | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| CA2949215C (en) | 2014-05-16 | 2023-03-14 | Protagonist Therapeutics, Inc. | .alpha.4.beta.7 integrin thioether peptide antagonists |
| SG10201810154WA (en) | 2014-07-17 | 2018-12-28 | Protagonist Therapeutics Inc | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| MA40132B1 (fr) * | 2014-09-11 | 2019-04-30 | Bristol Myers Squibb Co | Inhibiteurs macrocycliques des interactions protéine/protéine pd-1/pd-l1 et cd80(b7-1)/pd-li |
| JP2017535527A (ja) | 2014-10-01 | 2017-11-30 | プロタゴニスト セラピューティクス， インコーポレイテッド | 新規のα４β７ペプチド単量体及び二量体拮抗薬 |
| WO2016054445A1 (en) | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| GB2538947A (en) * | 2014-12-19 | 2016-12-07 | Neuro-Bio Ltd | Cancer |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| HK1257747A1 (zh) * | 2015-07-15 | 2019-10-25 | Protagonist Therapeutics Inc. | 白细胞介素-23受体的肽抑制剂以及其治疗炎症性疾病的用途 |
| CA3009834A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| CA3017926C (en) | 2016-03-23 | 2023-10-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing .alpha.4.beta.7 peptide antagonists |
| WO2018022937A1 (en) | 2016-07-27 | 2018-02-01 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases |
| US10975121B2 (en) | 2017-06-24 | 2021-04-13 | Cytogel Pharma, Llc | Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof |
| EP3681900A4 (de) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | Opioidagonistpeptide und verwendungen davon |
| WO2019157268A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CA3104418A1 (en) | 2018-07-12 | 2020-01-16 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| AU2020311395A1 (en) | 2019-07-10 | 2022-02-03 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| MX2022008740A (es) | 2020-01-15 | 2022-09-23 | Janssen Biotech Inc | Peptidos inhibidores del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias. |
| SMT202500254T1 (it) | 2020-01-15 | 2025-09-12 | Janssen Biotech Inc | Inibitori peptidici del recettore dell'interleuchina-23 e loro uso per trattare malattie infiammatorie |
| AU2021383828A1 (en) | 2020-11-20 | 2023-07-06 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| KR20240034224A (ko) | 2021-07-14 | 2024-03-13 | 얀센 바이오테크 인코포레이티드 | 인터류킨-23 수용체의 지질화된 펩티드 억제제 |
| WO2026019458A1 (en) | 2024-07-19 | 2026-01-22 | Monopar Therpeutics, Inc | Squaramide bi-functional chelators and associated radiopharmaceuticals and methods of use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69033653T2 (de) * | 1989-04-07 | 2001-06-07 | Cancerforskningsfonden Af 1989 (Fonden Til Fremme Af Eksperimental Cancerforskning), Kopenhagen | Plasminogen-aktivator-rezeptor vom urokinasetyp |
| US6120765A (en) * | 1993-04-02 | 2000-09-19 | Shiseido Co. Ltd. | Urokinase plasminogen activator fragments |
| WO1994028014A2 (en) * | 1993-05-28 | 1994-12-08 | Chiron Corporation | Peptide inhibitors of urokinase receptor activity |
| KR960702522A (ko) * | 1993-06-01 | 1996-04-27 | 로버트 피. 블랙버언 | 우로키나제 플라스미노겐 활성인자 억제인자의 발현(expression of urokinase plasminogen activator inhibitors) |
| US6277818B1 (en) * | 1998-10-29 | 2001-08-21 | Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
-
1996
- 1996-11-12 US US08/747,915 patent/US5942492A/en not_active Expired - Lifetime
-
1997
- 1997-10-12 JP JP52257798A patent/JP2001504819A/ja active Pending
- 1997-10-21 WO PCT/US1997/018967 patent/WO1998021230A1/en not_active Ceased
- 1997-10-21 ES ES97912822T patent/ES2193363T3/es not_active Expired - Lifetime
- 1997-10-21 CA CA002277832A patent/CA2277832C/en not_active Expired - Fee Related
- 1997-10-21 AU AU49912/97A patent/AU751146B2/en not_active Ceased
- 1997-10-21 DK DK97912822T patent/DK0941235T3/da active
- 1997-10-21 AT AT97912822T patent/ATE233277T1/de not_active IP Right Cessation
- 1997-10-21 EP EP97912822A patent/EP0941235B1/de not_active Expired - Lifetime
- 1997-10-21 DE DE69719359T patent/DE69719359T2/de not_active Expired - Lifetime
-
1999
- 1999-04-05 US US09/285,783 patent/US6514710B1/en not_active Expired - Fee Related
-
2003
- 2003-01-22 US US10/349,543 patent/US20030166514A1/en not_active Abandoned
-
2008
- 2008-07-23 JP JP2008189878A patent/JP2009024015A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998021230A1 (en) | 1998-05-22 |
| JP2001504819A (ja) | 2001-04-10 |
| AU4991297A (en) | 1998-06-03 |
| ES2193363T3 (es) | 2003-11-01 |
| DK0941235T3 (da) | 2003-06-23 |
| JP2009024015A (ja) | 2009-02-05 |
| US5942492A (en) | 1999-08-24 |
| CA2277832C (en) | 2007-04-24 |
| WO1998021230A8 (en) | 2000-12-21 |
| AU751146B2 (en) | 2002-08-08 |
| EP0941235B1 (de) | 2003-02-26 |
| US20030166514A1 (en) | 2003-09-04 |
| EP0941235A1 (de) | 1999-09-15 |
| DE69719359D1 (de) | 2003-04-03 |
| US6514710B1 (en) | 2003-02-04 |
| DE69719359T2 (de) | 2003-12-04 |
| CA2277832A1 (en) | 1998-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0941235 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |