ATE233277T1 - Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden - Google Patents

Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden

Info

Publication number
ATE233277T1
ATE233277T1 AT97912822T AT97912822T ATE233277T1 AT E233277 T1 ATE233277 T1 AT E233277T1 AT 97912822 T AT97912822 T AT 97912822T AT 97912822 T AT97912822 T AT 97912822T AT E233277 T1 ATE233277 T1 AT E233277T1
Authority
AT
Austria
Prior art keywords
urokinase
bind
plasminogen activator
cyclic peptides
type plasminogen
Prior art date
Application number
AT97912822T
Other languages
English (en)
Inventor
Terence R Jones
David N Haney
Janos Varga
Original Assignee
Angstrom Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angstrom Pharmaceuticals Inc filed Critical Angstrom Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE233277T1 publication Critical patent/ATE233277T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT97912822T 1996-11-12 1997-10-21 Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden ATE233277T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/747,915 US5942492A (en) 1996-11-12 1996-11-12 Cyclic peptides that bind to urokinase-type plasminogen activator receptor
PCT/US1997/018967 WO1998021230A1 (en) 1996-11-12 1997-10-21 Cyclic peptides that bind to urokinase-type plasminogen activator receptor

Publications (1)

Publication Number Publication Date
ATE233277T1 true ATE233277T1 (de) 2003-03-15

Family

ID=25007232

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97912822T ATE233277T1 (de) 1996-11-12 1997-10-21 Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden

Country Status (10)

Country Link
US (3) US5942492A (de)
EP (1) EP0941235B1 (de)
JP (2) JP2001504819A (de)
AT (1) ATE233277T1 (de)
AU (1) AU751146B2 (de)
CA (1) CA2277832C (de)
DE (1) DE69719359T2 (de)
DK (1) DK0941235T3 (de)
ES (1) ES2193363T3 (de)
WO (1) WO1998021230A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204348A1 (en) * 1996-11-12 2004-10-14 The Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
US6277818B1 (en) * 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
DE19933701A1 (de) 1999-07-19 2001-01-25 Wilex Biotechnology Gmbh Zyklische peptidomimetische Urokinaserezeptorantagonisten
US6896870B1 (en) 1999-10-01 2005-05-24 Angstrom Pharmaceuticals, Inc. Diagnostic probes and therapeutics targeting uPA and uPAR
AU780730B2 (en) * 1999-10-01 2005-04-14 Angstrom Pharmaceuticals, Inc. Diagnostic probes and therapeutics targeting uPA and uPAR
US6649597B1 (en) * 2000-06-22 2003-11-18 The University Of Iowa Research Foundation Targeting vector to the urokinase plasminogen activator receptor
EP1311856A2 (de) * 2000-08-23 2003-05-21 Wilex AG Peptid-strukturmimetika der urokinase
JP2004137151A (ja) * 2002-10-15 2004-05-13 Keio Gijuku 脳腫瘍の治療・診断薬
CA2580464A1 (en) * 2004-09-29 2006-04-06 Ge Healthcare As Urokinase plasminogen activator receptor targeted contrast agent
US7173110B2 (en) * 2004-11-08 2007-02-06 New York University Peptide anti-tumor agent
US9345739B2 (en) 2007-11-08 2016-05-24 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
CA2984218C (en) 2007-12-13 2019-12-31 Cytogel Pharma, Llc Advantageous salts of mu-opiate receptor peptides
ES2642793T3 (es) * 2008-11-06 2017-11-20 University Of Miami Papel de uPAR soluble en la patogenia de enfermedad renal proteinúrica
EP2427479B1 (de) 2009-05-07 2018-11-21 The Regents of The University of California Antikörper und verfahren zu ihrer verwendung
EP2574172A4 (de) * 2010-05-21 2013-10-30 Cytogel Pharma Llc Materialien und verfahren zur behandlung von entzündungen
EP2707055B1 (de) 2011-05-09 2019-10-23 The University of Miami Verminderung des löslichen urokinase-rezeptors im blutkreislauf
EP2846826B1 (de) 2012-05-08 2018-07-25 TRT Innovations APS 177-lu-markiertes peptid für standortspezifische upar-anzielung
CA3221851A1 (en) 2012-12-03 2014-06-12 Curasight A/S Positron emitting radionuclide labeled peptides for human upar pet imaging
WO2014120555A1 (en) 2013-01-31 2014-08-07 The Regents Of The University Of California Antibodies specific for urokinase-type plasminogen activator and methods of use thereof
US9308236B2 (en) * 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
KR102236829B1 (ko) 2013-03-15 2021-04-07 프로타고니스트 테라퓨틱스, 인코포레이티드 헵시딘 유사체 및 이의 용도
AU2015258863B2 (en) 2014-05-16 2019-10-24 Protagonist Therapeutics, Inc. Alpha4beta7 integrin thioether peptide antagonists
AU2015289642B2 (en) 2014-07-17 2021-02-25 Protagonist Therapeutics, Inc. Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
TN2017000084A1 (en) * 2014-09-11 2018-07-04 Bristol Myers Squibb Co Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions
EP3201217A4 (de) 2014-10-01 2018-07-18 Protagonist Therapeutics Inc. Neuartige cyclische monomer- und dimerpeptide mit integrin-antagonisten-aktivität
WO2016054411A1 (en) 2014-10-01 2016-04-07 Protagonist Therapeutics, Inc. NOVEL α4β7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
GB2538947A (en) * 2014-12-19 2016-12-07 Neuro-Bio Ltd Cancer
UA123772C2 (uk) * 2015-07-15 2021-06-02 Протагоніст Терепьютікс, Інк. Пептидний інгібітор рецептора інтерлейкіну-23 та спосіб лікування запального захворювання кишечнику (ibd)
US10787490B2 (en) 2015-07-15 2020-09-29 Protaganist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
WO2017117411A1 (en) 2015-12-30 2017-07-06 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
EP3432906A4 (de) 2016-03-23 2020-04-01 Protagonist Therapeutics, Inc. Verfahren zur synthetisierung von alpha4beta7-peptid-antagonisten
US10975121B2 (en) 2017-06-24 2021-04-13 Cytogel Pharma, Llc Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
US10278957B2 (en) 2017-09-11 2019-05-07 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof
EP3749345A4 (de) 2018-02-08 2022-04-06 Protagonist Therapeutics, Inc. Konjugierte hepcidin-mimetika
TW202019948A (zh) 2018-07-12 2020-06-01 美商領導醫療有限公司 介白素-23受體之肽抑制劑及其治療發炎疾病之用途
MX2022000397A (es) 2019-07-10 2022-04-25 Protagonist Therapeutics Inc Inhibidores peptídicos del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias.
KR20220141808A (ko) 2020-01-15 2022-10-20 얀센 바이오테크 인코포레이티드 인터루킨-23 수용체의 펩티드 억제제 및 염증성 질환을 치료하기 위한 이의 용도
CN118063554A (zh) 2020-01-15 2024-05-24 詹森生物科技公司 介白素-23受体的肽抑制剂及其治疗炎性疾病的用途
KR20230110570A (ko) 2020-11-20 2023-07-24 얀센 파마슈티카 엔.브이. 인터류킨-23 수용체의 펩티드 억제제의 조성물
TW202330013A (zh) 2021-07-14 2023-08-01 美商健生生物科技公司 介白素－２３受體之脂化肽抑制劑
WO2026019458A1 (en) 2024-07-19 2026-01-22 Monopar Therpeutics, Inc Squaramide bi-functional chelators and associated radiopharmaceuticals and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1013285A3 (de) * 1989-04-07 2004-05-19 Cancerforskningsfonden af 1989 (fonden til fremme af eksperimentel cancerforskning) Plasminogen-Aktivator-Rezeptor vom Urokinasetyp
US6120765A (en) * 1993-04-02 2000-09-19 Shiseido Co. Ltd. Urokinase plasminogen activator fragments
WO1994028014A2 (en) * 1993-05-28 1994-12-08 Chiron Corporation Peptide inhibitors of urokinase receptor activity
WO1994028145A2 (en) * 1993-06-01 1994-12-08 Chiron Corporation Expression of urokinase plasminogen activator inhibitors
US6277818B1 (en) * 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor

Also Published As

Publication number Publication date
US20030166514A1 (en) 2003-09-04
JP2009024015A (ja) 2009-02-05
AU751146B2 (en) 2002-08-08
WO1998021230A8 (en) 2000-12-21
US6514710B1 (en) 2003-02-04
WO1998021230A1 (en) 1998-05-22
DE69719359T2 (de) 2003-12-04
DK0941235T3 (da) 2003-06-23
AU4991297A (en) 1998-06-03
ES2193363T3 (es) 2003-11-01
CA2277832C (en) 2007-04-24
US5942492A (en) 1999-08-24
JP2001504819A (ja) 2001-04-10
CA2277832A1 (en) 1998-05-22
DE69719359D1 (de) 2003-04-03
EP0941235A1 (de) 1999-09-15
EP0941235B1 (de) 2003-02-26

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