ATE245435T1 - Totalsynthese des amino hip analogen von didemnin a - Google Patents

Totalsynthese des amino hip analogen von didemnin a

Info

Publication number: ATE245435T1
Authority: AT; Austria
Prior art keywords: didemnin; total synthesis; amino; hip analog; analog
Prior art date: 1996-10-24

Application number

AT97946294T

Other languages

English (en)

Inventor

Kenneth L Rinehart

Alexandra J Sanborn

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-24

Filing date

1997-10-24

Publication date

2003-08-15

1997-10-24 Application filed by Univ Illinois filed Critical Univ Illinois

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE245435T1 publication Critical patent/ATE245435T1/de

Links

XQZOGOCTPKFYKC-VSZULPIASA-N (2r)-n-[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]-4-methyl-2-(m Chemical compound C([C@H]1C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC)C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N1C)C(C)C)O)[C@@H](C)CC)C1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-VSZULPIASA-N 0.000 title abstract 3
-1 AMINO Chemical class 0.000 title 1
238000006257 total synthesis reaction Methods 0.000 title 1
108010061297 didemnins Proteins 0.000 abstract 2
XQZOGOCTPKFYKC-UHFFFAOYSA-N epididemnin A1 Natural products CN1C(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(C(C)C)OC(=O)CC(O)C(C(C)CC)NC(=O)C(NC(=O)C(CC(C)C)NC)C(C)OC(=O)C1CC1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Transplantation (AREA)
Virology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT97946294T 1996-10-24 1997-10-24 Totalsynthese des amino hip analogen von didemnin a ATE245435T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2910996P	1996-10-24	1996-10-24
PCT/US1997/019211 WO1998017302A1 (en)	1996-10-24	1997-10-24	Total synthesis of the amino hip analogue of didemnin a

Publications (1)

Publication Number	Publication Date
ATE245435T1 true ATE245435T1 (de)	2003-08-15

Family

ID=21847275

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97946294T ATE245435T1 (de)	1996-10-24	1997-10-24	Totalsynthese des amino hip analogen von didemnin a

Country Status (11)

Country	Link
US (1)	US6380156B1 (de)
EP (1)	EP0956033B1 (de)
JP (1)	JP2001504814A (de)
AT (1)	ATE245435T1 (de)
AU (1)	AU726146B2 (de)
CA (1)	CA2269878A1 (de)
DE (1)	DE69723728T2 (de)
DK (1)	DK0956033T3 (de)
ES (1)	ES2202644T3 (de)
PT (1)	PT956033E (de)
WO (1)	WO1998017302A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
CA2405779A1 (en)	2000-04-07	2001-10-18	The Trustees Of The University Of Pennsylvania	Tamandarin and didemnin analogs and methods of making and using them
GB0103750D0 (en) *	2001-02-15	2001-04-04	Pharma Mar Sa	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
GB0016148D0 (en) *	2000-06-30	2000-08-23	Pharma Mar Sa	Synthetic methods for aplidine and new antitiumoral derivatives
IL155273A0 (en)	2000-10-12	2003-11-23	Pharma Mar Sa	Pharmaceutical compositions comprising an aplidine compound
EP1620117A4 (de)	2003-03-12	2009-07-29	Pharma Mar Sa	Verbesserte antitumorale behandlungen
AU2004218883B2 (en)	2003-03-12	2009-10-01	Dana-Farber Cancer Institute, Inc.	Aplidine for multiple myeloma treatment
JP2006523214A (ja)	2003-03-21	2006-10-12	ジユーリー，マデレーン・エム	タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法
DE102004051025A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Substituierte Nonadepsipeptide
DE102004051023A1 (de) *	2004-10-20	2006-05-04	Bayer Healthcare Ag	Desoxo-Nonadepsipeptide
DE102004051024A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Heterocyclyl-substituierte Nonadepsipeptide
DE102004053410A1 (de) *	2004-11-05	2006-05-11	Bayer Healthcare Ag	Cyclische Nonadepsipeptidamide
DE102006003443A1 (de) *	2006-01-25	2007-07-26	Aicuris Gmbh & Co. Kg	Asparagin-10-substituierte Nonadepsipeptide
WO2007101235A2 (en)	2006-02-28	2007-09-07	Pharma Mar, S.A.	Improved antitumoral treatments
DE102006018080A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Lysobactinamide
DE102006018250A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Verfahren zum Herstellen von cyclischen Depsipeptiden
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물
KR20250007021A (ko)	2017-06-09	2025-01-13	추가이 세이야쿠 가부시키가이샤	N-치환 아미노산을 포함하는 펩타이드의 합성 방법
WO2020111238A1 (ja) *	2018-11-30	2020-06-04	中外製薬株式会社	ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法

1997
- 1997-10-24 US US09/284,905 patent/US6380156B1/en not_active Expired - Fee Related
- 1997-10-24 WO PCT/US1997/019211 patent/WO1998017302A1/en not_active Ceased
- 1997-10-24 AT AT97946294T patent/ATE245435T1/de not_active IP Right Cessation
- 1997-10-24 AU AU51495/98A patent/AU726146B2/en not_active Ceased
- 1997-10-24 ES ES97946294T patent/ES2202644T3/es not_active Expired - Lifetime
- 1997-10-24 DE DE69723728T patent/DE69723728T2/de not_active Expired - Fee Related
- 1997-10-24 PT PT97946294T patent/PT956033E/pt unknown
- 1997-10-24 CA CA002269878A patent/CA2269878A1/en not_active Abandoned
- 1997-10-24 JP JP51964998A patent/JP2001504814A/ja not_active Ceased
- 1997-10-24 EP EP97946294A patent/EP0956033B1/de not_active Expired - Lifetime
- 1997-10-24 DK DK97946294T patent/DK0956033T3/da active

Also Published As

Publication number	Publication date
EP0956033B1 (de)	2003-07-23
WO1998017302A1 (en)	1998-04-30
PT956033E (pt)	2003-10-31
JP2001504814A (ja)	2001-04-10
AU5149598A (en)	1998-05-15
AU726146B2 (en)	2000-11-02
US6380156B1 (en)	2002-04-30
EP0956033A4 (de)	2000-06-21
EP0956033A1 (de)	1999-11-17
ES2202644T3 (es)	2004-04-01
DK0956033T3 (da)	2003-10-06
DE69723728T2 (de)	2004-06-03
DE69723728D1 (de)	2003-08-28
CA2269878A1 (en)	1998-04-30

Similar Documents

Publication	Publication Date	Title
ATE245435T1 (de)	2003-08-15	Totalsynthese des amino hip analogen von didemnin a
EA199700117A1 (ru)	1997-12-30	Трициклические бензазепиновые антагонисты вазопрессина, способ их получения, фармацевтическая композиция и способ лечения млекопитающих с использованием трициклических бензазепинов
UA66750C2 (en)	2004-06-15	Substituted 1-phenylpirazole 3-carboxamides, a method for the preparation thereof and intermediary compounds, pharmaceutical composition having affinity to neurotensin receptors
DZ3482A1 (fr)	2002-04-25	Secretagogues de l'hormone de croissance
MY121543A (en)	2006-02-28	Preparation of 3,4,4-trisubstituted-piperidinyl-n- alkylcarboxylates and intermediates
LV12350A (lv)	1999-09-20	Heptapeptida oksitocina analogi
CA2104909A1 (en)	1994-03-04	Decahydroisoquinolines as excitatory amino acid receptor antagonists
MY113733A (en)	2002-05-31	Salts of an anti-migraine indole derivative
EP0982988A4 (de)	2000-04-05	Im wesentlichen reines zonulin als physiologischer modulator von "tight junctions" bei säugern
BG101893A (en)	1999-01-29	Nodulosporic acid derivatives
ES477832A1 (es)	1980-04-01	Un procedimiento para la preparacion de derivados de diben- zopirano.
MY138258A (en)	2009-05-29	Growth hormone secretagogues
IN2012DE00109A (de)	2015-05-08
SG49228A1 (en)	1998-05-18	Use of 2-amino-6-A-propyl-amino-4,5,6,7- tetrahydrobenzothiazole(pramipexol) as a antidepressant activity
AU8974298A (en)	1999-02-16	1,4,7,10-tetraazabicyclo{8.2.2}tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles
DE59409672D1 (de)	2001-04-12	Festphasensynthese von Oligoribonucleotiden
EP0973518A4 (de)	2004-05-26	Semisynthetisches verfahren zur herstellung von didemninanalogen
MX9709398A (es)	1998-07-31	N-aril-1,2,4-triazolin-5-onas.
RU94022277A (ru)	1996-04-20	Новые 19-норстероиды, имеющие в положении 11 - бета феноксиалкилсульфонамидную или феноксиалкилсульфонилкарбамидную цепь, метод и промежуточные продукты их получения, и содержащая их фармацевтическая композиция
EP0339549A3 (de)	1991-01-16	Tyr-Peptid-Analoge
MY118946A (en)	2005-02-28	Novel intermediates and their use to prepare n, n''- bridged bisindolylmaleimides
PT837677E (pt)	2006-08-31	Derivados hexa-hidroxibifenilo bromados
SE9800865D0 (sv)	1998-03-16	New Process
BG102610A (en)	1999-04-30	Herbicidal compositions containing 4-benzoyloxazoles and hydroxybenzonitrile
NO963255L (no)	1996-10-02	Sykliske neurokinin-A antagonister

Legal Events

Date

Code

Title

Description

2004-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0956033

Country of ref document: EP

2008-07-15

REN

Ceased due to non-payment of the annual fee