ATE245435T1 - Totalsynthese des amino hip analogen von didemnin a - Google Patents

Totalsynthese des amino hip analogen von didemnin a

Info

Publication number: ATE245435T1
Authority: AT; Austria
Prior art keywords: didemnin; total synthesis; amino; hip analog; analog
Prior art date: 1996-10-24

Application number

AT97946294T

Other languages

English (en)

Inventor

Kenneth L Rinehart

Alexandra J Sanborn

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-24

Filing date

1997-10-24

Publication date

2003-08-15

1997-10-24 Application filed by Univ Illinois filed Critical Univ Illinois

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE245435T1 publication Critical patent/ATE245435T1/de

Links

XQZOGOCTPKFYKC-VSZULPIASA-N (2r)-n-[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]-4-methyl-2-(m Chemical compound C([C@H]1C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC)C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N1C)C(C)C)O)[C@@H](C)CC)C1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-VSZULPIASA-N 0.000 title abstract 3
-1 AMINO Chemical class 0.000 title 1
238000006257 total synthesis reaction Methods 0.000 title 1
108010061297 didemnins Proteins 0.000 abstract 2
XQZOGOCTPKFYKC-UHFFFAOYSA-N epididemnin A1 Natural products CN1C(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(C(C)C)OC(=O)CC(O)C(C(C)CC)NC(=O)C(NC(=O)C(CC(C)C)NC)C(C)OC(=O)C1CC1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Virology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT97946294T 1996-10-24 1997-10-24 Totalsynthese des amino hip analogen von didemnin a ATE245435T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2910996P	1996-10-24	1996-10-24
PCT/US1997/019211 WO1998017302A1 (en)	1996-10-24	1997-10-24	Total synthesis of the amino hip analogue of didemnin a

Publications (1)

Publication Number	Publication Date
ATE245435T1 true ATE245435T1 (de)	2003-08-15

Family

ID=21847275

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97946294T ATE245435T1 (de)	1996-10-24	1997-10-24	Totalsynthese des amino hip analogen von didemnin a

Country Status (11)

Country	Link
US (1)	US6380156B1 (de)
EP (1)	EP0956033B1 (de)
JP (1)	JP2001504814A (de)
AT (1)	ATE245435T1 (de)
AU (1)	AU726146B2 (de)
CA (1)	CA2269878A1 (de)
DE (1)	DE69723728T2 (de)
DK (1)	DK0956033T3 (de)
ES (1)	ES2202644T3 (de)
PT (1)	PT956033E (de)
WO (1)	WO1998017302A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
ES2272462T3 (es)	2000-04-07	2007-05-01	The Trustees Of The University Of Pennsylvania	Analogos de tamadarina y didemnina y procedimiento de fabricacion y uso.
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
GB0016148D0 (en) *	2000-06-30	2000-08-23	Pharma Mar Sa	Synthetic methods for aplidine and new antitiumoral derivatives
GB0103750D0 (en) *	2001-02-15	2001-04-04	Pharma Mar Sa	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
CZ2003993A3 (cs)	2000-10-12	2004-02-18	Pharma Mar, S. A.	Léčivo pro léčení rakoviny podáváním aplidinu nebo analogu aplidinu a protektoru kosterního svalstva
WO2004080421A2 (en)	2003-03-12	2004-09-23	Pharma Mar, S.A.	Improved antitumoral treatments
ATE406171T1 (de)	2003-03-12	2008-09-15	Dana Farber Cancer Inst Inc	Aplidine zur behandlung von multiplem myelom
CA2519234A1 (en)	2003-03-21	2004-10-07	Madeleine M. Joullie	Tamandarin analogs and fragments thereof and methods of making and using
DE102004051025A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Substituierte Nonadepsipeptide
DE102004051023A1 (de) *	2004-10-20	2006-05-04	Bayer Healthcare Ag	Desoxo-Nonadepsipeptide
DE102004051024A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Heterocyclyl-substituierte Nonadepsipeptide
DE102004053410A1 (de) *	2004-11-05	2006-05-11	Bayer Healthcare Ag	Cyclische Nonadepsipeptidamide
DE102006003443A1 (de) *	2006-01-25	2007-07-26	Aicuris Gmbh & Co. Kg	Asparagin-10-substituierte Nonadepsipeptide
CN101389347B (zh)	2006-02-28	2013-03-27	法马马有限公司	提高的抗肿瘤治疗
DE102006018250A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Verfahren zum Herstellen von cyclischen Depsipeptiden
DE102006018080A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Lysobactinamide
HRP20231233T1 (hr)	2017-04-27	2024-01-19	Pharma Mar, S.A.	Antitumorski spojevi
WO2018225851A1 (ja)	2017-06-09	2018-12-13	中外製薬株式会社	Ｎ－置換アミノ酸を含むペプチドの合成方法
JP7568510B2 (ja) *	2018-11-30	2024-10-16	中外製薬株式会社	ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法

1997
- 1997-10-24 PT PT97946294T patent/PT956033E/pt unknown
- 1997-10-24 CA CA002269878A patent/CA2269878A1/en not_active Abandoned
- 1997-10-24 WO PCT/US1997/019211 patent/WO1998017302A1/en not_active Ceased
- 1997-10-24 US US09/284,905 patent/US6380156B1/en not_active Expired - Fee Related
- 1997-10-24 ES ES97946294T patent/ES2202644T3/es not_active Expired - Lifetime
- 1997-10-24 EP EP97946294A patent/EP0956033B1/de not_active Expired - Lifetime
- 1997-10-24 JP JP51964998A patent/JP2001504814A/ja not_active Ceased
- 1997-10-24 AT AT97946294T patent/ATE245435T1/de not_active IP Right Cessation
- 1997-10-24 DK DK97946294T patent/DK0956033T3/da active
- 1997-10-24 DE DE69723728T patent/DE69723728T2/de not_active Expired - Fee Related
- 1997-10-24 AU AU51495/98A patent/AU726146B2/en not_active Ceased

Also Published As

Publication number	Publication date
ES2202644T3 (es)	2004-04-01
EP0956033A1 (de)	1999-11-17
WO1998017302A1 (en)	1998-04-30
DE69723728D1 (de)	2003-08-28
EP0956033B1 (de)	2003-07-23
EP0956033A4 (de)	2000-06-21
PT956033E (pt)	2003-10-31
DK0956033T3 (da)	2003-10-06
DE69723728T2 (de)	2004-06-03
CA2269878A1 (en)	1998-04-30
US6380156B1 (en)	2002-04-30
AU5149598A (en)	1998-05-15
AU726146B2 (en)	2000-11-02
JP2001504814A (ja)	2001-04-10

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Legal Events

Date

Code

Title

Description

2004-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0956033

Country of ref document: EP

2008-07-15

REN

Ceased due to non-payment of the annual fee