ATE233324T1 - Trennung von chiralen aminen - Google Patents
Trennung von chiralen aminenInfo
- Publication number
- ATE233324T1 ATE233324T1 AT98959022T AT98959022T ATE233324T1 AT E233324 T1 ATE233324 T1 AT E233324T1 AT 98959022 T AT98959022 T AT 98959022T AT 98959022 T AT98959022 T AT 98959022T AT E233324 T1 ATE233324 T1 AT E233324T1
- Authority
- AT
- Austria
- Prior art keywords
- enantiomer
- chiral amines
- separation
- ester
- group
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title abstract 3
- 238000000926 separation method Methods 0.000 title 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Optical Integrated Circuits (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726229.9A GB9726229D0 (en) | 1997-12-12 | 1997-12-12 | Resolution of chiral amines |
| PCT/GB1998/003679 WO1999031264A1 (en) | 1997-12-12 | 1998-12-09 | Resolution of chiral amines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE233324T1 true ATE233324T1 (de) | 2003-03-15 |
Family
ID=10823474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98959022T ATE233324T1 (de) | 1997-12-12 | 1998-12-09 | Trennung von chiralen aminen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6335187B1 (de) |
| EP (1) | EP1036189B1 (de) |
| JP (1) | JP2002508189A (de) |
| AT (1) | ATE233324T1 (de) |
| AU (1) | AU1495999A (de) |
| CA (1) | CA2313684A1 (de) |
| DE (1) | DE69811723T2 (de) |
| GB (1) | GB9726229D0 (de) |
| WO (1) | WO1999031264A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624311B2 (en) | 2000-10-27 | 2003-09-23 | Bristol-Myers Squibb Pharma Company | Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester |
| JP4431389B2 (ja) | 2001-09-12 | 2010-03-10 | アノーメッド インコーポレイティド | 鏡像異性的に純粋なアミノ置換縮合二環式環の合成 |
| US7067291B2 (en) | 2002-12-20 | 2006-06-27 | Pfizer Inc. | Biocatalytic preparation of enantiomerically enriched aminopentanenitrile |
| KR100929437B1 (ko) | 2007-08-02 | 2009-12-03 | 포항공과대학교 산학협력단 | 광학 활성을 갖는 아민의 제조방법 |
| GB201020026D0 (en) | 2010-11-25 | 2011-01-12 | Cambrex Karlskoga Ab | New process |
| CN109069426B (zh) | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
| CA3008279A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| WO2017112894A1 (en) | 2015-12-22 | 2017-06-29 | X4 Pharmaceuticals, Inc. | Methods for treating immunodeficiency disease |
| CA3019394A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3472129A4 (de) | 2016-06-21 | 2019-12-04 | X4 Pharmaceuticals, Inc. | Cxcr4-inhibitoren und verwendungen davon |
| CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| CN109234352A (zh) * | 2018-10-30 | 2019-01-18 | 江苏理工学院 | 一种酶法拆分制备(r)-1-(1-萘基)乙胺的方法 |
| CA3171250A1 (en) | 2020-03-10 | 2021-09-16 | E. Lynne KELLEY | Methods for treating neutropenia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991019002A1 (en) | 1990-06-01 | 1991-12-12 | Carlbiotech Ltd. A/S | A process for chiral enrichment of asymmetric primary amines |
| DE4332738A1 (de) * | 1993-09-25 | 1995-03-30 | Basf Ag | Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung |
| DE19523151A1 (de) | 1995-02-03 | 1996-08-14 | Basf Ag | Racematspaltung primärer und sekundärer heteroatomsubstituierter Amine durch Enzym-katalysierte Acylierung |
-
1997
- 1997-12-12 GB GBGB9726229.9A patent/GB9726229D0/en not_active Ceased
-
1998
- 1998-12-09 AT AT98959022T patent/ATE233324T1/de not_active IP Right Cessation
- 1998-12-09 US US09/555,924 patent/US6335187B1/en not_active Expired - Fee Related
- 1998-12-09 DE DE69811723T patent/DE69811723T2/de not_active Expired - Fee Related
- 1998-12-09 AU AU14959/99A patent/AU1495999A/en not_active Abandoned
- 1998-12-09 WO PCT/GB1998/003679 patent/WO1999031264A1/en not_active Ceased
- 1998-12-09 CA CA002313684A patent/CA2313684A1/en not_active Abandoned
- 1998-12-09 JP JP2000539162A patent/JP2002508189A/ja not_active Withdrawn
- 1998-12-09 EP EP98959022A patent/EP1036189B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6335187B1 (en) | 2002-01-01 |
| JP2002508189A (ja) | 2002-03-19 |
| AU1495999A (en) | 1999-07-05 |
| EP1036189B1 (de) | 2003-02-26 |
| DE69811723D1 (de) | 2003-04-03 |
| DE69811723T2 (de) | 2003-12-18 |
| GB9726229D0 (en) | 1998-02-11 |
| EP1036189A1 (de) | 2000-09-20 |
| WO1999031264A1 (en) | 1999-06-24 |
| CA2313684A1 (en) | 1999-06-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69811723D1 (de) | Trennung von chiralen aminen | |
| ATE235546T1 (de) | Enzyme, ihre präparation und ihre verwendung für die produktion von ammonium-akrylat. | |
| ATE207964T1 (de) | Produktion von ammonium-acrylat | |
| EP1034302A4 (de) | De novo oder "universaler" sequenzierungs-array | |
| DE69133602D1 (de) | Pflanzliche Thioesterasen | |
| ES2176429T3 (es) | Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica. | |
| ATE263842T1 (de) | Multiplex-sequenzierungsverfahren | |
| ATE431416T1 (de) | Enzymatische synthese von deoxyribonucleotiden | |
| DK0904348T3 (da) | Fremgangsmåde til fremstilling af aminoalkoholer og derivater deraf | |
| ATE285474T1 (de) | Haemophilus adhäsionsproteinen | |
| AU2002361162A1 (en) | Evanescence-based multiplex sequencing method | |
| KR920000942A (ko) | 에난티오머 선택적 생체 촉매화 아실화 방법 | |
| AU2003210413A1 (en) | Device for applying liquid media and corresponding method | |
| DK1076718T3 (da) | Fremgangsmåde til fremstilling af syntesemellemprodukter | |
| DE50009670D1 (de) | Verfahren zur herstellung optisch aktiver amine | |
| ATE189804T1 (de) | Selektives verfahren zur deacylierung von acylverbindungen | |
| DE59909610D1 (de) | Enzymkatalysierte racematspaltung von primären aminen | |
| DK1002122T3 (da) | Fremgangsmåde til fremstilling af amider | |
| DK1218519T3 (da) | Enzym, som spalter estergrupper, og som er afledt af Thermomonospora fusca | |
| CY1105864T1 (el) | Ενζυμικη διαδικασια για την εναντιομepικη διασπαση αμινοξεων | |
| DE3779785D1 (de) | Verfahren zur enzymatischen auftrennung von racemischen 2-amino-1-alkanolen. | |
| WO2004058701A3 (en) | Biocatalytic preparation of enantiomerically enriched aminopentanenitrile | |
| EA199900098A1 (ru) | Способ отделения кетоксима или альдоксима от амида | |
| FR2804961B1 (fr) | Proteine a activite de phosphoserine phosphatase, adn le codant, vecteur et bacterie contenant cet adn et procede de production de l-serine | |
| PT983366E (pt) | Adn que codifica uma sintetase de quitina de artropode |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |