ES2176429T3 - Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica. - Google Patents

Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica.

Info

Publication number
ES2176429T3
ES2176429T3 ES96900601T ES96900601T ES2176429T3 ES 2176429 T3 ES2176429 T3 ES 2176429T3 ES 96900601 T ES96900601 T ES 96900601T ES 96900601 T ES96900601 T ES 96900601T ES 2176429 T3 ES2176429 T3 ES 2176429T3
Authority
ES
Spain
Prior art keywords
heteroatom
substituted amine
primary
racements
hteroatoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96900601T
Other languages
English (en)
Inventor
Friedhelm Balkenhohl
Klaus Ditrich
Christoph Nubling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19523151A external-priority patent/DE19523151A1/de
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2176429T3 publication Critical patent/ES2176429T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PREPARACION DE AMINAS PRIMARIAS Y SECUNDARIAS SUSTITUIDAS CON HETEROATOMOS OPTICAMENTE ACTIVAS A PARTIR DE LOS CORRESPONDIENTES RACEMATOS, CARACTERIZADO PORQUE A) UNA AMINA RACEMICA SUSTITUIDA CON HETEREOATOMOS SE ACILA DE FORMA SELECTIVA CON RELACION AL ENANTIOMERO CON UN ESTER, CUYOS COMPONENTES ACIDOS LLEVAN UN ATOMO DE FLUOR, NITROGENO, FOSFORO, OXIGENO O AZUFRE ADYACENTE AL ATOMO DE CARBONO DEL CARBONILO, EN PRESENCIA DE UNA HIDROLASA, B) LA MEZCLA DE AMINA SUSTITUIDA CON HETEROATOMOS OPTICAMENTE ACTIVA Y LA AMINA SUSTITUIDA CON HETEROATOMOS ACILADA Y OPTICAMENTE ACTIVA SE SEPARA, CON LO QUE SE OBTIENE UN ENANTIOMERO DE LA AMINA SUSTITUIDA CON HETEROATOMOS, (C) EVENTUALMENTE SE PUEDE OBTENER A PARTIR DE LA AMINA SUSTITUIDA CON HETEROATOMOS ACILADA EL OTRO ENANTIOMERO DE LA AMINA SUSTITUIDA CON HETEROATOMOS MEDIANTE LA SEPARACION DE LA AMIDA.
ES96900601T 1995-02-03 1996-01-20 Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica. Expired - Lifetime ES2176429T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19503605 1995-02-03
DE19523151A DE19523151A1 (de) 1995-02-03 1995-06-29 Racematspaltung primärer und sekundärer heteroatomsubstituierter Amine durch Enzym-katalysierte Acylierung

Publications (1)

Publication Number Publication Date
ES2176429T3 true ES2176429T3 (es) 2002-12-01

Family

ID=26012141

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96900601T Expired - Lifetime ES2176429T3 (es) 1995-02-03 1996-01-20 Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica.

Country Status (9)

Country Link
US (1) US6214608B1 (es)
EP (1) EP0801683B1 (es)
JP (1) JP3789938B2 (es)
CN (1) CN1087348C (es)
AT (1) ATE217024T1 (es)
DK (1) DK0801683T3 (es)
ES (1) ES2176429T3 (es)
PT (1) PT801683E (es)
WO (1) WO1996023894A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387692B1 (en) * 1995-12-06 2002-05-14 Bayer Aktiengesellschaft Process for the preparation of optically active amines
DE19727517A1 (de) * 1997-06-30 1999-01-07 Basf Ag Racematspaltung von Aminosäureestern durch Enzym-katalysierte Acylierung
CA2326777C (en) 1998-04-01 2011-12-20 Nortran Pharmaceuticals Inc. Aminocyclohexyl ether compounds and uses thereof
DE19837745A1 (de) * 1998-08-20 2000-02-24 Basf Ag Enzymkatalysierte Racematspaltung von primären Aminen
WO2000047547A2 (en) * 1999-02-12 2000-08-17 Nortran Pharmaceuticals Inc. Cycloalkyl amine compounds and uses thereof
US6979685B1 (en) 1999-02-12 2005-12-27 Cardiome Pharma Corp. Cycloalkyl amine compounds and uses thereof
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7067291B2 (en) * 2002-12-20 2006-06-27 Pfizer Inc. Biocatalytic preparation of enantiomerically enriched aminopentanenitrile
CA2524323C (en) 2003-05-02 2012-05-15 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
WO2005018635A2 (en) 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
WO2005097087A2 (en) 2004-04-01 2005-10-20 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
MXPA06011419A (es) 2004-04-01 2007-04-20 Cardiome Pharma Corp Profarmacos de compuestos moduladores de canales ionicos y usos de los mismos.
US7754897B2 (en) 2005-06-15 2010-07-13 Cardiome Pharma Corp. Synthetic processes for the preparation of aminocyclohexyl ether compounds
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
ES2483940T3 (es) 2004-11-08 2014-08-08 Cardiome Pharma Corp. Un nuevo régimen de dosificación para compuestos moduladores del canal iónico para el tratamiento de la fibrilación auricular aguda en un ser humano
EP1828099B1 (en) 2004-11-18 2020-01-22 Correvio International Sàrl Synthetic process for aminocyclohexyl ether compounds
DE102005028492A1 (de) * 2005-06-20 2006-12-28 Basf Ag Verfahren zur Herstellung von optisch aktiven Aminoalkylphenolen
ITMI20051943A1 (it) * 2005-10-14 2007-04-15 Procos Spa Processo di risoluzione anantiomerica di 2-aminometil-pirrolidine 1-sostitute per ammidazione in presenza di lipasi
US20090280544A1 (en) * 2006-09-13 2009-11-12 Basf Se Method for producing optically active 2-benzyloxycyclohexylamine
EP2387556B1 (de) * 2009-01-16 2014-07-30 Basf Se Trennung eines enantiomerengemischs von (r)- und (s)-3-amino-1-butanol
US20130345475A1 (en) 2012-06-25 2013-12-26 Basf Se Process for the racemization of optically active arylalkylamines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1191638B (it) * 1985-10-31 1988-03-23 Montedison Spa Processo per la separazione enzimatica degli isomeri ottici del 2-amminobutanolo
US5057607A (en) * 1990-06-08 1991-10-15 Eli Lilly And Company Enantiomerically selective biocatalyzed acylation
JP3409353B2 (ja) * 1992-04-30 2003-05-26 住友化学工業株式会社 アミド化合物の製造方法および使用される微生物
DE4332738A1 (de) * 1993-09-25 1995-03-30 Basf Ag Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung
US5512454A (en) * 1994-02-03 1996-04-30 Bristol-Myers Squibb Company Enzymatic acylation of 3-hydroxymethyl cephalosporins

Also Published As

Publication number Publication date
CN1087348C (zh) 2002-07-10
WO1996023894A1 (de) 1996-08-08
EP0801683A1 (de) 1997-10-22
EP0801683B1 (de) 2002-05-02
DK0801683T3 (da) 2002-06-17
JP3789938B2 (ja) 2006-06-28
US6214608B1 (en) 2001-04-10
PT801683E (pt) 2002-09-30
ATE217024T1 (de) 2002-05-15
CN1172504A (zh) 1998-02-04
JPH10512759A (ja) 1998-12-08

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