ATE431416T1 - Enzymatische synthese von deoxyribonucleotiden - Google Patents

Enzymatische synthese von deoxyribonucleotiden

Info

Publication number
ATE431416T1
ATE431416T1 AT00953180T AT00953180T ATE431416T1 AT E431416 T1 ATE431416 T1 AT E431416T1 AT 00953180 T AT00953180 T AT 00953180T AT 00953180 T AT00953180 T AT 00953180T AT E431416 T1 ATE431416 T1 AT E431416T1
Authority
AT
Austria
Prior art keywords
deoxyribonucleotides
enzymatic synthesis
synthesis
enzymatic
deoxyribonucleosides
Prior art date
Application number
AT00953180T
Other languages
English (en)
Inventor
Wilhelm Tischer
Hans-Georg Ihlenfeldt
Octavian Barzu
Hiroshi Sakamoto
Elisabeth Pistotnik
Philippe Marliere
Sylvie Pochet
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8238824&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE431416(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pasteur Institut filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE431416T1 publication Critical patent/ATE431416T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT00953180T 1999-08-20 2000-08-18 Enzymatische synthese von deoxyribonucleotiden ATE431416T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99116425 1999-08-20
PCT/EP2000/008088 WO2001014566A2 (en) 1999-08-20 2000-08-18 Enzymatic synthesis of deoxyribonucleosides

Publications (1)

Publication Number Publication Date
ATE431416T1 true ATE431416T1 (de) 2009-05-15

Family

ID=8238824

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00953180T ATE431416T1 (de) 1999-08-20 2000-08-18 Enzymatische synthese von deoxyribonucleotiden

Country Status (10)

Country Link
US (2) US7229797B1 (de)
EP (1) EP1206551B2 (de)
JP (1) JP2003507071A (de)
KR (1) KR20020048930A (de)
AT (1) ATE431416T1 (de)
AU (1) AU6571700A (de)
CA (1) CA2382462A1 (de)
DE (1) DE60042209D1 (de)
HU (1) HUP0203049A3 (de)
WO (1) WO2001014566A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001094413A2 (en) 2000-06-06 2001-12-13 Bristol-Myers Squibb Company B7-related nucleic acids and polypeptides and their uses for immunomodulation
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
US6858721B2 (en) 2001-05-01 2005-02-22 Mitsui Chemicals, Inc. Method for producing cytosine nucleoside compounds
US7381555B2 (en) 2001-09-14 2008-06-03 Institut Pasteur Lactobacillus N-deoxyribosyl transferases, corresponding nucleotide sequences and their uses
FR2829774B1 (fr) * 2001-09-14 2004-09-03 Pasteur Institut N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
US20040214314A1 (en) 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
DK1636246T3 (en) * 2003-06-24 2015-11-23 Scientist Of Fortune Sa Preparation of 2-desoxynucleosider and 2-desoxynucleosidforstadier from 2-dehydro-3-deoxy-D-gluconate
EP1491549A1 (de) * 2003-06-24 2004-12-29 Evologic S.A. Herstellung von 2'-Deoxynukleoside und 2'-Deoxynukleosidvorläufern von 2-Dehydro-3-Deoxy-D-Gluconat
GB2403950A (en) * 2003-07-18 2005-01-19 Mitsui Chemicals Inc Pyrimidine nucleosides from reaction of sugar phosphate with pyrimidine base derivative & enzyme having cytosine nucleoside phosphorylase activity
JP4437786B2 (ja) * 2003-11-11 2010-03-24 三井化学株式会社 ペントース−５−リン酸エステルの製造方法。
FR2853906B1 (fr) * 2004-06-07 2006-04-14 Pasteur Institut N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
CN102119225B (zh) 2008-06-11 2015-04-08 基因排列技术有限公司 等温核酸扩增
US9523084B2 (en) * 2012-11-08 2016-12-20 Centre National De La Recherche Scientifique (Cnrs) Phosphodeoxyribosyl transferase mutant enzymes and uses thereof
EP2992107B1 (de) * 2013-04-29 2019-12-11 Plasmia Biotech, S.L. Biokatalytische herstellung von nukleosid-analogen als pharmazeutische wirkstoffe
JP2015160832A (ja) * 2014-02-27 2015-09-07 大陽日酸株式会社 ヌクレオシド化合物の製造方法
CA3108728A1 (en) 2018-07-09 2020-01-16 Codexis, Inc. Engineered phosphopentomutase variant enzymes
AU2019302423B2 (en) 2018-07-09 2024-11-21 Codexis, Inc. Engineered purine nucleoside phosphorylase variant enzymes
CN118995846A (zh) 2018-07-09 2024-11-22 默沙东有限责任公司 4’-乙炔基核苷类似物的酶促合成
JP7678580B2 (ja) 2019-07-02 2025-05-16 コデクシス， インコーポレイテッド 操作されたスクロースホスホリラーゼバリアント酵素
EP3992294B1 (de) 2019-08-28 2025-09-24 Inner Mongolia Eppen Biotech Co., Ltd. Rekombinanter stamm auf escherichia coli-basis und verfahren zu seiner herstellung und seine verwendung
CN110592084B (zh) * 2019-08-28 2023-07-28 内蒙古伊品生物科技有限公司 一种rhtA基因启动子改造的重组菌株及其构建方法与应用
CN116287067A (zh) * 2021-12-20 2023-06-23 上海合全药物研发有限公司 一种2,6-二氯嘌呤核苷的制备方法及酶

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK149958C (da) 1980-04-23 1987-04-27 Wellcome Found Analogifremgangsmaade til fremstilling af 4-amino-1-(2-desoxy-beta-d-ribofuranosyl)-1h-imidazo-(4,5-c)pyridin eller estere eller salte deraf
JPS5863393A (ja) 1981-10-13 1983-04-15 Ajinomoto Co Inc リボノフラノシル又はデオキシリボフラノシルプリン誘導体の製造法
DE3379274D1 (en) 1982-04-01 1989-04-06 Yamasa Shoyu Kk Process for producing 3'-deoxyguanosine
EP0411158B1 (de) 1989-02-28 1996-05-29 Yamasa Shoyu Kabushiki Kaisha (Yamasa Corporation) Verfahren zur Herstellung von Nukleosiden durch Verwendung von aus Bacillus stearothermophilus erhältlichen Phosphorylasen
CA2064754C (en) * 1989-07-31 1996-06-18 Vladimir Ivanovich Baranov Method of preparing polypeptides in a cell-free translation system
US5728554A (en) * 1995-04-11 1998-03-17 Cytel Corporation Enzymatic synthesis of glycosidic linkages

Also Published As

Publication number Publication date
DE60042209D1 (de) 2009-06-25
EP1206551A2 (de) 2002-05-22
JP2003507071A (ja) 2003-02-25
US7229797B1 (en) 2007-06-12
HUP0203049A2 (hu) 2002-12-28
KR20020048930A (ko) 2002-06-24
US20080280329A1 (en) 2008-11-13
WO2001014566A3 (en) 2001-09-20
EP1206551B1 (de) 2009-05-13
EP1206551B2 (de) 2011-10-26
AU6571700A (en) 2001-03-19
CA2382462A1 (en) 2001-03-01
WO2001014566A2 (en) 2001-03-01
HUP0203049A3 (en) 2007-03-28

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