|
US5770396A
(en)
*
|
1992-04-16 |
1998-06-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Isolation characterization, and use of the human beta subunit of the high affinity receptor for immunoglobulin E
|
|
ATE264388T1
(de)
*
|
1992-09-24 |
2004-04-15 |
Tanox Biosystems Inc |
Umgestaltete monoklonale antikörper gegen ein immunglobulinisotyp
|
|
US5958708A
(en)
*
|
1992-09-25 |
1999-09-28 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
|
US6066718A
(en)
*
|
1992-09-25 |
2000-05-23 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
|
US5928904A
(en)
*
|
1993-09-07 |
1999-07-27 |
Smithkline Beecham Corporation |
DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
|
US20020193575A1
(en)
|
1993-09-07 |
2002-12-19 |
Smithkline Beecham P.L.C. |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
|
US5914110A
(en)
*
|
1993-09-07 |
1999-06-22 |
Smithkline Beecham Corporation |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
|
GB9324013D0
(en)
*
|
1993-11-22 |
1994-01-12 |
3I Res Expl Ltd |
Polypeptides
|
|
DK0739214T3
(da)
*
|
1994-01-18 |
1998-10-07 |
Genentech Inc |
Fremgangsmåde til behandling af parasitinfektionerunder anvendelse af IgE antagonister
|
|
US20040197326A1
(en)
*
|
1995-07-27 |
2004-10-07 |
Genentech, Inc. |
Method for treatment of allergic asthma
|
|
US6685940B2
(en)
|
1995-07-27 |
2004-02-03 |
Genentech, Inc. |
Protein formulation
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
KR100584051B1
(ko)
*
|
1996-03-01 |
2006-05-30 |
노파르티스 아게 |
알레르기에 대한 백신 접종 및 치료를 위한 펩티드임뮤노겐
|
|
US5958880A
(en)
*
|
1996-12-19 |
1999-09-28 |
Heska Corporation |
Feline Fc epsilon receptor alpha chain proteins and therapeutic uses thereof
|
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
|
US5994511A
(en)
|
1997-07-02 |
1999-11-30 |
Genentech, Inc. |
Anti-IgE antibodies and methods of improving polypeptides
|
|
US6172213B1
(en)
|
1997-07-02 |
2001-01-09 |
Genentech, Inc. |
Anti-IgE antibodies and method of improving polypeptides
|
|
US6057127A
(en)
*
|
1998-01-29 |
2000-05-02 |
Heska Corporation |
Equine Fc epsilon receptor alpha chain nucleic acid molecules and uses thereof
|
|
US6504013B1
(en)
*
|
2000-02-01 |
2003-01-07 |
Idexx Laboratories, Inc. |
Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
|
|
US7393529B2
(en)
*
|
1998-04-09 |
2008-07-01 |
Idexx Laboratories, Inc. |
Methods and compositions for inhibiting binding of IgE to a high affinity receptor
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US6299875B1
(en)
|
1998-06-04 |
2001-10-09 |
Panacea Pharmaceuticals, Llc |
Methods to block IGE binding to cell surface receptors of mast cells
|
|
TWI227241B
(en)
*
|
1998-06-20 |
2005-02-01 |
United Biomedical Inc |
IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
|
|
CN1520423A
(zh)
*
|
1999-02-25 |
2004-08-11 |
ʷ��˿�������ȳ�ķ����˾ |
来源于IgE的Cε3或Cε4区的抗原决定基或拟表位,其拮抗物,及其治疗用途
|
|
US6889145B1
(en)
|
2000-03-15 |
2005-05-03 |
Northwestern University |
Three-dimensional model of a Fc region of an IgE antibody and uses thereof
|
|
AU2002213441B2
(en)
|
2000-10-12 |
2006-10-26 |
Genentech, Inc. |
Reduced-viscosity concentrated protein formulations
|
|
US8703126B2
(en)
|
2000-10-12 |
2014-04-22 |
Genentech, Inc. |
Reduced-viscosity concentrated protein formulations
|
|
AU2003210802B2
(en)
|
2002-02-05 |
2009-09-10 |
Genentech Inc. |
Protein purification
|
|
CA2478925C
(en)
|
2002-04-26 |
2016-06-07 |
Robert Lee Fahrner |
Non-affinity purification of proteins
|
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US7365168B2
(en)
|
2002-10-15 |
2008-04-29 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
CA2505316C
(en)
|
2002-11-08 |
2014-08-05 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
WO2004041867A2
(en)
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders
|
|
CN1798575A
(zh)
|
2003-04-04 |
2006-07-05 |
健泰科生物技术公司 |
高浓度抗体和蛋白制剂
|
|
EP1648940B1
(de)
|
2003-07-28 |
2016-04-27 |
Genentech, Inc. |
Verminderung des auswaschens von protein a während der protein-a-affinitätschromatographie
|
|
JP2007531707A
(ja)
|
2003-10-15 |
2007-11-08 |
ピーディーエル バイオファーマ, インコーポレイテッド |
IGの重鎖定常領域の位置250、314および/または428の変異誘発によるFc融合タンパク質血清半減期の改変
|
|
US7655229B2
(en)
|
2004-09-02 |
2010-02-02 |
Chan Andrew C |
Anti-FC-gamma RIIB receptor antibody and uses therefor
|
|
US7662926B2
(en)
|
2004-09-02 |
2010-02-16 |
Genentech, Inc. |
Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
TWI391399B
(zh)
|
2005-05-25 |
2013-04-01 |
Hoffmann La Roche |
測定溶離多肽之鹽濃度之方法
|
|
WO2007032804A2
(en)
|
2005-06-30 |
2007-03-22 |
Clifford Risk |
Novel uses for anti-ige therapy
|
|
FR2902799B1
(fr)
|
2006-06-27 |
2012-10-26 |
Millipore Corp |
Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
|
|
US8362217B2
(en)
|
2006-12-21 |
2013-01-29 |
Emd Millipore Corporation |
Purification of proteins
|
|
WO2008079280A1
(en)
|
2006-12-21 |
2008-07-03 |
Millipore Corporation |
Purification of proteins
|
|
US8569464B2
(en)
|
2006-12-21 |
2013-10-29 |
Emd Millipore Corporation |
Purification of proteins
|
|
NZ577933A
(en)
|
2007-01-22 |
2011-12-22 |
Genentech Inc |
Polyelectrolyte precipitation and purification of antibodies
|
|
AR065368A1
(es)
|
2007-02-15 |
2009-06-03 |
Astrazeneca Ab |
Anticuerpos para moleculas de ige
|
|
KR20190140090A
(ko)
|
2007-07-09 |
2019-12-18 |
제넨테크, 인크. |
폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
|
|
PE20140196A1
(es)
|
2007-08-09 |
2014-03-19 |
Boehringer Ingelheim Int |
Anticuerpos anti-cd37
|
|
KR101491700B1
(ko)
|
2007-08-23 |
2015-02-11 |
가부시키가이샤 엘에스아이 메디엔스 |
비특이반응 억제제
|
|
CN101889025B
(zh)
|
2007-10-30 |
2013-11-13 |
健泰科生物技术公司 |
通过阳离子交换层析进行的抗体纯化
|
|
WO2009151514A1
(en)
|
2008-06-11 |
2009-12-17 |
Millipore Corporation |
Stirred tank bioreactor
|
|
MX2011001506A
(es)
|
2008-08-14 |
2011-03-15 |
Genentech Inc |
Metodos para eliminar un contaminante utilizado cromatografia de membrana de intercambio de ion en desplazamiento de proteina indigena.
|
|
BRPI0918978A2
(pt)
|
2008-09-10 |
2015-12-01 |
Genentech Inc |
composições e métodos a prevenção da degradação oxidativa das proteínas
|
|
CN102257122B
(zh)
|
2008-12-16 |
2015-07-29 |
Emd密理博公司 |
搅拌槽反应器及方法
|
|
US20110020327A1
(en)
|
2008-12-16 |
2011-01-27 |
Millipore Corporation |
Purification of proteins
|
|
EP2400992B1
(de)
|
2009-02-27 |
2015-07-22 |
Genentech, Inc. |
Verfahren und zusammensetzungen zur kennzeichnung von proteinen
|
|
AR076640A1
(es)
|
2009-03-06 |
2011-06-29 |
Genentech Inc |
Formulacion con anticuerpo. metodo para estabilizar anticuerpo. articulo de manufactura
|
|
CN104059955A
(zh)
|
2009-08-11 |
2014-09-24 |
弗·哈夫曼-拉罗切有限公司 |
在无谷氨酰胺的细胞培养基中的蛋白质生产
|
|
JP5787891B2
(ja)
|
2009-09-01 |
2015-09-30 |
ジェネンテック, インコーポレイテッド |
改変されたプロテインa溶離による向上したタンパク質精製
|
|
CN104998269B
(zh)
|
2010-03-22 |
2019-06-11 |
弗·哈夫曼-拉罗切有限公司 |
对于稳定含有蛋白质的制剂有用的组合物和方法
|
|
KR20130060227A
(ko)
|
2010-05-03 |
2013-06-07 |
제넨테크, 인크. |
단백질-함유 제제의 점도 감소에 유용한 조성물 및 방법
|
|
CN107312062B
(zh)
|
2010-05-17 |
2021-03-16 |
Emd密理博公司 |
用于纯化生物分子的刺激响应性聚合物
|
|
PL2576580T3
(pl)
|
2010-05-28 |
2017-03-31 |
F.Hoffmann-La Roche Ag |
Zmniejszenie poziomu mleczanu i zwiększenie wytwarzania polipeptydu przez obniżenie poziomu ekspresji dehydrogenazy mleczanowej i kinazy dehydrogenazy pirogronianowej
|
|
SG186783A1
(en)
|
2010-06-24 |
2013-02-28 |
Genentech Inc |
Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations
|
|
RU2013110844A
(ru)
|
2010-08-13 |
2014-09-20 |
Дженентек, Инк. |
АНТИТЕЛА ПРОТИВ IL-1β И IL-18, ИСПОЛЬЗУЕМЫЕ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ
|
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
|
UA112062C2
(uk)
|
2010-10-04 |
2016-07-25 |
Бьорінгер Інгельхайм Інтернаціональ Гмбх |
Cd33-зв'язувальний агент
|
|
CN103649297B
(zh)
|
2011-07-08 |
2017-03-01 |
Emd密理博公司 |
用于一次性生物技术方法的改良深层滤器
|
|
WO2013087912A1
(en)
|
2011-12-16 |
2013-06-20 |
Synthon Biopharmaceuticals B.V. |
Compounds and methods for treating inflammatory diseases
|
|
RU2648999C2
(ru)
|
2011-12-22 |
2018-03-29 |
Дженентек, Инк. |
Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии
|
|
AU2013240280A1
(en)
|
2012-03-27 |
2014-10-16 |
Genentech, Inc. |
Improved harvest operations for recombinant proteins
|
|
NZ701915A
(en)
|
2012-05-18 |
2016-11-25 |
Genentech Inc |
High-concentration monoclonal antibody formulations
|
|
GB2503883A
(en)
*
|
2012-07-09 |
2014-01-15 |
King S College London |
Variant IgE with reduced affinity to CD23
|
|
CN104994885B
(zh)
|
2012-12-19 |
2017-09-29 |
基因泰克公司 |
用于放射性卤素蛋白质标记的方法和组合物
|
|
BR112017000142B1
(pt)
|
2014-07-09 |
2021-08-17 |
Genentech, Inc |
Métodos para melhorar a recuperação por descongelamento de bancos de células e para congelamento de células cho para armazenamento, grupo de células cho para o congelamento de células de mamíferos, e banco de células
|
|
SG11201808562SA
(en)
|
2016-03-29 |
2018-10-30 |
Geltor Inc |
Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1
|
|
GB201610198D0
(en)
|
2016-06-10 |
2016-07-27 |
Ucb Biopharma Sprl |
Anti-ige antibodies
|
|
MX2019007433A
(es)
|
2016-12-22 |
2019-08-16 |
Genentech Inc |
Metodos y formulaciones para reducir el tiempo de reconstitucion de los polipeptidos liofilizados.
|
|
AU2018205484B2
(en)
*
|
2017-01-06 |
2024-11-21 |
Sixal, Inc. |
Therapeutic anti-lgE antibodies and methods and compositions thereof
|
|
EP3635093A1
(de)
|
2017-06-08 |
2020-04-15 |
Polpharma Biologics S.A. |
Verbesserte zellkulturverfahren
|
|
US11180541B2
(en)
|
2017-09-28 |
2021-11-23 |
Geltor, Inc. |
Recombinant collagen and elastin molecules and uses thereof
|
|
BR112020006339A2
(pt)
|
2017-11-07 |
2020-11-03 |
Hubit Genomix, Inc. |
método para prevenção primária de distúrbios alérgicos durante a infância através de imunossupressão específica da classe ige
|
|
EP3818078B1
(de)
|
2018-07-03 |
2024-02-28 |
Bristol-Myers Squibb Company |
Verfahren zur herstellung rekombinanter proteine
|
|
US12415980B2
(en)
|
2018-10-10 |
2025-09-16 |
Boehringer Ingelheim International Gmbh |
Method for membrane gas transfer in high density bioreactor culture
|
|
BR112021019612A2
(pt)
|
2019-04-01 |
2021-11-30 |
Genentech Inc |
Formulações, recipiente, artigo de fabricação, método para produzir a formulação e método para inibir a agregação de uma proteína presente em uma solução aquosa
|
|
KR20210151930A
(ko)
|
2019-04-12 |
2021-12-14 |
젤터, 인코포레이티드 |
재조합 엘라스틴 및 이의 제조
|
|
JP2022543781A
(ja)
|
2019-08-01 |
2022-10-14 |
ブリストル-マイヤーズ スクイブ カンパニー |
フェッドバッチ細胞培養におけるタンパク質産生性の改良方法
|
|
KR20220070215A
(ko)
*
|
2019-10-01 |
2022-05-30 |
엡실로겐 리미티드 |
하이브리드 항체
|
|
JP2023541217A
(ja)
|
2020-07-10 |
2023-09-29 |
シャンハイ ジェミンケア ファーマシューティカル カンパニー,リミティド |
抗IgE改変抗体及びその適用
|
|
JP7808097B2
(ja)
|
2020-09-22 |
2026-01-28 |
ブリストル-マイヤーズ スクイブ カンパニー |
治療タンパク質を生産するための方法
|
|
US20250115666A1
(en)
|
2021-08-05 |
2025-04-10 |
Bristol-Myers Squibb Company |
Cell culture methods for producing therapeutic proteins
|
|
WO2023049687A1
(en)
|
2021-09-21 |
2023-03-30 |
Bristol-Myers Squibb Company |
Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container
|
|
US12509529B2
(en)
|
2024-05-17 |
2025-12-30 |
Excellergy, Inc. |
Antibodies and antibody fragments that bind IgE
|