BR9610960A - Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso - Google Patents

Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso

Info

Publication number: BR9610960A
Authority: BR; Brazil
Prior art keywords: heteroaryl; alkynyl; cycloalkyl; alkenyl; alkyl
Prior art date: 1995-10-13

Application number

BR9610960A

Other languages

English (en)

Inventor

Jorgen Scheel-Kruger

Peter Moldt

Gunnar M Olsen

Elsebet Ostergaard Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

1996-10-11

Publication date

1999-03-02

1996-10-11 Application filed by Neurosearch As filed Critical Neurosearch As

1999-03-02 Publication of BR9610960A publication Critical patent/BR9610960A/pt

Links

125000003342 alkenyl group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 5
125000000304 alkynyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
-1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
230000001561 neurotransmitter reuptake Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BR9610960A 1995-10-13 1996-10-11 Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso BR9610960A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK115695		1995-10-13
PCT/EP1996/004449 WO1997013770A1 (en)	1995-10-13	1996-10-11	8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use

Publications (1)

Publication Number	Publication Date
BR9610960A true BR9610960A (pt)	1999-03-02

Family

ID=8101642

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9610960A BR9610960A (pt)	1995-10-13	1996-10-11	Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso

Country Status (24)

Country	Link
US (1)	US6100275A (pt)
EP (1)	EP0859777B1 (pt)
JP (1)	JP3462505B2 (pt)
KR (1)	KR100274829B1 (pt)
CN (1)	CN1083840C (pt)
AT (1)	ATE362931T1 (pt)
AU (1)	AU709327B2 (pt)
BR (1)	BR9610960A (pt)
CA (1)	CA2233541C (pt)
CZ (1)	CZ285093B6 (pt)
DE (1)	DE69637097T2 (pt)
DK (1)	DK0859777T3 (pt)
EE (1)	EE03446B1 (pt)
HU (1)	HUP9802433A3 (pt)
IL (1)	IL123583A (pt)
IS (1)	IS4681A (pt)
NO (1)	NO980919L (pt)
NZ (1)	NZ320216A (pt)
PL (1)	PL185357B1 (pt)
RU (1)	RU2157372C2 (pt)
SK (1)	SK283425B6 (pt)
TR (1)	TR199800628T2 (pt)
UA (1)	UA63894C2 (pt)
WO (1)	WO1997013770A1 (pt)

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GB9510459D0 (en) *	1995-05-24	1995-07-19	Zeneca Ltd	Bicyclic amines
EA001422B1 (ru) *	1996-05-13	2001-02-26	Зенека Лимитед	Бициклические амины в качестве инсектицидов
GB9623944D0 (en) *	1996-11-15	1997-01-08	Zeneca Ltd	Bicyclic amine derivatives
GB9624114D0 (en) *	1996-11-20	1997-01-08	Zeneca Ltd	Pesticidal bicyclic amine derivatives
GB9624611D0 (en) *	1996-11-26	1997-01-15	Zeneca Ltd	Bicyclic amine compounds
ES2216131T3 (es)	1996-11-26	2004-10-16	Syngenta Limited	Derivados de 8-azabiciclo 3,2,1 )octano-,8- azabiciclo 3,2.1) oct-6- eno- 9-azabiciclo 3.3.1) nonano-, 9-aza -3- oxabiciclo 3.3.1) nonano - y 9 -aza-3- tiabiciclo 3.3.1) nonano, su preparacion y su uso como insecticidas.
GB9706222D0 (en) *	1997-03-26	1997-05-14	Zeneca Ltd	Bicyclic amine derivatives
CA2289574C (en)	1997-05-30	2007-04-24	Neurosearch A/S	8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors
GB9726033D0 (en)	1997-12-09	1998-02-04	Zeneca Ltd	Chemical process
TWI221842B (en)	1997-12-11	2004-10-11	Syngenta Ltd	Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
JP2002501921A (ja) *	1998-01-28	2002-01-22	ニューロサーチ、アクティーゼルスカブ	標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法
US6403605B1 (en) *	1998-05-29	2002-06-11	Queen's University At Kingston	Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
CA2335336A1 (en) *	1998-06-19	1999-12-23	James Edmund Audia	Inhibition of serotonin reuptake
NZ510287A (en)	1998-11-27	2003-05-30	Neurosearch As	8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives useful as cholinergic ligands at the nicotinic acetyl choline receptor
RU2211216C2 (ru) *	1998-12-22	2003-08-27	Мерк Патент Гмбх	Производные амидов и мочевины в качестве ингибиторов вторичного поглощения 5-ht и лигандов 5-ht1b/1d
WO2000044746A1 (en) *	1999-01-28	2000-08-03	Neurosearch A/S	Novel azabicyclo derivatives and their use
AU2315400A (en) *	1999-03-01	2000-09-21	Middleton, Donald Stuart	1,2,3,4-tetrahydro-1-naphthalenamine compounds useful in therapy
PL211402B1 (pl)	1999-09-03	2012-05-31	Apbi Holdings	Zastosowanie dapoksetyny do leczenia lub zwalczania przedwczesnej ejakulacji
AU2049501A (en) *	1999-12-20	2001-07-03	Eli Lilly And Company	Benzofuran derivatives
KR20030004425A (ko)	2000-05-25	2003-01-14	타가셉트 인코포레이티드	니코틴성 콜린성 수용체 리간드로서의헤테로아릴디아자바이사이클로알칸
US6667314B2 (en)	2000-05-26	2003-12-23	Pfizer, Inc.	Tropane derivatives useful in therapy
US6579878B1 (en)	2000-07-07	2003-06-17	Targacept, Inc.	Pharmaceutical compositions and methods for use
US6624167B1 (en)	2000-08-04	2003-09-23	Targacept, Inc.	Pharmaceutical compositions and methods for use
DE60122015T2 (de)	2000-10-13	2006-11-23	Neurosearch A/S	Behandlung affektiver störungen durch kombinierte wirkung eines nikotinischen rezeptoragonisten und einer monoaminergischen substanz
DE60231386D1 (de)	2001-04-09	2009-04-16	Neurosearch As	Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
AR035898A1 (es)	2001-05-25	2004-07-21	Wyeth Corp	Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
RU2203044C1 (ru) *	2001-12-27	2003-04-27	Закрытое акционерное общество "Брынцалов-А"	Антидепрессант амитриптилин-ферейн
ATE401334T1 (de)	2002-05-07	2008-08-15	Neurosearch As	Neue azacyclische ethinylderivate
UA82517C2 (uk) *	2003-06-24	2008-04-25	Ньюросерч А/С	Нові похідні 8-аза-біцикло[3.2.1]октану та їх застосування як інгібіторів ресорбції моноамінових медіаторів
EP1797088B1 (en) *	2004-09-30	2011-01-05	NeuroSearch A/S	Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20090137625A1 (en) *	2005-04-08	2009-05-28	Dan Peters	Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
TW200744590A (en) *	2005-09-01	2007-12-16	Neurosearch As	Novel compounds
RU2315047C1 (ru) *	2006-09-04	2008-01-20	Институт нефтехимии и катализа РАН	Способ получения 8-этил-6,7-фуллеро[60]-3-окса-8-азабицикло[3.2.1]октана
KR100812499B1 (ko) *	2006-10-16	2008-03-11	이도훈	항경련제
TWI415850B (zh) *	2007-07-20	2013-11-21	Theravance Inc	製備ｍｕ類鴉片受體拮抗劑之中間物的方法
US20110082166A1 (en) *	2008-03-05	2011-04-07	Neurosearch A/S	Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

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GB9019973D0 (en) *	1990-09-12	1990-10-24	Wyeth John & Brother Ltd	Azabicyclic derivatives
FI111367B (fi) *	1991-02-04	2003-07-15	Aventis Pharma Inc	Menetelmä terapeuttisesti käyttökelpoisten N-(aryylioksialkyyli)heteroaryyli-8-atsabisyklo[3.2.1]oktaanijohdannaisten valmistamiseksi ja menetelmässä käytetyt välituotteet
NZ243065A (en) *	1991-06-13	1995-07-26	Lundbeck & Co As H	Piperidine derivatives and pharmaceutical compositions
DE4200145A1 (de) *	1992-01-07	1993-07-08	Kali Chemie Pharma Gmbh	7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
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1996
- 1996-10-11 DE DE69637097T patent/DE69637097T2/de not_active Expired - Lifetime
- 1996-10-11 IL IL12358396A patent/IL123583A/xx not_active IP Right Cessation
- 1996-10-11 BR BR9610960A patent/BR9610960A/pt not_active Application Discontinuation
- 1996-10-11 CZ CZ98758A patent/CZ285093B6/cs not_active IP Right Cessation
- 1996-10-11 NZ NZ320216A patent/NZ320216A/xx not_active IP Right Cessation
- 1996-10-11 CA CA002233541A patent/CA2233541C/en not_active Expired - Fee Related
- 1996-10-11 HU HU9802433A patent/HUP9802433A3/hu unknown
- 1996-10-11 PL PL96326195A patent/PL185357B1/pl not_active IP Right Cessation
- 1996-10-11 AT AT96934662T patent/ATE362931T1/de active
- 1996-10-11 AU AU72917/96A patent/AU709327B2/en not_active Ceased
- 1996-10-11 SK SK287-98A patent/SK283425B6/sk unknown
- 1996-10-11 CN CN96197566A patent/CN1083840C/zh not_active Expired - Fee Related
- 1996-10-11 EP EP96934662A patent/EP0859777B1/en not_active Expired - Lifetime
- 1996-10-11 EE EE9800062A patent/EE03446B1/xx not_active IP Right Cessation
- 1996-10-11 KR KR1019980702103A patent/KR100274829B1/ko not_active Expired - Fee Related
- 1996-10-11 DK DK96934662T patent/DK0859777T3/da active
- 1996-10-11 US US09/043,294 patent/US6100275A/en not_active Expired - Fee Related
- 1996-10-11 JP JP51472697A patent/JP3462505B2/ja not_active Expired - Fee Related
- 1996-10-11 RU RU98105169/04A patent/RU2157372C2/ru not_active IP Right Cessation
- 1996-10-11 TR TR1998/00628T patent/TR199800628T2/xx unknown
- 1996-10-11 WO PCT/EP1996/004449 patent/WO1997013770A1/en not_active Ceased
- 1996-11-10 UA UA98031543A patent/UA63894C2/uk unknown
1998
- 1998-03-03 NO NO19980919A patent/NO980919L/no not_active Application Discontinuation
- 1998-03-04 IS IS4681A patent/IS4681A/is unknown

Also Published As

Publication number	Publication date
JPH10512589A (ja)	1998-12-02
UA63894C2 (en)	2004-02-16
IL123583A0 (en)	1998-10-30
IS4681A (is)	1998-03-04
JP3462505B2 (ja)	2003-11-05
US6100275A (en)	2000-08-08
EE03446B1 (et)	2001-06-15
KR100274829B1 (ko)	2000-12-15
NO980919L (no)	1998-06-08
CZ75898A3 (cs)	1998-11-11
CA2233541C (en)	2002-04-30
CN1083840C (zh)	2002-05-01
CN1199400A (zh)	1998-11-18
DE69637097T2 (de)	2007-09-20
NZ320216A (en)	1999-05-28
KR19990063651A (ko)	1999-07-26
PL326195A1 (en)	1998-08-31
SK28798A3 (en)	1998-09-09
RU2157372C2 (ru)	2000-10-10
EP0859777B1 (en)	2007-05-23
AU709327B2 (en)	1999-08-26
HUP9802433A2 (hu)	1999-04-28
CZ285093B6 (cs)	1999-05-12
PL185357B1 (pl)	2003-04-30
SK283425B6 (sk)	2003-07-01
EE9800062A (et)	1998-08-17
DE69637097D1 (de)	2007-07-05
IL123583A (en)	2003-07-31
HUP9802433A3 (en)	2000-03-28
ATE362931T1 (de)	2007-06-15
EP0859777A1 (en)	1998-08-26
TR199800628T2 (xx)	1998-07-21
DK0859777T3 (da)	2007-09-03
WO1997013770A1 (en)	1997-04-17
NO980919D0 (no)	1998-03-03
AU7291796A (en)	1997-04-30
CA2233541A1 (en)	1997-04-17

Legal Events

Date	Code	Title	Description
2005-08-30	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2006-01-31	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PEDIDO DE PATENTE COM BASE NOS ARTIGOS 8 E 13 DA LPI NO9.279 DE 14/05/1996.
2006-05-02	B12B	Appeal against refusal [chapter 12.2 patent gazette]

Publication	Publication Date	Title
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