ATE234829T1 - Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxyden - Google Patents
Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxydenInfo
- Publication number
- ATE234829T1 ATE234829T1 AT98962044T AT98962044T ATE234829T1 AT E234829 T1 ATE234829 T1 AT E234829T1 AT 98962044 T AT98962044 T AT 98962044T AT 98962044 T AT98962044 T AT 98962044T AT E234829 T1 ATE234829 T1 AT E234829T1
- Authority
- AT
- Austria
- Prior art keywords
- enantiomerically enriched
- oxyde
- producing enantiomerically
- enriched tetrahydrobenzothiepine
- tetrahydrobenzothiepine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KZPHSSFCYARZCD-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1-benzothiepine Chemical compound S1CCCCC2=CC=CC=C21 KZPHSSFCYARZCD-UHFFFAOYSA-N 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6817097P | 1997-12-19 | 1997-12-19 | |
| PCT/US1998/026216 WO1999032478A1 (en) | 1997-12-19 | 1998-12-16 | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE234829T1 true ATE234829T1 (de) | 2003-04-15 |
Family
ID=22080853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98962044T ATE234829T1 (de) | 1997-12-19 | 1998-12-16 | Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxyden |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6369220B1 (de) |
| EP (1) | EP1042314B1 (de) |
| JP (1) | JP2001526284A (de) |
| KR (1) | KR20010015884A (de) |
| CN (2) | CN1106395C (de) |
| AT (1) | ATE234829T1 (de) |
| AU (1) | AU1721399A (de) |
| BR (1) | BR9814300A (de) |
| DE (1) | DE69812419T2 (de) |
| DK (1) | DK1042314T3 (de) |
| ES (1) | ES2195428T3 (de) |
| HU (1) | HUP0101193A3 (de) |
| IL (1) | IL136864A (de) |
| PT (1) | PT1042314E (de) |
| RU (1) | RU2236406C2 (de) |
| UA (1) | UA67764C2 (de) |
| WO (1) | WO1999032478A1 (de) |
| ZA (1) | ZA9811648B (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| WO2000038721A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| US6586434B2 (en) | 2000-03-10 | 2003-07-01 | G.D. Searle, Llc | Method for the preparation of tetrahydrobenzothiepines |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| AU2002329387B2 (en) | 2001-09-08 | 2007-06-07 | Albireo Ab | Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (IBAT) inhibitory activity for the treatment hyperlipidaemia |
| BR0213501A (pt) * | 2001-11-02 | 2004-08-24 | Searle Llc | Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato |
| US6852753B2 (en) | 2002-01-17 | 2005-02-08 | Pharmacia Corporation | Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| KR20070026392A (ko) | 2004-02-27 | 2007-03-08 | 아사히 가세이 파마 가부시키가이샤 | 신규 벤조티아제핀 및 벤조티에핀 화합물 |
| WO2010062861A2 (en) * | 2008-11-26 | 2010-06-03 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| ES2687027T3 (es) | 2010-11-04 | 2018-10-23 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepáticas |
| DK2637646T3 (en) | 2010-11-08 | 2016-08-29 | Albireo Ab | PHARMACEUTICAL COMBINATION CONTAINING AN IBAT inhibitor and a bile acid binder |
| CN102558250B (zh) * | 2010-12-14 | 2015-01-14 | 王芃 | 一种艾杜糖醛酸及其衍生物的制备方法 |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| AU2012328526B2 (en) | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| WO2014145251A1 (en) | 2013-03-15 | 2014-09-18 | Georgetown University | Determining stereoisomeric excess, concentration and absolute configuration |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CN106659726A (zh) | 2014-06-25 | 2017-05-10 | Ea制药株式会社 | 固体制剂及其着色防止或着色减少方法 |
| EP3012252A1 (de) | 2014-10-24 | 2016-04-27 | Ferring BV | Kristalline Form von elobixibat |
| ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| WO2017138878A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN108601739B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 考来烯胺丸剂及其制备方法 |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| EP3664782B1 (de) | 2017-08-09 | 2025-01-29 | Albireo AB | Cholestyraminpellets, orale cholestyraminformulierungen und ihre medizinische verwendung |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| PL3810581T3 (pl) | 2018-06-20 | 2025-04-28 | Albireo Ab | Modyfikacje kryształu odewiksibatu |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US12486293B2 (en) | 2018-07-30 | 2025-12-02 | Georgetown University | Chirality sensing with molecular click chemistry probes |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| WO2020056012A1 (en) | 2018-09-11 | 2020-03-19 | Georgetown University | Quantitative auxiliary-free chirality sensing with a metal probe |
| CN109516971B (zh) * | 2018-11-26 | 2020-09-25 | 山东永浩新材料科技有限公司 | 一种电池级硫酸乙烯酯的合成方法 |
| CN118852054A (zh) | 2019-02-06 | 2024-10-29 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| TWI835997B (zh) | 2019-02-06 | 2024-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其用作膽酸調節劑之用途 |
| EP3923943B1 (de) | 2019-02-12 | 2024-07-31 | Mirum Pharmaceuticals, Inc. | Genotyp und dosisabhängige reaktion auf einen asbti bei patienten mit gallensalzexportpumpenmangel |
| EP4069247B1 (de) | 2019-12-04 | 2025-03-26 | Albireo AB | Benzothiadiazepinverbindungen und ihre verwendung als gallensäuremodulatoren |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| IL293379B2 (en) | 2019-12-04 | 2026-04-01 | Albireo Ab | Benzothia(dia)azepine compounds and their use as bile acid modulators |
| JP7696898B2 (ja) | 2019-12-04 | 2025-06-23 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| EP4188541B1 (de) | 2020-08-03 | 2024-12-25 | Albireo AB | Benzothia(di)azepin-verbindungen und ihre verwendung als gallensäuremodulatoren |
| CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| PY2373529A (es) * | 2022-09-14 | 2024-03-25 | Mirum Pharmaceuticals Inc | Maralixibat formas sólidas, intermedios y procesos de hacer la misma |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59144777A (ja) | 1983-02-04 | 1984-08-18 | Tokawa Tetsuo | ベンゾチアゼピン誘導体の光学分割法 |
| US5559017A (en) | 1989-08-09 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Microbial reduction of benzazepines and benzothiazepine derivatives |
| TW197435B (de) * | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
| IT1249318B (it) | 1991-05-23 | 1995-02-22 | Zambon Spa | Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici |
| CN1084741C (zh) * | 1994-09-13 | 2002-05-15 | 孟山都公司 | 具有回肠胆汁酸转运和牛磺胆酸盐摄入抑制剂作用的新的苯并硫杂䓬 |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| HUP9903047A3 (en) * | 1996-03-11 | 2002-12-28 | G D Searle & Co Chicago | Novel benzothiazepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
-
1998
- 1998-12-16 AT AT98962044T patent/ATE234829T1/de not_active IP Right Cessation
- 1998-12-16 EP EP98962044A patent/EP1042314B1/de not_active Expired - Lifetime
- 1998-12-16 PT PT98962044T patent/PT1042314E/pt unknown
- 1998-12-16 UA UA2000074377A patent/UA67764C2/uk unknown
- 1998-12-16 AU AU17213/99A patent/AU1721399A/en not_active Abandoned
- 1998-12-16 RU RU2000119611/04A patent/RU2236406C2/ru not_active IP Right Cessation
- 1998-12-16 ES ES98962044T patent/ES2195428T3/es not_active Expired - Lifetime
- 1998-12-16 JP JP2000525415A patent/JP2001526284A/ja active Pending
- 1998-12-16 DK DK98962044T patent/DK1042314T3/da active
- 1998-12-16 WO PCT/US1998/026216 patent/WO1999032478A1/en not_active Ceased
- 1998-12-16 KR KR1020007006795A patent/KR20010015884A/ko not_active Ceased
- 1998-12-16 HU HU0101193A patent/HUP0101193A3/hu unknown
- 1998-12-16 US US09/581,897 patent/US6369220B1/en not_active Expired - Fee Related
- 1998-12-16 BR BR9814300-0A patent/BR9814300A/pt not_active IP Right Cessation
- 1998-12-16 IL IL13686498A patent/IL136864A/en not_active IP Right Cessation
- 1998-12-16 DE DE69812419T patent/DE69812419T2/de not_active Expired - Fee Related
- 1998-12-16 CN CN98813609A patent/CN1106395C/zh not_active Expired - Fee Related
- 1998-12-18 ZA ZA9811648A patent/ZA9811648B/xx unknown
-
2002
- 2002-02-11 US US10/072,600 patent/US6875877B2/en not_active Expired - Fee Related
-
2003
- 2003-02-28 CN CN03107046A patent/CN1439638A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69812419T2 (de) | 2003-08-14 |
| IL136864A0 (en) | 2001-06-14 |
| HUP0101193A3 (en) | 2001-12-28 |
| HK1034971A1 (en) | 2001-11-09 |
| WO1999032478A1 (en) | 1999-07-01 |
| HUP0101193A2 (hu) | 2001-08-28 |
| US20020188119A1 (en) | 2002-12-12 |
| BR9814300A (pt) | 2002-02-05 |
| EP1042314A1 (de) | 2000-10-11 |
| CN1106395C (zh) | 2003-04-23 |
| IL136864A (en) | 2004-07-25 |
| DE69812419D1 (de) | 2003-04-24 |
| EP1042314B1 (de) | 2003-03-19 |
| DK1042314T3 (da) | 2003-07-14 |
| KR20010015884A (ko) | 2001-02-26 |
| US6369220B1 (en) | 2002-04-09 |
| ZA9811648B (en) | 1999-12-20 |
| US6875877B2 (en) | 2005-04-05 |
| ES2195428T3 (es) | 2003-12-01 |
| RU2236406C2 (ru) | 2004-09-20 |
| AU1721399A (en) | 1999-07-12 |
| CN1284953A (zh) | 2001-02-21 |
| JP2001526284A (ja) | 2001-12-18 |
| PT1042314E (pt) | 2003-07-31 |
| CN1439638A (zh) | 2003-09-03 |
| UA67764C2 (uk) | 2004-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1042314 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |