ATE234829T1 - Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxyden - Google Patents
Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxydenInfo
- Publication number
- ATE234829T1 ATE234829T1 AT98962044T AT98962044T ATE234829T1 AT E234829 T1 ATE234829 T1 AT E234829T1 AT 98962044 T AT98962044 T AT 98962044T AT 98962044 T AT98962044 T AT 98962044T AT E234829 T1 ATE234829 T1 AT E234829T1
- Authority
- AT
- Austria
- Prior art keywords
- enantiomerically enriched
- oxyde
- producing enantiomerically
- enriched tetrahydrobenzothiepine
- tetrahydrobenzothiepine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KZPHSSFCYARZCD-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1-benzothiepine Chemical compound S1CCCCC2=CC=CC=C21 KZPHSSFCYARZCD-UHFFFAOYSA-N 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6817097P | 1997-12-19 | 1997-12-19 | |
| PCT/US1998/026216 WO1999032478A1 (en) | 1997-12-19 | 1998-12-16 | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE234829T1 true ATE234829T1 (de) | 2003-04-15 |
Family
ID=22080853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98962044T ATE234829T1 (de) | 1997-12-19 | 1998-12-16 | Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxyden |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6369220B1 (de) |
| EP (1) | EP1042314B1 (de) |
| JP (1) | JP2001526284A (de) |
| KR (1) | KR20010015884A (de) |
| CN (2) | CN1106395C (de) |
| AT (1) | ATE234829T1 (de) |
| AU (1) | AU1721399A (de) |
| BR (1) | BR9814300A (de) |
| DE (1) | DE69812419T2 (de) |
| DK (1) | DK1042314T3 (de) |
| ES (1) | ES2195428T3 (de) |
| HU (1) | HUP0101193A3 (de) |
| IL (1) | IL136864A (de) |
| PT (1) | PT1042314E (de) |
| RU (1) | RU2236406C2 (de) |
| UA (1) | UA67764C2 (de) |
| WO (1) | WO1999032478A1 (de) |
| ZA (1) | ZA9811648B (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| AU3103800A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications |
| EP1286984A2 (de) * | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Verfahren zur herstellung von tetrahydrobenzothiepinen |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| MY131995A (en) | 2001-09-08 | 2007-09-28 | Astrazeneca Ab | Benzothiazepine and benzothiadiazepine derivatives with illeal bile acid transport (ibat) inhibitory activity for the treatment hyperlipidaemia |
| BR0213501A (pt) * | 2001-11-02 | 2004-08-24 | Searle Llc | Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato |
| MXPA04006255A (es) | 2002-01-17 | 2004-09-27 | Pharmacia Corp | Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato. |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| AU2005217318B2 (en) | 2004-02-27 | 2010-07-01 | Asahi Kasei Pharma Corporation | Novel benzothiazepine and benzothiepine compounds |
| EP2367554A4 (de) | 2008-11-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Gallensäurerückflusshemmer zur behandlung von adipositas und diabetes |
| EP4137137A1 (de) | 2010-05-26 | 2023-02-22 | Satiogen Pharmaceuticals, Inc. | Gallensäurerecyclinghemmer und satiogene zur behandlung von diabetes, adipositas und entzündlichen magen-darm-erkrankungen |
| MX366925B (es) | 2010-11-04 | 2019-07-31 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepaticas. |
| US20130236541A1 (en) | 2010-11-08 | 2013-09-12 | Albireo Ab | Pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| CN102558250B (zh) * | 2010-12-14 | 2015-01-14 | 王芃 | 一种艾杜糖醛酸及其衍生物的制备方法 |
| EA038594B1 (ru) | 2011-10-28 | 2021-09-21 | Шайр Хьюман Дженетик Терапис, Инк. | Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени |
| JP6217938B2 (ja) | 2011-10-28 | 2017-10-25 | ルメナ ファーマシューティカルズ エルエルシー | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| KR20160002773A (ko) | 2013-03-15 | 2016-01-08 | 루메나 파마수티컬즈, 인코포레이티드 | 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제 |
| US10012627B2 (en) | 2013-03-15 | 2018-07-03 | Georgetown University | Determining stereoisomeric excess, concentration and absolute configuration |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CA2952406A1 (en) | 2014-06-25 | 2015-12-30 | Ea Pharma Co., Ltd. | Solid formulation and method for preventing or reducing coloration thereof |
| EP3012252A1 (de) | 2014-10-24 | 2016-04-27 | Ferring BV | Kristalline Form von elobixibat |
| CA3011595C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| JP6954927B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| CN108601744B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| JP7328207B2 (ja) | 2017-08-09 | 2023-08-16 | アルビレオ・アクチボラグ | コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用 |
| JP7391048B2 (ja) | 2018-06-05 | 2023-12-04 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| KR20210024033A (ko) | 2018-06-20 | 2021-03-04 | 알비레오 에이비 | 오데빅시바트의 약학 제제 |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| WO2020028396A1 (en) | 2018-07-30 | 2020-02-06 | Georgetown University | Chirality sensing with molecular click chemistry probes |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11860084B2 (en) | 2018-09-11 | 2024-01-02 | Georgetown University | Quantitative auxiliary-free chirality sensing with a metal probe |
| CN109516971B (zh) * | 2018-11-26 | 2020-09-25 | 山东永浩新材料科技有限公司 | 一种电池级硫酸乙烯酯的合成方法 |
| SG11202108566VA (en) | 2019-02-06 | 2021-09-29 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| CN113453753B (zh) | 2019-02-06 | 2024-07-23 | 阿尔比里奥公司 | 苯并硫氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| EP4424363B1 (de) | 2019-02-12 | 2026-04-29 | Mirum Pharmaceuticals, Inc. | Verfahren zur wachstumssteigerung bei pädiatrischen patienten mit cholestatischer lebererkrankung |
| WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| JP7665621B2 (ja) | 2019-12-04 | 2025-04-21 | アルビレオ・アクチボラグ | ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| CA3158181A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3158195A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN114786772B (zh) | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| ES3002777T3 (en) | 2020-08-03 | 2025-03-07 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| AU2021379076A1 (en) | 2020-11-12 | 2023-06-08 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| CN117412955A (zh) | 2021-06-03 | 2024-01-16 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| PY2373529A (es) * | 2022-09-14 | 2024-03-25 | Mirum Pharmaceuticals Inc | Maralixibat formas sólidas, intermedios y procesos de hacer la misma |
| CN122438841A (zh) | 2023-12-18 | 2026-07-21 | 浙江奥翔药业股份有限公司 | 用于制备药物Maralixibat的中间体化合物的方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59144777A (ja) | 1983-02-04 | 1984-08-18 | Tokawa Tetsuo | ベンゾチアゼピン誘導体の光学分割法 |
| US5559017A (en) | 1989-08-09 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Microbial reduction of benzazepines and benzothiazepine derivatives |
| TW197435B (de) * | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
| IT1249318B (it) | 1991-05-23 | 1995-02-22 | Zambon Spa | Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici |
| ES2155136T3 (es) * | 1994-09-13 | 2001-05-01 | Monsanto Co | Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato. |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| DE04010088T1 (de) * | 1996-03-11 | 2005-07-14 | G.D. Searle Llc | Neue Benzothiepine mit pharmazeutischer Wirkung. |
-
1998
- 1998-12-16 BR BR9814300-0A patent/BR9814300A/pt not_active IP Right Cessation
- 1998-12-16 JP JP2000525415A patent/JP2001526284A/ja active Pending
- 1998-12-16 KR KR1020007006795A patent/KR20010015884A/ko not_active Ceased
- 1998-12-16 EP EP98962044A patent/EP1042314B1/de not_active Expired - Lifetime
- 1998-12-16 CN CN98813609A patent/CN1106395C/zh not_active Expired - Fee Related
- 1998-12-16 PT PT98962044T patent/PT1042314E/pt unknown
- 1998-12-16 AU AU17213/99A patent/AU1721399A/en not_active Abandoned
- 1998-12-16 ES ES98962044T patent/ES2195428T3/es not_active Expired - Lifetime
- 1998-12-16 UA UA2000074377A patent/UA67764C2/uk unknown
- 1998-12-16 IL IL13686498A patent/IL136864A/en not_active IP Right Cessation
- 1998-12-16 DK DK98962044T patent/DK1042314T3/da active
- 1998-12-16 WO PCT/US1998/026216 patent/WO1999032478A1/en not_active Ceased
- 1998-12-16 AT AT98962044T patent/ATE234829T1/de not_active IP Right Cessation
- 1998-12-16 RU RU2000119611/04A patent/RU2236406C2/ru not_active IP Right Cessation
- 1998-12-16 HU HU0101193A patent/HUP0101193A3/hu unknown
- 1998-12-16 DE DE69812419T patent/DE69812419T2/de not_active Expired - Fee Related
- 1998-12-16 US US09/581,897 patent/US6369220B1/en not_active Expired - Fee Related
- 1998-12-18 ZA ZA9811648A patent/ZA9811648B/xx unknown
-
2002
- 2002-02-11 US US10/072,600 patent/US6875877B2/en not_active Expired - Fee Related
-
2003
- 2003-02-28 CN CN03107046A patent/CN1439638A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1284953A (zh) | 2001-02-21 |
| IL136864A (en) | 2004-07-25 |
| CN1106395C (zh) | 2003-04-23 |
| DE69812419D1 (de) | 2003-04-24 |
| PT1042314E (pt) | 2003-07-31 |
| RU2236406C2 (ru) | 2004-09-20 |
| US6369220B1 (en) | 2002-04-09 |
| HUP0101193A2 (hu) | 2001-08-28 |
| DE69812419T2 (de) | 2003-08-14 |
| IL136864A0 (en) | 2001-06-14 |
| BR9814300A (pt) | 2002-02-05 |
| EP1042314B1 (de) | 2003-03-19 |
| US20020188119A1 (en) | 2002-12-12 |
| DK1042314T3 (da) | 2003-07-14 |
| US6875877B2 (en) | 2005-04-05 |
| JP2001526284A (ja) | 2001-12-18 |
| ES2195428T3 (es) | 2003-12-01 |
| ZA9811648B (en) | 1999-12-20 |
| WO1999032478A1 (en) | 1999-07-01 |
| CN1439638A (zh) | 2003-09-03 |
| HUP0101193A3 (en) | 2001-12-28 |
| KR20010015884A (ko) | 2001-02-26 |
| AU1721399A (en) | 1999-07-12 |
| HK1034971A1 (en) | 2001-11-09 |
| EP1042314A1 (de) | 2000-10-11 |
| UA67764C2 (uk) | 2004-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1042314 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |