ATE234846T1 - Verfahren zur herstellung eines anitibiotkums - Google Patents

Verfahren zur herstellung eines anitibiotkums

Info

Publication number: ATE234846T1
Authority: AT; Austria
Prior art keywords: beta; antibiotic; lactam core; mother liquor; acylation
Prior art date: 1995-12-08

Application number

AT96940163T

Other languages

English (en)

Inventor

Wilhelmus Hubertus Jos Boesten

Den Tweel Wilhelmus Johann Van

Rocus Marinus Dekkers

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-08

Filing date

1996-12-06

Publication date

2003-04-15

1996-12-06 Application filed by Dsm Nv filed Critical Dsm Nv

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE234846T1 publication Critical patent/ATE234846T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
230000003115 biocidal effect Effects 0.000 abstract 4
150000003952 β-lactams Chemical group 0.000 abstract 4
238000005917 acylation reaction Methods 0.000 abstract 3
230000010933 acylation Effects 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
239000012452 mother liquor Substances 0.000 abstract 2
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
229960003022 amoxicillin Drugs 0.000 abstract 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
229960000723 ampicillin Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 abstract 1
229960005361 cefaclor Drugs 0.000 abstract 1
229960004841 cefadroxil Drugs 0.000 abstract 1
NBFNMSULHIODTC-CYJZLJNKSA-N cefadroxil monohydrate Chemical compound O.C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=C(O)C=C1 NBFNMSULHIODTC-CYJZLJNKSA-N 0.000 abstract 1
GPRBEKHLDVQUJE-VINNURBNSA-N cefotaxime Chemical compound N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C(O)=O)=O)C(=O)/C(=N/OC)C1=CSC(N)=N1 GPRBEKHLDVQUJE-VINNURBNSA-N 0.000 abstract 1
229960002588 cefradine Drugs 0.000 abstract 1
229940106164 cephalexin Drugs 0.000 abstract 1
ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 abstract 1
RDLPVSKMFDYCOR-UEKVPHQBSA-N cephradine Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CCC=CC1 RDLPVSKMFDYCOR-UEKVPHQBSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Cephalosporin Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

AT96940163T 1995-12-08 1996-12-06 Verfahren zur herstellung eines anitibiotkums ATE234846T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
BE9501015		1995-12-08
PCT/NL1996/000479 WO1997022610A1 (en)	1995-12-08	1996-12-06	Process for the preparation of an antibiotic

Publications (1)

Publication Number	Publication Date
ATE234846T1 true ATE234846T1 (de)	2003-04-15

Family

ID=3889338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96940163T ATE234846T1 (de)	1995-12-08	1996-12-06	Verfahren zur herstellung eines anitibiotkums

Country Status (10)

Country	Link
US (1)	US6503727B1 (de)
EP (1)	EP0865443B1 (de)
KR (1)	KR100455252B1 (de)
CN (1)	CN1107070C (de)
AT (1)	ATE234846T1 (de)
AU (1)	AU7711496A (de)
DE (1)	DE69626842D1 (de)
ES (1)	ES2195024T3 (de)
PL (1)	PL327134A1 (de)
WO (1)	WO1997022610A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998000382A1 (en)	1996-07-02	1998-01-08	Toray Industries, Inc.	Processes for the preparation of optically active ketones
JP2000512860A (ja) *	1997-04-22	2000-10-03	ギストブロカデスベスローテンフェンノートシャップ	β―ラクタム抗生物質を調製する方法
NL1007077C2 (nl) *	1997-09-19	1999-03-22	Dsm Nv	Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007076C2 (nl) *	1997-09-19	1999-03-22	Dsm Nv	Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007302C2 (nl) *	1997-10-17	1999-04-20	Dsm Nv	Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) *	1998-11-06	2000-05-09	Dsm Nv	Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP2024374A1 (de) *	2006-05-19	2009-02-18	DSMIP Assets B.V.	Verfahren zum kristallisieren von cefadroxil
CN102392060B (zh) *	2011-09-16	2013-07-31	石药集团中润制药(内蒙古)有限公司	一种利用纳滤回收酶法阿莫西林母液中有效成份的方法
CN103193800B (zh) *	2013-04-08	2016-03-02	中国医药集团总公司四川抗菌素工业研究所	一种从头孢克洛酶促反应液中分离纯化各组分的方法
CN103805672B (zh) *	2014-02-25	2016-05-25	华北制药集团先泰药业有限公司	一种酶法制备氨苄西林的工艺
CN104628587B (zh) *	2015-02-12	2016-06-22	艾美科健（中国）生物医药有限公司	一种回收阿莫西林生产废液中d-对羟基苯甘氨酸的方法
CN105294734B (zh) *	2015-10-16	2018-02-13	华北制药河北华民药业有限责任公司	一种制备头孢尼西二苄基乙二胺盐的方法
CN105603037B (zh) *	2015-12-24	2020-07-31	天津大学	一种酶催化酰化制备头孢菌素的方法
CN105567777A (zh) *	2016-03-07	2016-05-11	内蒙古常盛制药有限公司	一种循环利用阿莫西林母液的方法
CN111269076A (zh) *	2020-03-12	2020-06-12	山东钧睿科技服务有限公司	一种酶法合成β-内酰胺类抗生素离心母液回收处理工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4003896A (en) *	1974-12-17	1977-01-18	Novo Industri A/S	Method of preparing a sparingly soluble complex of cephalexin
JPS5645196A (en) *	1979-09-19	1981-04-24	Shionogi & Co Ltd	Enzymatic synthesis of beta-lactam antibacterial agent
CA2086250C (en) *	1990-07-04	2001-05-29	Svend Gunnar Kaasgaard	Process for preparation of beta-lactams
DE618979T1 (de) *	1991-12-19	1995-05-18	Novonordisk As	Verbesserte methode zur herstellung von bestimmten -g(b)-lactam-antibiotika.
AU4846196A (en) *	1995-02-02	1996-08-21	Chemferm V.O.F.	Process for the recovery of cephalexin

1996
- 1996-12-06 AT AT96940163T patent/ATE234846T1/de active
- 1996-12-06 DE DE69626842T patent/DE69626842D1/de not_active Expired - Lifetime
- 1996-12-06 PL PL96327134A patent/PL327134A1/xx unknown
- 1996-12-06 CN CN96199571A patent/CN1107070C/zh not_active Expired - Lifetime
- 1996-12-06 WO PCT/NL1996/000479 patent/WO1997022610A1/en not_active Ceased
- 1996-12-06 ES ES96940163T patent/ES2195024T3/es not_active Expired - Lifetime
- 1996-12-06 KR KR10-1998-0704287A patent/KR100455252B1/ko not_active Expired - Fee Related
- 1996-12-06 US US09/077,727 patent/US6503727B1/en not_active Expired - Fee Related
- 1996-12-06 AU AU77114/96A patent/AU7711496A/en not_active Abandoned
- 1996-12-06 EP EP96940163A patent/EP0865443B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1207742A (zh)	1999-02-10
ES2195024T3 (es)	2003-12-01
US6503727B1 (en)	2003-01-07
KR100455252B1 (ko)	2005-01-15
EP0865443A1 (de)	1998-09-23
CN1107070C (zh)	2003-04-30
KR20000064370A (ko)	2000-11-06
DE69626842D1 (de)	2003-04-24
WO1997022610A1 (en)	1997-06-26
PL327134A1 (en)	1998-11-23
EP0865443B1 (de)	2003-03-19
AU7711496A (en)	1997-07-14

Legal Events

Date

Code

Title

Description

2003-10-15

UEP

Publication of translation of european patent specification

Ref document number: 0865443

Country of ref document: EP

2004-05-15

EEIH

Change in the person of patent owner

Publication	Publication Date	Title
ATE234846T1 (de)	2003-04-15	Verfahren zur herstellung eines anitibiotkums
DE69133509T2 (de)	2006-08-24	Verfahren zur herstellung von beta-lactamen
DE4419591B4 (de)	2005-04-28	Verfahren zur Herstellung eines plastisch geformten Produkts
DE69301571D1 (de)	1996-03-28	Verfahren zur Herstellung von Clavulansäure
DE69323383D1 (de)	1999-03-18	Verfahren zur Herstellung eines elektronischen Bauelementes
ATE445629T1 (de)	2009-10-15	Verfahren zur pufferstabilisierten wässrigen deacetylierung
ATE261946T1 (de)	2004-04-15	Verfahren zur herstellung von thiazolidin
ATE207859T1 (de)	2001-11-15	Verfahren zur herstellung von pentafluorethan
HUP0004805A2 (hu)	2001-05-28	Lényegében vízmentes habosítószer és eljárás ennek előállítására
ATE234934T1 (de)	2003-04-15	Verfahren zur herstellung von einem beta-laktam antibiotikum
CA2187210A1 (en)	1996-08-15	Method for purifying diacetylrhein
ATE204580T1 (de)	2001-09-15	Verfahren zur gewinnung von cephalexin
DE59403272D1 (de)	1997-08-14	Verfahren zur Herstellung Kautschukmischungen
ATE95806T1 (de)	1993-10-15	Verfahren fuer die wasserreinigung.
ATA88691A (de)	1994-01-15	Verfahren zur enzymatischen hydrolyse eines carbonsäurederivates
ATE384067T1 (de)	2008-02-15	Verfahren zur herstellung von 3-cephemderivaten
EP0960945A3 (de)	1999-12-22	Verfahren zur enzymatischen Herstellung von Betalaktamantibiotika mit Produktrückgewinnung bei pH 1 in Gegenwart von immobilisiertes Penicillinamidase
ZA200004801B (en)	2001-07-25	Process for the fermentative production of cephalosporin.
DE60105016D1 (de)	2004-09-23	Verfahren zur reinigung eines salzes der clavulansäure
BR9600835A (pt)	1997-12-30	Processo para preparar penicilinas ou cefalosporinas e composiç o farmacêutica que as contêm
DE69811893D1 (de)	2003-04-10	Verfahren zur herstellung von azetidin-2-carbonsäure und zwischenprodukten davon
ATE220069T1 (de)	2002-07-15	Verfahren zur winnung von ampicillin
Guest et al.	1989	6α-fluoroalkyl penicillins
EP0984017A3 (de)	2001-05-16	Verbessertes Verfahren zur Herstellung von einem N-Acyl Derivat des O,S-Dialkylphosphoroamidothioats
DE69019672D1 (de)	1995-06-29	Verfahren zur Entfernung von Amin aus Feststoffen.