ATE235471T1 - Neue benzylpyrimidine - Google Patents

Neue benzylpyrimidine

Info

Publication number
ATE235471T1
ATE235471T1 AT95939267T AT95939267T ATE235471T1 AT E235471 T1 ATE235471 T1 AT E235471T1 AT 95939267 T AT95939267 T AT 95939267T AT 95939267 T AT95939267 T AT 95939267T AT E235471 T1 ATE235471 T1 AT E235471T1
Authority
AT
Austria
Prior art keywords
pct
date
heteroaryl
sec
aryl
Prior art date
Application number
AT95939267T
Other languages
English (en)
Inventor
Philippe Guerry
Synese Jolidon
Raffaello Masciadri
Henri Stalder
Rudolf Then
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Application granted granted Critical
Publication of ATE235471T1 publication Critical patent/ATE235471T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
AT95939267T 1994-11-24 1995-11-13 Neue benzylpyrimidine ATE235471T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH353694 1994-11-24
CH270495 1995-09-25
PCT/EP1995/004451 WO1996016046A2 (en) 1994-11-24 1995-11-13 Novel benzyl pyrimidines

Publications (1)

Publication Number Publication Date
ATE235471T1 true ATE235471T1 (de) 2003-04-15

Family

ID=25691190

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95939267T ATE235471T1 (de) 1994-11-24 1995-11-13 Neue benzylpyrimidine

Country Status (21)

Country Link
US (1) US5763450A (de)
EP (1) EP0793656B1 (de)
JP (1) JP3117721B2 (de)
KR (1) KR100417508B1 (de)
CN (1) CN1136198C (de)
AT (1) ATE235471T1 (de)
AU (1) AU704911B2 (de)
BR (1) BR9509768A (de)
CA (1) CA2205406C (de)
CZ (1) CZ157597A3 (de)
DE (1) DE69530104T2 (de)
DK (1) DK0793656T3 (de)
ES (1) ES2193205T3 (de)
FI (1) FI972194A7 (de)
HU (1) HUT77372A (de)
MX (1) MX9703687A (de)
NO (1) NO308845B1 (de)
NZ (1) NZ296532A (de)
PL (1) PL320458A1 (de)
PT (1) PT793656E (de)
WO (1) WO1996016046A2 (de)

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TW438796B (en) * 1996-05-15 2001-06-07 Hoffmann La Roche 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same
WO1998039328A1 (de) * 1997-03-03 1998-09-11 F.Hoffmann-La Roche Ag Substituted 2,4-diaminopyrimidines
JP4174077B2 (ja) * 1997-03-03 2008-10-29 バジリア ファルマスーチカ アーゲー 置換2,4−ジアミノピリミジン
WO1999000359A1 (en) 1997-06-27 1999-01-07 Fujisawa Pharmaceutical Co., Ltd. Aromatic ring derivatives
US6893815B1 (en) * 1997-06-30 2005-05-17 Isis Pharmaceuticals, Inc. Nucleobase heterocyclic combinatorialization
JP4370002B2 (ja) * 1997-08-08 2009-11-25 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
EP1042295B1 (de) * 1997-12-22 2005-09-07 Pharmacia & Upjohn Company LLC 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
ATE342897T1 (de) * 1998-04-06 2006-11-15 Toyama Chemical Co Ltd Chinoloncarbonsäurederivate oder deren salze
DE60041763D1 (de) * 1999-04-23 2009-04-23 Vertex Pharma Inhibitoren von c-jun n-terminal kinasen (jnk)
CN1186328C (zh) 1999-11-04 2005-01-26 巴斯利尔药物股份公司 取代的5-苄基-2,4-二氨基嘧啶
US7612065B2 (en) 2000-04-21 2009-11-03 Vertex Pharmaceuticals Incorporated Inhibitors of c-JUN N-terminal kinases (JNK)
PE20011349A1 (es) 2000-06-16 2002-01-19 Upjohn Co 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales
HUP0301189A3 (en) 2000-07-24 2003-11-28 Bayer Cropscience Ag Pyrazolyl biphenyl carboxamides, intermediates, preparation and use thereof for controlling undesired microorganisms
AU2001278480A1 (en) * 2000-07-24 2002-02-05 Bayer Crop Science Ag Biphenyl carboxamides
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
MXPA04002537A (es) 2001-10-12 2004-05-31 Warner Lambert Co Alquinos como inhibidores de metaloproteinasa de matriz.
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
ES2252600T3 (es) * 2002-09-25 2006-05-16 Degussa Ag Metodo para producir acido 5-formil-2-furilboronico.
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
ES2612890T3 (es) * 2005-09-01 2017-05-19 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores de P2X3 y P2X2/3
US8268825B2 (en) 2005-09-26 2012-09-18 The Board Of Regents For Oklahoma State University Method for the treatment of anthrax infections
DK2343281T3 (en) * 2006-10-04 2014-03-24 Hoffmann La Roche Process for the Synthesis of Phenoxydiamino-Pyrimidine Derivatives
WO2008140895A1 (en) 2007-04-20 2008-11-20 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
US8853228B2 (en) * 2007-06-04 2014-10-07 University Of Connecticut Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase
CN103351390A (zh) * 2007-11-21 2013-10-16 解码遗传Ehf公司 用于治疗肺部和心血管病症的联芳基pde4 抑制剂
JP5305704B2 (ja) * 2008-03-24 2013-10-02 富士フイルム株式会社 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版
GB0815962D0 (en) * 2008-09-02 2008-10-08 Merlion Pharmaceuticals Pte Ltd Hybrid antibacterial compounds and their use
CA2742007C (en) 2008-10-29 2014-07-08 Deciphera Pharmaceuticals, Llc Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities
US9950062B2 (en) 2009-09-02 2018-04-24 Glaxosmithkline Biologicals Sa Compounds and compositions as TLR activity modulators
CN102040591B (zh) * 2009-10-15 2013-12-11 山东轩竹医药科技有限公司 7-苯基喹诺酮类化合物
JP2013538217A (ja) 2010-09-01 2013-10-10 ノバルティス アーゲー 不溶性金属塩への免疫増強物質の吸着
CN103533954B (zh) 2011-03-02 2015-09-09 诺华股份有限公司 含较低剂量的抗原和/或佐剂的联合疫苗
CA2866406A1 (en) 2012-03-08 2013-09-12 Novartis Ag Adjuvanted formulations of booster vaccines
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CN118903436A (zh) 2018-01-31 2024-11-08 德西费拉制药有限责任公司 治疗肥大细胞增多症的组合疗法
KR102708177B1 (ko) 2018-01-31 2024-09-23 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
IL330104A (en) 2019-03-11 2026-08-01 Deciphera Pharmaceuticals Llc Crystalline forms of rifatinib
HRP20260411T1 (hr) 2019-08-12 2026-05-08 Deciphera Pharmaceuticals, Llc Ripretinib za liječenje gastrointestinalnih stromalnih tumora
US12691108B2 (en) 2019-08-12 2026-07-28 Deciphera Pharmaceuticals, Llc Methods for treating vascular malformations
FI4084779T3 (fi) 2019-12-30 2024-12-16 Deciphera Pharmaceuticals Llc 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors
TW202448872A (zh) * 2023-05-25 2024-12-16 美商安銳生物醫藥公司 Egfr抑制劑及其使用方法
CN117285511B (zh) * 2023-09-21 2026-04-21 西南大学 吲哚杂化的喹诺酮类化合物及其制备方法和应用

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US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4039543A (en) * 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
WO1992008461A1 (en) * 1990-11-14 1992-05-29 Protos Corporation Specific inhibition of dihydrofolate reductase and compounds therefor
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV

Also Published As

Publication number Publication date
AU4116196A (en) 1996-06-17
NO972393D0 (no) 1997-05-26
CN1166831A (zh) 1997-12-03
WO1996016046A3 (en) 1996-07-25
AU704911B2 (en) 1999-05-06
PL320458A1 (en) 1997-09-29
DK0793656T3 (da) 2003-07-21
ES2193205T3 (es) 2003-11-01
MX9703687A (es) 1997-08-30
EP0793656B1 (de) 2003-03-26
CA2205406C (en) 2008-02-05
FI972194A0 (fi) 1997-05-22
KR100417508B1 (ko) 2004-03-18
PT793656E (pt) 2003-07-31
NZ296532A (en) 2000-02-28
CN1136198C (zh) 2004-01-28
DE69530104T2 (de) 2003-12-24
US5763450A (en) 1998-06-09
CA2205406A1 (en) 1996-05-30
NO308845B1 (no) 2000-11-06
CZ157597A3 (en) 1997-09-17
JPH11507009A (ja) 1999-06-22
EP0793656A1 (de) 1997-09-10
HUT77372A (hu) 1998-03-30
FI972194L (fi) 1997-05-22
NO972393L (no) 1997-05-29
WO1996016046A2 (en) 1996-05-30
FI972194A7 (fi) 1997-05-22
JP3117721B2 (ja) 2000-12-18
BR9509768A (pt) 1998-07-07
DE69530104D1 (de) 2003-04-30

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