DK0611767T3 - Heterocyclisk substituerede phenylcyclohexancarboxylsyrederivater som angiotension II-antagonister - Google Patents

Heterocyclisk substituerede phenylcyclohexancarboxylsyrederivater som angiotension II-antagonister

Info

Publication number: DK0611767T3
Authority: DK; Denmark
Prior art keywords: angiotension; antagonists; carboxylic acid; acid derivatives; heterocyclic substituted
Prior art date: 1993-02-15

Application number

DK94101543T

Other languages

English (en)

Inventor

Siegfried Dr Zaiss

Stefan Dr Wohlfeil

Andreas Dr Knorr

Juergen Dr Dressel

Peter Dr Fey

Walter Dr Huebsch

Thomas Dr Kraemer

Ulrich E Dr Mueller

Stanislav Prof Dr Kazda

Johannes-Peter Dr Stasch

Matthias Dr Mueller-Gliemann

Rudolf H Dr Hanko

Martin Dr Beuck

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-15

Filing date

1994-02-02

Publication date

2001-01-02

1994-02-02 Application filed by Bayer Ag filed Critical Bayer Ag

2001-01-02 Application granted granted Critical

2001-01-02 Publication of DK0611767T3 publication Critical patent/DK0611767T3/da

Links

QXXHHHWXFHPNOS-UHFFFAOYSA-N 1-phenylcyclohexane-1-carboxylic acid Chemical class C=1C=CC=CC=1C1(C(=O)O)CCCCC1 QXXHHHWXFHPNOS-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 title 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

DK94101543T 1993-02-15 1994-02-02 Heterocyclisk substituerede phenylcyclohexancarboxylsyrederivater som angiotension II-antagonister DK0611767T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4304455A DE4304455A1 (de)	1993-02-15	1993-02-15	Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate

Publications (1)

Publication Number	Publication Date
DK0611767T3 true DK0611767T3 (da)	2001-01-02

Family

ID=6480447

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94101543T DK0611767T3 (da)	1993-02-15	1994-02-02	Heterocyclisk substituerede phenylcyclohexancarboxylsyrederivater som angiotension II-antagonister

Country Status (25)

Country	Link
US (1)	US5395840A (da)
EP (1)	EP0611767B1 (da)
JP (1)	JPH06293741A (da)
KR (1)	KR940019708A (da)
CN (1)	CN1057085C (da)
AT (1)	ATE196141T1 (da)
AU (1)	AU672262B2 (da)
CA (1)	CA2115536C (da)
CZ (1)	CZ289096B6 (da)
DE (2)	DE4304455A1 (da)
DK (1)	DK0611767T3 (da)
ES (1)	ES2151908T3 (da)
FI (1)	FI106716B (da)
GR (1)	GR3034957T3 (da)
IL (1)	IL108625A (da)
MY (1)	MY131595A (da)
NO (1)	NO300810B1 (da)
NZ (1)	NZ250864A (da)
PH (1)	PH30172A (da)
PL (1)	PL177834B1 (da)
PT (1)	PT611767E (da)
RU (1)	RU2119480C1 (da)
SK (1)	SK15294A3 (da)
UA (1)	UA35574C2 (da)
ZA (1)	ZA94984B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW300219B (da) *	1991-09-14	1997-03-11	Hoechst Ag
HRP960015B1 (en) *	1995-02-01	2000-12-31	Bayer Ag	Substituted indole derivatives
DE19503160A1 (de) *	1995-02-01	1996-08-08	Bayer Ag	Verwendung von Phenylcyclohexylcarbonsäureamiden
DE19525028A1 (de) *	1995-07-10	1997-01-16	Bayer Ag	Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
JP2002507996A (ja)	1997-07-03	2002-03-12	デュポンファーマシューティカルズカンパニー	神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
US6124463A (en) *	1998-07-02	2000-09-26	Dupont Pharmaceuticals	Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en)	1998-07-02	2002-04-02	Bristol-Myers Squibb Pharma Company	Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
AU755694B2 (en) *	1998-11-17	2002-12-19	Basf Aktiengesellschaft	2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
DE19924819A1 (de) *	1999-05-29	2000-11-30	Bayer Ag	Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)
DE19924818A1 (de) *	1999-05-29	2000-11-30	Bayer Ag	Substituierte Phenylcyclohexancarbonsäureamide
DE10044792A1 (de)	2000-09-11	2002-04-04	Bayer Ag	Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
ES2443616T3 (es)	2006-05-09	2014-02-19	Mitsubishi Gas Chemical Company, Inc.	Procedimiento para la isomerización de alquilciclohexilbenceno
DK2442809T3 (da)	2009-06-17	2016-12-19	Vertex Pharma	Inhibitorer for replikation af influenzavirus
AU2011343642A1 (en)	2010-12-16	2013-05-02	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
MY157429A (en)	2011-06-24	2016-06-15	Amgen Inc	Trpm8 antagonists and their use in treatments
JP2014517074A (ja)	2011-06-24	2014-07-17	アムジエン・インコーポレーテツド	Ｔｒｐｍ８アンタゴニストおよび治療におけるそれらの使用
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
MD20140130A2 (ro)	2012-06-29	2015-04-30	Pfizer Inc.	4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2
US8952009B2 (en)	2012-08-06	2015-02-10	Amgen Inc.	Chroman derivatives as TRPM8 inhibitors
RS57541B1 (sr)	2013-11-13	2018-10-31	Vertex Pharma	Postupci za pripremu inhibitora replikacije virusa gripa
EP3068776B1 (en)	2013-11-13	2019-05-29	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
WO2015092592A1 (en)	2013-12-17	2015-06-25	Pfizer Inc.	Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
MA42422A (fr)	2015-05-13	2018-05-23	Vertex Pharma	Inhibiteurs de la réplication des virus de la grippe
JP6704416B2 (ja)	2015-05-13	2020-06-03	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	インフルエンザウイルスの複製の阻害剤を調製する方法
CN108137586B (zh)	2015-09-14	2021-04-13	辉瑞大药厂	作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物
US20250109363A1 (en) *	2022-03-08	2025-04-03	Kj Chemicals Corporation	Composition containing highly safe amide compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5138069A (en) *	1986-07-11	1992-08-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
IE64514B1 (en) *	1989-05-23	1995-08-09	Zeneca Ltd	Azaindenes
GB8911854D0 (en) *	1989-05-23	1989-07-12	Ici Plc	Heterocyclic compounds
US5164407A (en) *	1989-07-03	1992-11-17	Merck & Co., Inc.	Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
ES2121773T3 (es) *	1990-06-08	1998-12-16	Hoechst Marion Roussel Inc	Derivados de bencimidazol, su procedimiento de preparacion, productos intermedios, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
RU1836357C (ru) *	1990-07-23	1993-08-23	Др.Карл Томэ ГмбХ	Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (de) *	1990-08-10	1992-02-12	Dr. Karl Thomae GmbH	Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
DE4031635A1 (de) *	1990-10-05	1992-04-09	Thomae Gmbh Dr K	Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4224133A1 (de) *	1992-07-22	1994-01-27	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4200954A1 (de) *	1991-04-26	1992-10-29	Bayer Ag	Heterocyclisch substituierte phenylessigsaeurederivate

1993
- 1993-02-15 DE DE4304455A patent/DE4304455A1/de not_active Withdrawn
1994
- 1994-01-31 AU AU54807/94A patent/AU672262B2/en not_active Ceased
- 1994-02-02 ES ES94101543T patent/ES2151908T3/es not_active Expired - Lifetime
- 1994-02-02 DK DK94101543T patent/DK0611767T3/da active
- 1994-02-02 PT PT94101543T patent/PT611767E/pt unknown
- 1994-02-02 DE DE59409509T patent/DE59409509D1/de not_active Expired - Fee Related
- 1994-02-02 EP EP94101543A patent/EP0611767B1/de not_active Expired - Lifetime
- 1994-02-02 AT AT94101543T patent/ATE196141T1/de not_active IP Right Cessation
- 1994-02-08 US US08/193,835 patent/US5395840A/en not_active Expired - Fee Related
- 1994-02-09 SK SK152-94A patent/SK15294A3/sk unknown
- 1994-02-11 PL PL94302213A patent/PL177834B1/pl unknown
- 1994-02-11 NZ NZ250864A patent/NZ250864A/en unknown
- 1994-02-11 IL IL108625A patent/IL108625A/xx not_active IP Right Cessation
- 1994-02-11 CA CA002115536A patent/CA2115536C/en not_active Expired - Fee Related
- 1994-02-11 UA UA94005092A patent/UA35574C2/uk unknown
- 1994-02-11 FI FI940659A patent/FI106716B/fi active
- 1994-02-14 ZA ZA94984A patent/ZA94984B/xx unknown
- 1994-02-14 PH PH47762A patent/PH30172A/en unknown
- 1994-02-14 JP JP6037543A patent/JPH06293741A/ja active Pending
- 1994-02-14 MY MYPI94000321A patent/MY131595A/en unknown
- 1994-02-14 RU RU94004975A patent/RU2119480C1/ru active
- 1994-02-14 KR KR1019940002533A patent/KR940019708A/ko not_active Abandoned
- 1994-02-14 NO NO940506A patent/NO300810B1/no not_active IP Right Cessation
- 1994-02-15 CZ CZ1994329A patent/CZ289096B6/cs not_active IP Right Cessation
- 1994-02-15 CN CN94101553A patent/CN1057085C/zh not_active Expired - Fee Related
2000
- 2000-11-30 GR GR20000402660T patent/GR3034957T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI106716B (fi)	2001-03-30
NO940506D0 (no)	1994-02-14
ZA94984B (en)	1994-08-24
CA2115536C (en)	2004-11-02
IL108625A0 (en)	1994-05-30
RU2119480C1 (ru)	1998-09-27
ATE196141T1 (de)	2000-09-15
CZ32994A3 (en)	1994-08-17
NO940506L (da)	1994-08-16
DE59409509D1 (de)	2000-10-12
NZ250864A (en)	1995-03-28
CZ289096B6 (cs)	2001-11-14
US5395840A (en)	1995-03-07
CA2115536A1 (en)	1994-08-16
CN1108257A (zh)	1995-09-13
PH30172A (en)	1997-01-21
PL302213A1 (en)	1994-08-22
EP0611767A1 (de)	1994-08-24
EP0611767B1 (de)	2000-09-06
FI940659A0 (fi)	1994-02-11
JPH06293741A (ja)	1994-10-21
NO300810B1 (no)	1997-07-28
PT611767E (pt)	2001-02-28
GR3034957T3 (en)	2001-02-28
ES2151908T3 (es)	2001-01-16
CN1057085C (zh)	2000-10-04
AU672262B2 (en)	1996-09-26
FI940659A7 (fi)	1994-08-16
PL177834B1 (pl)	2000-01-31
UA35574C2 (uk)	2001-04-16
SK15294A3 (en)	1994-12-07
IL108625A (en)	1997-09-30
KR940019708A (ko)	1994-09-14
MY131595A (en)	2007-08-30
DE4304455A1 (de)	1994-08-18
AU5480794A (en)	1994-08-18

Publication	Publication Date	Title
NO940506D0 (no)	1994-02-14	Heterocykliske, substituerte fenyl-cykloheksan-karboksylsyrederivater
NO2004009I1 (no)	2004-12-20	Melagatran, stereoisomerer derav eller fysiologisksalter eller estrer derav
GR3023635T3 (en)	1997-08-29	Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments.
TR199500826A2 (tr)	1996-06-21	Multipl ünite tablet doz formu 2.
DE59407431D1 (de)	1999-01-21	Verwendung aromatischer Carbonsäurederivate zur Herstellung von pharmazeutischen Präparaten
ATE308322T1 (de)	2005-11-15	Arzneimittel zur behandlung der herzinsuffizienz
HU901617D0 (en)	1990-06-28	Herbicide compositions containing {[(1,3,5-triazin-2-yl)-amino-carbonyl]-amino-sulfonyl}-benzoic acid esters and process for the preparation of the active ingredients
AU2443888A (en)	1989-05-04	Agents for treating high blood pressure and cardiac insufficiency
DE3778642D1 (de)	1992-06-04	Therapeutikum zur behandlung von magengeschwueren.
ES2117114T3 (es)	1998-08-01	Nuevos derivados de tiaxolidin-diona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DE58907390D1 (de)	1994-05-11	Sulfonamide mit Tetrazolylrest, Verfahren zu ihrer Herstellung sowie Arzneimittel.
IL129088A0 (en)	2000-02-17	Subepithelial turbidity inhibitor