ATE235556T1 - Schimmel-protease - Google Patents

Schimmel-protease

Info

Publication number: ATE235556T1
Authority: AT; Austria
Prior art keywords: protease; aspergillus; preparation; mutant strain; aspartic
Prior art date: 1993-11-03

Application number

AT94810616T

Other languages

English (en)

Inventor

Frank Buxton

Gabor Jarai

Jacob Visser

Original Assignee

Novartis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-03

Filing date

1994-10-25

Publication date

2003-04-15

1994-10-25 Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE235556T1 publication Critical patent/ATE235556T1/de

Links

108091005804 Peptidases Proteins 0.000 title abstract 2
239000004365 Protease Substances 0.000 title abstract 2
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
241000228212 Aspergillus Species 0.000 abstract 3
102000035101 Aspartic proteases Human genes 0.000 abstract 2
108091005502 Aspartic proteases Proteins 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
230000002950 deficient Effects 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Detergent Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94810616T 1993-11-03 1994-10-25 Schimmel-protease ATE235556T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP93810764		1993-11-03

Publications (1)

Publication Number	Publication Date
ATE235556T1 true ATE235556T1 (de)	2003-04-15

Family

ID=8215057

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94810616T ATE235556T1 (de)	1993-11-03	1994-10-25	Schimmel-protease

Country Status (18)

Country	Link
US (2)	US5674728A (de)
EP (1)	EP0655497B1 (de)
JP (1)	JP3727678B2 (de)
KR (1)	KR100378507B1 (de)
AT (1)	ATE235556T1 (de)
AU (1)	AU688379B2 (de)
CA (1)	CA2134863C (de)
CY (1)	CY2471B1 (de)
DE (1)	DE69432336T2 (de)
DK (1)	DK0655497T3 (de)
ES (1)	ES2196019T3 (de)
FI (1)	FI119060B (de)
HU (1)	HU220360B (de)
IL (2)	IL168245A (de)
NO (1)	NO315330B1 (de)
NZ (1)	NZ264839A (de)
PT (1)	PT655497E (de)
ZA (1)	ZA948619B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1092297A (en) *	1995-12-07	1997-06-27	Novo Nordisk A/S	Selective inactivation of enzyme activities
AU1092897A (en) *	1995-12-15	1997-07-14	Novo Nordisk A/S	A funguns wherein the area, pepc and/or pepe genes have been inactivated
EP0907744A1 (de) *	1996-06-05	1999-04-14	Gist-Brocades B.V.	Pilzmetalloproteasegene
EP0956338B1 (de) *	1996-09-19	2005-12-21	Novozymes A/S	Wirtszellen und methoden für die produktion von proteinen
AU2006202723B2 (en) *	2001-02-23	2008-06-26	Dsm Ip Assets B.V.	Novel genes encoding novel proteolytic enzymes
AU2002308306B2 (en) *	2001-02-23	2007-03-01	Dsm Ip Assets B.V.	Genes encoding proteolytic enzymes from aspargilli
KR100880087B1 (ko) *	2001-02-23	2009-01-23	디에스엠 아이피 어셋츠 비.브이.	신규 단백질 분해효소를 암호화하는 신규 유전자
US20090253173A1 (en) *	2008-04-08	2009-10-08	Danisco Us Inc., Genencor Division	Filamentous fungi with inactivated protease genes for altered protein production
FI121712B (fi) *	2009-04-30	2011-03-15	Ab Enzymes Oy	Uusi sieniperäinen proteaasi ja sen käyttö
RU2645252C2 (ru)	2012-01-05	2018-02-19	Глюкос Финланд Ой	Клетка нитчатых грибов с дефицитом протеаз и способы ее применения
EP2852610B1 (de)	2012-05-23	2018-07-11	Glykos Finland Oy	Herstellung von fucosylierten glykoproteinen
SG11201600115SA (en)	2013-07-10	2016-02-26	Novartis Ag	Multiple proteases deficient filamentous fungal cells and methods of use thereof
SG11201700446XA (en)	2014-07-21	2017-02-27	Glykos Finland Oy	Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
CN106222096B (zh) *	2016-08-18	2018-02-23	滨州学院	一株塔宾曲霉菌ct1及其在盐碱地解磷方面的应用
CN121022803B (zh) *	2025-10-29	2026-01-09	内蒙古科为博生物科技有限公司	一种耐热性提高的酸性蛋白酶突变体PepA4及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8415186D0 (en) *	1984-06-14	1984-07-18	Ciba Geigy Ag	Polypeptides
US4885249A (en) *	1984-12-05	1989-12-05	Allelix, Inc.	Aspergillus niger transformation system
GB8521496D0 (en) *	1985-08-29	1985-10-02	Ciba Geigy Ag	Repressible yeast promoters
GB8702475D0 (en) *	1987-02-04	1987-03-11	Ciba Geigy Ag	Expression system
AU1572588A (en) *	1987-03-12	1988-10-10	Genex Corp.	Production of bioadhesive precursor protein analogs by genetically-engineered organisms
US4871824A (en) *	1987-03-13	1989-10-03	Minnesota Mining And Manufacturing Company	Variably crosslinked polymeric supports
US5252726A (en) *	1987-09-04	1993-10-12	Novo Nordisk A/S	Promoters for use in aspergillus
CA1333777C (en) *	1988-07-01	1995-01-03	Randy M. Berka	Aspartic proteinase deficient filamentous fungi
ES2063162T5 (es) *	1988-07-28	2002-11-16	Novartis Ag	Nuevo sistema de expresion.
EP0421919A3 (en) *	1989-09-02	1992-04-15	Ciba-Geigy Ag	Polygalacturonase encoding fungal expression system
IE68457B1 (en) *	1990-01-29	1996-06-26	Ciba Geigy Ag	Novel fungal expression system
ATE220105T1 (de) *	1991-04-01	2002-07-15	Merck & Co Inc	Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung
DK47493D0 (da) *	1993-04-27	1993-04-27	Novo Nordisk As	Fremgangsmaade til fremstilling af ost

1994
- 1994-10-24 US US08/328,314 patent/US5674728A/en not_active Expired - Lifetime
- 1994-10-25 ES ES94810616T patent/ES2196019T3/es not_active Expired - Lifetime
- 1994-10-25 AT AT94810616T patent/ATE235556T1/de active
- 1994-10-25 DE DE69432336T patent/DE69432336T2/de not_active Expired - Lifetime
- 1994-10-25 PT PT94810616T patent/PT655497E/pt unknown
- 1994-10-25 EP EP94810616A patent/EP0655497B1/de not_active Expired - Lifetime
- 1994-10-25 DK DK94810616T patent/DK0655497T3/da active
- 1994-10-27 AU AU77514/94A patent/AU688379B2/en not_active Expired
- 1994-10-31 JP JP26757094A patent/JP3727678B2/ja not_active Expired - Lifetime
- 1994-11-01 IL IL168245A patent/IL168245A/en not_active IP Right Cessation
- 1994-11-01 IL IL11148294A patent/IL111482A/xx not_active IP Right Cessation
- 1994-11-01 NZ NZ264839A patent/NZ264839A/en not_active IP Right Cessation
- 1994-11-01 CA CA002134863A patent/CA2134863C/en not_active Expired - Lifetime
- 1994-11-01 HU HU9403136A patent/HU220360B/hu unknown
- 1994-11-02 FI FI945163A patent/FI119060B/fi not_active IP Right Cessation
- 1994-11-02 KR KR1019940028594A patent/KR100378507B1/ko not_active Expired - Lifetime
- 1994-11-02 ZA ZA948619A patent/ZA948619B/xx unknown
- 1994-11-02 NO NO19944181A patent/NO315330B1/no not_active IP Right Cessation
1996
- 1996-10-08 US US08/731,045 patent/US5756338A/en not_active Expired - Lifetime
2004
- 2004-08-10 CY CY0400062A patent/CY2471B1/xx unknown

Also Published As

Publication number	Publication date
PT655497E (pt)	2003-07-31
CA2134863C (en)	2008-12-30
EP0655497A3 (de)	1997-05-07
FI945163L (fi)	1995-05-04
AU688379B2 (en)	1998-03-12
FI945163A0 (fi)	1994-11-02
IL168245A (en)	2009-12-24
DK0655497T3 (da)	2003-07-21
KR100378507B1 (ko)	2003-09-19
NZ264839A (en)	1996-03-26
NO944181L (no)	1995-05-04
IL111482A (en)	2005-08-31
CY2471B1 (en)	2005-06-03
IL111482A0 (en)	1995-01-24
DE69432336D1 (de)	2003-04-30
ZA948619B (en)	1995-06-27
DE69432336T2 (de)	2003-12-04
NO944181D0 (no)	1994-11-02
NO315330B1 (no)	2003-08-18
HU220360B (hu)	2001-12-28
CA2134863A1 (en)	1995-05-04
EP0655497B1 (de)	2003-03-26
HU9403136D0 (en)	1994-12-28
US5756338A (en)	1998-05-26
AU7751494A (en)	1995-05-18
EP0655497A2 (de)	1995-05-31
HUT69954A (en)	1995-09-28
KR950014309A (ko)	1995-06-15
US5674728A (en)	1997-10-07
FI119060B (fi)	2008-07-15
JPH07213286A (ja)	1995-08-15
JP3727678B2 (ja)	2005-12-14
ES2196019T3 (es)	2003-12-16

Legal Events

Date

Code

Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

Ref document number: 0655497

Country of ref document: EP

Publication	Publication Date	Title
ATE235556T1 (de)	2003-04-15	Schimmel-protease
FI931634A0 (fi)	1993-04-08	Nytt svampproteas
DE68923123D1 (de)	1995-07-27	Herstellung von Proteinen.
IL104075A (en)	2003-01-12	Process for the preparation of a heterologous protein cleaved off a pro-sequence in a eukaryotic host cell
DE69028890D1 (de)	1996-11-21	Ergiebige Herstellung von Protease-Mutanten
EP0606917A3 (de)	1995-07-19	Ein Methylo- und glucotropischer Mutantstamm zur Herstellung von heterologem Protein.
HUT63654A (en)	1993-09-28	Process for producing recombinant iga proteases
ATE78870T1 (de)	1992-08-15	Verfahren zur herstellung von neutraler protease.
ATE52805T1 (de)	1990-06-15	Psm112-plasmidvektor zur expression in bacillus subtilis.
ATE107694T1 (de)	1994-07-15	Für a.nidulans-isopenicillin-n-synthetase codierende dns, deren verwendung und dafür codierende vektoren.