DK0655497T3 - Svampeprotease - Google Patents

Svampeprotease

Info

Publication number
DK0655497T3
DK0655497T3 DK94810616T DK94810616T DK0655497T3 DK 0655497 T3 DK0655497 T3 DK 0655497T3 DK 94810616 T DK94810616 T DK 94810616T DK 94810616 T DK94810616 T DK 94810616T DK 0655497 T3 DK0655497 T3 DK 0655497T3
Authority
DK
Denmark
Prior art keywords
aspergillus
protease
preparation
mutant strain
aspartic
Prior art date
Application number
DK94810616T
Other languages
English (en)
Inventor
Gabor Jarai
Frank Buxton
Jacob Visser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0655497T3 publication Critical patent/DK0655497T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK94810616T 1993-11-03 1994-10-25 Svampeprotease DK0655497T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810764 1993-11-03

Publications (1)

Publication Number Publication Date
DK0655497T3 true DK0655497T3 (da) 2003-07-21

Family

ID=8215057

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94810616T DK0655497T3 (da) 1993-11-03 1994-10-25 Svampeprotease

Country Status (18)

Country Link
US (2) US5674728A (da)
EP (1) EP0655497B1 (da)
JP (1) JP3727678B2 (da)
KR (1) KR100378507B1 (da)
AT (1) ATE235556T1 (da)
AU (1) AU688379B2 (da)
CA (1) CA2134863C (da)
CY (1) CY2471B1 (da)
DE (1) DE69432336T2 (da)
DK (1) DK0655497T3 (da)
ES (1) ES2196019T3 (da)
FI (1) FI119060B (da)
HU (1) HU220360B (da)
IL (2) IL111482A (da)
NO (1) NO315330B1 (da)
NZ (1) NZ264839A (da)
PT (1) PT655497E (da)
ZA (1) ZA948619B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1203627A (zh) * 1995-12-07 1998-12-30 诺沃挪第克公司 酶活性的选择性灭活
JP2000501620A (ja) * 1995-12-15 2000-02-15 ノボ ノルディスク アクティーゼルスカブ ａｒｅＡ，ｐｅｐＣ及び／又はｐｅｐＥ遺伝子が不活性化されている菌類
EP0907744A1 (en) * 1996-06-05 1999-04-14 Gist-Brocades B.V. Fungal metallo protease genes
DK0956338T3 (da) * 1996-09-19 2006-05-08 Novozymes As Værtsceller og fremgangsmåder til produktion af proteiner
WO2002068623A2 (en) * 2001-02-23 2002-09-06 Dsm Ip Assets B.V. Genes encoding proteolytic enzymes from aspargilli
AU2006202723B2 (en) * 2001-02-23 2008-06-26 Dsm Ip Assets B.V. Novel genes encoding novel proteolytic enzymes
KR100880087B1 (ko) * 2001-02-23 2009-01-23 디에스엠 아이피 어셋츠 비.브이. 신규 단백질 분해효소를 암호화하는 신규 유전자
US20090253173A1 (en) * 2008-04-08 2009-10-08 Danisco Us Inc., Genencor Division Filamentous fungi with inactivated protease genes for altered protein production
FI121712B (fi) * 2009-04-30 2011-03-15 Ab Enzymes Oy Uusi sieniperäinen proteaasi ja sen käyttö
DK2800809T3 (da) 2012-01-05 2018-05-22 Glykos Finland Oy Protease-defekte filamentøse svampeceller og fremgangsmåder til anvendelse deraf
WO2013174927A1 (en) 2012-05-23 2013-11-28 Novartis International Pharmaceutical Limited Production of fucosylated glycoproteins
US10435731B2 (en) 2013-07-10 2019-10-08 Glykos Finland Oy Multiple proteases deficient filamentous fungal cells and methods of use thereof
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
CN106222096B (zh) * 2016-08-18 2018-02-23 滨州学院 一株塔宾曲霉菌ct1及其在盐碱地解磷方面的应用
CN121022803B (zh) * 2025-10-29 2026-01-09 内蒙古科为博生物科技有限公司 一种耐热性提高的酸性蛋白酶突变体PepA4及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8415186D0 (en) * 1984-06-14 1984-07-18 Ciba Geigy Ag Polypeptides
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
GB8521496D0 (en) * 1985-08-29 1985-10-02 Ciba Geigy Ag Repressible yeast promoters
GB8702475D0 (en) * 1987-02-04 1987-03-11 Ciba Geigy Ag Expression system
JPH02500082A (ja) * 1987-03-12 1990-01-18 ジェネックス・コーポレーション 遺伝子操作された生物による生物粘着物質前駆体タンパク質類似体の生産
US4871824A (en) * 1987-03-13 1989-10-03 Minnesota Mining And Manufacturing Company Variably crosslinked polymeric supports
US5252726A (en) * 1987-09-04 1993-10-12 Novo Nordisk A/S Promoters for use in aspergillus
CA1333777C (en) * 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
DE68913846T3 (de) * 1988-07-28 2002-10-02 Novartis Ag, Basel Expressionssystem.
EP0421919A3 (en) * 1989-09-02 1992-04-15 Ciba-Geigy Ag Polygalacturonase encoding fungal expression system
ZA909987B (en) * 1990-01-29 1991-09-25 Ciba Geigy Novel fungal expression system
ATE220105T1 (de) * 1991-04-01 2002-07-15 Merck & Co Inc Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung
DK47493D0 (da) * 1993-04-27 1993-04-27 Novo Nordisk As Fremgangsmaade til fremstilling af ost

Also Published As

Publication number Publication date
KR950014309A (ko) 1995-06-15
IL111482A0 (en) 1995-01-24
PT655497E (pt) 2003-07-31
EP0655497A2 (en) 1995-05-31
AU688379B2 (en) 1998-03-12
ZA948619B (en) 1995-06-27
KR100378507B1 (ko) 2003-09-19
NO944181L (no) 1995-05-04
US5674728A (en) 1997-10-07
JPH07213286A (ja) 1995-08-15
NZ264839A (en) 1996-03-26
HU220360B (hu) 2001-12-28
HUT69954A (en) 1995-09-28
NO944181D0 (no) 1994-11-02
NO315330B1 (no) 2003-08-18
JP3727678B2 (ja) 2005-12-14
AU7751494A (en) 1995-05-18
EP0655497A3 (en) 1997-05-07
HU9403136D0 (en) 1994-12-28
ES2196019T3 (es) 2003-12-16
FI945163L (fi) 1995-05-04
EP0655497B1 (en) 2003-03-26
FI945163A0 (fi) 1994-11-02
DE69432336T2 (de) 2003-12-04
IL111482A (en) 2005-08-31
CA2134863C (en) 2008-12-30
DE69432336D1 (de) 2003-04-30
ATE235556T1 (de) 2003-04-15
CY2471B1 (en) 2005-06-03
IL168245A (en) 2009-12-24
CA2134863A1 (en) 1995-05-04
FI119060B (fi) 2008-07-15
US5756338A (en) 1998-05-26

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