ATE236123T1 - Thermodynamisch stabile modifizierung von 1-(4- carbazolyloxy)-3- (2-(2- methoxyphenoxy)ethylamino)-2-propanol, verfahren zu ihrer herstellung und ihre enthaltende pharmazeutische zusammensetzungen - Google Patents
Thermodynamisch stabile modifizierung von 1-(4- carbazolyloxy)-3- (2-(2- methoxyphenoxy)ethylamino)-2-propanol, verfahren zu ihrer herstellung und ihre enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- ATE236123T1 ATE236123T1 AT98937576T AT98937576T ATE236123T1 AT E236123 T1 ATE236123 T1 AT E236123T1 AT 98937576 T AT98937576 T AT 98937576T AT 98937576 T AT98937576 T AT 98937576T AT E236123 T1 ATE236123 T1 AT E236123T1
- Authority
- AT
- Austria
- Prior art keywords
- carbazolyloxy
- methoxyphenoxy
- ethylamino
- propanol
- production
- Prior art date
Links
- OGHNVEJMJSYVRP-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2 OGHNVEJMJSYVRP-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97112491A EP0893440A1 (de) | 1997-07-22 | 1997-07-22 | Eine thermodynamisch stabile Modifikation von 1-(4-Carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]- 2-propanole, Verfahren zu ihrer Herstellung und ihre enthaltende Arznemittel |
| PCT/EP1998/004475 WO1999005105A1 (en) | 1997-07-22 | 1998-07-18 | Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236123T1 true ATE236123T1 (de) | 2003-04-15 |
Family
ID=8227094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98937576T ATE236123T1 (de) | 1997-07-22 | 1998-07-18 | Thermodynamisch stabile modifizierung von 1-(4- carbazolyloxy)-3- (2-(2- methoxyphenoxy)ethylamino)-2-propanol, verfahren zu ihrer herstellung und ihre enthaltende pharmazeutische zusammensetzungen |
Country Status (31)
| Country | Link |
|---|---|
| EP (2) | EP0893440A1 (de) |
| JP (1) | JP2001510824A (de) |
| KR (1) | KR100336229B1 (de) |
| CN (1) | CN1125047C (de) |
| AR (1) | AR015133A1 (de) |
| AT (1) | ATE236123T1 (de) |
| AU (1) | AU740453B2 (de) |
| BR (1) | BR9810776A (de) |
| CA (1) | CA2296637C (de) |
| CZ (1) | CZ296947B6 (de) |
| DE (1) | DE69812964T2 (de) |
| DK (1) | DK1000027T3 (de) |
| ES (1) | ES2195366T3 (de) |
| HR (1) | HRP980406A2 (de) |
| HU (1) | HUP0003198A3 (de) |
| IL (1) | IL133677A (de) |
| MA (1) | MA26523A1 (de) |
| MY (1) | MY117734A (de) |
| NO (1) | NO313588B1 (de) |
| NZ (1) | NZ502136A (de) |
| PE (1) | PE96999A1 (de) |
| PL (1) | PL191602B1 (de) |
| PT (1) | PT1000027E (de) |
| RU (1) | RU2202542C2 (de) |
| SI (1) | SI1000027T1 (de) |
| TR (1) | TR200000148T2 (de) |
| TW (1) | TW505631B (de) |
| UY (1) | UY25108A1 (de) |
| WO (1) | WO1999005105A1 (de) |
| YU (1) | YU2200A (de) |
| ZA (1) | ZA986475B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001074356A1 (en) * | 2000-04-03 | 2001-10-11 | F. Hoffmann-La Roche Ag | Concentrated solutions of carvedilol |
| CA2413702A1 (en) | 2000-06-28 | 2002-01-03 | Teva Pharmaceuticals Industries Ltd. | Carvedilol |
| EP1655285A1 (de) * | 2000-06-28 | 2006-05-10 | Teva Pharmaceutical Industries Ltd. | Verfahren zur Herstellung einer kristallinen Form von Carvedilol (Form II) |
| WO2003005970A2 (en) * | 2001-07-13 | 2003-01-23 | Smithkline Beecham Corporation | Carvedilol polymorph |
| US20050019399A1 (en) | 2001-09-21 | 2005-01-27 | Gina Fischer | Controlled release solid dispersions |
| PL370412A1 (en) * | 2001-09-28 | 2005-05-30 | F.Hoffmann-La Roche Ag | Pseudopolymorphic forms of carvedilol |
| US6710184B2 (en) * | 2002-01-15 | 2004-03-23 | Teva Pharmaceutical Industries Ltd. | Crystalline solids of carvedilol and processes for their preparation |
| JP2006500320A (ja) * | 2002-04-30 | 2006-01-05 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール一クエン酸塩一水和物 |
| CA2492084A1 (en) * | 2002-06-27 | 2004-01-08 | Sb Pharmco Puerto Rico Inc. | Carvedilol hydobromide |
| BR0312102A (pt) | 2002-06-27 | 2007-05-29 | Sb Pharmco Inc | sais de fosfato de carvedilol e/ou seus solvatos, composições correspondentes, e/ou métodos de tratamento |
| WO2004041252A1 (en) * | 2002-11-08 | 2004-05-21 | Egalet A/S | Controlled release carvedilol compositions |
| US8877241B2 (en) | 2003-03-26 | 2014-11-04 | Egalet Ltd. | Morphine controlled release system |
| WO2004094378A1 (en) * | 2003-04-21 | 2004-11-04 | Matrix Laboratories Ltd | Process for the preparation of carvedilol form-ii |
| SI21616A (sl) * | 2003-09-02 | 2005-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove kristalne oblike karvedilola |
| JP2007512372A (ja) * | 2003-11-25 | 2007-05-17 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール塩、対応する組成物、送達および/または治療方法 |
| CA2589699A1 (en) * | 2004-12-09 | 2006-06-15 | Zach System S.P.A. | Process for the preparation of carvedilol and its enantiomers |
| EP1781611A1 (de) * | 2005-06-09 | 2007-05-09 | Teva Pharmaceutical Industries Ltd. | Kristalline formen des carvediols und verfahren zu ihrer herstellung |
| WO2008002683A2 (en) | 2006-06-28 | 2008-01-03 | Teva Pharmaceutical Industries Ltd. | Polymorphous forms of carvedilol phosphate |
| RU2366653C2 (ru) * | 2006-07-03 | 2009-09-10 | Ооо "Нанокриохимия" | Способ получения рентгеноаморфной модификации карведилола |
| US20080249317A1 (en) * | 2007-04-04 | 2008-10-09 | Apotex Inc. | Novel amorphous form of carvedilol phosphate and processes for the preparation thereof |
| US8821928B2 (en) | 2007-06-04 | 2014-09-02 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
| NZ594207A (en) | 2009-02-06 | 2013-03-28 | Egalet Ltd | Immediate release composition resistant to abuse by intake of alcohol |
| AU2010265213B2 (en) | 2009-06-24 | 2012-08-23 | Egalet Ltd. | Controlled release formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE2805404A1 (de) * | 1978-02-09 | 1979-08-16 | Merck Patent Gmbh | 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung |
| DE3319027A1 (de) * | 1983-05-26 | 1984-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
-
1997
- 1997-07-22 EP EP97112491A patent/EP0893440A1/de not_active Withdrawn
-
1998
- 1998-07-15 MY MYPI98003245A patent/MY117734A/en unknown
- 1998-07-15 PE PE1998000626A patent/PE96999A1/es not_active Application Discontinuation
- 1998-07-18 AU AU86319/98A patent/AU740453B2/en not_active Ceased
- 1998-07-18 ES ES98937576T patent/ES2195366T3/es not_active Expired - Lifetime
- 1998-07-18 JP JP2000504104A patent/JP2001510824A/ja active Pending
- 1998-07-18 WO PCT/EP1998/004475 patent/WO1999005105A1/en not_active Ceased
- 1998-07-18 TR TR2000/00148T patent/TR200000148T2/xx unknown
- 1998-07-18 AT AT98937576T patent/ATE236123T1/de not_active IP Right Cessation
- 1998-07-18 CZ CZ20000221A patent/CZ296947B6/cs not_active IP Right Cessation
- 1998-07-18 SI SI9830442T patent/SI1000027T1/xx unknown
- 1998-07-18 CN CN98807436A patent/CN1125047C/zh not_active Expired - Fee Related
- 1998-07-18 NZ NZ502136A patent/NZ502136A/en unknown
- 1998-07-18 PL PL338432A patent/PL191602B1/pl unknown
- 1998-07-18 YU YU2200A patent/YU2200A/sh unknown
- 1998-07-18 CA CA002296637A patent/CA2296637C/en not_active Expired - Fee Related
- 1998-07-18 DK DK98937576T patent/DK1000027T3/da active
- 1998-07-18 TW TW087111738A patent/TW505631B/zh not_active IP Right Cessation
- 1998-07-18 IL IL13367798A patent/IL133677A/en not_active IP Right Cessation
- 1998-07-18 KR KR1020007000667A patent/KR100336229B1/ko not_active Expired - Fee Related
- 1998-07-18 RU RU2000103033/04A patent/RU2202542C2/ru not_active IP Right Cessation
- 1998-07-18 HU HU0003198A patent/HUP0003198A3/hu unknown
- 1998-07-18 BR BR9810776-3A patent/BR9810776A/pt not_active Application Discontinuation
- 1998-07-18 DE DE69812964T patent/DE69812964T2/de not_active Expired - Fee Related
- 1998-07-18 EP EP98937576A patent/EP1000027B1/de not_active Expired - Lifetime
- 1998-07-18 PT PT98937576T patent/PT1000027E/pt unknown
- 1998-07-20 MA MA25178A patent/MA26523A1/fr unknown
- 1998-07-21 AR ARP980103547A patent/AR015133A1/es unknown
- 1998-07-21 ZA ZA9806475A patent/ZA986475B/xx unknown
- 1998-07-22 UY UY25108A patent/UY25108A1/es not_active IP Right Cessation
- 1998-07-22 HR HR97112491.2A patent/HRP980406A2/hr not_active Application Discontinuation
-
2000
- 2000-01-21 NO NO20000301A patent/NO313588B1/no unknown
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| UEP | Publication of translation of european patent specification |
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| REN | Ceased due to non-payment of the annual fee |