NO20000301L - Termodynamisk stabil modifikasjon av 1-(4-karbazolyloksy)-3- [2-(2-metoksyfenoksy)etylamino]-2-propanol, fremgangsmåte for fremstilling derav og farmasøytiske blandinger som inneholder den - Google Patents

Termodynamisk stabil modifikasjon av 1-(4-karbazolyloksy)-3- [2-(2-metoksyfenoksy)etylamino]-2-propanol, fremgangsmåte for fremstilling derav og farmasøytiske blandinger som inneholder den

Info

Publication number: NO20000301L
Authority: NO; Norway
Prior art keywords: carbazolyloxy; methoxyphenoxy; ethylamino; propanol; preparation
Prior art date: 1997-07-22

Application number

NO20000301A

Other languages

English (en)

Other versions

NO20000301D0 (no

NO313588B1 (no

Inventor

Erhard Reinholz

Peter Beyer

Original Assignee

Roche Diagnostics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-22

Filing date

2000-01-21

Publication date

2000-01-21

2000-01-21 Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh

2000-01-21 Publication of NO20000301L publication Critical patent/NO20000301L/no

2000-01-21 Publication of NO20000301D0 publication Critical patent/NO20000301D0/no

2002-10-28 Publication of NO313588B1 publication Critical patent/NO313588B1/no

Links

OGHNVEJMJSYVRP-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2 OGHNVEJMJSYVRP-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
230000004048 modification Effects 0.000 title 1
238000012986 modification Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

NO20000301A 1997-07-22 2000-01-21 Termodynamisk stabil modifikasjon av 1-(4-karbazolyloksy)-3- [2-(2-metoksyfenoksy)etylamino]-2-propanol, fremgangsmåte forfremstilling derav og farmasöytiske blandinger som inneholder den NO313588B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97112491A EP0893440A1 (en)	1997-07-22	1997-07-22	Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
PCT/EP1998/004475 WO1999005105A1 (en)	1997-07-22	1998-07-18	Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it

Publications (3)

Publication Number	Publication Date
NO20000301L true NO20000301L (no)	2000-01-21
NO20000301D0 NO20000301D0 (no)	2000-01-21
NO313588B1 NO313588B1 (no)	2002-10-28

Family

ID=8227094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20000301A NO313588B1 (no)	1997-07-22	2000-01-21	Termodynamisk stabil modifikasjon av 1-(4-karbazolyloksy)-3- [2-(2-metoksyfenoksy)etylamino]-2-propanol, fremgangsmåte forfremstilling derav og farmasöytiske blandinger som inneholder den

Country Status (31)

Country	Link
EP (2)	EP0893440A1 (no)
JP (1)	JP2001510824A (no)
KR (1)	KR100336229B1 (no)
CN (1)	CN1125047C (no)
AR (1)	AR015133A1 (no)
AT (1)	ATE236123T1 (no)
AU (1)	AU740453B2 (no)
BR (1)	BR9810776A (no)
CA (1)	CA2296637C (no)
CZ (1)	CZ296947B6 (no)
DE (1)	DE69812964T2 (no)
DK (1)	DK1000027T3 (no)
ES (1)	ES2195366T3 (no)
HR (1)	HRP980406A2 (no)
HU (1)	HUP0003198A3 (no)
IL (1)	IL133677A (no)
MA (1)	MA26523A1 (no)
MY (1)	MY117734A (no)
NO (1)	NO313588B1 (no)
NZ (1)	NZ502136A (no)
PE (1)	PE96999A1 (no)
PL (1)	PL191602B1 (no)
PT (1)	PT1000027E (no)
RU (1)	RU2202542C2 (no)
SI (1)	SI1000027T1 (no)
TR (1)	TR200000148T2 (no)
TW (1)	TW505631B (no)
UY (1)	UY25108A1 (no)
WO (1)	WO1999005105A1 (no)
YU (1)	YU2200A (no)
ZA (1)	ZA986475B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003528914A (ja) *	2000-04-03	2003-09-30	エフ．ホフマン−ラロシュアーゲー	カルベジロールの濃縮溶液
EP1655285A1 (en) *	2000-06-28	2006-05-10	Teva Pharmaceutical Industries Ltd.	Method for preparation of a crystalline form of carvedilol (form II)
JP2004501191A (ja)	2000-06-28	2004-01-15	テバ　ファーマシューティカル　インダストリーズ　リミティド	カルベジロール
AU2002326391A1 (en) *	2001-07-13	2003-01-29	Smithkline Beecham Corporation	Carvedilol polymorph
ATE381924T1 (de)	2001-09-21	2008-01-15	Egalet As	Feste dispersionen mit kontrollierter freisetzung von carvedilol
WO2003029214A1 (en) *	2001-09-28	2003-04-10	F. Hoffmann-La Roche Ag	Pseudopolymorphic forms of carvedilol
KR20040077872A (ko)	2002-01-15	2004-09-07	테바 파마슈티컬 인더스트리즈 리미티드	카베디롤의 결정질 고체 및 그 제조 방법
AU2003231283A1 (en) *	2002-04-30	2003-11-17	Sb Pharmco Puerto Rico Inc.	Carvedilol monocitrate monohydrate
JP2005533822A (ja)	2002-06-27	2005-11-10	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	臭化水素酸カルベジロール
KR101468827B1 (ko)	2002-06-27	2014-12-03	스미스클라인 비이참 (코르크) 리미티드	카베딜롤 인산염 및(또는) 그의 용매화물, 상응하는 조성물, 및(또는) 치료 방법
AU2003275953A1 (en) *	2002-11-08	2004-06-07	Egalet A/S	Controlled release carvedilol compositions
WO2004084868A1 (en)	2003-03-26	2004-10-07	Egalet A/S	Morphine controlled release system
EP1615888A1 (en) *	2003-04-21	2006-01-18	Matrix Laboratories Ltd	Process for the preparation of carvedilol form-ii
SI21616A (sl) *	2003-09-02	2005-04-30	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nove kristalne oblike karvedilola
EP1686986A4 (en) *	2003-11-25	2009-05-27	Sb Pharmco Inc	CARVEDILOL SALTS, CORRESPONDING COMPOSITIONS, METHODS OF ADMINISTRATION AND / OR TREATMENT
PT1838670E (pt) *	2004-12-09	2009-12-18	Zach System Spa	Processo para a preparação de carvedilol e seus enantiómeros
EP1781611A1 (en) *	2005-06-09	2007-05-09	Teva Pharmaceutical Industries Ltd.	Crystalline forms of carvedilol and processes for their preparation
WO2008002683A2 (en)	2006-06-28	2008-01-03	Teva Pharmaceutical Industries Ltd.	Polymorphous forms of carvedilol phosphate
RU2366653C2 (ru) *	2006-07-03	2009-09-10	Ооо "Нанокриохимия"	Способ получения рентгеноаморфной модификации карведилола
US20080249317A1 (en) *	2007-04-04	2008-10-09	Apotex Inc.	Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
US8821928B2 (en)	2007-06-04	2014-09-02	Egalet Ltd.	Controlled release pharmaceutical compositions for prolonged effect
CA2751667C (en)	2009-02-06	2016-12-13	Egalet Ltd.	Immediate release composition resistant to abuse by intake of alcohol
NZ597283A (en)	2009-06-24	2013-07-26	Egalet Ltd	Controlled release formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2815926A1 (de) *	1978-04-13	1979-10-18	Boehringer Mannheim Gmbh	Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2805404A1 (de) *	1978-02-09	1979-08-16	Merck Patent Gmbh	1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung
DE3319027A1 (de) *	1983-05-26	1984-11-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten

1997
- 1997-07-22 EP EP97112491A patent/EP0893440A1/en not_active Withdrawn
1998
- 1998-07-15 PE PE1998000626A patent/PE96999A1/es not_active Application Discontinuation
- 1998-07-15 MY MYPI98003245A patent/MY117734A/en unknown
- 1998-07-18 BR BR9810776-3A patent/BR9810776A/pt not_active Application Discontinuation
- 1998-07-18 DE DE69812964T patent/DE69812964T2/de not_active Expired - Fee Related
- 1998-07-18 CA CA002296637A patent/CA2296637C/en not_active Expired - Fee Related
- 1998-07-18 PT PT98937576T patent/PT1000027E/pt unknown
- 1998-07-18 YU YU2200A patent/YU2200A/sh unknown
- 1998-07-18 JP JP2000504104A patent/JP2001510824A/ja active Pending
- 1998-07-18 CN CN98807436A patent/CN1125047C/zh not_active Expired - Fee Related
- 1998-07-18 KR KR1020007000667A patent/KR100336229B1/ko not_active Expired - Fee Related
- 1998-07-18 DK DK98937576T patent/DK1000027T3/da active
- 1998-07-18 SI SI9830442T patent/SI1000027T1/xx unknown
- 1998-07-18 IL IL13367798A patent/IL133677A/en not_active IP Right Cessation
- 1998-07-18 HU HU0003198A patent/HUP0003198A3/hu unknown
- 1998-07-18 NZ NZ502136A patent/NZ502136A/en unknown
- 1998-07-18 TR TR2000/00148T patent/TR200000148T2/xx unknown
- 1998-07-18 TW TW087111738A patent/TW505631B/zh not_active IP Right Cessation
- 1998-07-18 EP EP98937576A patent/EP1000027B1/en not_active Expired - Lifetime
- 1998-07-18 AT AT98937576T patent/ATE236123T1/de not_active IP Right Cessation
- 1998-07-18 AU AU86319/98A patent/AU740453B2/en not_active Ceased
- 1998-07-18 PL PL338432A patent/PL191602B1/pl unknown
- 1998-07-18 RU RU2000103033/04A patent/RU2202542C2/ru not_active IP Right Cessation
- 1998-07-18 ES ES98937576T patent/ES2195366T3/es not_active Expired - Lifetime
- 1998-07-18 WO PCT/EP1998/004475 patent/WO1999005105A1/en not_active Ceased
- 1998-07-18 CZ CZ20000221A patent/CZ296947B6/cs not_active IP Right Cessation
- 1998-07-20 MA MA25178A patent/MA26523A1/fr unknown
- 1998-07-21 AR ARP980103547A patent/AR015133A1/es unknown
- 1998-07-21 ZA ZA9806475A patent/ZA986475B/xx unknown
- 1998-07-22 HR HR97112491.2A patent/HRP980406A2/hr not_active Application Discontinuation
- 1998-07-22 UY UY25108A patent/UY25108A1/es not_active IP Right Cessation
2000
- 2000-01-21 NO NO20000301A patent/NO313588B1/no unknown

Also Published As

Publication number	Publication date
EP0893440A1 (en)	1999-01-27
IL133677A (en)	2004-06-01
CZ2000221A3 (cs)	2000-05-17
TW505631B (en)	2002-10-11
HUP0003198A2 (en)	2001-03-28
CA2296637A1 (en)	1999-02-04
KR20010022097A (ko)	2001-03-15
BR9810776A (pt)	2000-09-19
NO20000301D0 (no)	2000-01-21
HRP980406A2 (en)	1999-04-30
AU740453B2 (en)	2001-11-01
DE69812964D1 (de)	2003-05-08
IL133677A0 (en)	2001-04-30
WO1999005105A1 (en)	1999-02-04
NZ502136A (en)	2002-05-31
EP1000027B1 (en)	2003-04-02
PE96999A1 (es)	1999-10-12
MA26523A1 (fr)	2004-12-20
DE69812964T2 (de)	2004-03-04
NO313588B1 (no)	2002-10-28
ES2195366T3 (es)	2003-12-01
JP2001510824A (ja)	2001-08-07
EP1000027A1 (en)	2000-05-17
PT1000027E (pt)	2003-07-31
MY117734A (en)	2004-07-31
TR200000148T2 (tr)	2000-07-21
AR015133A1 (es)	2001-04-18
CN1125047C (zh)	2003-10-22
HUP0003198A3 (en)	2002-10-28
ZA986475B (en)	2000-01-21
DK1000027T3 (da)	2003-07-21
YU2200A (sh)	2002-03-18
CN1264366A (zh)	2000-08-23
SI1000027T1 (en)	2003-10-31
CA2296637C (en)	2005-11-15
UY25108A1 (es)	2000-12-29
ATE236123T1 (de)	2003-04-15
AU8631998A (en)	1999-02-16
HK1029339A1 (en)	2001-03-30
CZ296947B6 (cs)	2006-08-16
KR100336229B1 (ko)	2002-05-09
PL191602B1 (pl)	2006-06-30
RU2202542C2 (ru)	2003-04-20
PL338432A1 (en)	2000-11-06

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