ATE236163T1 - Pyrroloazepinverbindungen - Google Patents

Pyrroloazepinverbindungen

Info

Publication number
ATE236163T1
ATE236163T1 AT92916814T AT92916814T ATE236163T1 AT E236163 T1 ATE236163 T1 AT E236163T1 AT 92916814 T AT92916814 T AT 92916814T AT 92916814 T AT92916814 T AT 92916814T AT E236163 T1 ATE236163 T1 AT E236163T1
Authority
AT
Austria
Prior art keywords
alkyl
aralkyl
aryl
represent
general formula
Prior art date
Application number
AT92916814T
Other languages
English (en)
Inventor
Akira Mizuno
Mikiko Miya
Norio Inomata
Toshio Tatsuoka
Takafumi Ishihara
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ATE236163T1 publication Critical patent/ATE236163T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
AT92916814T 1991-08-07 1992-08-06 Pyrroloazepinverbindungen ATE236163T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22119291 1991-08-07
PCT/JP1992/001009 WO1993003032A1 (fr) 1991-08-07 1992-08-06 Compose de pyrroloazepine

Publications (1)

Publication Number Publication Date
ATE236163T1 true ATE236163T1 (de) 2003-04-15

Family

ID=16762916

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92916814T ATE236163T1 (de) 1991-08-07 1992-08-06 Pyrroloazepinverbindungen

Country Status (9)

Country Link
US (1) US5399557A (de)
EP (1) EP0557526B8 (de)
JP (1) JP3242653B2 (de)
KR (1) KR100243513B1 (de)
AT (1) ATE236163T1 (de)
CA (1) CA2093630C (de)
DE (1) DE69232981T2 (de)
ES (1) ES2196000T3 (de)
WO (1) WO1993003032A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
AU719230B2 (en) * 1995-12-01 2000-05-04 Daiichi Suntory Pharma Co., Ltd Pyrroloazepine derivatives
JPH10251258A (ja) 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
JPH11193290A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物
NZ511674A (en) * 1998-12-23 2003-11-28 Du Pont Pharm Co Nitrogen containing heterobicycles as factor Xa inhibitors
CN101735222B (zh) * 2009-11-02 2012-05-23 中山大学 吡咯并氮杂卓酮类化合物及其作为蛋白酪氨酸磷酸酯酶1b抑制剂的应用
CN102276612B (zh) * 2011-06-21 2013-08-28 中山大学 C-2位取代Aldisin衍生物及其药用盐，它们的药物组合物，及其在制备抗肿瘤药物中的应用
IL283725B2 (en) 2017-06-20 2024-04-01 Imbria Pharmaceuticals Inc Compositions and methods for increasing efficiency of cardiac metabolism
EP3866794B1 (de) 2018-10-17 2024-12-04 Imbria Pharmaceuticals, Inc. Verfahren zur behandlung von rheumatischen erkrankungen unter verwendung von trimetazidinbasierten verbindungen
EP3976101A4 (de) 2019-05-31 2023-06-21 Imbria Pharmaceuticals, Inc. Verfahren zur behandlung von fibrose unter verwendung von verbindungen zur förderung der glucoseoxidation
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563979A (en) * 1966-10-21 1971-02-16 Upjohn Co 1,2,3,4,5,6 - hexahydroazepino(4,3 - b)indoles and 1,2,3,4,5,6-hexahydroazepino(3,2-b)indoles
US3573323A (en) * 1969-02-28 1971-03-30 Upjohn Co 1,2,3,4,5,10-hexahydroazepino(2,3-b)indoles
US3573324A (en) * 1969-02-28 1971-03-30 Upjohn Co 2,3,4,5,10,10a-hexahydroazepino(2,3-b)indoles
JPS62161786A (ja) * 1986-01-08 1987-07-17 Mitsubishi Chem Ind Ltd ピロ−ル化合物
US4729996A (en) * 1986-05-29 1988-03-08 Harbor Branch Oceanographic Institution, Inc. Antitumor compositions and their methods of use
JP3198117B2 (ja) * 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体

Also Published As

Publication number Publication date
JP3242653B2 (ja) 2001-12-25
KR100243513B1 (en) 2000-03-02
ES2196000T3 (es) 2003-12-16
CA2093630C (en) 2004-01-06
EP0557526B8 (de) 2003-08-13
US5399557A (en) 1995-03-21
DE69232981T2 (de) 2004-01-08
CA2093630A1 (en) 1993-02-08
DE69232981D1 (de) 2003-05-08
KR930702355A (ko) 1993-09-08
EP0557526A1 (de) 1993-09-01
WO1993003032A1 (fr) 1993-02-18
EP0557526A4 (de) 1994-08-31
AU2403092A (en) 1993-03-02
AU645441B2 (en) 1994-01-13
EP0557526B1 (de) 2003-04-02

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties