ATE236185T1 - Makrozyklische derivate von erythromycin a und b mit 13 ringatomen - Google Patents

Makrozyklische derivate von erythromycin a und b mit 13 ringatomen

Info

Publication number: ATE236185T1
Authority: AT; Austria
Prior art keywords: erythromycin; ring atoms; macrocyclic derivatives; hypermotilinemia; pharmaceutical compositions
Prior art date: 1996-06-18

Application number

AT97922483T

Other languages

English (en)

Inventor

Paul A Lartey

Cynthia Brunell Curty

Ramin Faghih

Hugh Nerby Nellans

Albert Christian Petersen

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-18

Filing date

1997-04-25

Publication date

2003-04-15

1997-04-25 Application filed by Abbott Lab filed Critical Abbott Lab

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236185T1 publication Critical patent/ATE236185T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
IDRYSCOQVVUBIJ-UHFFFAOYSA-N Erythromycin-B Natural products CC1C(OC2C(C(CC(C)O2)N(C)C)O)C(C)(O)CC(C)C(=O)C(C)C(O)C(C)C(CC)OC(=O)C(C)C1OC1CC(C)(OC)C(O)C(C)O1 IDRYSCOQVVUBIJ-UHFFFAOYSA-N 0.000 title 1
IDRYSCOQVVUBIJ-PPGFLMPOSA-N erythromycin B Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@H]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)C)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 IDRYSCOQVVUBIJ-PPGFLMPOSA-N 0.000 title 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT97922483T 1996-06-18 1997-04-25 Makrozyklische derivate von erythromycin a und b mit 13 ringatomen ATE236185T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/668,050 US5712253A (en)	1996-06-18	1996-06-18	Macrocyclic 13-membered ring derivatives of erythromycins A and B
PCT/US1997/007015 WO1997048713A1 (en)	1996-06-18	1997-04-25	Macrocyclic 13-membered ring derivatives of erythromycins a and b

Publications (1)

Publication Number	Publication Date
ATE236185T1 true ATE236185T1 (de)	2003-04-15

Family

ID=24680797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97922483T ATE236185T1 (de)	1996-06-18	1997-04-25	Makrozyklische derivate von erythromycin a und b mit 13 ringatomen

Country Status (10)

Country	Link
US (1)	US5712253A (de)
EP (1)	EP1021456B1 (de)
JP (1)	JP2000512653A (de)
AT (1)	ATE236185T1 (de)
CA (1)	CA2257361A1 (de)
DE (1)	DE69720551T2 (de)
DK (1)	DK1021456T3 (de)
ES (1)	ES2196331T3 (de)
PT (1)	PT1021456E (de)
WO (1)	WO1997048713A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4968997A (en) *	1996-11-26	1998-06-22	Chugai Seiyaku Kabushiki Kaisha	13-membered ring macrolide compounds, medicine containing the same, and process for producing the same
TW460478B (en)	1997-08-15	2001-10-21	Chugai Pharmaceutical Co Ltd	Phenethylamine derivatives
US5780605A (en) *	1997-09-08	1998-07-14	Abbott Laboratories	6,9-bridged erythromycin derivatives
US6165985A (en) *	1998-02-13	2000-12-26	Solvay Pharmaceuticals Gmbh	11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
DE19805822B4 (de) *	1998-02-13	2009-02-05	Solvay Pharmaceuticals Gmbh	11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
CA2330251A1 (en) *	1998-06-12	1999-12-16	Merck & Co., Inc.	Cloning and identification of the motilin receptor
TW509699B (en)	1998-09-24	2002-11-11	Chugau Pharmaceutical Co Ltd	Ethylamine derivatives
EP1149843A4 (de)	1999-01-28	2012-06-06	Chugai Pharmaceutical Co Ltd	Substituierte phenethylamin-derivate
US7179886B1 (en)	1999-06-08	2007-02-20	Merck & Co., Inc.	Cloning and identification of the motilin receptor
AU2001238476A1 (en)	2000-02-18	2001-08-27	Kosan Biosciences, Inc.	Motocide compounds
AU2002245051A1 (en) *	2000-11-29	2002-07-30	Lifespan Biosciences, Inc.	Diagnostic and therapeutic compositions and methods related to grp 38
US20030186336A1 (en) *	2001-11-29	2003-10-02	Burmer Glenna C.	Diagnostic and therapeutic compositions and methods related to GPCR 38, a G protein-coupled receptor (GPCR)
CN100363359C (zh) *	2002-08-29	2008-01-23	菲塞股份有限公司	运动内酯化合物
TW200420573A (en)	2002-09-26	2004-10-16	Rib X Pharmaceuticals Inc	Bifunctional heterocyclic compounds and methods of making and using same
WO2004111077A1 (en) *	2003-06-18	2004-12-23	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor
US7452862B2 (en)	2003-07-31	2008-11-18	Tranzyme Pharma, Inc.	Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists
EP1648923B1 (de) *	2003-07-31	2008-12-31	Tranzyme Pharma Inc.	Räumlich definierte makrocyclen, die peptidbindungssurrogate enthalten
US20050113319A1 (en) *	2003-08-26	2005-05-26	Christopher Carreras	11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) *	2003-08-26	2008-08-05	Pfizer, Inc.	N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7211568B2 (en) *	2003-12-18	2007-05-01	Kosan Biosciences Incorporated	9-Desoxoerythromycin compounds as prokinetic agents
US8202843B2 (en)	2004-02-27	2012-06-19	Rib-X Pharmaceuticals, Inc.	Macrocyclic compounds and methods of making and using the same
US20080249034A1 (en) *	2005-03-21	2008-10-09	Zambon S.P.A.	Use of Macrolides for Treating Intestinal Inflammation
WO2006102350A1 (en) *	2005-03-23	2006-09-28	Washington University In St. Louis	The use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota
US7582611B2 (en) *	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
US20070135362A1 (en) *	2005-12-08	2007-06-14	Yaoquan Liu	Method for demethylating the 3'-dimethylamino group of erythromycin compounds
US8088733B2 (en)	2006-07-06	2012-01-03	Tranzyme Pharma Inc.	Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
EP2431380A3 (de)	2006-09-11	2013-07-03	Tranzyme Pharma, Inc.	Makrozyklischer Antagonist des Motilinrezeptors zur Behandlung von Magen-Darm-Motilitätsstörungen
RU2422453C2 (ru)	2006-12-05	2011-06-27	Пфайзер Инк.	Полиморфы мотилида
US20080287371A1 (en) *	2007-05-17	2008-11-20	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3878192A (en) *	1972-06-05	1975-04-15	Blasina Lab Chim Farm	Sweet and palatable water soluble derivatives of erythromycin
JPS6187625A (ja) *	1984-10-05	1986-05-06	Satoshi Omura	消化管収縮運動促進剤
US5008249A (en) *	1985-08-31	1991-04-16	Kitasato Kenkyusho	Therapeutic method of stimulating digestive tract contractile motion in mammals
DE3689758T2 (de) *	1985-08-31	1994-08-18	Kitasato Inst	Erythromycinderivat und Verfahren zu dessen Herstellung.
US4640910A (en) *	1985-11-12	1987-02-03	Abbott Laboratories	Erythromycin A silylated compounds and method of use
US4681872A (en) *	1985-11-12	1987-07-21	Abbott Laboratories	Erythromycin A 11,12-carbonate and method of use
JPS63107994A (ja) *	1986-05-02	1988-05-12	Taisho Pharmaceut Co Ltd	エリスロマイシン誘導体
MY103197A (en) *	1987-02-20	1993-05-29	Kitasato Inst	A growth promoting composition and production thereof
US4920102A (en) *	1988-04-18	1990-04-24	Eli Lilly And Company	Method for treating gastrointestinal disorders

1996
- 1996-06-18 US US08/668,050 patent/US5712253A/en not_active Expired - Lifetime
1997
- 1997-04-25 EP EP97922483A patent/EP1021456B1/de not_active Expired - Lifetime
- 1997-04-25 WO PCT/US1997/007015 patent/WO1997048713A1/en not_active Ceased
- 1997-04-25 AT AT97922483T patent/ATE236185T1/de not_active IP Right Cessation
- 1997-04-25 ES ES97922483T patent/ES2196331T3/es not_active Expired - Lifetime
- 1997-04-25 CA CA002257361A patent/CA2257361A1/en not_active Abandoned
- 1997-04-25 PT PT97922483T patent/PT1021456E/pt unknown
- 1997-04-25 DE DE69720551T patent/DE69720551T2/de not_active Expired - Fee Related
- 1997-04-25 DK DK97922483T patent/DK1021456T3/da active
- 1997-04-25 JP JP10502937A patent/JP2000512653A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
US5712253A (en)	1998-01-27
DE69720551D1 (de)	2003-05-08
CA2257361A1 (en)	1997-12-24
ES2196331T3 (es)	2003-12-16
JP2000512653A (ja)	2000-09-26
WO1997048713A1 (en)	1997-12-24
DE69720551T2 (de)	2004-02-26
DK1021456T3 (da)	2003-08-18
PT1021456E (pt)	2003-08-29
EP1021456B1 (de)	2003-04-02
EP1021456A1 (de)	2000-07-26

Legal Events

Date

Code

Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1021456

Country of ref document: EP

2010-01-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE236185T1 (de)	2003-04-15	Makrozyklische derivate von erythromycin a und b mit 13 ringatomen
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
ZA9711607B (en)	1998-06-24	Novel cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
CA2258548A1 (en)	1997-12-31	Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
IL124537A0 (en)	1998-12-06	Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
AP9801253A0 (en)	1999-12-04	9-Oxime erythromycin derivatives.
ZA9711606B (en)	1998-06-25	Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
TR200103395T2 (tr)	2002-04-22	13-metil eritromisin türevleri.
AU697679B2 (en)	1998-10-15	Treatment of tinnitis using neuroprotective agents
GB9322643D0 (en)	1993-12-22	Lactam derivatives
DK0876388T3 (da)	2004-06-07	Tricykliske erythromycinderivater
DE69317877D1 (en)	1998-05-14	4''-deoxyerythromycinderivate
ATE211729T1 (de)	2002-01-15	Therapeutisch wirksame verbindungen
CA2146763A1 (en)	1994-04-28	Quinolone and acridinone derivatives for the treatment of urinary incontinence
CA2286511A1 (en)	2000-04-09	Novel macrolide derivatives
ZA955793B (en)	1996-03-05	Benzothiadiazine compound process for its preparation and the pharmaceutical compositions which contain it
AP9801377A0 (en)	2000-04-29	Tricyclic erythromycin derivatives.
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
AP9801235A0 (en)	1999-11-07	Erythromycin derivatives.
AP9901559A0 (en)	1999-06-30	Tricyclic 3-keto derivatives of 6-0-methylerythromycin.
ATE231878T1 (de)	2003-02-15	3-deoxy-3-descladinosederivate von erythromycin a und b