ATE315066T1 - Cyaninfarbstoffe - Google Patents

Cyaninfarbstoffe

Info

Publication number
ATE315066T1
ATE315066T1 AT01971229T AT01971229T ATE315066T1 AT E315066 T1 ATE315066 T1 AT E315066T1 AT 01971229 T AT01971229 T AT 01971229T AT 01971229 T AT01971229 T AT 01971229T AT E315066 T1 ATE315066 T1 AT E315066T1
Authority
AT
Austria
Prior art keywords
cyanine dyes
dye
compound
formula
biomolecules
Prior art date
Application number
AT01971229T
Other languages
English (en)
Inventor
Ananda G Lugade
Narasimhachari Narayanan
Daniel R Draney
Original Assignee
Li Cor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Li Cor Inc filed Critical Li Cor Inc
Application granted granted Critical
Publication of ATE315066T1 publication Critical patent/ATE315066T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Peptides Or Proteins (AREA)
AT01971229T 2000-09-19 2001-09-18 Cyaninfarbstoffe ATE315066T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23351100P 2000-09-19 2000-09-19

Publications (1)

Publication Number Publication Date
ATE315066T1 true ATE315066T1 (de) 2006-02-15

Family

ID=22877542

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01971229T ATE315066T1 (de) 2000-09-19 2001-09-18 Cyaninfarbstoffe

Country Status (7)

Country Link
US (2) US6995274B2 (de)
EP (1) EP1319047B1 (de)
JP (3) JP4989013B2 (de)
AT (1) ATE315066T1 (de)
CA (1) CA2424454C (de)
DE (1) DE60116510T2 (de)
WO (1) WO2002024815A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172866A1 (en) * 2000-07-07 2007-07-26 Susan Hardin Methods for sequence determination using depolymerizing agent
ATE377093T1 (de) * 2000-07-07 2007-11-15 Visigen Biotechnologies Inc Sequenzbestimmung in echtzeit
DE60116510T2 (de) * 2000-09-19 2006-07-13 Li-Cor, Inc., Lincoln Cyaninfarbstoffe
US7597878B2 (en) 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
AU2002227156A1 (en) 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7668697B2 (en) * 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US20030105299A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US20050249668A1 (en) * 2002-03-29 2005-11-10 Ralph Weissleder Nir-fluorescent cyanine dyes, their synthesis and biological use
US7005518B2 (en) 2002-10-25 2006-02-28 Li-Cor, Inc. Phthalocyanine dyes
US20090186343A1 (en) * 2003-01-28 2009-07-23 Visigen Biotechnologies, Inc. Methods for preparing modified biomolecules, modified biomolecules and methods for using same
US7018775B2 (en) 2003-12-15 2006-03-28 Eastman Kodak Company Infrared absorbing N-alkylsulfate cyanine compounds
WO2005080331A1 (ja) * 2004-02-23 2005-09-01 Tetsuo Nagano 蛍光プローブ
US7312326B2 (en) * 2004-04-09 2007-12-25 Beckman Coulter, Inc. Fluorescent labeled nucleotide derivatives
EP2270106A3 (de) * 2005-04-22 2011-06-29 GE Healthcare UK Limited Fluorhaltige Indoliumverbindungen
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
FR2889700B1 (fr) * 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
JP4889088B2 (ja) * 2005-12-07 2012-02-29 日本化薬株式会社 メチン化合物
US20070281363A1 (en) * 2006-04-13 2007-12-06 Ewald Terpetschnig Luminescent compounds
US20080076188A1 (en) * 2006-06-19 2008-03-27 Patsenker Leonid D Luminescent compounds
US20080091005A1 (en) * 2006-07-20 2008-04-17 Visigen Biotechnologies, Inc. Modified nucleotides, methods for making and using same
US20080241938A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Automated synthesis or sequencing apparatus and method for making and using same
US20080241951A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Method and apparatus for moving stage detection of single molecular events
EP2129788B1 (de) 2007-01-30 2014-09-03 SETA BioMedicals, LLC Lumineszente verbindungen
US8221721B2 (en) * 2007-02-09 2012-07-17 Visen Medical, Inc. Polycyclo dyes and use thereof
DE102007030403A1 (de) * 2007-06-29 2009-01-08 Universität Bielefeld Verfahren zur Verbesserung der Photostabilität von Fluoreszenzfarbstoffen
WO2009023813A1 (en) * 2007-08-15 2009-02-19 Applied Soil Water Technologies Llc Metals recovery from mining heap leach ore
US8367714B2 (en) * 2007-08-28 2013-02-05 Vanderbilt University Cannabinoid receptor targeted agent
ES2523669T3 (es) * 2007-12-20 2014-11-28 Agfa Graphics N.V. Precursor de plancha de impresión litográfica.
US20090214436A1 (en) * 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
CA2723315A1 (en) 2008-04-30 2009-11-05 Ben-Gurion University Of The Negev Research And Development Authority Vascular delivery systems
JP5798043B2 (ja) 2009-02-06 2015-10-21 ベス・イスラエル・ディーコネス・メディカル・センター,インコーポレイテッド 電荷均衡造影剤
JP2012524153A (ja) 2009-04-17 2012-10-11 ライコア インコーポレイテッド 置換シアニン染料を用いた蛍光イメージング
EP2435096A1 (de) 2009-05-27 2012-04-04 Lumicell Diagnostics, Inc. Verfahren und systeme zur räumlichen identifizierung anomaler zellen
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
US8309059B2 (en) 2009-08-31 2012-11-13 Promega Corporation Reactive cyanine compounds
WO2011119114A1 (en) 2010-03-24 2011-09-29 National University Of Singapore Development of photostable near-ir cyanine dyes for in vivo imaging
US10167319B2 (en) 2010-05-29 2019-01-01 Ben-Gurion University Of Negev Research & Development Authority Caged cell penetrating peptide-polymer conjugates for diagnostic and therapeutic applications
WO2012054784A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
WO2013044156A1 (en) * 2011-09-23 2013-03-28 Li-Cor, Inc. Application of reduced dyes in imaging
EP2806781B1 (de) 2012-01-23 2018-03-21 Washington University Brillenbildgebungssysteme und -verfahren
US9763577B2 (en) 2013-03-14 2017-09-19 Lumicell, Inc. Imaging agent for detection of diseased cells
WO2014144702A2 (en) * 2013-03-15 2014-09-18 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
WO2014149069A1 (en) 2013-03-15 2014-09-25 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
EP3019559A4 (de) 2013-08-22 2017-04-05 Sony Corporation Wasserlösliche fluoreszierende oder gefärbte farbstoffe und verfahren zu verwendung
KR101829159B1 (ko) 2014-01-16 2018-02-13 소니 주식회사 수용성 형광 또는 유색 염료
US10588972B2 (en) 2014-06-02 2020-03-17 Li-Cor, Inc. Phthalocyanine probes and uses thereof
US9663554B2 (en) 2014-09-19 2017-05-30 Li-Cor, Inc. Multifunctional protein molecular weight ladders
AR102743A1 (es) 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
US11827661B2 (en) 2015-02-26 2023-11-28 Sony Group Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
KR102646956B1 (ko) 2015-02-26 2024-03-14 소니그룹주식회사 페닐에티닐나프탈렌 염료 및 이의 사용 방법
US10806804B2 (en) 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
CN107709470B (zh) 2015-05-11 2021-01-29 索尼公司 超亮二聚或多聚染料
US20180236089A1 (en) * 2015-08-11 2018-08-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Radiation emitting peptide nucleic acid conjugates and uses thereof for diagnosis, imaging, and treatment of diseases, conditions and disorders
US10300153B2 (en) 2015-11-30 2019-05-28 Asthra, Llc Immunological detection of altered cells
CN109415574B (zh) 2016-04-01 2021-05-28 索尼公司 具有刚性间隔基团的超亮二聚体或聚合物染料
AU2017240154B2 (en) 2016-04-01 2021-08-12 Sony Group Corporation Ultra bright dimeric or polymeric dyes
WO2017177065A2 (en) 2016-04-06 2017-10-12 Sony Corporation Ultra bright dimeric or polymeric dyes with spacing linker groups
EP3455299B1 (de) 2016-05-10 2024-01-17 Sony Group Corporation Zusammensetzungen mit einem polymeren farbstoff und einem cyclodextrin und verwendungen davon
JP7527537B2 (ja) 2016-05-10 2024-08-05 ソニーグループ株式会社 ペプチド骨格を有する超明色ポリマー染料
EP3455300A1 (de) 2016-05-11 2019-03-20 Sony Corporation Ultrahelle dimere oder polymere farbstoffe
EP3464477A1 (de) 2016-06-06 2019-04-10 Sony Corporation Ionische polymere mit fluoreszierenden oder gefärbten reportergruppen
US9796854B1 (en) * 2016-07-07 2017-10-24 Intuitive Surgical Operations, Inc. Method of synthesizing near IR, closed chain sulfo-cyanine dyes
JP7312929B2 (ja) 2016-07-29 2023-07-24 ソニーグループ株式会社 超明色二量体またはポリマー色素およびその調製のための方法
CN109890915B (zh) 2016-10-28 2022-03-01 爱克发有限公司 具有红外吸收染料的喷墨油墨
CN110505886A (zh) 2017-04-11 2019-11-26 利康公司 固体花菁染料
CN107266928B (zh) * 2017-06-19 2019-11-15 中国人民解放军第四军医大学 一种近红外荧光七甲川菁染料及其在制备肿瘤诊断试剂和/或成像试剂中的应用
KR20260011205A (ko) 2017-10-05 2026-01-22 소니그룹주식회사 프로그램가능한 중합체성 약물
WO2019071153A1 (en) 2017-10-05 2019-04-11 Sony Corporation PROGRAMMABLE DENDRITIC MEDICINES
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
US12539334B2 (en) 2018-01-12 2026-02-03 Sony Group Corporation Phosphoalkyl polymers comprising biologically active agents
EP3737417B1 (de) 2018-01-12 2025-08-27 Sony Group Corporation Phosphoalkyl-ribose-polymere mit biologisch aktiven verbindungen
CN111565756A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的具有刚性间隔基团的聚合物
KR102742386B1 (ko) 2018-03-19 2024-12-16 소니그룹주식회사 형광 신호 향상을 위한 2가 금속의 사용
CN118480073A (zh) 2018-03-21 2024-08-13 索尼公司 具有连接体基团的聚合串联染料
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
KR20210032434A (ko) 2018-07-13 2021-03-24 소니 주식회사 유기인산염 단위를 포함하는 백본을 갖는 중합체성 염료
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups
EP4038081A1 (de) 2019-09-30 2022-08-10 Sony Group Corporation Nukleotidsonden
US11712482B2 (en) 2019-12-13 2023-08-01 Washington University Near infrared fluorescent dyes, formulations and related methods
CA3167456A1 (en) * 2020-02-10 2021-08-19 C-Biomex Co., Ltd. Amphoteric fluorescent substance capable of being attached to biomaterials
JP7747660B2 (ja) 2020-06-23 2025-10-01 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 近赤外シアニン色素およびそのコンジュゲート
EP4256078A1 (de) 2020-12-07 2023-10-11 Sony Group Corporation Abstandslinkergruppendesign zur helligkeitsverstärkung in dimeren oder polymeren farbstoffen

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571388A (en) * 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
DE3912046B4 (de) * 1988-09-02 2004-03-25 Carnegie Mellon University Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt
JP2955803B2 (ja) * 1992-07-22 1999-10-04 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
JPH06123740A (ja) * 1992-10-12 1994-05-06 Canon Inc 蛋白質標識用(メロ)シアニン色素、及び色素標識蛋白質
JPH06145539A (ja) * 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
US5556959A (en) * 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
DE4326466A1 (de) 1993-08-06 1995-02-09 Boehringer Mannheim Gmbh Infrarot-Farbstoff-markierte Nucleotide und ihre Verwendung in der Nucleinsäure-Detektion
US5519145A (en) * 1994-02-14 1996-05-21 E. I. Du Pont De Nemours And Company Photographic element with ether dyes for near-infrared antihalation
JPH07287346A (ja) * 1994-04-08 1995-10-31 E I Du Pont De Nemours & Co 近赤外ハレーション防止用の新規なエーテル色素を有する写真エレメント
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
ATE264694T1 (de) * 1995-01-30 2004-05-15 Daiichi Pure Chemicals Co Ltd Diagnostisches markierungsmittel
IT1276833B1 (it) * 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
US6027709A (en) * 1997-01-10 2000-02-22 Li-Cor Inc. Fluorescent cyanine dyes
JP4024354B2 (ja) * 1997-01-21 2007-12-19 富士フイルム株式会社 ハロゲン化銀写真感光材料およびヘプタメチンシアニン化合物
GB9710049D0 (en) 1997-05-19 1997-07-09 Nycomed Imaging As Method
EP1037947B1 (de) * 1997-07-28 2003-09-10 Amersham plc Cyaninfarbstoffe
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
DE19911102A1 (de) * 1999-03-12 2000-09-14 Few Chemicals Gmbh Wolfen Cyanin-Farbstoffe
US6642375B2 (en) * 1999-12-07 2003-11-04 Fuji Photo Film Co., Ltd. Fluorescent substances
US6180087B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
DE60116510T2 (de) 2000-09-19 2006-07-13 Li-Cor, Inc., Lincoln Cyaninfarbstoffe
DE10055093A1 (de) * 2000-11-07 2002-05-16 Agfa Gevaert Ag Cyaninfarbstoff
EP1221465A1 (de) * 2001-01-03 2002-07-10 Innosense S.r.l. Symmetrische, monofunktionalisierte Polymethinfarbstoffe als Markierungsreagenzien
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
US20100142643A1 (en) * 2007-07-27 2010-06-10 Panasonic Corporation Multi-carrier signal transmitter, multi-carrier signal receiver, and method of transmitting and receiving multi-carrier signal

Also Published As

Publication number Publication date
WO2002024815A1 (en) 2002-03-28
US6995274B2 (en) 2006-02-07
JP2004510011A (ja) 2004-04-02
US20060063247A1 (en) 2006-03-23
US7504089B2 (en) 2009-03-17
DE60116510D1 (de) 2006-03-30
DE60116510T2 (de) 2006-07-13
US20040014981A1 (en) 2004-01-22
CA2424454C (en) 2010-07-20
EP1319047A1 (de) 2003-06-18
EP1319047B1 (de) 2006-01-04
CA2424454A1 (en) 2002-03-28
JP4989013B2 (ja) 2012-08-01
JP2014065919A (ja) 2014-04-17
JP2012021161A (ja) 2012-02-02

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