ATE315066T1 - Cyaninfarbstoffe - Google Patents
CyaninfarbstoffeInfo
- Publication number
- ATE315066T1 ATE315066T1 AT01971229T AT01971229T ATE315066T1 AT E315066 T1 ATE315066 T1 AT E315066T1 AT 01971229 T AT01971229 T AT 01971229T AT 01971229 T AT01971229 T AT 01971229T AT E315066 T1 ATE315066 T1 AT E315066T1
- Authority
- AT
- Austria
- Prior art keywords
- cyanine dyes
- dye
- compound
- formula
- biomolecules
- Prior art date
Links
- 239000000975 dye Substances 0.000 title 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000002372 labelling Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23351100P | 2000-09-19 | 2000-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE315066T1 true ATE315066T1 (de) | 2006-02-15 |
Family
ID=22877542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01971229T ATE315066T1 (de) | 2000-09-19 | 2001-09-18 | Cyaninfarbstoffe |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6995274B2 (de) |
| EP (1) | EP1319047B1 (de) |
| JP (3) | JP4989013B2 (de) |
| AT (1) | ATE315066T1 (de) |
| CA (1) | CA2424454C (de) |
| DE (1) | DE60116510T2 (de) |
| WO (1) | WO2002024815A1 (de) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070172866A1 (en) * | 2000-07-07 | 2007-07-26 | Susan Hardin | Methods for sequence determination using depolymerizing agent |
| EP2100971A3 (de) * | 2000-07-07 | 2009-11-25 | Visigen Biotechnologies, Inc. | Echtzeit-Sequenzbestimmung |
| WO2002024815A1 (en) * | 2000-09-19 | 2002-03-28 | Li-Cor, Inc. | Cyanine dyes |
| US7597878B2 (en) | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
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| US7668697B2 (en) * | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
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| US20090186343A1 (en) * | 2003-01-28 | 2009-07-23 | Visigen Biotechnologies, Inc. | Methods for preparing modified biomolecules, modified biomolecules and methods for using same |
| US7018775B2 (en) | 2003-12-15 | 2006-03-28 | Eastman Kodak Company | Infrared absorbing N-alkylsulfate cyanine compounds |
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| FR2889700B1 (fr) * | 2005-08-11 | 2012-11-23 | Synthinnove Lab | Marqueurs, leur procede de fabrication et leurs applications |
| JP4889088B2 (ja) * | 2005-12-07 | 2012-02-29 | 日本化薬株式会社 | メチン化合物 |
| US20070281363A1 (en) * | 2006-04-13 | 2007-12-06 | Ewald Terpetschnig | Luminescent compounds |
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| US20080241938A1 (en) * | 2006-07-20 | 2008-10-02 | Visigen Biotechnologies, Inc. | Automated synthesis or sequencing apparatus and method for making and using same |
| US20080091005A1 (en) * | 2006-07-20 | 2008-04-17 | Visigen Biotechnologies, Inc. | Modified nucleotides, methods for making and using same |
| EP2129788B1 (de) | 2007-01-30 | 2014-09-03 | SETA BioMedicals, LLC | Lumineszente verbindungen |
| EP2118206B9 (de) | 2007-02-09 | 2018-08-29 | Visen Medical, Inc. | Polycyclofarbstoffe und verwendung davon |
| DE102007030403A1 (de) * | 2007-06-29 | 2009-01-08 | Universität Bielefeld | Verfahren zur Verbesserung der Photostabilität von Fluoreszenzfarbstoffen |
| WO2009023813A1 (en) * | 2007-08-15 | 2009-02-19 | Applied Soil Water Technologies Llc | Metals recovery from mining heap leach ore |
| US8367714B2 (en) * | 2007-08-28 | 2013-02-05 | Vanderbilt University | Cannabinoid receptor targeted agent |
| EP2072570B1 (de) * | 2007-12-20 | 2014-10-08 | Agfa Graphics N.V. | Vorprodukt einer lithografischen Druckplatte |
| US20090214436A1 (en) * | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| CA2723315A1 (en) | 2008-04-30 | 2009-11-05 | Ben-Gurion University Of The Negev Research And Development Authority | Vascular delivery systems |
| SG2014009146A (en) | 2009-02-06 | 2014-05-29 | Beth Israel Hospital | Charge-balanced imaging agents |
| EP2419478B1 (de) | 2009-04-17 | 2018-02-28 | Li-Cor, Inc. | Fluoreszenzbasierte bildgebung mit substituierten cyaninfarbstoffen |
| US20110021908A1 (en) | 2009-05-27 | 2011-01-27 | Lumicell Diagnostics, Inc. | Methods and systems for spatially identifying abnormal cells |
| US9155471B2 (en) | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
| JP5730311B2 (ja) | 2009-08-31 | 2015-06-10 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 反応性シアニン化合物 |
| EP2550338A4 (de) | 2010-03-24 | 2014-03-05 | Univ Singapore | Entwicklung photostabiler nahinfrarot-cyanin-farbstoffe für die in-vivo-bildgebung |
| US10167319B2 (en) | 2010-05-29 | 2019-01-01 | Ben-Gurion University Of Negev Research & Development Authority | Caged cell penetrating peptide-polymer conjugates for diagnostic and therapeutic applications |
| EP2630196B1 (de) * | 2010-10-20 | 2017-09-06 | Li-Cor, Inc. | Cyaninfarbstoffe und deren konjugate |
| US9314304B2 (en) | 2010-12-08 | 2016-04-19 | Lumicell, Inc. | Methods and system for image guided cell ablation with microscopic resolution |
| AU2012312041B2 (en) | 2011-09-23 | 2017-03-16 | Li-Cor, Inc. | Application of reduced dyes in imaging |
| EP3553075B1 (de) | 2012-01-23 | 2025-01-08 | Washington University | Brillenbildgebungssysteme und -verfahren |
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| EP3019559A4 (de) | 2013-08-22 | 2017-04-05 | Sony Corporation | Wasserlösliche fluoreszierende oder gefärbte farbstoffe und verfahren zu verwendung |
| EP3094687B1 (de) | 2014-01-16 | 2020-02-12 | Sony Corporation | Wasserlösliche fluoreszierende oder gefärbte farbstoffe |
| EP3148583B1 (de) | 2014-06-02 | 2020-04-29 | Li-Cor, Inc. | Phthalocyaninsonden und verwendungen davon |
| US9663554B2 (en) | 2014-09-19 | 2017-05-30 | Li-Cor, Inc. | Multifunctional protein molecular weight ladders |
| AR102743A1 (es) | 2014-11-26 | 2017-03-22 | Li Cor Inc | Medios de contraste ir para imágenes por fluorescencia |
| KR102646956B1 (ko) | 2015-02-26 | 2024-03-14 | 소니그룹주식회사 | 페닐에티닐나프탈렌 염료 및 이의 사용 방법 |
| WO2016138461A1 (en) | 2015-02-26 | 2016-09-01 | Sony Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| WO2016179350A1 (en) | 2015-05-06 | 2016-11-10 | Washington University | Compounds having rd targeting motifs and methods of use thereof |
| KR102765335B1 (ko) | 2015-05-11 | 2025-02-13 | 소니그룹주식회사 | 초휘도 이량체성 또는 중합체성 염료 |
| WO2017025968A1 (en) * | 2015-08-11 | 2017-02-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Radiation emitting peptide nucleic acid conjugates and uses thereof for diagnosis, imaging, and treatment of diseases, conditions and disorders |
| US10300153B2 (en) | 2015-11-30 | 2019-05-28 | Asthra, Llc | Immunological detection of altered cells |
| BR112018070164B1 (pt) | 2016-04-01 | 2022-09-27 | Sony Corporation Of America | Corantes diméricos ou poliméricos ultrabrilhantes |
| EP3436528B1 (de) | 2016-04-01 | 2025-07-02 | Sony Group Corporation | Ultrahelle dimere oder polymere farbstoffe mit gruppen mit starrem abstand |
| CN109153860B (zh) | 2016-04-06 | 2021-04-23 | 索尼公司 | 具有间隔连接体基团的超高亮二聚体或聚合物染料 |
| JP7527537B2 (ja) | 2016-05-10 | 2024-08-05 | ソニーグループ株式会社 | ペプチド骨格を有する超明色ポリマー染料 |
| US11390754B2 (en) | 2016-05-10 | 2022-07-19 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| BR112018073199A2 (pt) | 2016-05-11 | 2019-04-16 | Sony Corporation | corantes diméricos ou poliméricos ultrabrilhantes |
| EP3464477A1 (de) | 2016-06-06 | 2019-04-10 | Sony Corporation | Ionische polymere mit fluoreszierenden oder gefärbten reportergruppen |
| US9796854B1 (en) * | 2016-07-07 | 2017-10-24 | Intuitive Surgical Operations, Inc. | Method of synthesizing near IR, closed chain sulfo-cyanine dyes |
| WO2018022925A1 (en) | 2016-07-29 | 2018-02-01 | Sony Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| EP3532551B1 (de) | 2016-10-28 | 2022-01-12 | Agfa Nv | Tintenstrahltinten mit ir-absorbierendem farbstoff |
| EP3609543A1 (de) | 2017-04-11 | 2020-02-19 | Li-Cor, Inc. | Feste cyaninfarbstoffe |
| CN107266928B (zh) * | 2017-06-19 | 2019-11-15 | 中国人民解放军第四军医大学 | 一种近红外荧光七甲川菁染料及其在制备肿瘤诊断试剂和/或成像试剂中的应用 |
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| KR20260011205A (ko) | 2017-10-05 | 2026-01-22 | 소니그룹주식회사 | 프로그램가능한 중합체성 약물 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| WO2019140128A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| US12076407B2 (en) | 2018-01-12 | 2024-09-03 | Sony Group Corporation | Polymers with rigid spacing groups comprising biologically active compounds |
| EP3737417B1 (de) | 2018-01-12 | 2025-08-27 | Sony Group Corporation | Phosphoalkyl-ribose-polymere mit biologisch aktiven verbindungen |
| EP3769085B1 (de) | 2018-03-19 | 2022-08-24 | Sony Group Corporation | Verwendung von zweiwertigen metallen zur verstärkung von fluoreszenzsignalen |
| KR102864292B1 (ko) | 2018-03-21 | 2025-09-26 | 소니그룹주식회사 | 링커 군을 갖는 중합체성 텐덤 염료 |
| JP7580689B2 (ja) | 2018-06-27 | 2024-11-12 | ソニーグループ株式会社 | デオキシリボースを含むリンカー基を有するポリマー色素 |
| US12578342B2 (en) | 2018-07-13 | 2026-03-17 | Sony Group Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| EP3861074A2 (de) | 2019-09-26 | 2021-08-11 | Sony Group Corporation | Polymere tandemfarbstoffe mit linkergruppen |
| EP4038081A1 (de) | 2019-09-30 | 2022-08-10 | Sony Group Corporation | Nukleotidsonden |
| WO2021119423A1 (en) | 2019-12-13 | 2021-06-17 | Washington University | Near infrared fluorescent dyes, formulations and related methods |
| JP7587292B2 (ja) * | 2020-02-10 | 2024-11-20 | シーバイオメックス カンパニー リミテッド | 生体物質と連結し得る両性蛍光物質 |
| US11851421B2 (en) | 2020-06-23 | 2023-12-26 | Bracco Imaging S.P.A. | Near-infrared cyanine dyes and conjugates thereof |
| EP4256078A1 (de) | 2020-12-07 | 2023-10-11 | Sony Group Corporation | Abstandslinkergruppendesign zur helligkeitsverstärkung in dimeren oder polymeren farbstoffen |
| JP2023159873A (ja) * | 2022-04-20 | 2023-11-01 | 三菱ケミカル株式会社 | 化合物 |
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| US5571388A (en) * | 1984-03-29 | 1996-11-05 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof |
| US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| DE3912046B4 (de) * | 1988-09-02 | 2004-03-25 | Carnegie Mellon University | Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt |
| JP2955803B2 (ja) * | 1992-07-22 | 1999-10-04 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| JPH06123740A (ja) * | 1992-10-12 | 1994-05-06 | Canon Inc | 蛋白質標識用（メロ）シアニン色素、及び色素標識蛋白質 |
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-
2001
- 2001-09-18 WO PCT/US2001/029385 patent/WO2002024815A1/en not_active Ceased
- 2001-09-18 JP JP2002529216A patent/JP4989013B2/ja not_active Expired - Lifetime
- 2001-09-18 DE DE60116510T patent/DE60116510T2/de not_active Expired - Lifetime
- 2001-09-18 EP EP01971229A patent/EP1319047B1/de not_active Expired - Lifetime
- 2001-09-18 CA CA2424454A patent/CA2424454C/en not_active Expired - Lifetime
- 2001-09-18 AT AT01971229T patent/ATE315066T1/de not_active IP Right Cessation
-
2003
- 2003-01-28 US US10/354,812 patent/US6995274B2/en not_active Expired - Lifetime
-
2005
- 2005-11-04 US US11/267,643 patent/US7504089B2/en not_active Expired - Lifetime
-
2011
- 2011-09-05 JP JP2011192233A patent/JP2012021161A/ja active Pending
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2013
- 2013-12-16 JP JP2013258977A patent/JP2014065919A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2424454C (en) | 2010-07-20 |
| WO2002024815A1 (en) | 2002-03-28 |
| US20060063247A1 (en) | 2006-03-23 |
| JP2004510011A (ja) | 2004-04-02 |
| EP1319047B1 (de) | 2006-01-04 |
| EP1319047A1 (de) | 2003-06-18 |
| US7504089B2 (en) | 2009-03-17 |
| US20040014981A1 (en) | 2004-01-22 |
| US6995274B2 (en) | 2006-02-07 |
| JP2014065919A (ja) | 2014-04-17 |
| DE60116510D1 (de) | 2006-03-30 |
| JP4989013B2 (ja) | 2012-08-01 |
| DE60116510T2 (de) | 2006-07-13 |
| JP2012021161A (ja) | 2012-02-02 |
| CA2424454A1 (en) | 2002-03-28 |
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