ATE236632T1 - Inhibitoren der protein-isoprenyl-transferase - Google Patents

Inhibitoren der protein-isoprenyl-transferase

Info

Publication number: ATE236632T1
Authority: AT; Austria
Prior art keywords: heterocyclic; formula; protein isoprenyl; protein; haloalkyl
Prior art date: 1995-11-06

Application number

AT96938647T

Other languages

English (en)

Inventor

Said M Sebti

Andrew D Hamilton

Saul H Rosenberg

David J Augeri

Kenneth J Barr

Bernard G Donner

Stephen A Fakhhoury

David A Janowick

Douglas M Kalvin

John J Larsen

Gang Liu

Stephen J O'connor

Wang Shen

Rolf E Swenson

Bryan K Sorenson

Gerard M Sullivan

Bruce Szczepankiewicz

Andrew S Tasker

James T Wasicak

Martin Winn

Original Assignee

Univ Pittsburgh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-06

Filing date

1996-11-05

Publication date

2003-04-15

1996-11-05 Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236632T1 publication Critical patent/ATE236632T1/de

Links

101710163622 Isoprenyl transferase Proteins 0.000 title abstract 4
239000003558 transferase inhibitor Substances 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001188 haloalkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002883 imidazolyl group Chemical group 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
-1 arylakyl Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005309 thioalkoxy group Chemical group 0.000 abstract 1

Classifications

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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
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General Health & Medical Sciences (AREA)
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Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Enzymes And Modification Thereof (AREA)

AT96938647T 1995-11-06 1996-11-05 Inhibitoren der protein-isoprenyl-transferase ATE236632T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US724795P	1995-11-06	1995-11-06
PCT/US1996/017092 WO1997017070A1 (en)	1995-11-06	1996-11-05	Inhibitors of protein isoprenyl transferases

Publications (1)

Publication Number	Publication Date
ATE236632T1 true ATE236632T1 (de)	2003-04-15

Family

ID=21725070

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96938647T ATE236632T1 (de)	1995-11-06	1996-11-05	Inhibitoren der protein-isoprenyl-transferase

Country Status (12)

Country	Link
EP (1)	EP0873123B1 (de)
JP (1)	JP4533466B2 (de)
AT (1)	ATE236632T1 (de)
AU (1)	AU7597596A (de)
CA (1)	CA2235986C (de)
DE (1)	DE69627377T2 (de)
DK (1)	DK0873123T3 (de)
ES (1)	ES2196186T3 (de)
MX (1)	MX9803589A (de)
PT (1)	PT873123E (de)
WO (1)	WO1997017070A1 (de)
ZA (1)	ZA969273B (de)

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1996
- 1996-11-05 AT AT96938647T patent/ATE236632T1/de active
- 1996-11-05 ZA ZA9609273A patent/ZA969273B/xx unknown
- 1996-11-05 EP EP96938647A patent/EP0873123B1/de not_active Expired - Lifetime
- 1996-11-05 CA CA002235986A patent/CA2235986C/en not_active Expired - Lifetime
- 1996-11-05 PT PT96938647T patent/PT873123E/pt unknown
- 1996-11-05 DK DK96938647T patent/DK0873123T3/da active
- 1996-11-05 DE DE69627377T patent/DE69627377T2/de not_active Expired - Lifetime
- 1996-11-05 ES ES96938647T patent/ES2196186T3/es not_active Expired - Lifetime
- 1996-11-05 JP JP51820897A patent/JP4533466B2/ja not_active Expired - Lifetime
- 1996-11-05 AU AU75975/96A patent/AU7597596A/en not_active Abandoned
- 1996-11-05 WO PCT/US1996/017092 patent/WO1997017070A1/en not_active Ceased
1998
- 1998-05-06 MX MX9803589A patent/MX9803589A/es unknown

Also Published As

Publication number	Publication date
CA2235986C (en)	2006-09-12
EP0873123A1 (de)	1998-10-28
WO1997017070A1 (en)	1997-05-15
ES2196186T3 (es)	2003-12-16
EP0873123A4 (de)	1999-02-03
DK0873123T3 (da)	2003-08-04
EP0873123B1 (de)	2003-04-09
DE69627377D1 (de)	2003-05-15
DE69627377T2 (de)	2004-02-05
PT873123E (pt)	2003-08-29
JP2000500745A (ja)	2000-01-25
ZA969273B (en)	1998-05-05
CA2235986A1 (en)	1997-05-15
MX9803589A (es)	1998-11-30
AU7597596A (en)	1997-05-29
JP4533466B2 (ja)	2010-09-01

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